| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Florian Sperling, Danny Misiak, Stefan Hüttelmaier, Patrick Michl, Heidi Griesman. IGF2BP1 Promotes Proliferation of Neuroendocrine Neoplasms by Post-Transcriptional Enhancement of EZH2. Cancers. vol 14. issue 9. 2022-05-14. PMID:35565249. |
combined targeting of igf2bp1, ezh2, and myc, a transcriptional activator of ezh2 and well-known target of igf2bp1 cooperatively induces tumor cell apoptosis. |
2022-05-14 |
2023-08-13 |
Not clear |
| Junhui Yu, Kui Yang, Jianbao Zheng, Pengwei Zhao, Jie Xia, Xuejun Sun, Wei Zha. Activation of FXR and inhibition of EZH2 synergistically inhibit colorectal cancer through cooperatively accelerating FXR nuclear location and upregulating CDX2 expression. Cell death & disease. vol 13. issue 4. 2022-04-22. PMID:35449124. |
the combination of fxr agonist oca plus ezh2 inhibitor gsk126 acted in a synergistic manner across four colon cancer cells, efficiently inhibiting clonogenic growth and invasion in vitro, retarding tumor growth in vivo, preventing the g0/g1 to s phase transition, and inducing caspase-dependent apoptosis. |
2022-04-22 |
2023-08-13 |
Not clear |
| Wenqiang Lv, Mei Yu, Yilin S. miR-22-5p regulates the self-renewal of spermatogonial stem cells by targeting EZH2. Open medicine (Warsaw, Poland). vol 17. issue 1. 2022-04-13. PMID:35415251. |
moreover, ezh2 overexpression could reverse the effect of mir-22-5p mimic on sscs' proliferation, apoptosis, and expression of ssc marker proteins. |
2022-04-13 |
2023-08-13 |
Not clear |
| Mujie Ye, Runnan Gao, Shiyu Chen, Meng Wei, Jing Wang, Bowen Zhang, Suwen Wu, Yuexin Xu, Peixuan Wu, Xin Chen, Jing Ma, Duan Ma, Kuiran Don. Downregulation of MEG3 and upregulation of EZH2 cooperatively promote neuroblastoma progression. Journal of cellular and molecular medicine. 2022-03-08. PMID:35257481. |
two nb cell lines, sk-n-as and sk-n-be(2)c, were overexpressed meg3 and rescued with ezh2 and then were subjected to proliferation, migration, invasion, apoptosis and autophagy experiments. |
2022-03-08 |
2023-08-13 |
mouse |
| Francesco Casciello, Gregory M Kelly, Priya Ramarao-Milne, Nabilah Kamal, Teneale A Stewart, Pamela Mukhopadhyay, Stephen H Kazakoff, Mariska Miranda, Dorim Kim, Felicity M Davis, Nicholas K Hayward, Paula M Vertino, Nicola Waddell, Frank Gannon, Jason S Le. Combined inhibition of G9a and EZH2 suppresses tumor growth via synergistic induction of IL24-mediated apoptosis. Cancer research. 2022-02-12. PMID:35149587. |
combined inhibition of g9a and ezh2 suppresses tumor growth via synergistic induction of il24-mediated apoptosis. |
2022-02-12 |
2023-08-13 |
human |
| Francesco Casciello, Gregory M Kelly, Priya Ramarao-Milne, Nabilah Kamal, Teneale A Stewart, Pamela Mukhopadhyay, Stephen H Kazakoff, Mariska Miranda, Dorim Kim, Felicity M Davis, Nicholas K Hayward, Paula M Vertino, Nicola Waddell, Frank Gannon, Jason S Le. Combined inhibition of G9a and EZH2 suppresses tumor growth via synergistic induction of IL24-mediated apoptosis. Cancer research. 2022-02-12. PMID:35149587. |
loss-of-function of g9a and ezh2 activated the il24-er stress axis and increased apoptosis in cancer cells while not affecting normal cells. |
2022-02-12 |
2023-08-13 |
human |
| Francesco Casciello, Gregory M Kelly, Priya Ramarao-Milne, Nabilah Kamal, Teneale A Stewart, Pamela Mukhopadhyay, Stephen H Kazakoff, Mariska Miranda, Dorim Kim, Felicity M Davis, Nicholas K Hayward, Paula M Vertino, Nicola Waddell, Frank Gannon, Jason S Le. Combined inhibition of G9a and EZH2 suppresses tumor growth via synergistic induction of IL24-mediated apoptosis. Cancer research. 2022-02-12. PMID:35149587. |
these results indicate that g9a and ezh2 promotes the evasion of er stress-mediated apoptosis by repressing il24 transcription, therefore suggesting that their inhibition may represent a potential therapeutic strategy for solid cancers. |
2022-02-12 |
2023-08-13 |
human |
| Xiaoqin Zhang, Xuemei Tang, Lingai Pan, Yongheng Li, Junlei Li, Chunling L. Elevated lncRNA-UCA1 upregulates EZH2 to promote inflammatory response in sepsis-induced pneumonia via inhibiting HOXA1. Carcinogenesis. 2022-01-12. PMID:35018436. |
then, the clp rats were respectively treated with uca1 up-regulation or uca1 silencing, ezh2 overexpression to measure their roles in the pathology, apoptosis, inflammation and nf-κb mrna and phosphorylated nf-κb p-65 levels in clp rat lung tissues. |
2022-01-12 |
2023-08-13 |
rat |
| Xiaoqin Zhang, Xuemei Tang, Lingai Pan, Yongheng Li, Junlei Li, Chunling L. Elevated lncRNA-UCA1 upregulates EZH2 to promote inflammatory response in sepsis-induced pneumonia via inhibiting HOXA1. Carcinogenesis. 2022-01-12. PMID:35018436. |
the cells were subjected to same treatment to examine the effects of uca1, ezh2 and hoxa1 on viability, apoptosis, inflammation and nf-κb mrna and phosphorylated nf-κb p-65 levels in lps-induced rle-6tn cells. |
2022-01-12 |
2023-08-13 |
rat |
| Xiaoqin Zhang, Xuemei Tang, Lingai Pan, Yongheng Li, Junlei Li, Chunling L. Elevated lncRNA-UCA1 upregulates EZH2 to promote inflammatory response in sepsis-induced pneumonia via inhibiting HOXA1. Carcinogenesis. 2022-01-12. PMID:35018436. |
elevated uca1 or increased ezh2 aggravated pathology and promoted apoptosis, inflammation and nf-κb mrna and phosphorylated nf-κb p-65 levels in clp rat lung tissues, and inhibited viability while facilitated apoptosis, inflammation and nf-κb mrna and phosphorylated nf-κb p-65 levels in lps-induced rle-6tn cells. |
2022-01-12 |
2023-08-13 |
rat |
| Bruno Calabretta, Patrizia Porazzi, Svetlana Petruk, Luca Pagliaroli, Marco De Dominici, David Deming, Matthew V Puccetti, Saul Kushinsky, Gaurav Kumar, Valentina Minieri, Elisa Barbieri, Sandra Deliard, Alexis Grande, Marco Trizzino, Alessandro Gardini, Eli Canaani, Neil Palmisiano, Pierluigi Porcu, Adam Ertel, Paolo M Fortina, Christine M Eischen, Alexander Maz. Targeting chemotherapy to de-condensed H3K27me3-marked chromatin of AML cells enhances leukemia suppression. Cancer research. 2021-12-14. PMID:34903608. |
in cell lines, primary cells and xenograft mouse models, inhibition of the h3k27 histone methyltransferase ezh2 to de-condense the h3k27me3-marked chromatin of aml cells enhanced chromatin accessibility and chemotherapy-induced dna damage, apoptosis, and leukemia suppression. |
2021-12-14 |
2023-08-13 |
mouse |
| Zixin Hou, Ji Chen, Huan Yang, Xiaoling Hu, Fengrui Yan. PIAS1 alleviates diabetic peripheral neuropathy through SUMOlation of PPAR-γ and miR-124-induced downregulation of EZH2/STAT3. Cell death discovery. vol 7. issue 1. 2021-12-03. PMID:34857740. |
furthermore, mir-124 targeted and inversely modulated ezh2 and stat3, promoting the autophagy of schwann cells and inhibiting their apoptosis. |
2021-12-03 |
2023-08-13 |
mouse |
| Chuandong Cheng, Yongfei Dong, Xiaoyu Ru, Yanghua Xia, Ying J. LncRNA ANCR promotes glioma cells invasion, migration, proliferation and inhibits apoptosis via interacting with EZH2 and repressing PTEN expression. Cancer gene therapy. vol 28. issue 9. 2021-11-30. PMID:33293663. |
lncrna ancr promotes glioma cells invasion, migration, proliferation and inhibits apoptosis via interacting with ezh2 and repressing pten expression. |
2021-11-30 |
2023-08-13 |
human |
| Chuandong Cheng, Yongfei Dong, Xiaoyu Ru, Yanghua Xia, Ying J. LncRNA ANCR promotes glioma cells invasion, migration, proliferation and inhibits apoptosis via interacting with EZH2 and repressing PTEN expression. Cancer gene therapy. vol 28. issue 9. 2021-11-30. PMID:33293663. |
the apoptosis, transwell invasion, migration, colony formation, and proliferation assays were conducted to evaluate the influences of lncrna ancr depletion, ezh2 reduction, or pten elevation on the cell biology of glioma cells. |
2021-11-30 |
2023-08-13 |
human |
| Chuandong Cheng, Yongfei Dong, Xiaoyu Ru, Yanghua Xia, Ying J. LncRNA ANCR promotes glioma cells invasion, migration, proliferation and inhibits apoptosis via interacting with EZH2 and repressing PTEN expression. Cancer gene therapy. vol 28. issue 9. 2021-11-30. PMID:33293663. |
inhibited ancr, reduced ezh2, or elevated pten could reduce the ability of invasion, migration, and proliferation, and promote apoptosis of glioma cells. |
2021-11-30 |
2023-08-13 |
human |
| Chuandong Cheng, Yongfei Dong, Xiaoyu Ru, Yanghua Xia, Ying J. LncRNA ANCR promotes glioma cells invasion, migration, proliferation and inhibits apoptosis via interacting with EZH2 and repressing PTEN expression. Cancer gene therapy. vol 28. issue 9. 2021-11-30. PMID:33293663. |
in conclusion, we have found that restrained ancr could repress invasion, migration, and proliferation, as well as promote apoptosis of glioma cells through interacting with ezh2 and regulating the expression of pten, offering an effective therapeutic target for patients with glioma. |
2021-11-30 |
2023-08-13 |
human |
| Elham Barazeghi, Per Hellman, Olov Norlén, Gunnar Westin, Peter Stålber. EZH2 presents a therapeutic target for neuroendocrine tumors of the small intestine. Scientific reports. vol 11. issue 1. 2021-11-27. PMID:34815475. |
silencing ezh2 in the si-net cell line cndt2.5 reduced cell proliferation and induced apoptosis. |
2021-11-27 |
2023-08-13 |
mouse |
| Elham Barazeghi, Per Hellman, Olov Norlén, Gunnar Westin, Peter Stålber. EZH2 presents a therapeutic target for neuroendocrine tumors of the small intestine. Scientific reports. vol 11. issue 1. 2021-11-27. PMID:34815475. |
furthermore, ezh2 knockout inhibited tumor progression in a cndt2.5 si-net xenograft mouse model, and treatment of si-net cell lines cndt2.5 and got1 with the ezh2-specific inhibitor cpi-1205 decreased cell viability and promoted apoptosis. |
2021-11-27 |
2023-08-13 |
mouse |
| Kejia Huang, Rong Sun, Jiarong Chen, Qianye Yang, Yucheng Wang, Yang Zhang, Kun Xie, Tiantian Zhang, Rui Li, Qi Zhao, Liang Zou, Jian L. A novel EZH2 inhibitor induces synthetic lethality and apoptosis in PBRM1-deficient cancer cells. Cell cycle (Georgetown, Tex.). vol 19. issue 7. 2021-11-25. PMID:32093567. |
a novel ezh2 inhibitor induces synthetic lethality and apoptosis in pbrm1-deficient cancer cells. |
2021-11-25 |
2023-08-13 |
Not clear |
| Jinliang Gao, Tao Luo, Na Lin, Shuyan Zhang, Jinke Wan. A New Tool for CRISPR-Cas13a-Based Cancer Gene Therapy. Molecular therapy oncolytics. vol 19. 2021-11-25. PMID:33102691. |
dcug could also similarly knock down the expression of endogenous oncogenes (tert, ezh2, and rela) at both mrna and protein levels in a human hepatoma cell hepg2, which led to significant apoptosis and growth inhibition. |
2021-11-25 |
2023-08-13 |
mouse |