| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Julia M Kempf, Sabrina Weser, Michael D Bartoschek, Klaus H Metzeler, Binje Vick, Tobias Herold, Kerstin Völse, Raphael Mattes, Manuela Scholz, Lucas E Wange, Moreno Festini, Enes Ugur, Maike Roas, Oliver Weigert, Sebastian Bultmann, Heinrich Leonhardt, Gunnar Schotta, Wolfgang Hiddemann, Irmela Jeremias, Karsten Spiekerman. Loss-of-function mutations in the histone methyltransferase EZH2 promote chemotherapy resistance in AML. Scientific reports. vol 11. issue 1. 2021-11-24. PMID:33712646. |
proteomics and transcriptomics analysis reveal that resistance is conferred by upregulation of multiple direct and indirect ezh2 target genes that are involved in apoptosis evasion, augmentation of proliferation and alteration of transmembrane transporter function. |
2021-11-24 |
2023-08-13 |
Not clear |
| Mohammad Imran Khan, Mazin A Zamzami, Aftab Ahmad, Hani Choudhr. Molecular profiling of epigenetic landscape of cancer cells during extracellular matrix detachment. Scientific reports. vol 11. issue 1. 2021-11-15. PMID:33531586. |
inhibition of ezh2 results in a significant reduction in cell proliferation, spheroids size, and induction in apoptosis in e.c.m. |
2021-11-15 |
2023-08-13 |
Not clear |
| Lin Xie, Shengchao Ma, Ning Ding, Yanhua Wang, Guanjun Lu, Lingbo Xu, Qingqing Wang, Kun Liu, Yuzheng Jie, Hui Zhang, Anning Yang, Yujing Gao, Huiping Zhang, Yideng Jian. Homocysteine induces podocyte apoptosis by regulating miR-1929-5p expression through c-Myc, DNMT1 and EZH2. Molecular oncology. vol 15. issue 11. 2021-11-10. PMID:34057794. |
homocysteine induces podocyte apoptosis by regulating mir-1929-5p expression through c-myc, dnmt1 and ezh2. |
2021-11-10 |
2023-08-13 |
Not clear |
| Qianwei Wang, Xiang Mao, Fen Luo, Jun Wan. LINC00511 promotes gastric cancer progression by regulating SOX4 and epigenetically repressing PTEN to activate PI3K/AKT pathway. Journal of cellular and molecular medicine. vol 25. issue 19. 2021-11-10. PMID:34427967. |
on the whole, the present study disclosed that sox4-induced linc00511 activated sox4 via competing endogenous rna (cerna) pattern and epigenetically repressed pten to activate pi3k/akt pathway by recruiting ezh2, thus facilitating gc cell proliferation, migration and stemness while inhibiting gc cell apoptosis. |
2021-11-10 |
2023-08-13 |
Not clear |
| Liang Ai, Xiaojun Luo, Xiong Yan, Shan Jian. MicroRNA-506-3p inhibits colorectal cancer cell proliferation through targeting enhancer of zeste homologue 2. Bioengineered. vol 12. issue 1. 2021-11-09. PMID:34288823. |
overexpressing mir-506-3p or silencing ezh2 inhibited crc cell proliferation, migration and invasion and promoted apoptosis. |
2021-11-09 |
2023-08-13 |
Not clear |
| Mengti Zhang, Mengli Zhang, Ruijia Li, Rui Zhang, Yueli Zhan. Melatonin sensitizes esophageal cancer cells to 5‑fluorouracil via promotion of apoptosis by regulating EZH2 expression. Oncology reports. vol 45. issue 4. 2021-10-28. PMID:33649858. |
melatonin sensitizes esophageal cancer cells to 5‑fluorouracil via promotion of apoptosis by regulating ezh2 expression. |
2021-10-28 |
2023-08-13 |
Not clear |
| Mengti Zhang, Mengli Zhang, Ruijia Li, Rui Zhang, Yueli Zhan. Melatonin sensitizes esophageal cancer cells to 5‑fluorouracil via promotion of apoptosis by regulating EZH2 expression. Oncology reports. vol 45. issue 4. 2021-10-28. PMID:33649858. |
mlt and 5‑fu combination inhibited cell proliferation and promoted apoptosis by regulating ezh2 expression. |
2021-10-28 |
2023-08-13 |
Not clear |
| Mengti Zhang, Mengli Zhang, Ruijia Li, Rui Zhang, Yueli Zhan. Melatonin sensitizes esophageal cancer cells to 5‑fluorouracil via promotion of apoptosis by regulating EZH2 expression. Oncology reports. vol 45. issue 4. 2021-10-28. PMID:33649858. |
in conclusion, mlt enhanced 5‑fu‑mediated inhibition of cell proliferation via promotion of apoptosis by regulating ezh2 expression in esophageal cancer. |
2021-10-28 |
2023-08-13 |
Not clear |
| Yang Xie, Feng Wang, Jun Yu, Jing Zhang, Yuting Liu, Mengying Li, Jian Q. Silencing of MBD2 and EZH2 inhibits the proliferation of colorectal carcinoma cells by rescuing the expression of SFRP. Oncology reports. vol 46. issue 6. 2021-10-22. PMID:34617573. |
the functions of mbd2 and ezh2 in regards to cell proliferation, cell cycle distribution, apoptosis and invasion were examined in crc cell lines. |
2021-10-22 |
2023-08-13 |
Not clear |
| Yang Xie, Feng Wang, Jun Yu, Jing Zhang, Yuting Liu, Mengying Li, Jian Q. Silencing of MBD2 and EZH2 inhibits the proliferation of colorectal carcinoma cells by rescuing the expression of SFRP. Oncology reports. vol 46. issue 6. 2021-10-22. PMID:34617573. |
flow cytometric analysis showed that knockdown of mbd2 and ezh2 together in crc affected cell apoptosis and the cell cycle progression more effectively than knockdown of one of each. |
2021-10-22 |
2023-08-13 |
Not clear |
| Abdulhameed Al-Ghabkari, Aru Narendra. Targeting EZH2-mediated methylation of histone 3 inhibits proliferation of pediatric acute monocytic leukemia cells Cancer biology & therapy. vol 22. issue 4. 2021-10-15. PMID:33978549. |
screening a panel of methyltransferase inhibitors revealed that three inhibitors; gsk126, unc1999 and epz-5687 are the most potent inhibitors that suppressed ezh2 activity selectively on lysine 27 which resulted in increased apoptosis and inhibition of akt and erk protein phosphorylation in thp-1 cells. |
2021-10-15 |
2023-08-13 |
human |
| Yiqiang Cao, Wenying Chai, Yonggang Wang, Dang Tang, Dongchuan Shao, Hai Song, Jiang Lon. lncRNA TUG1 inhibits the cancer stem cell‑like properties of temozolomide‑resistant glioma cells by interacting with EZH2. Molecular medicine reports. vol 24. issue 1. 2021-10-15. PMID:34036375. |
knockdown of tug1 or overexpression of ezh2 promoted a172/tmz cell proliferation and cscs‑like properties, as well as inhibited their apoptosis, thereby enhancing the tmz resistance of a172/tmz cells. |
2021-10-15 |
2023-08-13 |
Not clear |
| Hok Shing Li, Yao X. Inhibition of EZH2 via the STAT3/HOTAIR signalling axis contributes to cell cycle arrest and apoptosis induced by polyphyllin I in human non-small cell lung cancer cells. Steroids. vol 164. 2021-10-14. PMID:32941921. |
inhibition of ezh2 via the stat3/hotair signalling axis contributes to cell cycle arrest and apoptosis induced by polyphyllin i in human non-small cell lung cancer cells. |
2021-10-14 |
2023-08-13 |
human |
| Qiongqiong Yu, Yajing Du, Suping Wang, Xiaofei Zhen. LncRNA PART1 promotes cell proliferation and inhibits apoptosis of oral squamous cell carcinoma by blocking EZH2 degradation. Journal of biochemistry. vol 169. issue 6. 2021-09-28. PMID:33725092. |
lncrna part1 promotes cell proliferation and inhibits apoptosis of oral squamous cell carcinoma by blocking ezh2 degradation. |
2021-09-28 |
2023-08-13 |
mouse |
| Yunning Huang, Wenjun Wang, Yuan-Yi Xu, Jiaxin Guo, Longxing Jiao, Honghong Wang, Mengqi Li, Qi Yan. Dextran sulfate inhibits cell proliferation and induces apoptosis by regulating EZH2 in gastric carcinoma. Current cancer drug targets. 2021-09-23. PMID:34551698. |
dextran sulfate inhibits cell proliferation and induces apoptosis by regulating ezh2 in gastric carcinoma. |
2021-09-23 |
2023-08-13 |
human |
| Xuwei Zheng, Xiaoyan Zhao, Zhanying Han, Kui Che. Enhancer of zeste homolog 2 participates in the process of atherosclerosis by modulating microRNA-139-5p methylation and signal transducer and activator of transcription 1 expression. IUBMB life. vol 73. issue 1. 2021-09-21. PMID:33331071. |
human arterial smooth muscle cells (hasmcs) induced with oxidized low-density lipoprotein (ox-ldl) and the mice fed with high fat diet were treated with silenced ezh2 or upregulated mir-139-5p to explore their roles in proliferation and apoptosis of hasmcs, together with inflammation response and oxidative stress of mice. |
2021-09-21 |
2023-08-13 |
mouse |
| Xuwei Zheng, Xiaoyan Zhao, Zhanying Han, Kui Che. Enhancer of zeste homolog 2 participates in the process of atherosclerosis by modulating microRNA-139-5p methylation and signal transducer and activator of transcription 1 expression. IUBMB life. vol 73. issue 1. 2021-09-21. PMID:33331071. |
silenced ezh2 or elevated mir-139-5p facilitated proliferation and restrained apoptosis of ox-ldl-treated hasmcs, and restrained oxidative stress and cell apoptosis in arterial tissues of as mice. |
2021-09-21 |
2023-08-13 |
mouse |
| Xuwei Zheng, Xiaoyan Zhao, Zhanying Han, Kui Che. Enhancer of zeste homolog 2 participates in the process of atherosclerosis by modulating microRNA-139-5p methylation and signal transducer and activator of transcription 1 expression. IUBMB life. vol 73. issue 1. 2021-09-21. PMID:33331071. |
this study manifests that down-regulated ezh2 or elevated mir-139-5p inhibits ox-ldl-induced hasmcs apoptosis, plaque formation, and inflammatory response in as mice, which may be related to down-regulated stat1. |
2021-09-21 |
2023-08-13 |
mouse |
| Zhen Zhao, Yan Xing, Fei Yang, Zhijun Zhao, Yupeng Shen, Junjian Song, Shanghua Jin. LncRNA HOXA-AS2 Promotes Oral Squamous Cell Proliferation, Migration, and Invasion via Upregulating EZH2 as an Oncogene. Technology in cancer research & treatment. vol 20. 2021-09-20. PMID:34519570. |
in summary, the findings suggested that hoxa-as2 may inhibit cell proliferation, invasion, and migration, induce cell cycle arrest in the g0/g1 phase, and increase cell apoptosis by targeting ezh2. |
2021-09-20 |
2023-08-13 |
human |
| Ying Yang, Xiaoqing Yang, Yi Wu, Meijiao F. METTL3 promotes inflammation and cell apoptosis in a pediatric pneumonia model by regulating EZH2. Allergologia et immunopathologia. vol 49. issue 5. 2021-09-03. PMID:34476922. |
mettl3 promotes inflammation and cell apoptosis in a pediatric pneumonia model by regulating ezh2. |
2021-09-03 |
2023-08-13 |
Not clear |