| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lei Fan, Chang-Geng Rua. [Advance of study on Mer function]. Zhongguo shi yan xue ye xue za zhi. vol 15. issue 4. 2009-12-08. PMID:17708828. |
mer is one member of axl receptor tyrosine kinase family, and its ligand gas6 can stimulate activity of mer receptor tyrosine kinase after binding it, and then activate the downstream signal transduction pathway, mer participates in cell inflammation, apoptosis, tumorigenesis, thrombosis and hemostasis. |
2009-12-08 |
2023-08-12 |
Not clear |
| Lei Fan, Lan Dai, Fei Shen, Meng-Yun Zhou, Ning-Zheng Dong, Chang-Geng Rua. [Expression of Mer on Jurkat cells and its anti-apoptosis effect]. Ai zheng = Aizheng = Chinese journal of cancer. vol 26. issue 7. 2009-10-27. PMID:17626743. |
mer is a member of axl receptor tyrosine kinase family; its ligand gas6 can bind mer, then stimulate the tyrosine kinase activity and downstream cell signal pathway of mer, and take part in cell inflammation and apoptosis. |
2009-10-27 |
2023-08-12 |
Not clear |
| Sara Scutera, Tiziana Fraone, Tiziana Musso, Paola Cappello, Silvia Rossi, Daniele Pierobon, Zane Orinska, Ralf Paus, Silvia Bulfone-Paus, Mirella Giovarell. Survival and migration of human dendritic cells are regulated by an IFN-alpha-inducible Axl/Gas6 pathway. Journal of immunology (Baltimore, Md. : 1950). vol 183. issue 5. 2009-09-18. PMID:19657094. |
furthermore, stimulation of axl by its ligand, gas6, induced chemotaxis of human dc and rescued them from growth factor deprivation-induced apoptosis. |
2009-09-18 |
2023-08-12 |
human |
| J G Ganopolsky, Md R Abid, W C Aird, M D Blostei. GAS6-induced signaling in human endothelial cells is mediated by FOXO1a. Journal of thrombosis and haemostasis : JTH. vol 6. issue 10. 2008-12-18. PMID:18680538. |
growth arrest specific gene product 6 (gas6) is a gamma-carboxylated protein that protects endothelial cells against apoptosis. |
2008-12-18 |
2023-08-12 |
human |
| Bo-Kyung Son, Masahiro Akishit. [Vascular calcification and anti-aging]. Clinical calcium. vol 18. issue 7. 2008-09-26. PMID:18591741. |
we suggested that apoptosis plays an important role in vascular smooth muscle cells (vsmc) calcification which is dependent on downregulation of the growth arrest-specific gene 6 (gas6) -mediated survival pathway. |
2008-09-26 |
2023-08-12 |
Not clear |
| Bo-Kyung Son, Masahiro Akishita, Katsuya Iijima, Masato Eto, Yasuyoshi Ouch. Mechanism of pi-induced vascular calcification. Journal of atherosclerosis and thrombosis. vol 15. issue 2. 2008-09-18. PMID:18385534. |
in this review, we discuss the role of apoptosis in inorganic phosphate (pi)- induced calcification, focusing on regulation of the survival pathway mediated by growth arrest- specific gene 6 (gas6). |
2008-09-18 |
2023-08-12 |
Not clear |
| Bo-Kyung Son, Masahiro Akishit. [Mechanism of vascular calcification]. Clinical calcium. vol 17. issue 3. 2007-05-01. PMID:17339734. |
during the process of vascular calcification, growth arrest-specific gene 6 (gas6) mediated-survival pathway is downregulated in vsmc, leading to apoptosis. |
2007-05-01 |
2023-08-12 |
Not clear |
| Bo-Kyung Son, Koichi Kozaki, Katsuya Iijima, Masato Eto, Toru Nakano, Masahiro Akishita, Yasuyoshi Ouch. Gas6/Axl-PI3K/Akt pathway plays a central role in the effect of statins on inorganic phosphate-induced calcification of vascular smooth muscle cells. European journal of pharmacology. vol 556. issue 1-3. 2007-04-05. PMID:17196959. |
recently, we showed that 3-hydroxy-3-methylglutaryl (hmg) coa reductase inhibitors (statins) have a protective effect against vascular smooth muscle cell calcification by inhibiting apoptosis, where growth arrest-specific gene 6 (gas6) plays a pivotal role. |
2007-04-05 |
2023-08-12 |
human |
| Bo-Kyung Son, Koichi Kozaki, Katsuya Iijima, Masato Eto, Toru Nakano, Masahiro Akishita, Yasuyoshi Ouch. Gas6/Axl-PI3K/Akt pathway plays a central role in the effect of statins on inorganic phosphate-induced calcification of vascular smooth muscle cells. European journal of pharmacology. vol 556. issue 1-3. 2007-04-05. PMID:17196959. |
gas6 and its receptor, axl, expression were downregulated in the presence of pi, and recombinant human gas6 (rhgas6) significantly inhibited apoptosis and calcification in a concentration-dependent manner. |
2007-04-05 |
2023-08-12 |
human |
| Bo-Kyung Son, Koichi Kozaki, Katsuya Iijima, Masato Eto, Toru Nakano, Masahiro Akishita, Yasuyoshi Ouch. Gas6/Axl-PI3K/Akt pathway plays a central role in the effect of statins on inorganic phosphate-induced calcification of vascular smooth muscle cells. European journal of pharmacology. vol 556. issue 1-3. 2007-04-05. PMID:17196959. |
the inhibitory effect of statins on pi-induced apoptosis was accompanied by restoration of the gas6-mediated survival signal pathway: upregulation of gas6 and axl expression, increased phosphorylation of akt and bcl2, and inhibition of bad and caspase 3 activation. |
2007-04-05 |
2023-08-12 |
human |
| Tateo Sawabu, Hiroshi Seno, Tomoko Kawashima, Akihisa Fukuda, Yoshito Uenoyama, Mayumi Kawada, Naoki Kanda, Akira Sekikawa, Hirokazu Fukui, Motoko Yanagita, Hiroshi Yoshibayashi, Seiji Satoh, Yoshiharu Sakai, Toru Nakano, Tsutomu Chib. Growth arrest-specific gene 6 and Axl signaling enhances gastric cancer cell survival via Akt pathway. Molecular carcinogenesis. vol 46. issue 2. 2007-03-26. PMID:17186543. |
with recombinant gas6 and a decoy-receptor of axl in vitro, we demonstrated that gas6-axl signaling pathway enhanced cellular survival and invasion and suppressed apoptosis via akt pathway. |
2007-03-26 |
2023-08-12 |
human |
| Bo-Kyung Son, Koichi Kozaki, Katsuya Iijima, Masato Eto, Taro Kojima, Hidetaka Ota, Yuka Senda, Koji Maemura, Toru Nakano, Masahiro Akishita, Yasuyoshi Ouch. Statins protect human aortic smooth muscle cells from inorganic phosphate-induced calcification by restoring Gas6-Axl survival pathway. Circulation research. vol 98. issue 8. 2006-06-02. PMID:16556867. |
in this study, we investigated the effect of statins on vsmc calcification by testing their effect on apoptosis, focusing in particular on regulation of the survival pathway mediated by growth arrest-specific gene 6 (gas6), a member of the vitamin k-dependent protein family, and its receptor, axl. |
2006-06-02 |
2023-08-12 |
human |
| Bo-Kyung Son, Koichi Kozaki, Katsuya Iijima, Masato Eto, Taro Kojima, Hidetaka Ota, Yuka Senda, Koji Maemura, Toru Nakano, Masahiro Akishita, Yasuyoshi Ouch. Statins protect human aortic smooth muscle cells from inorganic phosphate-induced calcification by restoring Gas6-Axl survival pathway. Circulation research. vol 98. issue 8. 2006-06-02. PMID:16556867. |
suppression of gas6 using small interfering rna and the axl-extracellular domain abolished the preventive effect of statins on pi-induced apoptosis and calcification. |
2006-06-02 |
2023-08-12 |
human |
| I Hasanbasic, I Rajotte, M Blostei. The role of gamma-carboxylation in the anti-apoptotic function of gas6. Journal of thrombosis and haemostasis : JTH. vol 3. issue 12. 2006-02-21. PMID:16359517. |
furthermore, the role of gamma-carboxylation in gas6's survival effect on endothelium is demonstrated directly in that only carboxylated, but not decarboxylated, gas6 protects endothelial cells from serum starvation-induced apoptosis. |
2006-02-21 |
2023-08-12 |
Not clear |
| Delphine Borgel, Sylvain Clauser, Caroline Bornstain, Ivan Bièche, Alvine Bissery, Véronique Remones, Jean-Yves Fagon, Martine Aiach, Jean-Luc Dieh. Elevated growth-arrest-specific protein 6 plasma levels in patients with severe sepsis. Critical care medicine. vol 34. issue 1. 2006-01-20. PMID:16374177. |
as the gas6 system has been implicated in mouse susceptibility to sepsis, and as leukocyte apoptosis is thought to play a major role in the physiopathology of human severe sepsis, we studied gas6 plasma levels and possibly related variables in patients with severe sepsis. |
2006-01-20 |
2023-08-12 |
mouse |
| Matthew G Melaragno, Megan E Cavet, Chen Yan, Lung-Kuo Tai, Zheng-Gen Jin, Judith Haendeler, Bradford C Ber. Gas6 inhibits apoptosis in vascular smooth muscle: role of Axl kinase and Akt. Journal of molecular and cellular cardiology. vol 37. issue 4. 2005-03-01. PMID:15380678. |
gas6 inhibits apoptosis in vascular smooth muscle: role of axl kinase and akt. |
2005-03-01 |
2023-08-12 |
human |
| Matthew G Melaragno, Megan E Cavet, Chen Yan, Lung-Kuo Tai, Zheng-Gen Jin, Judith Haendeler, Bradford C Ber. Gas6 inhibits apoptosis in vascular smooth muscle: role of Axl kinase and Akt. Journal of molecular and cellular cardiology. vol 37. issue 4. 2005-03-01. PMID:15380678. |
treatment of vsmc with 100 ng/ml gas6 (the putative ligand for axl) decreased apoptosis to 8.9 +/- 0.7% (p = 0.002, n = 17) as compared to a decrease with 10% serum to 3.0 +/- 0.2% (p = 0.001, n = 17). |
2005-03-01 |
2023-08-12 |
human |
| Matthew G Melaragno, Megan E Cavet, Chen Yan, Lung-Kuo Tai, Zheng-Gen Jin, Judith Haendeler, Bradford C Ber. Gas6 inhibits apoptosis in vascular smooth muscle: role of Axl kinase and Akt. Journal of molecular and cellular cardiology. vol 37. issue 4. 2005-03-01. PMID:15380678. |
the ability of gas6 to prevent apoptosis required both gas6 binding to axl and axl kinase activity since treatment with a soluble, competitive axl extracellular domain protein or transfection of a kinase inactive mutant (axl-k567r) completely prevented the anti-apoptotic effect. |
2005-03-01 |
2023-08-12 |
human |
| Ines Hasanbasic, Jessica Cuerquis, Brian Varnum, Mark D Blostei. Intracellular signaling pathways involved in Gas6-Axl-mediated survival of endothelial cells. American journal of physiology. Heart and circulatory physiology. vol 287. issue 3. 2004-09-10. PMID:15130893. |
using flow cytometry, we first confirmed that gas6 can abrogate apoptosis induced by serum starvation of primary cultures of human umbilical vein endothelial cells (huvecs). |
2004-09-10 |
2023-08-12 |
human |
| Ines Hasanbasic, Jessica Cuerquis, Brian Varnum, Mark D Blostei. Intracellular signaling pathways involved in Gas6-Axl-mediated survival of endothelial cells. American journal of physiology. Heart and circulatory physiology. vol 287. issue 3. 2004-09-10. PMID:15130893. |
taken together, these experiments provide new information about the mechanism underlying gas6 protection from apoptosis in primary endothelial cell cultures. |
2004-09-10 |
2023-08-12 |
human |