| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Valverde, M S Obin, A Taylo. Role of Gas6/Axl signaling in lens epithelial cell proliferation and survival. Experimental eye research. vol 78. issue 1. 2004-01-09. PMID:14667825. |
in contrast, gas6 is not able to block apoptosis induced by staurosporin (1microm, 5-24hr) in human lens epithelial cells. |
2004-01-09 |
2023-08-12 |
human |
| Tatsurou Yagami, Keiichi Ueda, Kenji Asakura, Noboru Okamura, Toshiyuki Sakaeda, Gaku Sakaguchi, Naohiro Itoh, Yutaka Hashimoto, Toru Nakano, Masafumi Fujimot. Effect of Gas6 on secretory phospholipase A(2)-IIA-induced apoptosis in cortical neurons. Brain research. vol 985. issue 2. 2003-11-10. PMID:12967718. |
effect of gas6 on secretory phospholipase a(2)-iia-induced apoptosis in cortical neurons. |
2003-11-10 |
2023-08-12 |
human |
| Tatsurou Yagami, Keiichi Ueda, Kenji Asakura, Noboru Okamura, Toshiyuki Sakaeda, Gaku Sakaguchi, Naohiro Itoh, Yutaka Hashimoto, Toru Nakano, Masafumi Fujimot. Effect of Gas6 on secretory phospholipase A(2)-IIA-induced apoptosis in cortical neurons. Brain research. vol 985. issue 2. 2003-11-10. PMID:12967718. |
gas6, a product of the growth-arrest-specific gene 6, protects cortical neurons from amyloid beta protein (abeta)-induced apoptosis. |
2003-11-10 |
2023-08-12 |
human |
| Tatsurou Yagami, Keiichi Ueda, Kenji Asakura, Noboru Okamura, Toshiyuki Sakaeda, Gaku Sakaguchi, Naohiro Itoh, Yutaka Hashimoto, Toru Nakano, Masafumi Fujimot. Effect of Gas6 on secretory phospholipase A(2)-IIA-induced apoptosis in cortical neurons. Brain research. vol 985. issue 2. 2003-11-10. PMID:12967718. |
in conclusion, we demonstrate that gas6 rescues cortical neurons from spla(2)-iia-induced apoptosis. |
2003-11-10 |
2023-08-12 |
human |
| T Yagami, K Ueda, K Asakura, T Sakaeda, H Nakazato, T Kuroda, S Hata, G Sakaguchi, N Itoh, T Nakano, Y Kambayashi, H Tsuzuk. Gas6 rescues cortical neurons from amyloid beta protein-induced apoptosis. Neuropharmacology. vol 43. issue 8. 2003-03-28. PMID:12527478. |
gas6 rescues cortical neurons from amyloid beta protein-induced apoptosis. |
2003-03-28 |
2023-08-12 |
rat |
| T Yagami, K Ueda, K Asakura, T Sakaeda, H Nakazato, T Kuroda, S Hata, G Sakaguchi, N Itoh, T Nakano, Y Kambayashi, H Tsuzuk. Gas6 rescues cortical neurons from amyloid beta protein-induced apoptosis. Neuropharmacology. vol 43. issue 8. 2003-03-28. PMID:12527478. |
gas6, a product of the growth-arrest-specific gene 6, protects neurons from serum deprivation-induced apoptosis. |
2003-03-28 |
2023-08-12 |
rat |
| T Yagami, K Ueda, K Asakura, T Sakaeda, H Nakazato, T Kuroda, S Hata, G Sakaguchi, N Itoh, T Nakano, Y Kambayashi, H Tsuzuk. Gas6 rescues cortical neurons from amyloid beta protein-induced apoptosis. Neuropharmacology. vol 43. issue 8. 2003-03-28. PMID:12527478. |
in conclusion, we demonstrate that gas6 rescues cortical neurons from abeta-induced apoptosis. |
2003-03-28 |
2023-08-12 |
rat |
| Wei-Ping Lee, Yong Wen, Brian Varnum, Mien-Chie Hun. Akt is required for Axl-Gas6 signaling to protect cells from E1A-mediated apoptosis. Oncogene. vol 21. issue 3. 2002-02-14. PMID:11821945. |
to determine how the axl-gas6 interaction prevents e1a-mediated apoptosis, we analysed the expression of anti-apoptotic molecules and found that the activated form of akt was suppressed in the e1a transfectant ip 1-e1a and that gas6 was able to activate akt in ip 1-e1a cells reexpressing axl (ip 1-e1a-axl). |
2002-02-14 |
2023-08-12 |
Not clear |
| Wei-Ping Lee, Yong Wen, Brian Varnum, Mien-Chie Hun. Akt is required for Axl-Gas6 signaling to protect cells from E1A-mediated apoptosis. Oncogene. vol 21. issue 3. 2002-02-14. PMID:11821945. |
in both cases, gas6 no longer protected the cells from serum deprivation-induced apoptosis. |
2002-02-14 |
2023-08-12 |
Not clear |
| W P Lee, Y Liao, D Robinson, H J Kung, E T Liu, M C Hun. Axl-gas6 interaction counteracts E1A-mediated cell growth suppression and proapoptotic activity. Molecular and cellular biology. vol 19. issue 12. 2000-01-06. PMID:10567533. |
the axl ligand gas6 triggered a greater mitogenic effect in these ip1-e1a-axl cells than in ip1-e1a control cells and protected the axl-expressing cells from serum deprivation-induced apoptosis. |
2000-01-06 |
2023-08-12 |
Not clear |
| K O'Donnell, I C Harkes, L Dougherty, I P Wick. Expression of receptor tyrosine kinase Axl and its ligand Gas6 in rheumatoid arthritis: evidence for a novel endothelial cell survival pathway. The American journal of pathology. vol 154. issue 4. 1999-06-10. PMID:10233855. |
exogenous gas6 protected huvecs from apoptosis in response to growth factor withdrawal and from tnfalpha-mediated cytotoxicity. |
1999-06-10 |
2023-08-12 |
human |
| G Krupitza, M Grusch, K Braun, G Fuhrmann, R Steinbrugger, W Hulla, I Simonitsch, A Chott, M Hengstschläge. TNFalpha-mediated cell death is independent of cdc25A. Cell death and differentiation. vol 5. issue 9. 1999-05-28. PMID:10200535. |
cdc25a suppression was related to tnfalpha-induced apoptosis but not to a tnfalpha-induced g0 arrest because cyclin d1 expression was unaffected and the gene gas6 (growth arrest specific 6) was not induced. |
1999-05-28 |
2023-08-12 |
Not clear |
| M P Allen, C Zeng, K Schneider, X Xiong, M K Meintzer, P Bellosta, C Basilico, B Varnum, K A Heidenreich, M E Wierma. Growth arrest-specific gene 6 (Gas6)/adhesion related kinase (Ark) signaling promotes gonadotropin-releasing hormone neuronal survival via extracellular signal-regulated kinase (ERK) and Akt. Molecular endocrinology (Baltimore, Md.). vol 13. issue 2. 1999-05-03. PMID:9973250. |
gn10 (ark positive) gnrh cells were more resistant to serum withdrawal-induced apoptosis than gt1-7 (ark negative) cells, and this effect was augmented with the addition of gas6, the ark (ax1) ligand. |
1999-05-03 |
2023-08-12 |
mouse |
| M P Allen, C Zeng, K Schneider, X Xiong, M K Meintzer, P Bellosta, C Basilico, B Varnum, K A Heidenreich, M E Wierma. Growth arrest-specific gene 6 (Gas6)/adhesion related kinase (Ark) signaling promotes gonadotropin-releasing hormone neuronal survival via extracellular signal-regulated kinase (ERK) and Akt. Molecular endocrinology (Baltimore, Md.). vol 13. issue 2. 1999-05-03. PMID:9973250. |
gas6 rescued gn10 cells from apoptosis, and this effect was blocked by coincubation of the cells with the mitogen-activated protein/erk kinase (mek) inhibitor, pd98059, or wortmannin (but not rapamycin). |
1999-05-03 |
2023-08-12 |
mouse |
| P Bellosta, Q Zhang, S P Goff, C Basilic. Signaling through the ARK tyrosine kinase receptor protects from apoptosis in the absence of growth stimulation. Oncogene. vol 15. issue 20. 1997-12-29. PMID:9395235. |
here we show that constitutive expression of gas6 in an nih3t3 cell line that does not spontaneously express this protein does not result in cell transformation or uncontrolled growth, but protects from apoptosis induced by serum deprivation. |
1997-12-29 |
2023-08-12 |
mouse |
| P Bellosta, Q Zhang, S P Goff, C Basilic. Signaling through the ARK tyrosine kinase receptor protects from apoptosis in the absence of growth stimulation. Oncogene. vol 15. issue 20. 1997-12-29. PMID:9395235. |
recombinant exogenous gas6 was also capable of protecting cells from apoptosis at concentrations that did not result in significant induction of dna synthesis. |
1997-12-29 |
2023-08-12 |
mouse |
| P Bellosta, Q Zhang, S P Goff, C Basilic. Signaling through the ARK tyrosine kinase receptor protects from apoptosis in the absence of growth stimulation. Oncogene. vol 15. issue 20. 1997-12-29. PMID:9395235. |
the antiapoptotic effect of ark signaling was confirmed by studies using fibroblasts from ark knock-out mice, that showed that the absence of ark resulted in higher levels of serum deprivation-induced apoptosis, that could not be rescued by the addition of gas6. |
1997-12-29 |
2023-08-12 |
mouse |
| S Goruppi, E Ruaro, B Varnum, C Schneide. Requirement of phosphatidylinositol 3-kinase-dependent pathway and Src for Gas6-Axl mitogenic and survival activities in NIH 3T3 fibroblasts. Molecular and cellular biology. vol 17. issue 8. 1997-08-25. PMID:9234702. |
we have shown that gas6 is able to induce cell cycle reentry of serum-starved nih 3t3 cells and to efficiently prevent apoptosis after complete growth factor removal, a survival effect uncoupled from gas6-induced mitogenesis. |
1997-08-25 |
2023-08-12 |
Not clear |
| S Goruppi, E Ruaro, C Schneide. Gas6, the ligand of Axl tyrosine kinase receptor, has mitogenic and survival activities for serum starved NIH3T3 fibroblasts. Oncogene. vol 12. issue 3. 1996-07-05. PMID:8637702. |
finally we present evidences indicating that gas6 is able to protect serum starved nih3t3 cells from cell death by apoptosis as induced by complete growth factor depletion. |
1996-07-05 |
2023-08-12 |
Not clear |