| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anna Staskiewicz, Erica Wong, Begum Farhin, Michael Tucker, Xinyu Wan. Synergistic Effects of Resveratrol Derivatives with Bortezomib on Reducing Viability and Inducing Apoptosis in Multiple Myeloma Cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556992. |
bortezomib (btz), a common treatment for mm, is a proteasome inhibitor that induces apoptosis in mm cells. |
2022-05-13 |
2023-08-13 |
human |
| Anna Staskiewicz, Erica Wong, Begum Farhin, Michael Tucker, Xinyu Wan. Synergistic Effects of Resveratrol Derivatives with Bortezomib on Reducing Viability and Inducing Apoptosis in Multiple Myeloma Cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556992. |
we hypothesize that combining btz with a res derivative at certain concentrations is synergistic in reducing viability and inducing apoptosis in mm cells. |
2022-05-13 |
2023-08-13 |
human |
| Anna Staskiewicz, Erica Wong, Begum Farhin, Michael Tucker, Xinyu Wan. Synergistic Effects of Resveratrol Derivatives with Bortezomib on Reducing Viability and Inducing Apoptosis in Multiple Myeloma Cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556992. |
to address this hypothesis, we performed viability assays to assess the effects of increasing concentrations of res derivatives and btz on human mm cell viability over time (24, 48, 72 hours) and western blots to assess the compounds' effects on inducing apoptosis in mm cells following 24 hour treatment. |
2022-05-13 |
2023-08-13 |
human |
| Anna Staskiewicz, Erica Wong, Begum Farhin, Michael Tucker, Xinyu Wan. Synergistic Effects of Resveratrol Derivatives with Bortezomib on Reducing Viability and Inducing Apoptosis in Multiple Myeloma Cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556992. |
in conclusion, a combination of low doses of btz and pin synergistically decreases mm cell viability, possibly through inducing apoptosis. |
2022-05-13 |
2023-08-13 |
human |
| Duygu Mutluay, Gözde Yücel Tenekeci, Yanad Abou Monse. Bortezomib-Induced Ovarian Toxicity in Mice. Toxicologic pathology. 2022-03-30. PMID:35352576. |
btz specifically targets granulosa cells by inducing granulosa cell apoptosis and may have long-term effects on follicles. |
2022-03-30 |
2023-08-13 |
mouse |
| Masoud Farshbaf, Solmaz Mojarad-Jabali, Salar Hemmati, Ahmad Yari Khosroushahi, Hamidreza Motasadizadeh, Amir Zarebkohan, Hadi Valizade. Enhanced BBB and BBTB penetration and improved anti-glioma behavior of Bortezomib through dual-targeting nanostructured lipid carriers. Journal of controlled release : official journal of the Controlled Release Society. 2022-03-18. PMID:35301054. |
when loaded with bortezomib (btz), dual nlcs attained the highest therapeutic efficiency by means of in vitro cytotoxicity and apoptosis and prolonged survival rate and anti-glioma behavior in intracranial glioma bearing mice. |
2022-03-18 |
2023-08-13 |
mouse |
| Swethika H Sundaravel, Rosalyn I Marar, Muhannad A Abbasi, Muhamed Baljevic, Jeremy R Ston. Bortezomib-Induced Reversible Cardiomyopathy: Recovered With Guideline-Directed Medical Therapy. Cureus. vol 13. issue 12. 2022-01-13. PMID:35024253. |
by inhibiting this system, btz induces cellular apoptosis in cancer cells, and possibly the cardiomyocytes. |
2022-01-13 |
2023-08-13 |
Not clear |
| Chao Zhang, Xiaoxuan Xu, Timothy N Trotter, Pramod S Gowda, Yun Lu, Mark J Suto, Amjad Javed, Joanne E Murphy-Ullrich, Juan Li, Yang Yan. Runx2 deficiency in osteoblasts promotes myeloma resistance to bortezomib by increasing TSP-1-dependent TGF-β1 activation and suppressing immunity in bone marrow. Molecular cancer therapeutics. 2021-12-15. PMID:34907087. |
furthermore, treatment with sri31277 combined with btz alleviated mm cell resistance to btz-induced apoptosis caused by ob-runx2 deficiency in co-cultured cells and produced a synergistic effect on tumor burden in ob-runx2-/- mice. |
2021-12-15 |
2023-08-13 |
mouse |
| Yan-Ping Yin, Wen-Hao Shi, Ke Deng, Xiao-Li Liu, Hong Li, Xiao-Tong Lv, Vivian Wai Yan Lui, Chen Ding, Bo Hong, Wen-Chu Li. Combinations of proteasome inhibitors with obatoclax are effective for small cell lung cancer. Acta pharmacologica Sinica. vol 42. issue 8. 2021-11-01. PMID:33139838. |
both btz-obx and cfz-obx combinations displayed marked synergism on inducing apoptosis (~50% increase vs btz or cfz alone). |
2021-11-01 |
2023-08-13 |
mouse |
| Margot S F Roeten, Johan van Meerloo, Zinia J Kwidama, Giovanna Ter Huizen, Wouter H Segerink, Sonja Zweegman, Gertjan J L Kaspers, Gerrit Jansen, Jacqueline Cloo. Pre-Clinical Evaluation of the Proteasome Inhibitor Ixazomib against Bortezomib-Resistant Leukemia Cells and Primary Acute Leukemia Cells. Cells. vol 10. issue 3. 2021-10-22. PMID:33802801. |
the mechanism of action (proteasome subunit inhibition, apoptosis induction) and growth inhibitory potential of ixa vs. btz were tested in vitro in human (btz-resistant) leukemia cell lines. |
2021-10-22 |
2023-08-13 |
human |
| Xiaolan Lai, Chuanqian Huang, Xuekun Nie, Qi Chen, Yirong Tang, Xianguo Fu, Ying Lin, Chengjun Nie, Xinyu Xu, Xiukang Wang, Renli Chen, Zichun Che. Bortezomib Inhibits Multiple Myeloma Cells by Transactivating ATF3 to Trigger miR-135a-5p- Dependent Apoptosis. Frontiers in oncology. vol 11. 2021-10-12. PMID:34631548. |
in addition, atf3 could regulate cell apoptosis under btz treatment. |
2021-10-12 |
2023-08-13 |
Not clear |
| Zhipeng Su, Shengnan Han, Qiumei Jin, Ningning Zhou, Junwan Lu, Fugen Shangguan, Shiyi Yu, Yongzhang Liu, Lu Wang, Jianglong Lu, Qun Li, Lin Cai, Chengde Wang, Xiaohe Tian, Lingyan Chen, Weiming Zheng, Bin L. Ciclopirox and bortezomib synergistically inhibits glioblastoma multiforme growth via simultaneously enhancing JNK/p38 MAPK and NF-κB signaling. Cell death & disease. vol 12. issue 3. 2021-09-14. PMID:33674562. |
in combination with btz, cpx promotes apoptosis in gbm cells through the induction of reactive oxygen species (ros)-mediated c-jun n-terminal kinase (jnk)/p38 mitogen-activated protein kinase (mapk) signaling. |
2021-09-14 |
2023-08-13 |
Not clear |
| Giuseppina Camiolo, Alessandro Barbato, Cesarina Giallongo, Nunzio Vicario, Alessandra Romano, Nunziatina L Parrinello, Rosalba Parenti, Joaquín Cantón Sandoval, Diana García-Moreno, Giacomo Lazzarino, Roberto Avola, Giuseppe A Palumbo, Victoriano Mulero, Giovanni Li Volti, Daniele Tibullo, Francesco Di Raimond. Iron regulates myeloma cell/macrophage interaction and drives resistance to bortezomib. Redox biology. vol 36. 2021-06-18. PMID:32863212. |
we further demonstrated that pcs pre-treated with ferric ammonium citrate (fac) decreased bortezomib (btz)-induced apoptosis in vitro and successfully engrafted in zebrafish larvae treated with btz. |
2021-06-18 |
2023-08-13 |
human |
| Sang Wu Lee, Soo-Keun Yeon, Go Woon Kim, Dong Hoon Lee, Yu Hyun Jeon, Jung Yoo, So Yeon Kim, So Hee Kwo. HDAC6-Selective Inhibitor Overcomes Bortezomib Resistance in Multiple Myeloma. International journal of molecular sciences. vol 22. issue 3. 2021-04-16. PMID:33572814. |
furthermore, combining a452 with btz or cfz leads to synergistic cancer cell growth inhibition, viability decreases, and apoptosis induction in the btz-resistant mm cells. |
2021-04-16 |
2023-08-13 |
Not clear |
| b' Silvia Sevilla-Movilla, Nohem\\xc3\\xad Arellano-S\\xc3\\xa1nchez, M\\xc3\\xb3nica Mart\\xc3\\xadnez-Moreno, Consuelo Gajate, Anna S\\xc3\\xa1nchez-Vencells, Luis V Valc\\xc3\\xa1rcel, Xabier Agirre, Antonio Valeri, Joaquin Mart\\xc3\\xadnez-L\\xc3\\xb3pez, Felipe Pr\\xc3\\xb3sper, Faustino Mollinedo, Joaquin Teixid\\xc3\\xb. Upregulated expression and function of the \\xce\\xb14\\xce\\xb21 integrin in multiple myeloma cells resistant to bortezomib. The Journal of pathology. vol 252. issue 1. 2021-03-17. PMID:32501543.' |
the α4β1 integrin is a main adhesion receptor mediating mm cell-stroma interactions and mm cell survival, and its expression and function are downregulated by btz, leading to inhibition of cell adhesion-mediated drug resistance (cam-dr) and mm cell apoptosis. |
2021-03-17 |
2023-08-13 |
Not clear |
| Jesus Delgado-Calle, Noriyoshi Kurihara, Emily G Atkinson, Jessica Nelson, Kazuaki Miyagawa, Carlos Maria Galmarini, G David Roodman, Teresita Bellid. Aplidin (plitidepsin) is a novel anti-myeloma agent with potent anti-resorptive activity mediated by direct effects on osteoclasts. Oncotarget. vol 10. issue 28. 2021-02-16. PMID:31105871. |
in vitro, aplidin potently inhibited mm cell growth and induced apoptosis, effects that were enhanced by dexamethasone (dex) and bortezomib (btz). |
2021-02-16 |
2023-08-13 |
Not clear |
| Zhiwei Zhang, Xuewei Fu, Ling Xu, Xiaolei Hu, Feng Deng, Zhiqiang Yang, Lin Jiang, Tiwei Fu, Pengfei Zhou, Jinlin Song, Ping Ji, Jiao Huang, Xiaomian W. Nanosized Alumina Particle and Proteasome Inhibitor Bortezomib Prevented inflammation and Osteolysis Induced by Titanium Particle via Autophagy and NF-κB Signaling. Scientific reports. vol 10. issue 1. 2020-11-30. PMID:32221318. |
we found that al particles and btz could block apoptosis and nf- κb activation in osteoblasts in vitro and in a mouse model of calvarial resorption induced by ti particles. |
2020-11-30 |
2023-08-13 |
mouse |
| Zhe Sha, Alfred L Goldber. Multiple myeloma cells are exceptionally sensitive to heat shock, which overwhelms their proteostasis network and induces apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 35. 2020-11-13. PMID:32817432. |
the apoptosis seen at 43 °c and at 39 °c with btz was mediated by caspase-9 and was linked to an accumulation of the proapoptotic bcl-2-family member noxa. |
2020-11-13 |
2023-08-13 |
Not clear |
| Lijie Xing, Liang Lin, Tengteng Yu, Yuyin Li, Shih-Feng Cho, Jiye Liu, Kenneth Wen, Phillip A Hsieh, Krista Kinneer, Nikhil Munshi, Kenneth C Anderson, Yu-Tzu Ta. A novel BCMA PBD-ADC with ATM/ATR/WEE1 inhibitors or bortezomib induce synergistic lethality in multiple myeloma. Leukemia. vol 34. issue 8. 2020-11-03. PMID:32060401. |
moreover, suboptimal doses of medi2228 and bortezomib (btz) synergistically trigger apoptosis of even drug-resistant mm cells partly via modulation of rad51 and accumulation of impaired dna. |
2020-11-03 |
2023-08-13 |
Not clear |
| Fang-I Huang, Yi-Wen Wu, Ting-Yi Sung, Jing-Ping Liou, Mei-Hsiang Lin, Shiow-Lin Pan, Chia-Ron Yan. MPT0G413, A Novel HDAC6-Selective Inhibitor, and Bortezomib Synergistically Exert Anti-tumor Activity in Multiple Myeloma Cells. Frontiers in oncology. vol 9. 2020-10-01. PMID:31024851. |
accordingly, a combination of an hdac6 inhibitor and bortezomib (btz) could increase ubiquitinated protein accumulation, leading to further apoptosis. |
2020-10-01 |
2023-08-13 |
Not clear |