| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lujun Yang, Shuangfeng Zhang, Suraj Konnath George, Rong Teng, Xuefen You, Mengqi Xu, Hong Liu, Xiaoping Sun, Hesham M Amin, Wenyu Sh. Targeting Notch1 and proteasome as an effective strategy to suppress T-cell lymphoproliferative neoplasms. Oncotarget. vol 6. issue 17. 2016-04-26. PMID:25879451. |
gsi-i and btz synergistically decreased cell viability, proliferation, and colony formation, and induced apoptosis in t-lpn cell lines. |
2016-04-26 |
2023-08-13 |
mouse |
| Weiguo Xu, Jianxun Ding, Lingyu Li, Chunsheng Xiao, Xiuli Zhuang, Xuesi Che. Acid-labile boronate-bridged dextran-bortezomib conjugate with up-regulated hypoxic tumor suppression. Chemical communications (Cambridge, England). vol 51. issue 31. 2015-12-15. PMID:25787235. |
the prodrug exhibits intracellular acidity-accelerated btz release, and up-regulated inhibition efficacies toward hypoxic tumor in vitro and in vivo through both nf-κb- and ers-mediated apoptosis signaling pathways. |
2015-12-15 |
2023-08-13 |
Not clear |
| Wei Li, Jianfang Fu, Shun Zhang, Jie Zhao, Nianlin Xie, Guoqing Ca. The proteasome inhibitor bortezomib induces testicular toxicity by upregulation of oxidative stress, AMP-activated protein kinase (AMPK) activation and deregulation of germ cell development in adult murine testis. Toxicology and applied pharmacology. vol 285. issue 2. 2015-07-21. PMID:25886977. |
of particular interest, the upregulated testicular apoptosis and the following disturbance of sertoli-germ cell interaction may both stem from the excessive oxidative stress elicited by btz exposure. |
2015-07-21 |
2023-08-13 |
mouse |
| M Loi, P Becherini, L Emionite, A Giacomini, I Cossu, E Destefanis, C Brignole, D Di Paolo, F Piaggio, P Perri, M Cilli, F Pastorino, M Ponzon. sTRAIL coupled to liposomes improves its pharmacokinetic profile and overcomes neuroblastoma tumour resistance in combination with Bortezomib. Journal of controlled release : official journal of the Controlled Release Society. vol 192. 2015-07-20. PMID:25041999. |
furthermore, the possibility to combine strail-sl with the proteasome inhibitor bortezomib (btz) was investigated, being btz able to sensitize tumour cells toward trail-induced apoptosis. |
2015-07-20 |
2023-08-13 |
mouse |
| Wenbin Xu, Wei Wei, Qing Yu, Chao Wu, Chenjing Ye, Yingli Wu, Hua Ya. Arsenic trioxide and bortezomib interact synergistically to induce apoptosis in chronic myelogenous leukemia cells resistant to imatinib mesylate through Bcr/Abl‑dependent mechanisms. Molecular medicine reports. vol 10. issue 3. 2015-05-13. PMID:24939418. |
co‑treatment of k562r cells with subtoxic concentrations of as2o3 (2 µm) and btz (24 nm) resulted in a synergistic enhancement in growth inhibition and apoptosis, as demonstrated by increased annexin v staining. |
2015-05-13 |
2023-08-13 |
Not clear |
| Wenbin Xu, Wei Wei, Qing Yu, Chao Wu, Chenjing Ye, Yingli Wu, Hua Ya. Arsenic trioxide and bortezomib interact synergistically to induce apoptosis in chronic myelogenous leukemia cells resistant to imatinib mesylate through Bcr/Abl‑dependent mechanisms. Molecular medicine reports. vol 10. issue 3. 2015-05-13. PMID:24939418. |
collectively, these findings suggest that btz and as2o3 act synergistically to induce apoptosis in k562r cells. |
2015-05-13 |
2023-08-13 |
Not clear |
| Yingxing Yue, Ying Wang, Yang He, Shuting Yang, Zixing Chen, Yuanyuan Wang, Shanshan Xing, Congcong Shen, Hesham M Amin, Depei Wu, Yao-Hua Son. Reversal of bortezomib resistance in myelodysplastic syndrome cells by MAPK inhibitors. PloS one. vol 9. issue 3. 2015-02-12. PMID:24608798. |
treatment by btz led to reduced skm-1 cell viability as well as increased apoptosis and autophagy. |
2015-02-12 |
2023-08-12 |
Not clear |
| Li Yin, Turner Kufe, David Avigan, Donald Kuf. Targeting MUC1-C is synergistic with bortezomib in downregulating TIGAR and inducing ROS-mediated myeloma cell death. Blood. vol 123. issue 19. 2014-06-30. PMID:24632713. |
the present results demonstrate that go-203 and btz synergistically downregulate expression of the p53-inducible regulator of glycolysis and apoptosis (tigar), which promotes shunting of glucose-6-phosphate into the pentose phosphate pathway to generate reduced glutathione (gsh). |
2014-06-30 |
2023-08-12 |
Not clear |
| S S Xing, C C Shen, M P Godard, J J Wang, Y Y Yue, S T Yang, Q Zhao, S B Zhang, T X Wang, X L Yang, P Delafontaine, Y He, Y H Son. Bortezomib inhibits C2C12 growth by inducing cell cycle arrest and apoptosis. Biochemical and biophysical research communications. vol 445. issue 2. 2014-06-03. PMID:24525132. |
consistent with the results of cell viability, annexin v/pi analysis showed a significant increase in apoptosis after exposing the cells to btz for 24h. |
2014-06-03 |
2023-08-12 |
Not clear |
| S S Xing, C C Shen, M P Godard, J J Wang, Y Y Yue, S T Yang, Q Zhao, S B Zhang, T X Wang, X L Yang, P Delafontaine, Y He, Y H Son. Bortezomib inhibits C2C12 growth by inducing cell cycle arrest and apoptosis. Biochemical and biophysical research communications. vol 445. issue 2. 2014-06-03. PMID:24525132. |
the apoptosis induced by btz was associated with reduced expression of p-erk. |
2014-06-03 |
2023-08-12 |
Not clear |
| Kelley Salem, Charles O Brown, Jeanine Schibler, Apollina Goe. Combination chemotherapy increases cytotoxicity of multiple myeloma cells by modification of nuclear factor (NF)-κB activity. Experimental hematology. vol 41. issue 2. 2013-04-19. PMID:23063726. |
our results show that combined treatment of dex with btz enhanced direct apoptosis of drug-sensitive and drug-resistant myeloma cells. |
2013-04-19 |
2023-08-12 |
human |
| Luhong Sun, Liang Zhang, Jianfei Qian, Jing Yang, Qing Yi, Wenli Dong, Michael Wan. Combination of atiprimod and the proteasome inhibitor bortezomib induces apoptosis of mantle cell lymphoma in vitro and in vivo. Leukemia research. vol 36. issue 3. 2012-03-06. PMID:22000823. |
the ati and btz combination significantly inhibited growth and induced apoptosis of both cultured mcl cell lines and freshly isolated tumor cells from patients with refractory or relapsed mcl. |
2012-03-06 |
2023-08-12 |
mouse |
| Luhong Sun, Liang Zhang, Jianfei Qian, Jing Yang, Qing Yi, Wenli Dong, Michael Wan. Combination of atiprimod and the proteasome inhibitor bortezomib induces apoptosis of mantle cell lymphoma in vitro and in vivo. Leukemia research. vol 36. issue 3. 2012-03-06. PMID:22000823. |
furthermore, ati and btz induced apoptosis via two different signaling pathways. |
2012-03-06 |
2023-08-12 |
mouse |
| Ai-Jun Liao, Bei-Bei Fu, Hui-Han Wang, Ying-Chun Li, Kun Yao, Rong Zhang, Wei Yang, Zhuo-Gang Li. [Effect of bortezomib on MAPK signaling pathway of K562/DNR cells]. Zhongguo shi yan xue ye xue za zhi. vol 18. issue 6. 2011-10-06. PMID:21176351. |
meanwhile, the apoptosis rate in cells treated with dnr combined with btz increased compared with dnr only. |
2011-10-06 |
2023-08-12 |
Not clear |
| Ai-Jun Liao, Bei-Bei Fu, Hui-Han Wang, Ying-Chun Li, Kun Yao, Rong Zhang, Wei Yang, Zhuo-Gang Li. [Effect of bortezomib on MAPK signaling pathway of K562/DNR cells]. Zhongguo shi yan xue ye xue za zhi. vol 18. issue 6. 2011-10-06. PMID:21176351. |
it is concluded that the btz can reverse the drug resistance in k562/dnr cells by mapk signaling pathway and increase the apoptosis of leukemic cells. |
2011-10-06 |
2023-08-12 |
Not clear |
| M P Albero, J M Vaquer, E J Andreu, J J Villanueva, L Franch, C Ivorra, E Poch, X Agirre, F Prosper, I Pérez-Roge. Bortezomib decreases Rb phosphorylation and induces caspase-dependent apoptosis in Imatinib-sensitive and -resistant Bcr-Abl1-expressing cells. Oncogene. vol 29. issue 22. 2010-09-27. PMID:20305692. |
furthermore, we show that btz also induces cell-cycle arrest and apoptosis in cells expressing bcr-abl1 mutants that are resistant to im. |
2010-09-27 |
2023-08-12 |
Not clear |
| M Wang, X H Han, L Zhang, J Yang, J F Qian, Y K Shi, L W Kwak, J Romaguera, Q Y. Bortezomib is synergistic with rituximab and cyclophosphamide in inducing apoptosis of mantle cell lymphoma cells in vitro and in vivo. Leukemia. vol 22. issue 1. 2008-03-06. PMID:17898787. |
the proteasome inhibitor bortezomib (btz) induces apoptosis and sensitizes mcl cells to chemotherapy in relapsed mcl, but cr rates are low, with a short duration of response and severe toxicity. |
2008-03-06 |
2023-08-12 |
mouse |