| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Younghun Jung, Ann M Decker, Jingcheng Wang, Eunsohl Lee, Lulia A Kana, Kenji Yumoto, Frank C Cackowski, James Rhee, Peter Carmeliet, Laura Buttitta, Todd M Morgan, Russell S Taichma. Endogenous GAS6 and Mer receptor signaling regulate prostate cancer stem cells in bone marrow. Oncotarget. vol 7. issue 18. 2017-12-06. PMID:27028863. |
previously we have demonstrated that gas6 signaling regulates invasion, proliferation, chemotherapy-induced apoptosis of prostate cancer (pca) cells. |
2017-12-06 |
2023-08-13 |
Not clear |
| Guiling Wu, Zhiqiang Ma, Wei Hu, Dongjin Wang, Bing Gong, Chongxi Fan, Shuai Jiang, Tian Li, Jianyuan Gao, Yang Yan. Molecular insights of Gas6/TAM in cancer development and therapy. Cell death & disease. vol 8. issue 3. 2017-11-13. PMID:28333143. |
since growth arrest-specific gene 6 (gas6) was discovered in 1988, numerous studies have highlighted the role of the gas6 protein and its receptors tyro3, axl and mer (collectively referred to as tam), in proliferation, apoptosis, efferocytosis, leukocyte migration, sequestration and platelet aggregation. |
2017-11-13 |
2023-08-13 |
Not clear |
| Eunsohl Lee, Ann M Decker, Frank C Cackowski, Lulia A Kana, Kenji Yumoto, Younghun Jung, Jingcheng Wang, Laura Buttitta, Todd M Morgan, Russell S Taichma. Growth Arrest-Specific 6 (GAS6) Promotes Prostate Cancer Survival by G Journal of cellular biochemistry. vol 117. issue 12. 2017-08-22. PMID:27153245. |
here, we explored how gas6 regulates the cell cycle and apoptosis of pca cells in response to chemotherapy. |
2017-08-22 |
2023-08-13 |
Not clear |
| Miki Furukawa, Hiroshi Ohkawara, Kazuei Ogawa, Kazuhiko Ikeda, Koki Ueda, Akiko Shichishima-Nakamura, Emi Ito, Jun-Ichi Imai, Yuka Yanagisawa, Reiko Honma, Shinya Watanabe, Satoshi Waguri, Takayuki Ikezoe, Yasuchika Takeish. Autocrine and Paracrine Interactions between Multiple Myeloma Cells and Bone Marrow Stromal Cells by Growth Arrest-specific Gene 6 Cross-talk with Interleukin-6. The Journal of biological chemistry. vol 292. issue 10. 2017-07-27. PMID:28154173. |
exogenous gas6 suppressed apoptosis induced by serum deprivation and enhanced cell proliferation of the mm cells. |
2017-07-27 |
2023-08-13 |
human |
| Michiko Nanao-Hamai, Bo-Kyung Son, Tsuyoshi Hashizume, Sumito Ogawa, Masahiro Akishit. Protective effects of estrogen against vascular calcification via estrogen receptor α-dependent growth arrest-specific gene 6 transactivation. Biochemical and biophysical research communications. vol 480. issue 3. 2017-05-29. PMID:27771246. |
mechanistically, e2 restored the inhibited expression of gas6 and phospho-akt in pi-induced apoptosis through erα. |
2017-05-29 |
2023-08-13 |
human |
| Michiko Nanao-Hamai, Bo-Kyung Son, Tsuyoshi Hashizume, Sumito Ogawa, Masahiro Akishit. Protective effects of estrogen against vascular calcification via estrogen receptor α-dependent growth arrest-specific gene 6 transactivation. Biochemical and biophysical research communications. vol 480. issue 3. 2017-05-29. PMID:27771246. |
taken together, these results indicate that e2 exerts inhibitory effects on vsmc apoptosis and calcification through erα-mediated gas6 transactivation. |
2017-05-29 |
2023-08-13 |
human |
| Miao Wu, Shijuan Lu, Jianghua Zhong, Kang Huang, Saidan Zhan. Protective Effects of Pterostilbene Against Myocardial Ischemia/Reperfusion Injury in Rats. Inflammation. vol 40. issue 2. 2017-05-03. PMID:28054238. |
our findings suggest that ptb treatment exerts cardioprotection against mi/r injury via attenuating inflammatory response, oxidative stress, and apoptosis and up-regulating the expression of gas6 and axl. |
2017-05-03 |
2023-08-13 |
rat |
| Xiaoyu Jiang, Huiren Tao, Cuiting Qiu, Xiaolei Ma, Shan Li, Xian Guo, Anlin Lv, Huan L. Vitamin K2 regression aortic calcification induced by warfarin via Gas6/Axl survival pathway in rats. European journal of pharmacology. vol 786. 2017-03-10. PMID:27212383. |
alizarin red s staining measured aortic calcium depositions; alkaline phosphatase activity in serum was measured by a kit; apoptosis was evaluated by tunel assay; protein expression levels of gas6, axl, phosphorylated akt (p-akt), and bcl-2 were determined by western blotting. |
2017-03-10 |
2023-08-13 |
rat |
| Xiaoyu Jiang, Huiren Tao, Cuiting Qiu, Xiaolei Ma, Shan Li, Xian Guo, Anlin Lv, Huan L. Vitamin K2 regression aortic calcification induced by warfarin via Gas6/Axl survival pathway in rats. European journal of pharmacology. vol 786. 2017-03-10. PMID:27212383. |
100μg/g vitamin k2 treatment decreased calcium depositions, alp activity and apoptosis significantly, but increased gas6, axl, p-akt and bcl-2 expression. |
2017-03-10 |
2023-08-13 |
rat |
| Pawel Szul. Abdominal aortic calcification: A reappraisal of epidemiological and pathophysiological data. Bone. vol 84. 2016-11-07. PMID:26688274. |
vitamin k-dependent proteins protect vascular tunica media against formation of calcified deposits (matrix gla protein, gla-rich protein) and against vsmc apoptosis (gas6). |
2016-11-07 |
2023-08-13 |
Not clear |
| Kuo-Sheng Wu, Yi-Jen Hung, Chien-Hsing Lee, Fone-Ching Hsiao, Po-Shiuan Hsie. The Involvement of GAS6 Signaling in the Development of Obesity and Associated Inflammation. International journal of endocrinology. vol 2015. 2015-05-08. PMID:25954309. |
growth arrest-specific 6 (gas6), a vitamin k-dependent protein, plays a role in the survival, proliferation, migration, differentiation, adhesion, and apoptosis of cells. |
2015-05-08 |
2023-08-13 |
Not clear |
| Bo-Kyung Son, Masahiro Akishita, Katsuya Iijima, Sumito Ogawa, Tomio Arai, Hidemi Ishii, Koji Maemura, Hiroyuki Aburatani, Masato Eto, Yasuyoshi Ouch. Thrombomodulin, a novel molecule regulating inorganic phosphate-induced vascular smooth muscle cell calcification. Journal of molecular and cellular cardiology. vol 56. 2013-07-23. PMID:23274063. |
we further found that tm suppressed both of mrna and protein expression of growth arrest-specific gene 6 (gas6), a key molecule regulating apoptosis. |
2013-07-23 |
2023-08-12 |
human |
| Bo-Kyung Son, Masahiro Akishita, Katsuya Iijima, Sumito Ogawa, Tomio Arai, Hidemi Ishii, Koji Maemura, Hiroyuki Aburatani, Masato Eto, Yasuyoshi Ouch. Thrombomodulin, a novel molecule regulating inorganic phosphate-induced vascular smooth muscle cell calcification. Journal of molecular and cellular cardiology. vol 56. 2013-07-23. PMID:23274063. |
these results indicate that tm is a novel molecule that promotes apoptosis and vascular calcification by regulation of gas6, presumably via egf receptor/erk axis. |
2013-07-23 |
2023-08-12 |
human |
| Sandrine Laurance, Catherine A Lemarié, Mark D Blostei. Growth arrest-specific gene 6 (gas6) and vascular hemostasis. Advances in nutrition (Bethesda, Md.). vol 3. issue 2. 2012-09-18. PMID:22516727. |
gas6 has been shown to be involved in vascular homeostasis and more precisely is involved in proliferation, apoptosis, efferocytosis, leukocyte migration, and sequestration and platelet aggregation. |
2012-09-18 |
2023-08-12 |
mouse |
| Guylaine Ferlan. Vitamin K, an emerging nutrient in brain function. BioFactors (Oxford, England). vol 38. issue 2. 2012-08-09. PMID:22419547. |
functionally, gas6 has been involved in a wide range of cellular processes that include cell growth, survival, and apoptosis. |
2012-08-09 |
2023-08-12 |
Not clear |
| Hyunsoo Kim, Han-Jong Kim, Kyunghee Lee, Jin-Man Kim, Hee Sun Kim, Jae-Ryong Kim, Chae-Myeong Ha, Young-Keun Choi, Sun Joo Lee, Joon-Young Kim, Robert A Harris, Daewon Jeong, In-Kyu Le. α-Lipoic acid attenuates vascular calcification via reversal of mitochondrial function and restoration of Gas6/Axl/Akt survival pathway. Journal of cellular and molecular medicine. vol 16. issue 2. 2012-06-25. PMID:21362131. |
moreover, ala inhibited pi-induced down-regulation of cell survival signals through the binding of growth arrest-specific gene 6 (gas6) to its cognate receptor axl and subsequent akt activation, resulting in increased survival and decreased apoptosis. |
2012-06-25 |
2023-08-12 |
mouse |
| Mony Shuvy, Suzan Abedat, Ronen Beeri, Michael Valitsky, Sameh Daher, Miriam Kott-Gutkowski, Anca Gal-Moscovici, Jacob Sosna, Nalini M Rajamannan, Chaim Lota. Raloxifene attenuates Gas6 and apoptosis in experimental aortic valve disease in renal failure. American journal of physiology. Heart and circulatory physiology. vol 300. issue 5. 2011-07-07. PMID:21335463. |
raloxifene attenuates gas6 and apoptosis in experimental aortic valve disease in renal failure. |
2011-07-07 |
2023-08-12 |
rat |
| Chang-Hee Suh, Brendan Hilliard, Sophia Li, Joan T Merrill, Philip L Cohe. TAM receptor ligands in lupus: protein S but not Gas6 levels reflect disease activity in systemic lupus erythematosus. Arthritis research & therapy. vol 12. issue 4. 2011-01-19. PMID:20637106. |
gas6 and protein s are ligands for these tam kinases and bind to phosphatidyl serine residues exposed during apoptosis. |
2011-01-19 |
2023-08-12 |
human |
| Tilo Dehne, Rita Schenk, Carsten Perka, Lars Morawietz, Axel Pruss, Michael Sittinger, Christian Kaps, Jochen Ring. Gene expression profiling of primary human articular chondrocytes in high-density micromasses reveals patterns of recovery, maintenance, re- and dedifferentiation. Gene. vol 462. issue 1-2. 2010-08-04. PMID:20433912. |
likewise, a steady increase of genes associated with proliferation (gas6, serpinf1, vegfb and vegfc) and apoptosis (dram, dpak1, hspb, gpx1, ngfrap1 and tia1) was observed. |
2010-08-04 |
2023-08-12 |
human |
| Yusuke Shiozawa, Elisabeth A Pedersen, Lalit R Patel, Anne M Ziegler, Aaron M Havens, Younghun Jung, Jingcheng Wang, Stephanie Zalucha, Robert D Loberg, Kenneth J Pienta, Russell S Taichma. GAS6/AXL axis regulates prostate cancer invasion, proliferation, and survival in the bone marrow niche. Neoplasia (New York, N.Y.). vol 12. issue 2. 2010-04-23. PMID:20126470. |
in addition, gas6 produced by osteoblasts prevents pca proliferation and protects pca from chemotherapy-induced apoptosis. |
2010-04-23 |
2023-08-12 |
Not clear |