| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ruosi Yao, Xiaoyang Sun, Yu Xie, Linlin Liu, Danyang Han, Yao Yao, Hujun Li, Zhenyu Li, Kailin X. Lithium chloride inhibits cell survival, overcomes drug resistance, and triggers apoptosis in multiple myeloma via activation of the Wnt/β-catenin pathway. American journal of translational research. vol 10. issue 8. 2020-09-30. PMID:30210697. |
moreover, licl overcomes bortezomib (btz)-mediated resistance in mm cells and induces apoptosis in btz-resistant cells. |
2020-09-30 |
2023-08-13 |
Not clear |
| Ruosi Yao, Xiaoyang Sun, Yu Xie, Linlin Liu, Danyang Han, Yao Yao, Hujun Li, Zhenyu Li, Kailin X. Lithium chloride inhibits cell survival, overcomes drug resistance, and triggers apoptosis in multiple myeloma via activation of the Wnt/β-catenin pathway. American journal of translational research. vol 10. issue 8. 2020-09-30. PMID:30210697. |
overall, our results define licl as an inducer of mm cell apoptosis and unveil a crosstalk between btz and licl in facilitating cell apoptosis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Cesarina Giallongo, Daniele Tibullo, Fabrizio Puglisi, Alessandro Barbato, Nunzio Vicario, Daniela Cambria, Nunziatina Laura Parrinello, Alessandra Romano, Concetta Conticello, Stefano Forte, Rosalba Parenti, Angela Maria Amorini, Giuseppe Lazzarino, Giovanni Li Volti, Giuseppe Alberto Palumbo, Francesco Di Raimond. Inhibition of TLR4 Signaling Affects Mitochondrial Fitness and Overcomes Bortezomib Resistance in Myeloma Plasma Cells. Cancers. vol 12. issue 8. 2020-09-28. PMID:32707760. |
a combination of btz with tak-242, a selective tlr4 inhibitor, overcame drug resistance through the generation of higher and extended oxidative stress, strong mitochondrial depolarization and severe impairment of mitochondrial fitness which in turn caused cell energy crisis and activated mitophagy and apoptosis. |
2020-09-28 |
2023-08-13 |
human |
| Qingxiu Dang, Lili Chen, Mengqi Xu, Xuefen You, Hong Zhou, Yaping Zhang, Wenyu Sh. The γ-secretase inhibitor GSI-I interacts synergistically with the proteasome inhibitor bortezomib to induce ALK+ anaplastic large cell lymphoma cell apoptosis. Cellular signalling. vol 59. 2020-08-03. PMID:30878517. |
we found that alk+ alcl cells treated with the btz and gsi-i combination treatment showed elevated apoptosis, consistent with increased caspase activation, compared with btz or gsi-i alone. |
2020-08-03 |
2023-08-13 |
Not clear |
| Yubo Liu, Xue Wang, Tong Zhu, Nana Zhang, Lingyan Wang, Tianmiao Huang, Yu Cao, Wenli Li, Jianing Zhan. Resistance to bortezomib in breast cancer cells that downregulate Bim through FOXA1 O-GlcNAcylation. Journal of cellular physiology. vol 234. issue 10. 2020-06-08. PMID:30793308. |
bortezomib (btz), a well-established proteasome inhibitor used in the clinical therapy, leads the modulation of several biological alterations and in turn induces apoptosis. |
2020-06-08 |
2023-08-13 |
Not clear |
| Yafang Pan, Yu Zhang, Wenwen Liu, Yan Huang, Xianjuan Shen, Rongrong Jing, Jiang Pu, Xudong Wang, Shaoqing Ju, Hui Cong, Hongmei Che. LncRNA H19 overexpression induces bortezomib resistance in multiple myeloma by targeting MCL-1 via miR-29b-3p. Cell death & disease. vol 10. issue 2. 2020-06-04. PMID:30728351. |
it was found that h19 reduced cell sensitivity to the chemotherapeutic drug btz by working as a mirna sponge to inhibit the expression of mir-29b-3p, enhance mcl-1 transcriptional translation and inhibit apoptosis. |
2020-06-04 |
2023-08-13 |
Not clear |
| Gongwei Xiao, Yanqing Li, Yanyu Wang, Bingbing Zhao, Zhilan Zou, Shuang Hou, Xiaohong Jia, Xi Liu, Ye Yao, Jun Wan, Hong Xion. LncRNA PRAL is closely related to clinical prognosis of multiple myeloma and the bortezomib sensitivity. Experimental cell research. vol 370. issue 2. 2019-09-17. PMID:29944867. |
then cell proliferation, viability, ki67 expression, and caspase-3 activity detection showed that pral promoted mm cell growth inhibition and apoptosis, and potentiated the anti-mm effect of btz in vitro. |
2019-09-17 |
2023-08-13 |
Not clear |
| Chuiming Jia, Dejuan Kong, Yiwei Guo, Lianqiao Li, Lina Qua. Enhanced antitumor effect of combination of annexin A1 knockdown and bortezomib treatment in multiple myeloma in vitro and in vivo. Biochemical and biophysical research communications. vol 505. issue 3. 2019-05-28. PMID:30292410. |
cell apoptosis was dramatically promoted in mm cells following silencing of anxa1 and btz administration versus that in anxa1-silenced alone or btz-treated alone cells, as evidenced by decreased expression of phosphorylated signal transducers and activators of transcription 3 and bcl2, and increased expression of bax. |
2019-05-28 |
2023-08-13 |
Not clear |
| Francesca Punzo, Chiara Tortora, Daniela Di Pinto, Elvira Pota, Maura Argenziano, Alessandra Di Paola, Fiorina Casale, Francesca Ross. Bortezomib and endocannabinoid/endovanilloid system: a synergism in osteosarcoma. Pharmacological research. vol 137. 2019-04-22. PMID:30267762. |
bortezomib (btz) is an approved anticancer drug, classified as a selective reversible inhibitor of the ubiquitin-dependent proteasome system, that leads to cancer cell cycle arrest and apoptosis reducing the invasion ability of osteosarcoma cells in vitro. |
2019-04-22 |
2023-08-13 |
Not clear |
| Francesca Punzo, Chiara Tortora, Daniela Di Pinto, Elvira Pota, Maura Argenziano, Alessandra Di Paola, Fiorina Casale, Francesca Ross. Bortezomib and endocannabinoid/endovanilloid system: a synergism in osteosarcoma. Pharmacological research. vol 137. 2019-04-22. PMID:30267762. |
we analyzed the effects of btz, alone and in combination with selective agonists at cb2 (jwh-133) and trpv1 (rtx) receptors, in the osteosarcoma cell line (hos) on apoptosis, cell cycle progression, migration and bone balance. |
2019-04-22 |
2023-08-13 |
Not clear |
| Francesca Punzo, Chiara Tortora, Daniela Di Pinto, Elvira Pota, Maura Argenziano, Alessandra Di Paola, Fiorina Casale, Francesca Ross. Bortezomib and endocannabinoid/endovanilloid system: a synergism in osteosarcoma. Pharmacological research. vol 137. 2019-04-22. PMID:30267762. |
we observed that the stimulation of cb2 and trpv1 receptors increase the efficacy of btz in inducing apoptosis and reducing invasion, cell cycle progression and by modulating bone balance. |
2019-04-22 |
2023-08-13 |
Not clear |
| Hak-Min Lee, Eunmyong Lee, So-Young Yeo, Sang Shin, Hyun-Kyu Park, Do-Hyun Nam, Seok-Hyung Ki. Drug repurposing screening identifies bortezomib and panobinostat as drugs targeting cancer associated fibroblasts (CAFs) by synergistic induction of apoptosis. Investigational new drugs. vol 36. issue 4. 2019-03-27. PMID:29349597. |
it was confirmed that btz and pst could decrease the viability of various patients derived cafs through inducing of caspase-3 mediated apoptosis. |
2019-03-27 |
2023-08-13 |
mouse |
| Changping Wang, Huajun Sang, Yitong Wang, Fang Zhu, Xinhao Hu, Xinyu Wang, Xing Wang, Yiwen Li, Yiyun Chen. Foe to Friend: Supramolecular Nanomedicines Consisting of Natural Polyphenols and Bortezomib. Nano letters. vol 18. issue 11. 2018-12-11. PMID:30264573. |
our investigation revealed that the supramolecular nanomedicine consisting of natural polyphenol, btz and ferric ion dramatically induced apoptosis on cancer cells and suppressed tumor growth in both subcutaneous and bone tumor models with limited adverse effects. |
2018-12-11 |
2023-08-13 |
Not clear |
| Chun Xie, Ai-Ping Tan. [Combined Effect of Bortezomib and Homoharringtonine on K562 Cells and their Mechanisms]. Zhongguo shi yan xue ye xue za zhi. vol 26. issue 2. 2018-10-25. PMID:29665904. |
to explore the effects of btz plus hht on proliferation and apoptosis of k562 cells, and to clarify the relationship between the mechanism inderlying the effect of btz plus hht on k562 cells and bcl-2, bax, mcl-1 proteins. |
2018-10-25 |
2023-08-13 |
Not clear |
| Teru Hideshima, Jun Qi, Ronald M Paranal, Weiping Tang, Edward Greenberg, Nathan West, Meaghan E Colling, Guillermina Estiu, Ralph Mazitschek, Jennifer A Perry, Hiroto Ohguchi, Francesca Cottini, Naoya Mimura, Güllü Görgün, Yu-Tzu Tai, Paul G Richardson, Ruben D Carrasco, Olaf Wiest, Stuart L Schreiber, Kenneth C Anderson, James E Bradne. Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 46. 2018-04-27. PMID:27799547. |
wt161 in combination with btz triggers significant accumulation of polyubiquitinated proteins and cell stress, followed by caspase activation and apoptosis. |
2018-04-27 |
2023-08-13 |
mouse |
| Juan J Gu, Gregory P Kaufman, Cory Mavis, Myron S Czuczman, Francisco J Hernandez-Ilizaliturr. Mitotic catastrophe and cell cycle arrest are alternative cell death pathways executed by bortezomib in rituximab resistant B-cell lymphoma cells. Oncotarget. vol 8. issue 8. 2017-09-18. PMID:28055975. |
our data suggest that btz can induce apoptosis or mitotic catastrophe and that p21 has a pivotal role in btz activity against rrcl. |
2017-09-18 |
2023-08-13 |
Not clear |
| Hao Xi, Lu Li, Juan Du, Ran An, Rong Fan, Jing Lu, Yin-Xiang Wu, Shu-Xie Wu, Jian Hou, Li-Ming Zha. hsa-miR-631 resensitizes bortezomib-resistant multiple myeloma cell lines by inhibiting UbcH10. Oncology reports. vol 37. issue 2. 2017-04-11. PMID:28000886. |
following overexpression of mir-631, both btz sensitivity and btz-induced apoptosis were enhanced in the resistant cells. |
2017-04-11 |
2023-08-13 |
Not clear |
| Masaki R. Endoplasmic-reticulum stress pathway-associated mechanisms of action of proteasome inhibitors in multiple myeloma. International journal of hematology. vol 104. issue 3. 2017-03-16. PMID:27169614. |
low levels of xbp1, atf3, and atf4, which regulate upr and er stress-induced apoptosis, have been observed in poor responders to btz treatment, and three other genes, klf9, nampt, and cdk5, are associated with response to btz-containing therapy. |
2017-03-16 |
2023-08-13 |
Not clear |
| Ling-Ling Zhao, Yuan-Fang Liu, Li-Jun Peng, Ai-Mei Fei, Wen Cui, Sheng-Chao Miao, Olivier Hermine, Remy Gressin, Saadi Khochbin, Sai-Juan Chen, Jin Wang, Jian-Qing M. Arsenic trioxide rewires mantle cell lymphoma response to bortezomib. Cancer medicine. vol 4. issue 11. 2016-09-15. PMID:26310857. |
to investigate the efficacy and mechanism of arsenic trioxide (ato) with btz in inducing apoptosis of mcl cells, two mcl cell lines, along with primary cells from mcl patients (n = 4), were used. |
2016-09-15 |
2023-08-13 |
mouse |
| Ling-Ling Zhao, Yuan-Fang Liu, Li-Jun Peng, Ai-Mei Fei, Wen Cui, Sheng-Chao Miao, Olivier Hermine, Remy Gressin, Saadi Khochbin, Sai-Juan Chen, Jin Wang, Jian-Qing M. Arsenic trioxide rewires mantle cell lymphoma response to bortezomib. Cancer medicine. vol 4. issue 11. 2016-09-15. PMID:26310857. |
ato treatment highly improved btz capacity to inhibit proliferation and induce apoptosis of mcl cells. |
2016-09-15 |
2023-08-13 |
mouse |