| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hui Yu, Xianrong Xu, Lirong Zhu, Shengjie Chen, Jincheng H. MELK aggravates lung adenocarcinoma by regulating EZH2 ubiquitination and H3K27me3 histone methylation of LATS2. Journal of cellular and molecular medicine. vol 28. issue 8. 2024-04-23. PMID:38652219. |
silencing melk or ezh2 or overexpressing lats2 restrained luad cell proliferation and invasion, and facilitated their apoptosis. |
2024-04-23 |
2024-04-26 |
mouse |
| Parminder Kaur, Eswar Shankar, Sanjay Gupt. EZH2-mediated development of therapeutic resistance in cancer. Cancer letters. 2024-02-08. PMID:38331087. |
enhancer of zeste homolog 2 (ezh2) regulates gene expression and plays a definite role in cell proliferation, apoptosis, and senescence. |
2024-02-08 |
2024-02-11 |
human |
| Yanyang Cai, Haibin Yan, Fang Wang, Lufan Xi. Knocking down of lncRNA SBF2-AS1 inhibits proliferation, invasion and induces apoptosis of colorectal cancer through regulating PTEN. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 14. 2024-01-27. PMID:38279439. |
knocking down of lncrna sbf2-as1 inhibits proliferation, and invasion and induces apoptosis of colorectal cancer by interacting with ezh2 to downregulate pten level. |
2024-01-27 |
2024-01-29 |
Not clear |
| Jianmin Wang, Cheng Yang, Huashen Xu, Xinyu Fan, Lina Jia, Yang Du, Shougeng Liu, Wenjing Wang, Jie Zhang, Yu Zhang, Xiaoxue Wang, Zhongbo Liu, Jie Bao, Songping Li, Jingyu Yang, Chunfu Wu, Jing Tang, Guoliang Chen, Lihui Wan. The Interplay Between HIF-1α and EZH2 in Lung Cancer and Dual-Targeted Drug Therapy. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023-12-10. PMID:38072662. |
dyb-03 showed promising antitumor activity in a xenograft tumor model by promoting apoptosis and inhibiting angiogenesis, which could be almost abolished by the deletion of hif-1α and ezh2. |
2023-12-10 |
2023-12-17 |
Not clear |
| Guanli Liang, Lei Han, Ming Qu, Jun Xue, Dandan Xu, Xueliang Wu, Yonggang L. Down-regulation of EZH2 genes targeting RUNX3 affects proliferation, invasion, and metastasis of human colon cancer cells by Wnt/β-catenin signaling pathway. Aging. vol 15. 2023-12-04. PMID:38048186. |
in order to detect the effect of ezh2 genes on proliferation, migration, invasion, and apoptosis of colon carcinoma cell strains hct116 and ht29 by the wnt/β-catenin signaling pathway, qrt-pcr was applied to measure relative expressions of ezh2, runx3, cea, ca199, mmp-9, vegf, β-catenin, and cyclind1 in each group; western-blot was employed with the intention of exploring relative expressions of these proteins |
2023-12-04 |
2023-12-10 |
human |
| Tai Zhou, Lei Zhang, Li He, Yan Lan, Lei Ding, Li Li, Zhongcheng Wan. GSK-126 Attenuates Cell Apoptosis in Ischemic Brain Injury by Modulating the EZH2-H3K27me3-Bcl2l1 Axis. Molecular neurobiology. 2023-11-22. PMID:37989985. |
gsk-126, a specific inhibitor of enhancer of zeste homolog 2 (ezh2), significantly decreased h3k27me3 levels and inhibited middle cerebral artery occlusion (mcao) induced and oxygen glucose deprivation (ogd) induced cell apoptosis. |
2023-11-22 |
2023-11-29 |
Not clear |
| Yingyan Chen, Leilei Ai, Yingyi Zhang, Xiang Li, Shiqian Xu, Weijie Yang, Jiamin Jin, Yerong Ma, Zhanhong Hu, Yinli Zhang, Yan Rong, Songying Zhan. The EZH2-H3K27me3 axis modulates aberrant transcription and apoptosis in cyclophosphamide-induced ovarian granulosa cell injury. Cell death discovery. vol 9. issue 1. 2023-11-14. PMID:37963880. |
specifically, ctx and its active metabolite 4-hydroperoxy cyclophosphamide (4-hc) were found to increase the apoptosis of granulosa cells (gcs) by reducing ezh2 and h3k27me3 levels, both in vivo and in vitro. |
2023-11-14 |
2023-11-20 |
Not clear |
| Eleanor O'Brien, Carmen Tse, Ian Tracy, Ian Reddin, Joanna Selfe, Jane Gibson, William Tapper, Reuben J Pengelly, Jinhui Gao, Ewa Aladowicz, Gemma Petts, Khin Thway, Sergey Popov, Anna Kelsey, Timothy J Underwood, Janet Shipley, Zoë S Walter. Pharmacological EZH2 inhibition combined with retinoic acid treatment promotes differentiation and apoptosis in rhabdomyosarcoma cells. Clinical epigenetics. vol 15. issue 1. 2023-10-20. PMID:37858275. |
pharmacological ezh2 inhibition combined with retinoic acid treatment promotes differentiation and apoptosis in rhabdomyosarcoma cells. |
2023-10-20 |
2023-11-08 |
Not clear |
| Yuanjian Chen, Jun Ma, Mingming Zhan. TRIM29 promotes the progression of colorectal cancer by suppressing EZH2 degradation. Experimental biology and medicine (Maywood, N.J.). 2023-10-14. PMID:37837384. |
in conclusion, ezh2 interacted with silenced trim29 to suppress its stability, thereby inhibiting cell proliferation, migration, and tumor growth, and promoting apoptosis in crc. |
2023-10-14 |
2023-11-08 |
Not clear |
| Ying Lin, Huanjun Su, Baoyi Zou, Minli Huan. EZH2 Promotes Corneal Endothelial Cell Apoptosis by Mediating H3K27me3 and Inhibiting HO-1 Transcription. Current eye research. 2023-10-06. PMID:37800319. |
ezh2 promotes corneal endothelial cell apoptosis by mediating h3k27me3 and inhibiting ho-1 transcription. |
2023-10-06 |
2023-10-07 |
human |
| Ying Lin, Huanjun Su, Baoyi Zou, Minli Huan. EZH2 Promotes Corneal Endothelial Cell Apoptosis by Mediating H3K27me3 and Inhibiting HO-1 Transcription. Current eye research. 2023-10-06. PMID:37800319. |
this paper aims to explore the molecular mechanism of enhancer of zeste homolog 2 (ezh2)-mediated h3k27me3 in human corneal endothelial cells (hcec) apoptosis by inhibiting heme oxygenase-1 (ho-1) transcription to provide a potential target for the treatment of corneal apoptosis. |
2023-10-06 |
2023-10-07 |
human |
| Christophe Le Clorennec, Karen Lee, Yuchen Huo, Peter E Zag. USP7 Inhibition Suppresses Neuroblastoma Growth via Induction of p53-Mediated Apoptosis and EZH2 and N-Myc Downregulation. International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37762082. |
usp7 inhibition suppresses neuroblastoma growth via induction of p53-mediated apoptosis and ezh2 and n-myc downregulation. |
2023-09-28 |
2023-10-07 |
Not clear |
| Yunfei Wu, Zhijie Xu, Xiaoyi Chen, Guanghou Fu, Junjie Tian, Baiye Ji. RCC1 functions as a tumor facilitator in clear cell renal cell carcinoma by dysregulating cell cycle, apoptosis, and EZH2 stability. Cancer medicine. 2023-09-25. PMID:37747077. |
rcc1 functions as a tumor facilitator in clear cell renal cell carcinoma by dysregulating cell cycle, apoptosis, and ezh2 stability. |
2023-09-25 |
2023-10-07 |
Not clear |
| Mengmeng Lv, Sheng Guo, Xinyu Zhang, Yan Zou, Qiang Chen, Chongyi Zang, Shuo Huang, Yuhan Hu, Yanling Wang, Qianqing Wang, Jiateng Zhon. Attenuated Salmonella-delivered PD-1 siRNA enhances the antitumor effects of EZH2 inhibitors in colorectal cancer. International immunopharmacology. vol 124. issue Pt A. 2023-09-14. PMID:37708707. |
our results demonstrated that ezh2 inhibitors can not only significantly inhibit the survival of colorectal cancer (crc) cells and induce apoptosis, effectively inhibit cell invasion and migration, but also cause an increase in the expression of pd-l1 receptors on the cell surface. |
2023-09-14 |
2023-10-07 |
Not clear |
| Yu Cai, Peiyong Chen, Hui Xu, Shanglai Li, Bingru Zhao, Yixuan Fan, Feng Wang, Yanli Zhan. International journal of molecular sciences. vol 24. issue 13. 2023-07-14. PMID:37445833. |
ezh2 is a histone methyltransferase that inhibits proliferation and aggravates apoptosis in stem cells subjected to pathological stimuli. |
2023-07-14 |
2023-08-14 |
Not clear |
| Yu Cai, Zifei Liu, Guomin Zhang, Yingnan Yang, Yanli Zhang, Feng Wang, Mingtian Den. miR-101-5p overexpression suppresses the proliferation of goat spermatogonial stem cells by targeting EZH2. Animal reproduction science. vol 255. 2023-06-23. PMID:37352705. |
collectively, our data implicates that mir-101-5p overexpression aggravates cell apoptosis, and suppresses cell proliferation of goat sscs via targeting ezh2, which may impair spermatogenesis. |
2023-06-23 |
2023-08-14 |
Not clear |
| Mengqi Zhou, Yue Gao, Shujuan Wu, Jiao Chen, Jinli Ding, Yaqin Wang, Jing Yan. USP7 prevents recurrent spontaneous abortion by targeting EZH2 to regulate trophoblast proliferation, apoptosis, migration and invasion through the Wnt/β-catenin pathway†. Biology of reproduction. 2023-05-30. PMID:37249558. |
usp7 prevents recurrent spontaneous abortion by targeting ezh2 to regulate trophoblast proliferation, apoptosis, migration and invasion through the wnt/β-catenin pathway†. |
2023-05-30 |
2023-08-14 |
Not clear |
| Zhaoyun Liu, Yue Jia, Chun Yang, Hui Liu, Hongli Shen, Hao Wang, Rong F. Study on the Effect of EZH2 Inhibitor Combined with TIGIT Monoclonal Antibody against Multiple Myeloma Cells. International journal of molecular sciences. vol 24. issue 10. 2023-05-27. PMID:37239949. |
here, we showed that the apoptosis rate and apoptotic protein expression increased after ezh2 inhibition, whereas key molecules of the nf-κb signaling pathway and the downstream target genes were inhibited. |
2023-05-27 |
2023-08-14 |
Not clear |
| Yuankai Liu, Qiong Yan. The roles of EZH2 in cancer and its inhibitors. Medical oncology (Northwood, London, England). vol 40. issue 6. 2023-05-06. PMID:37148376. |
ezh2 is involved in the cell cycle, dna damage repair, cell differentiation, autophagy, apoptosis, and immunological modulation. |
2023-05-06 |
2023-08-14 |
Not clear |
| Katherine Shishido, Ian J Purvis, Kiran K Velpula, Sujatha Venkataraman, Rajeev Vibhakar, Swapna Asuthka. Targeting B7‑H3 through EZH2 inhibition in MYC‑positive Group 3 medulloblastoma. Oncology reports. vol 49. issue 6. 2023-04-28. PMID:37114557. |
further, ezh2 silencing induced apoptosis and reduced colony‑forming ability in mb cells, whereas ezh2 inhibition in myc‑amplified c17.2 neural stem cells induced g2/m phase arrest while downregulating b7‑h3 expression. |
2023-04-28 |
2023-08-14 |
Not clear |