| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chenxi Lu, Yanbin Song, Xiaopeng Wu, Wangrui Lei, Junmin Chen, Xin Zhang, Qiong Liu, Chao Deng, Zhenxing Liang, Ying Chen, Jun Ren, Yang Yan. Pleiotropic role of GAS6 in cardioprotection against ischemia-reperfusion injury. Journal of advanced research. 2024-04-23. PMID:38653371. |
growth arrest-specific gene 6 (gas6) is vitamin k-dependent secretory protein, to promote cell proliferation and inhibit inflammation and apoptosis through binding with tyro3, axl, and mertk (tam) receptors. |
2024-04-23 |
2024-04-26 |
Not clear |
| Ting Ji, Qiong Liu, Liming Yu, Wangrui Lei, Chenxi Lu, Junmin Chen, Xin Xie, Zhenhua Zhang, Zhenxing Liang, Chao Deng, Ying Chen, Jun Ren, Yang Yan. GAS6 attenuates sepsis-induced cardiac dysfunction through a NLRP3 inflammasome-dependent mechanism. Free radical biology & medicine. 2023-11-18. PMID:37979891. |
using adeno-associated virus 9 (aav9) technique, gas6 overexpression overtly improved cardiac dysfunction in cecum ligation and puncture (clp)-challenged mice, along with alleviated mitochondrial injury, endoplasmic reticulum stress, oxidative stress, and apoptosis. |
2023-11-18 |
2023-11-20 |
mouse |
| Xinli Fan, Xiaoran Zhao, Jianfei Xu, Jing Wang, Qian Wang, Xinjing Tan. Triton modified polyethyleneimine conjugates assembled with growth arrest-specific protein 6 for androgenetic alopecia transdermal gene therapy. Materials today. Bio. vol 19. 2023-02-23. PMID:36815198. |
the transfected gas6 prolongs the anagen status, inhibits the apoptosis of hair follicle cells, and further promotes the proliferation and differentiation of hair follicle cells. |
2023-02-23 |
2023-08-14 |
mouse |
| Chuanbo Ha, Lihong Hu, Yuanyuan Ren, Jie Yang, Lingbiao Xi. SND1 confers chemoresistance to cisplatin-induced apoptosis by targeting GAS6-AKT in SKOV3 ovarian cancer cells. Medical oncology (Northwood, London, England). vol 39. issue 11. 2022-08-16. PMID:35972612. |
moreover, snd1 can regulate the expression of growth arrest-specific 6 (gas6) and then activate the akt signaling pathway to achieve the regulation of sensitivity to cisplatin-induced apoptosis in ovarian cancer. |
2022-08-16 |
2023-08-14 |
Not clear |
| Wangrui Lei, Songdi Wu, Aizhen Zhao, Zhen Wu, Baoping Ding, Wenwen Yang, Chenxi Lu, Xue Wu, Xiyang Li, Shaofei Zhang, Ye Tian, Yang Yan. Psoralidin protects against cerebral hypoxia/reoxygenation injury: Role of GAS6/Axl signaling. Phytotherapy research : PTR. 2022-05-18. PMID:35583809. |
growth arrest-specific gene 6 (gas6) and its receptor, axl, modulate cellular oxidative stress, apoptosis, survival, proliferation, migration, and mitogenesis. |
2022-05-18 |
2023-08-13 |
Not clear |
| Xiaochen Niu, Ye Cheng, Meng Zhang, Luyang Du, Xue Wu, Chenxi Lu, Xiyang Li, Shuai Liu, Aizhen Zhao, Shaofei Zhang, Zhen Wu, Baoping Ding, Wenzhen Shi, Changyu Wang, Yang Yang, Ye Tia. Neuroprotective Effects of Omentin-1 Against Cerebral Hypoxia/Reoxygenation Injury via Activating GAS6/Axl Signaling Pathway in Neuroblastoma Cells. Frontiers in cell and developmental biology. vol 9. 2022-02-10. PMID:35141232. |
the biological functions of gas6 are mediated by the interaction with tam (tyro3, axl and mertk) receptors, including cell survival and proliferation, immune regulation and apoptosis. |
2022-02-10 |
2023-08-13 |
human |
| Bo-Min Kim, Ye-Ji Lee, Youn-Hee Choi, Eun-Mi Park, Jihee Lee Kan. Gas6 Ameliorates Inflammatory Response and Apoptosis in Bleomycin-Induced Acute Lung Injury. Biomedicines. vol 9. issue 11. 2021-11-30. PMID:34829903. |
gas6 ameliorates inflammatory response and apoptosis in bleomycin-induced acute lung injury. |
2021-11-30 |
2023-08-13 |
mouse |
| Kelsey M Hirschi, Kary Y F Tsai, Taylor Davis, J Christian Clark, M Nekel Knowlton, Benjamin T Bikman, Paul R Reynolds, Juan A Arroy. Growth arrest-specific protein-6/AXL signaling induces preeclampsia in rats†. Biology of reproduction. vol 102. issue 1. 2021-06-09. PMID:31347670. |
animals dispensed gas6 experienced elevated blood pressure, increased proteinuria, augmented caspase-3-mediated placental apoptosis, and diminished trophoblast invasion. |
2021-06-09 |
2023-08-13 |
rat |
| Mattia Bellan, Marco Quaglia, Alessandra Nerviani, Daniele Mauro, Myles Lewis, Federica Goegan, Antonello Gibbin, Sara Pagani, Livia Salmi, Luca Molinari, Luigi Mario Castello, Gian Carlo Avanzi, Vincenzo Cantaluppi, Mario Pirisi, Pier Paolo Sainaghi, Costantino Pitzali. Increased plasma levels of Gas6 and its soluble tyrosine kinase receptors Mer and Axl are associated with immunological activity and severity of lupus nephritis. Clinical and experimental rheumatology. vol 39. issue 1. 2021-02-10. PMID:32573415. |
growth arrest-specific 6 (gas6) and its receptors have been shown to play a crucial role in the homeostasis of the innate immune system by regulating apoptosis and inflammation. |
2021-02-10 |
2023-08-13 |
Not clear |
| Li Wen, Yuanquan Zheng, Xiaoyi Wen, Yitian Zhang, Weihui Zen. Increased expression of long noncoding RNA GAS6-AS2 promotes proliferation and inhibits apoptosis of melanoma cells via upregulating GAS6 expression. IUBMB life. vol 71. issue 10. 2020-05-15. PMID:31162889. |
increased expression of long noncoding rna gas6-as2 promotes proliferation and inhibits apoptosis of melanoma cells via upregulating gas6 expression. |
2020-05-15 |
2023-08-13 |
Not clear |
| Li Wen, Yuanquan Zheng, Xiaoyi Wen, Yitian Zhang, Weihui Zen. Increased expression of long noncoding RNA GAS6-AS2 promotes proliferation and inhibits apoptosis of melanoma cells via upregulating GAS6 expression. IUBMB life. vol 71. issue 10. 2020-05-15. PMID:31162889. |
in addition, deficiency of gas6 reverses the biological roles of gas6-as2 overexpression in melanoma cell proliferation and apoptosis. |
2020-05-15 |
2023-08-13 |
Not clear |
| Mengfang Li, Jingjing Ye, Guangju Zhao, Guangliang Hong, Xiyi Hu, Kaiqiang Cao, You Wu, Zhongqiu L. Gas6 attenuates lipopolysaccharide‑induced TNF‑α expression and apoptosis in H9C2 cells through NF‑κB and MAPK inhibition via the Axl/PI3K/Akt pathway. International journal of molecular medicine. vol 44. issue 3. 2020-02-04. PMID:31524235. |
gas6 attenuates lipopolysaccharide‑induced tnf‑α expression and apoptosis in h9c2 cells through nf‑κb and mapk inhibition via the axl/pi3k/akt pathway. |
2020-02-04 |
2023-08-13 |
Not clear |
| Mengfang Li, Jingjing Ye, Guangju Zhao, Guangliang Hong, Xiyi Hu, Kaiqiang Cao, You Wu, Zhongqiu L. Gas6 attenuates lipopolysaccharide‑induced TNF‑α expression and apoptosis in H9C2 cells through NF‑κB and MAPK inhibition via the Axl/PI3K/Akt pathway. International journal of molecular medicine. vol 44. issue 3. 2020-02-04. PMID:31524235. |
the results demonstrated that gas6 suppressed tnf‑α release and inhibited cell apoptosis, and attenuated nuclear factor (nf)‑κb and mitogen‑activated protein kinase (mapk) activation via the axl/pi3k/akt pathway. |
2020-02-04 |
2023-08-13 |
Not clear |
| Mengfang Li, Jingjing Ye, Guangju Zhao, Guangliang Hong, Xiyi Hu, Kaiqiang Cao, You Wu, Zhongqiu L. Gas6 attenuates lipopolysaccharide‑induced TNF‑α expression and apoptosis in H9C2 cells through NF‑κB and MAPK inhibition via the Axl/PI3K/Akt pathway. International journal of molecular medicine. vol 44. issue 3. 2020-02-04. PMID:31524235. |
furthermore, the cardioprotective properties of gas6 on the suppression of lps‑induced tnf‑α release and apoptosis were abolished by treatment with tp‑0903 (an axl inhibitor) and wortmannin (a pi3k inhibitor). |
2020-02-04 |
2023-08-13 |
Not clear |
| Mengfang Li, Jingjing Ye, Guangju Zhao, Guangliang Hong, Xiyi Hu, Kaiqiang Cao, You Wu, Zhongqiu L. Gas6 attenuates lipopolysaccharide‑induced TNF‑α expression and apoptosis in H9C2 cells through NF‑κB and MAPK inhibition via the Axl/PI3K/Akt pathway. International journal of molecular medicine. vol 44. issue 3. 2020-02-04. PMID:31524235. |
these findings suggested that activation of axl/pi3k/akt signaling by gas6 may inhibit lps‑induced tnf‑α expression and apoptosis, as well as mapk and nf‑κb activation. |
2020-02-04 |
2023-08-13 |
Not clear |
| Xuren Sun, Haixia Guan, Shiqiao Peng, Yu Zhao, Le Zhang, Xinyi Wang, Chenyan Li, Zhongyan Shan, Weiping Ten. Growth arrest-specific protein 6 (Gas6) attenuates inflammatory injury and apoptosis in iodine-induced NOD.H-2 International immunopharmacology. vol 73. 2020-01-28. PMID:31129420. |
growth arrest-specific protein 6 (gas6) attenuates inflammatory injury and apoptosis in iodine-induced nod.h-2 growth arrest-specific protein 6 (gas6) is a vitamin k-dependent protein that plays an important role in the pathogenesis of autoimmune diseases. |
2020-01-28 |
2023-08-13 |
Not clear |
| Michiko Nanao-Hamai, Bo-Kyung Son, Aya Komuro, Yusuke Asari, Tsuyoshi Hashizume, Ken-Ichi Takayama, Sumito Ogawa, Masahiro Akishit. Ginsenoside Rb1 inhibits vascular calcification as a selective androgen receptor modulator. European journal of pharmacology. vol 859. 2020-01-28. PMID:31319068. |
rb1 significantly inhibited apoptosis, one of the regulatory mechanisms of calcification, and restored growth arrest-specific gene 6 (gas6) expression that was suppressed by pi. |
2020-01-28 |
2023-08-13 |
human |
| Shengshuai Shan, Zhenyu Liu, Tangmeng Guo, Min Wang, Shaobo Tian, Yanqing Zhang, Kun Wang, Huabo Zheng, Xiaofang Zhao, Peiyuan Zuo, Yingxuan Wang, Dazhu Li, Chengyun Li. Growth arrest-specific gene 6 transfer promotes mesenchymal stem cell survival and cardiac repair under hypoxia and ischemia via enhanced autocrine signaling and paracrine action. Archives of biochemistry and biophysics. vol 660. 2019-07-10. PMID:30365934. |
functional studies demonstrated that gas6 transfer significantly reduced msc apoptosis, increased survival of mscs in vitro and in vivo, and that gas6-engineered mscs (msc |
2019-07-10 |
2023-08-13 |
rat |
| Sayaka Namba, Minako Yamaoka-Tojo, Ryota Kakizaki, Teruyoshi Nemoto, Kazuhiro Fujiyoshi, Takehiro Hashikata, Lisa Kitasato, Takuya Hashimoto, Ryo Kameda, Kentaro Meguro, Takao Shimohama, Taiki Tojo, Junya Ak. Effects on bone metabolism markers and arterial stiffness by switching to rivaroxaban from warfarin in patients with atrial fibrillation. Heart and vessels. vol 32. issue 8. 2018-04-23. PMID:28233091. |
gas6 prevents the apoptosis of vascular smooth muscle cells. |
2018-04-23 |
2023-08-13 |
Not clear |
| Maria Fusaro, Claudia D'Alessandro, Marianna Noale, Giovanni Tripepi, Mario Plebani, Nicola Veronese, Giorgio Iervasi, Sandro Giannini, Maurizio Rossini, Giovanni Tarroni, Sandro Lucatello, Alberto Vianello, Irene Santinello, Luciana Bonfante, Fabrizio Fabris, Stefania Sella, Antonio Piccoli, Agostino Naso, Daniele Ciurlino, Andrea Aghi, Maurizio Gallieni, Adamasco Cupist. Low vitamin K1 intake in haemodialysis patients. Clinical nutrition (Edinburgh, Scotland). vol 36. issue 2. 2018-02-28. PMID:27234935. |
gas6 activity prevents the apoptosis of vascular smooth muscle cells. |
2018-02-28 |
2023-08-13 |
Not clear |