| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Samali, C I Holmberg, L Sistonen, S Orreniu. Thermotolerance and cell death are distinct cellular responses to stress: dependence on heat shock proteins. FEBS letters. vol 461. issue 3. 1999-12-28. PMID:10567716. |
despite activation of heat shock transcription factor 1 at temperatures ranging from 40 to 46 degrees c, hsp72 and hsp27 were not induced above 42 degrees c. moreover, cells underwent apoptosis at 44 degrees c and necrosis at 46 degrees c, with mitochondrial cytochrome c release at both temperatures. |
1999-12-28 |
2023-08-12 |
Not clear |
| R K Hansen, I Parra, P Lemieux, S Oesterreich, S G Hilsenbeck, S A Fuqu. Hsp27 overexpression inhibits doxorubicin-induced apoptosis in human breast cancer cells. Breast cancer research and treatment. vol 56. issue 2. 1999-12-17. PMID:10573111. |
hsp27 overexpression inhibits doxorubicin-induced apoptosis in human breast cancer cells. |
1999-12-17 |
2023-08-12 |
human |
| R K Hansen, I Parra, P Lemieux, S Oesterreich, S G Hilsenbeck, S A Fuqu. Hsp27 overexpression inhibits doxorubicin-induced apoptosis in human breast cancer cells. Breast cancer research and treatment. vol 56. issue 2. 1999-12-17. PMID:10573111. |
since induction of apoptosis is one underlying mechanism of chemotherapeutic drug action, we investigated the effect of hsp27 overexpression on doxorubicin-induced apoptosis, finding that hsp27 protects mda-mb-231 cells from apoptosis. |
1999-12-17 |
2023-08-12 |
human |
| C Garrido, J M Bruey, A Fromentin, A Hammann, A P Arrigo, E Solar. HSP27 inhibits cytochrome c-dependent activation of procaspase-9. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 13. issue 14. 1999-11-18. PMID:10544189. |
the present study demonstrates that hsp27 overexpression decreases u937 human leukemic cell sensitivity to etoposide-induced cytotoxicity by preventing apoptosis. |
1999-11-18 |
2023-08-12 |
human |
| C Garrido, J M Bruey, A Fromentin, A Hammann, A P Arrigo, E Solar. HSP27 inhibits cytochrome c-dependent activation of procaspase-9. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 13. issue 14. 1999-11-18. PMID:10544189. |
we conclude that hsp27 inhibits etoposide-induced apoptosis by preventing cytochrome c and datp-triggered activity of caspase-9, downstream of cytochrome c release. |
1999-11-18 |
2023-08-12 |
human |
| G Tezel, M B Wa. Inhibition of caspase activity in retinal cell apoptosis induced by various stimuli in vitro. Investigative ophthalmology & visual science. vol 40. issue 11. 1999-10-07. PMID:10509663. |
the purpose of this study was to investigate caspase activation in retinal cell apoptosis induced by various stimuli, including simulated ischemia, excitotoxicity, and antibody to heat shock protein 27 (hsp27), and to assess whether the inhibition of caspases can block apoptosis in retinal cells induced by different stimuli. |
1999-10-07 |
2023-08-12 |
Not clear |
| P Mehlen, V Coronas, V Ljubic-Thibal, C Ducasse, L Granger, F Jourdan, A P Arrig. Small stress protein Hsp27 accumulation during dopamine-mediated differentiation of rat olfactory neurons counteracts apoptosis. Cell death and differentiation. vol 6. issue 3. 1999-07-26. PMID:10200573. |
small stress protein hsp27 accumulation during dopamine-mediated differentiation of rat olfactory neurons counteracts apoptosis. |
1999-07-26 |
2023-08-12 |
rat |
| P Mehlen, V Coronas, V Ljubic-Thibal, C Ducasse, L Granger, F Jourdan, A P Arrig. Small stress protein Hsp27 accumulation during dopamine-mediated differentiation of rat olfactory neurons counteracts apoptosis. Cell death and differentiation. vol 6. issue 3. 1999-07-26. PMID:10200573. |
we report here that the dopamine induced differentiation and apoptosis are associated with a transient and specific accumulation of hsp27. |
1999-07-26 |
2023-08-12 |
rat |
| P Mehlen, V Coronas, V Ljubic-Thibal, C Ducasse, L Granger, F Jourdan, A P Arrig. Small stress protein Hsp27 accumulation during dopamine-mediated differentiation of rat olfactory neurons counteracts apoptosis. Cell death and differentiation. vol 6. issue 3. 1999-07-26. PMID:10200573. |
moreover, transfection experiments have shown that hsp27 overexpression drastically decreases the fraction of cells undergoing apoptosis. |
1999-07-26 |
2023-08-12 |
rat |
| P Mehlen, V Coronas, V Ljubic-Thibal, C Ducasse, L Granger, F Jourdan, A P Arrig. Small stress protein Hsp27 accumulation during dopamine-mediated differentiation of rat olfactory neurons counteracts apoptosis. Cell death and differentiation. vol 6. issue 3. 1999-07-26. PMID:10200573. |
furthermore, in the normal cell population we show that hsp27 accumulation takes place only in differentiating cells that were not undergoing apoptosis. |
1999-07-26 |
2023-08-12 |
rat |
| b' M J\\xc3\\xa4\\xc3\\xa4ttel\\xc3\\xa. Escaping cell death: survival proteins in cancer. Experimental cell research. vol 248. issue 1. 1999-06-03. PMID:10094811.' |
proteins fulfilling these criteria include antiapoptotic members of the bcl-2 protein family, heat shock proteins, hsp70 and hsp27, as well as survivin, the novel cancer-associated member of the inhibitor of apoptosis protein family. |
1999-06-03 |
2023-08-12 |
human |
| M J Champagne, P Dumas, S N Orlov, M R Bennett, P Hamet, J Trembla. Protection against necrosis but not apoptosis by heat-stress proteins in vascular smooth muscle cells: evidence for distinct modes of cell death. Hypertension (Dallas, Tex. : 1979). vol 33. issue 3. 1999-04-13. PMID:10082507. |
hsp72 and hsp27 expression evoked in vsmc by mild hs (44 degrees c, 15 minutes) 6 hours before acute hs prevented the inhibition of proliferation and induction of necrosis with no effect on serum deprivation-induced or staurosporine-induced apoptosis. |
1999-04-13 |
2023-08-12 |
rat |
| M J Champagne, P Dumas, S N Orlov, M R Bennett, P Hamet, J Trembla. Protection against necrosis but not apoptosis by heat-stress proteins in vascular smooth muscle cells: evidence for distinct modes of cell death. Hypertension (Dallas, Tex. : 1979). vol 33. issue 3. 1999-04-13. PMID:10082507. |
this induced expression of hsp72 and hsp27 did not eliminate the higher basal proliferation, apoptosis, and necrosis of shr vsmc compared with bn.lx vsmc, suggesting that these hsps are not involved in altered shr vsmc proliferation and death. |
1999-04-13 |
2023-08-12 |
rat |
| M J Wagstaff, Y Collaço-Moraes, J Smith, J S de Belleroche, R S Coffin, D S Latchma. Protection of neuronal cells from apoptosis by Hsp27 delivered with a herpes simplex virus-based vector. The Journal of biological chemistry. vol 274. issue 8. 1999-03-18. PMID:9988753. |
protection of neuronal cells from apoptosis by hsp27 delivered with a herpes simplex virus-based vector. |
1999-03-18 |
2023-08-12 |
Not clear |
| M J Wagstaff, Y Collaço-Moraes, J Smith, J S de Belleroche, R S Coffin, D S Latchma. Protection of neuronal cells from apoptosis by Hsp27 delivered with a herpes simplex virus-based vector. The Journal of biological chemistry. vol 274. issue 8. 1999-03-18. PMID:9988753. |
in contrast, only hsp27 can protect dorsal root ganglion neurons from apoptosis induced by nerve growth factor withdrawal, and hsp27 also protects the nd7 neuronal cell line from retinoic acid-induced apoptosis. |
1999-03-18 |
2023-08-12 |
Not clear |
| C Garrido, A Fromentin, B Bonnotte, N Favre, M Moutet, A P Arrigo, P Mehlen, E Solar. Heat shock protein 27 enhances the tumorigenicity of immunogenic rat colon carcinoma cell clones. Cancer research. vol 58. issue 23. 1998-12-31. PMID:9850085. |
the expression of hsp27 in reg cells increases their resistance to apoptosis in vitro and dramatically enhances their tumorigenicity when injected s.c. into syngeneic rats. |
1998-12-31 |
2023-08-12 |
rat |
| P Mehlen, A Mehlen, J Godet, A P Arrig. hsp27 as a switch between differentiation and apoptosis in murine embryonic stem cells. The Journal of biological chemistry. vol 272. issue 50. 1998-01-15. PMID:9395507. |
hsp27 as a switch between differentiation and apoptosis in murine embryonic stem cells. |
1998-01-15 |
2023-08-12 |
human |
| P Mehlen, A Mehlen, J Godet, A P Arrig. hsp27 as a switch between differentiation and apoptosis in murine embryonic stem cells. The Journal of biological chemistry. vol 272. issue 50. 1998-01-15. PMID:9395507. |
in contrast, hsp27 underexpression, which attenuated cell growth arrest, induced differentiation abortion because of an overall cell death by apoptosis. |
1998-01-15 |
2023-08-12 |
human |
| P Mehlen, A Mehlen, J Godet, A P Arrig. hsp27 as a switch between differentiation and apoptosis in murine embryonic stem cells. The Journal of biological chemistry. vol 272. issue 50. 1998-01-15. PMID:9395507. |
hence, hsp27 transient expression seems essential for preventing differentiating es cells from undergoing apoptosis, a switch that may be redox regulated. |
1998-01-15 |
2023-08-12 |
human |
| S Horman, P Galand, R Mosselmans, N Legros, G Leclercq, N Mairess. Changes in the phosphorylation status of the 27 kDa heat shock protein (HSP27) associated with the modulation of growth and/or differentiation in MCF-7 cells. Cell proliferation. vol 30. issue 1. 1997-11-06. PMID:9332492. |
with oh-tam and tnf the increase in hsp27 phosphorylation was concomitant with the appearance of apoptosis, not observed with tpa. |
1997-11-06 |
2023-08-12 |
human |