| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yiqi Yang, Yibo Zhang, Jieqiong Cao, Zijian Su, Fu Li, Peiguang Zhang, Bihui Zhang, Rongzhan Liu, Linhao Zhang, Junye Xie, Jingsheng Li, Jinting Zhang, Xiaojia Chen, An Hon. FGFR4 and EZH2 inhibitors synergistically induce hepatocellular carcinoma apoptosis via repressing YAP signaling. Journal of experimental & clinical cancer research : CR. vol 42. issue 1. 2023-04-21. PMID:37085881. |
fgfr4 and ezh2 inhibitors synergistically induce hepatocellular carcinoma apoptosis via repressing yap signaling. |
2023-04-21 |
2023-08-14 |
Not clear |
| Xiao-Kai Duan, Yong-Xiang Sun, Hong-Yun Wang, Yan-Yan Xu, Shi-Zhen Fan, Jin-Ya Tian, Yong Yu, Yan-Yun Zhao, Yan-Li Jian. miR-124 is upregulated in diabetic mice and inhibits proliferation and promotes apoptosis of high-glucose-induced β-cells by targeting EZH2. World journal of diabetes. vol 14. issue 3. 2023-04-10. PMID:37035229. |
mir-124 is upregulated in diabetic mice and inhibits proliferation and promotes apoptosis of high-glucose-induced β-cells by targeting ezh2. |
2023-04-10 |
2023-08-14 |
mouse |
| Ran Tan, Jia Liu, Jiang Wang, Wei Zhang, Meng He, Yueli Zhan. Long noncoding RNA SNHG6 silencing sensitized esophageal cancer cells to 5-FU via EZH2/STAT pathway. Scientific reports. vol 13. issue 1. 2023-04-03. PMID:37005451. |
this work conducted cell viability assay, clone formation, scratch assays together with cell apoptosis for evaluating the roles of snhg6 and enhancer of zeste homolog 2 (ezh2, the histone-lysine n-methyltransferase). |
2023-04-03 |
2023-08-14 |
Not clear |
| Na Qiang, Junjie Ao, Masato Nakamura, Tetsuhiro Chiba, Yuko Kusakabe, Tatsuya Kaneko, Akane Kurosugi, Tadayoshi Kogure, Yaojia Ma, Jiaqi Zhang, Keita Ogawa, Motoyasu Kan, Terunao Iwanaga, Takafumi Sakuma, Kengo Kanayama, Hiroaki Kanzaki, Ryuta Kojima, Ryo Nakagawa, Takayuki Kondo, Shingo Nakamoto, Ryosuke Muroyama, Jun Kato, Naoya Mimura, Anqi Ma, Jian Jin, Naoya Kat. Alteration of the tumor microenvironment by pharmacological inhibition of EZH2 in hepatocellular carcinoma. International immunopharmacology. vol 118. 2023-03-31. PMID:37001386. |
unc1999, an ezh2 inhibitor, impaired growth of the murine hcc cells (h22 cells) and induced apoptosis in a dose-dependent manner. |
2023-03-31 |
2023-08-14 |
mouse |
| Tingting Gu, Chang Xu, Xiaozhou Meng, Dapeng Gao, Guanghao Jiang, Anqi Yin, Qingzhen Liu, Lidong Zhan. Sevoflurane Preconditioning Alleviates Posttraumatic Stress Disorder-Induced Apoptosis in the Hippocampus via the EZH2-Regulated Akt/mTOR Axis and Improves Synaptic Plasticity. Journal of molecular neuroscience : MN. 2023-03-17. PMID:36930428. |
sevoflurane preconditioning restored ezh2 expression and significantly inhibited apoptosis by regulating phosphorylation of the akt/mtor pathway. |
2023-03-17 |
2023-08-14 |
rat |
| Bao-Feng Song, Li-Zhe Xu, Kun Jiang, Fan Chen. MiR-124-3p inhibits tumor progression in prostate cancer by targeting EZH2. Functional & integrative genomics. vol 23. issue 2. 2023-03-08. PMID:36884182. |
our findings depict that mir-124-3p prevents pca proliferative and invasive processes while promoting apoptosis by targeting ezh2. |
2023-03-08 |
2023-08-14 |
Not clear |
| Jian Wang, Xiang Wang, Xu Ding, Tao Huang, Dengxin Song, Hairong Ta. EZH2 is associated with cartilage degeneration in osteoarthritis by promoting SDC1 expression via histone methylation of the microRNA-138 promoter. Laboratory investigation; a journal of technical methods and pathology. vol 101. issue 5. 2023-02-12. PMID:36775382. |
ezh2 depletion ameliorated oa, as evidenced by reduced cell apoptosis in il-1β-treated chondrocytes and decreased levels of cartilage catabolism-related factors. |
2023-02-12 |
2023-08-14 |
mouse |
| Lei Shi, Cai-Wen Shi, Ke-Wei Chen. HMGA2 Synergizes with EZH2 to Mediate Epithelial Cell Inflammation and Apoptosis in Septic Lung Dysfunction. Annals of clinical and laboratory science. vol 52. issue 6. 2022-12-23. PMID:36564076. |
hmga2 synergizes with ezh2 to mediate epithelial cell inflammation and apoptosis in septic lung dysfunction. |
2022-12-23 |
2023-08-14 |
Not clear |
| Hannah E Arbach, Marcus Harland-Dunaway, Christopher Braden, Alexander D Chitsazan, Eleanor Pickering, Jeet H Patel, Andrea E Will. Chromatin accessibility analysis reveals distinct functions for HDAC and EZH2 activities in early appendage regeneration. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 2022-10-27. PMID:36301622. |
upon hdac inhibition, regulatory regions neighboring genes associated with neuronal regeneration are preferentially accessible, whereas regions associated with immune response and apoptosis are preferentially accessible following ezh2 inhibition. |
2022-10-27 |
2023-08-14 |
xenopus_laevis |
| Chen Lyu, Lili Wang, Birgit Stadlbauer, Elfriede Noessner, Alexander Buchner, Heike Pohl. Identification of EZH2 as Cancer Stem Cell Marker in Clear Cell Renal Cell Carcinoma and the Anti-Tumor Effect of Epigallocatechin-3-Gallate (EGCG). Cancers. vol 14. issue 17. 2022-09-09. PMID:36077742. |
epigallocatechin-3-gallate (egcg) was identified as the most potent suppressor of ezh2, was able to inhibit viability, migration, and invasion, and to increase the apoptosis rate of ccrcc cscs. |
2022-09-09 |
2023-08-14 |
Not clear |
| Yi Yu, Yu-Feng Zou, Run-Qi Hong, Wen-Jie Chen, Liang Chen, Wen-Qi Chen, Hui-Peng Wang, Yuan Y. Long non-coding RNA SNHG16 decreased SMAD4 to induce gemcitabine resistance in pancreatic cancer via EZH2-mediated epigenetic modification. The Kaohsiung journal of medical sciences. 2022-09-02. PMID:36053032. |
finally, both ezh2 inhibition and smad4 upregulation increased gemcitabine cytotoxicity and apoptosis in pc cells during snhg16 overexpression. |
2022-09-02 |
2023-08-14 |
Not clear |
| Hong-Yu Zhong, Chong Yuan, Xiao-Lin Liu, Qian-Qian Wang, Xiao Li, Ya-Chao Zhao, Xuan Li, Dong-Dong Liu, Teng-Fei Zheng, Mei Zhan. Mechanical stretch aggravates vascular smooth muscle cell apoptosis and vascular remodeling by downregulating EZH2. The international journal of biochemistry & cell biology. 2022-08-19. PMID:35985452. |
mechanical stretch aggravates vascular smooth muscle cell apoptosis and vascular remodeling by downregulating ezh2. |
2022-08-19 |
2023-08-14 |
Not clear |
| Yu Peng, Kai Liao, Feng Tan, Yuqin Liang, Xihao Sun, Zekai Cui, Bo Ye, Zhongping Chen, Shibo Tang, Jiansu Che. Suppression of EZH2 inhibits TGF-β1-induced EMT in human retinal pigment epithelial cells. Experimental eye research. 2022-07-05. PMID:35780904. |
moreover, silencing ezh2 inhibited cellular migration and proliferation, but didn't affect cell apoptosis. |
2022-07-05 |
2023-08-14 |
human |
| Xueyuan Yu, Nuonuo Cong, Xiangyu Liu, Rui Wang, Daxu L. SASH1 knockdown suppresses TRAF6 ubiquitination to regulate hemangioma progression by mediating EZH2 degradation. Experimental cell research. 2022-06-30. PMID:35772492. |
cck-8, cell cycle, apoptosis, wound healing and transwell assays were performed to evaluate the effects of sash1 and ezh2 exerted on ha cells. |
2022-06-30 |
2023-08-14 |
Not clear |
| Xueyuan Yu, Nuonuo Cong, Xiangyu Liu, Rui Wang, Daxu L. SASH1 knockdown suppresses TRAF6 ubiquitination to regulate hemangioma progression by mediating EZH2 degradation. Experimental cell research. 2022-06-30. PMID:35772492. |
sash1 knockdown inhibited hemecs proliferation, migration, as well as invasion, and induced g0/g1 cell cycle arrest and apoptosis, while ezh2 overexpression reversed these effects. |
2022-06-30 |
2023-08-14 |
Not clear |
| Hong Xu, Wei Ye, Baochang Sh. LncRNA MALAT1 Regulates USP22 Expression Through EZH2-Mediated H3K27me3 Modification to Accentuate Sepsis-Induced Myocardial Dysfunction. Cardiovascular toxicology. 2022-06-21. PMID:35726125. |
metastasis-associated lung adenocarcinoma transcript 1 (malat1), a long non-coding rna (lncrna), has been confirmed to recruit enhancer of zeste 2 polycomb repressive complex 2 subunit (ezh2) to regulate cardiomyocyte apoptosis in diabetic cardiomyopathy. |
2022-06-21 |
2023-08-14 |
rat |
| Xiao-Qi Weng, Wei Wan. miR-137 Modulates Human Gastric Cancer Cell Proliferation, Apoptosis, and Migration by Targeting EZH2. Critical reviews in eukaryotic gene expression. vol 32. issue 4. 2022-06-13. PMID:35695663. |
mir-137 modulates human gastric cancer cell proliferation, apoptosis, and migration by targeting ezh2. |
2022-06-13 |
2023-08-14 |
human |
| Xiao-Qi Weng, Wei Wan. miR-137 Modulates Human Gastric Cancer Cell Proliferation, Apoptosis, and Migration by Targeting EZH2. Critical reviews in eukaryotic gene expression. vol 32. issue 4. 2022-06-13. PMID:35695663. |
in conclusion, our findings indicate that mir-137 restrains migration and proliferation and induces apoptosis partially through negatively regulating the expression of ezh2 in gc cells. |
2022-06-13 |
2023-08-14 |
human |
| Hao Gu, Qing Chen, Jian L. The MiR-101/EZH2 negative feedback signaling drives oxygen-glucose deprivation/reperfusion-induced injury by activating the MAPK14 signaling pathway in SH-SY5Y cells. Acta biochimica Polonica. 2022-05-26. PMID:35617639. |
luciferase reporter assay indicated that enhancer of zeste 2 polycomb repressive complex 2 subunit (ezh2) was a direct target of mir-101, and ezh2 sirna obviously increased the viability, inhibited ldh release and apoptosis in ogd/r-exposed sh-sy5y cells. |
2022-05-26 |
2023-08-13 |
Not clear |
| Hao Gu, Qing Chen, Jian L. The MiR-101/EZH2 negative feedback signaling drives oxygen-glucose deprivation/reperfusion-induced injury by activating the MAPK14 signaling pathway in SH-SY5Y cells. Acta biochimica Polonica. 2022-05-26. PMID:35617639. |
besides, ezh2 sirna could inhibit the activation of mitogen-activated protein kinase (mapk14) signaling pathway and the mapk14 agonist (anisomycin) could reverse ezh2 sirna-induced increase in cell viability, and decreases in ldh release and apoptosis. |
2022-05-26 |
2023-08-13 |
Not clear |