| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bernadett Kalmár, Geoffrey Burnstock, Gerta Vrbová, Linda Greensmit. The effect of neonatal nerve injury on the expression of heat shock proteins in developing rat motoneurones. Journal of neurotrauma. vol 19. issue 5. 2002-07-24. PMID:12042100. |
since neonatal nerve injury induces apoptotic motoneurone death, we also studied the co-expression of hsp27 with markers of apoptosis. |
2002-07-24 |
2023-08-12 |
rat |
| S R Kirchhoff, S Gupta, A A Knowlto. Cytosolic heat shock protein 60, apoptosis, and myocardial injury. Circulation. vol 105. issue 24. 2002-06-28. PMID:12070120. |
considering the role of key mitochondrial proteins in apoptosis and the known antiapoptotic effects of hsp27 and hsp72, we postulated that hsp60, primarily a mitochondrial protein, also exerts an antiapoptotic effect. |
2002-06-28 |
2023-08-12 |
Not clear |
| Rosy Leonardi, Giuseppe Pannone, Gaetano Magro, Yasusei Kudo, Takashi Takata, Lorenzo Lo Muzi. Differential expression of heat shock protein 27 in normal oral mucosa, oral epithelial dysplasia and squamous cell carcinoma. Oncology reports. vol 9. issue 2. 2002-05-17. PMID:11836590. |
these findings indicated that hsp27 expression seems to protect cells from apoptosis during inflammation, while the down-regulation in dysplasia could impair the protective mechanism against mutagenesis induced by environmental factors and thus enhancing the transformation of oral epithelial dysplasia into osccs. |
2002-05-17 |
2023-08-12 |
human |
| Sandra Tan, Teck Keong Seow, Rosa Cynthia M Y Liang, Shiuan Koh, Christine P C Lee, Maxey C M Chung, Shing Chuan Hoo. Proteome analysis of butyrate-treated human colon cancer cells (HT-29). International journal of cancer. vol 98. issue 4. 2002-05-10. PMID:11920611. |
however, in hct-116 cells, which were 5-fold more sensitive to butyrate-induced apoptosis, the upregulation of cathepsin d with time was not accompanied by a similar increase in hsp27 levels. |
2002-05-10 |
2023-08-12 |
human |
| Catherine Paul, Florence Manero, Sandrine Gonin, Carole Kretz-Remy, Sophie Virot, André-Patrick Arrig. Hsp27 as a negative regulator of cytochrome C release. Molecular and cellular biology. vol 22. issue 3. 2002-02-11. PMID:11784858. |
we previously showed that hsp27 protects against apoptosis through its interaction with cytosolic cytochrome c. we have revisited this protective activity in murine cell lines expressing different levels of hsp27. |
2002-02-11 |
2023-08-12 |
Not clear |
| Catherine Paul, Florence Manero, Sandrine Gonin, Carole Kretz-Remy, Sophie Virot, André-Patrick Arrig. Hsp27 as a negative regulator of cytochrome C release. Molecular and cellular biology. vol 22. issue 3. 2002-02-11. PMID:11784858. |
moreover, a decreased level of endogenous hsp27, which sensitized hela cells to apoptosis, reduced the delay required for cytochrome c release and procaspase 3 activation. |
2002-02-11 |
2023-08-12 |
Not clear |
| O Amano, Y Kudo, M Shimada, T Wakayama, M Yamamoto, S Isek. Transient occurrence of 27 kDa heat-shock protein in the terminal tubule cells during postnatal development of the rat submandibular gland. The Anatomical record. vol 264. issue 4. 2002-01-31. PMID:11745091. |
it has been suggested that the 27 kda heat-shock protein (hsp27) plays a role at crucial cellular checkpoints for proliferation, apoptosis, and differentiation. |
2002-01-31 |
2023-08-12 |
rat |
| O Sanz, L Acarin, B González, B Castellan. Expression of 27 kDa heat shock protein (Hsp27) in immature rat brain after a cortical aspiration lesion. Glia. vol 36. issue 3. 2002-01-22. PMID:11746764. |
the 27 kda heat shock protein (hsp27) is a well-known member of the astroglial response to injury, playing a protective role against oxidative stress, apoptosis, and cytoskeletal destruction. |
2002-01-22 |
2023-08-12 |
rat |
| Y Sun, P L Huang, J J Li, Y Q Huang, L Zhang, P L Huang, S Lee-Huan. Anti-HIV agent MAP30 modulates the expression profile of viral and cellular genes for proliferation and apoptosis in AIDS-related lymphoma cells infected with Kaposi's sarcoma-associated virus. Biochemical and biophysical research communications. vol 287. issue 4. 2001-12-04. PMID:11573962. |
by pathway-specific cdna microarray analysis, we found that bc-2 cells express high levels of egr-1, atf-2, hsp27, hsp90, ikappab, mdm2, skp1, and il-2, cellular genes involved in mitogenesis, tumorigenesis, and inhibition of apoptosis in nfkappab and p53 signaling pathways. |
2001-12-04 |
2023-08-12 |
human |
| A Enomoto, N Suzuki, C Liu, Y Kang, J Zhu, S Serizawa, Y Matsumoto, A Morita, M Ito, Y Hoso. Involvement of c-Jun NH2-terminal kinase-1 in heat-induced apoptotic cell death of human monoblastic leukaemia U937 cells. International journal of radiation biology. vol 77. issue 8. 2001-10-11. PMID:11571020. |
to determine the involvement of c-jun nh(2)-terminal kinase-1 (jnk1) and possibly of hsp27 in heat-induced apoptosis of human monoblastic leukaemia u937 cells. |
2001-10-11 |
2023-08-12 |
human |
| A Samali, J D Robertson, E Peterson, F Manero, L van Zeijl, C Paul, I A Cotgreave, A P Arrigo, S Orreniu. Hsp27 protects mitochondria of thermotolerant cells against apoptotic stimuli. Cell stress & chaperones. vol 6. issue 1. 2001-10-04. PMID:11525243. |
here we present additional evidence in support of the hypothesis that the induction of hsp27 and hsp72 during acquired thermotolerance in jurkat t-lymphocytes prevents apoptosis. |
2001-10-04 |
2023-08-12 |
Not clear |
| A Samali, J D Robertson, E Peterson, F Manero, L van Zeijl, C Paul, I A Cotgreave, A P Arrigo, S Orreniu. Hsp27 protects mitochondria of thermotolerant cells against apoptotic stimuli. Cell stress & chaperones. vol 6. issue 1. 2001-10-04. PMID:11525243. |
a model is presented for the inhibition of apoptosis during thermotolerance in which hsp27 preferentially blocks mitochondrial cytochrome c release, whereas hsp72 interferes with apoptosomal caspase activation. |
2001-10-04 |
2023-08-12 |
Not clear |
| J E Ricci, L Maulon, V Battaglione-Hofman, C Bertolotto, F Luciano, B Mari, P Hofman, P Auberge. A Jurkat T cell variant resistant to death receptor-induced apoptosis. Correlation with heat shock protein (Hsp) 27 and 70 levels. European cytokine network. vol 12. issue 1. 2001-05-31. PMID:11282556. |
a prior heat-shock increases hsp27 and 70 expression and protects jd and jr cells from fas- and staurosporine-induced apoptosis. |
2001-05-31 |
2023-08-12 |
Not clear |
| J E Ricci, L Maulon, V Battaglione-Hofman, C Bertolotto, F Luciano, B Mari, P Hofman, P Auberge. A Jurkat T cell variant resistant to death receptor-induced apoptosis. Correlation with heat shock protein (Hsp) 27 and 70 levels. European cytokine network. vol 12. issue 1. 2001-05-31. PMID:11282556. |
staurosporine, but not the anti-fas antibody ch11, abrogates constitutive hsp70 expression at 37 degrees c and staurosporine also inhibit hsp27 expression in jd and jr cells at 42 degrees c. these data suggest that constitutive expression of hsp27 inhibits fas-mediated apoptosis, but only induced expression of hsp70 can protect t cells from staurosporine-induced apoptosis. |
2001-05-31 |
2023-08-12 |
Not clear |
| J E Ricci, L Maulon, V Battaglione-Hofman, C Bertolotto, F Luciano, B Mari, P Hofman, P Auberge. A Jurkat T cell variant resistant to death receptor-induced apoptosis. Correlation with heat shock protein (Hsp) 27 and 70 levels. European cytokine network. vol 12. issue 1. 2001-05-31. PMID:11282556. |
thus, hsp27 could play a role in the regulation of death receptor-mediated apoptosis, while hsp70 could regulate mitochondrial-dependent cell death. |
2001-05-31 |
2023-08-12 |
Not clear |
| Y Rong, E B Yang, K Zhang, P Mac. Quercetin-induced apoptosis in the monoblastoid cell line U937 in vitro and the regulation of heat shock proteins expression. Anticancer research. vol 20. issue 6B. 2001-03-01. PMID:11205268. |
these results suggested that it is dependent on the dose and exposure time of quercetin to induce apoptosis of u937 cells in vitro, to affect the cell cycle distribution and to regulate the expression of hsp27 and hsp70. |
2001-03-01 |
2023-08-12 |
Not clear |
| S J Charette, J Landr. The interaction of HSP27 with Daxx identifies a potential regulatory role of HSP27 in Fas-induced apoptosis. Annals of the New York Academy of Sciences. vol 926. 2001-02-01. PMID:11193028. |
the interaction of hsp27 with daxx identifies a potential regulatory role of hsp27 in fas-induced apoptosis. |
2001-02-01 |
2023-08-12 |
Not clear |
| S J Charette, J Landr. The interaction of HSP27 with Daxx identifies a potential regulatory role of HSP27 in Fas-induced apoptosis. Annals of the New York Academy of Sciences. vol 926. 2001-02-01. PMID:11193028. |
the heat shock protein hsp27 protects cells against a wide variety of toxic treatments and blocks apoptosis induced by exposures to anticancer drugs and activation of the death receptor fas. |
2001-02-01 |
2023-08-12 |
Not clear |
| S J Charette, J Landr. The interaction of HSP27 with Daxx identifies a potential regulatory role of HSP27 in Fas-induced apoptosis. Annals of the New York Academy of Sciences. vol 926. 2001-02-01. PMID:11193028. |
we found that phosphorylated dimers of hsp27 interact with daxx, preventing its interaction with ask1 and fas and blocking daxx-mediated apoptosis. |
2001-02-01 |
2023-08-12 |
Not clear |
| C Paul, A P Arrig. Comparison of the protective activities generated by two survival proteins: Bcl-2 and Hsp27 in L929 murine fibroblasts exposed to menadione or staurosporine. Experimental gerontology. vol 35. issue 6-7. 2001-01-11. PMID:11053666. |
both hsp27 and bcl-2 also conferred cellular resistance to staurosporine, a kinase inhibitor that induces apoptosis without generating an oxidative stress. |
2001-01-11 |
2023-08-12 |
Not clear |