| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sheng-Jie Hou, Ya-Ru Huang, Jie Zhu, Ying-Bo Jia, Xiao-Yun Niu, Jin-Ju Yang, Xiao-Lin Yu, Xiao-Yu Du, Shi-Yu Liang, Fang Cui, Ling-Jie Li, Chen Tian, Rui-Tian Li. Mouse serum albumin induces neuronal apoptosis and tauopathies. Acta neuropathologica communications. vol 12. issue 1. 2024-04-23. PMID:38654316. |
intracerebroventricular injection of msa into the brains of c57bl/6j mice to a similar concentration as in patient brains induced neuronal apoptosis, neuroinflammation, increased tau phosphorylation, and decreased the spatial learning and memory abilities, while elovl1 knockdown significantly prevented the deleterious effect of msa. |
2024-04-23 |
2024-04-26 |
mouse |
| Sheng-Jie Hou, Ya-Ru Huang, Jie Zhu, Ying-Bo Jia, Xiao-Yun Niu, Jin-Ju Yang, Xiao-Lin Yu, Xiao-Yu Du, Shi-Yu Liang, Fang Cui, Ling-Jie Li, Chen Tian, Rui-Tian Li. Mouse serum albumin induces neuronal apoptosis and tauopathies. Acta neuropathologica communications. vol 12. issue 1. 2024-04-23. PMID:38654316. |
overall, our study here revealed that msa induced tau phosphorylation and neuron apoptosis based on msa-activated microglia and astrocytes, respectively, showing the critical roles of msa in initiating the occurrence of tauopathies and cognitive decline, and providing potential therapeutic targets for msa-induced neuropathology in multiple neurodegenerative disorders. |
2024-04-23 |
2024-04-26 |
mouse |
| Benjamin Ongnok, Nanthip Prathumsap, Titikorn Chunchai, Patcharapong Pantiya, Busarin Arunsak, Nipon Chattipakorn, Siriporn C Chattipakor. Nicotinic and Muscarinic Acetylcholine Receptor Agonists Counteract Cognitive Impairment in a Rat Model of Doxorubicin-Induced Chemobrain via Attenuation of Multiple Programmed Cell Death Pathways. Molecular neurobiology. 2024-04-03. PMID:38568417. |
dox insult also mediated hyperphosphorylation of tau and simultaneously induced various pcd, including apoptosis, necroptosis, and pyroptosis in the hippocampus. |
2024-04-03 |
2024-04-05 |
rat |
| Benjamin Ongnok, Nanthip Prathumsap, Titikorn Chunchai, Patcharapong Pantiya, Busarin Arunsak, Nipon Chattipakorn, Siriporn C Chattipakor. Nicotinic and Muscarinic Acetylcholine Receptor Agonists Counteract Cognitive Impairment in a Rat Model of Doxorubicin-Induced Chemobrain via Attenuation of Multiple Programmed Cell Death Pathways. Molecular neurobiology. 2024-04-03. PMID:38568417. |
concomitant treatment with either pnu-282987, bethanechol, or a combination of the two potently attenuated neuroinflammation, mitochondrial dyshomeostasis, and tau hyperphosphorylation, thereby suppressing excessive apoptosis, necroptosis, and pyroptosis and improving cognitive function in dox-treated rats. |
2024-04-03 |
2024-04-05 |
rat |
| Bidemi Emmanuel Ekundayo, Tajudeen Olabisi Obafemi, Olusola Bolaji Adewale, Blessing Ariyo Obafemi, Babatunji Emmanuel Oyinloye, Stella Kemilola Ekunday. Oxidative Stress, Endoplasmic Reticulum Stress and Apoptosis in the Pathology of Alzheimer's Disease. Cell biochemistry and biophysics. 2024-03-13. PMID:38472715. |
a number of mechanisms have been identified in its pathogenesis and progression which include the amyloid beta (aβ) aggregation, hyperphosphorylation of tau protein, oxidative stress, endoplasmic reticulum (er) stress and apoptosis. |
2024-03-13 |
2024-03-15 |
Not clear |
| Bizhan Helli, Seyedeh Parisa Navabi, Seyed Ahmad Hosseini, Ali Sabahi, Layasadat Khorsandi, Nasrin Amirrajab, Masoud Mahdavinia, Sohrab Rahmani, Mohammad Amin Dehghan. The Protective Effects of Syringic Acid on Bisphenol A-Induced Neurotoxicity Possibly Through AMPK/PGC-1α/Fndc5 and CREB/BDNF Signaling Pathways. Molecular neurobiology. 2024-03-02. PMID:38430353. |
overall, bpa could lead to the development of ad by affecting the mitochondria-dependent apoptosis pathway, as well as ampk/pgc-1α/fndc5 and creb/bdnf/trkb signaling pathways, and finally, by increasing the expression of tau and aβ proteins. |
2024-03-02 |
2024-03-04 |
rat |
| Carlos Cruchaga, Muhammad Ali, Yuanyuan Shen, Anh Do, Lihua Wang, Daniel Western, Menghan Liu, Aleksandra Beric, John Budde, Jen Gentsch, Suzanne Schindler, John Morris, David Holtzman, Maria Fernández, Agustín Ruiz, Ignacio Alvarez, Miquel Aguilar, Pau Pastor, Jarod Rutledge, Hamilton Oh, Edward Wilson, Yann Le Guen, Rana Khalid, Chloe Robins, David Pulford, Laura Ibanez, Tony Wyss-Coray, Yun Ju Sun. Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures for asymptomatic and symptomatic Alzheimer's disease. Research square. 2024-02-27. PMID:38410465. |
the associated proteins cluster in four different protein pseudo-trajectories groups spanning the ad continuum and were enrichment in specific pathways including neuronal death, apoptosis and tau phosphorylation (early stages), microglia dysregulation and endolysosomal dysfuncton(mid-stages), brain plasticity and longevity (mid-stages) and late microglia-neuron crosstalk (late stages). |
2024-02-27 |
2024-03-02 |
Not clear |
| D-Y Liu, L Zhan. Retraction Note: MicroRNA-132 promotes neurons cell apoptosis and activates Tau phosphorylation by targeting GTDC-1 in Alzheimer's disease. European review for medical and pharmacological sciences. vol 28. issue 3. 2024-02-20. PMID:38375693. |
retraction note: microrna-132 promotes neurons cell apoptosis and activates tau phosphorylation by targeting gtdc-1 in alzheimer's disease. |
2024-02-20 |
2024-02-22 |
Not clear |
| D-Y Liu, L Zhan. Retraction Note: MicroRNA-132 promotes neurons cell apoptosis and activates Tau phosphorylation by targeting GTDC-1 in Alzheimer's disease. European review for medical and pharmacological sciences. vol 28. issue 3. 2024-02-20. PMID:38375693. |
the article "microrna-132 promotes neurons cell apoptosis and activates tau phosphorylation by targeting gtdc-1 in alzheimer's disease", by d.-y. |
2024-02-20 |
2024-02-22 |
Not clear |
| Xu-Jia Chen, Zhou Deng, Le-Le Zhang, Yan Pan, Jia Fu, Liang Zou, Zhaofang Bai, Xiaohe Xiao, Feiya Shen. Therapeutic potential of the medicinal mushroom Ganoderma lucidum against Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 172. 2024-02-04. PMID:38310653. |
the underlying mechanisms mainly include inhibiting tau hyperphosphorylation, inhibiting aβ formation, affecting activated microglia, regulating nf-κb/mapk signalling pathway, inhibiting neuronal apoptosis, modulating immune system, and inhibiting acetylcholinesterase, etc. |
2024-02-04 |
2024-02-07 |
Not clear |
| Lívia Cristina Ribeiro Teixeira, Izabela Mamede, Marcelo Rizzatti Luizon, Karina Braga Gome. Role of long non-coding RNAs in the pathophysiology of Alzheimer's disease and other dementias. Molecular biology reports. vol 51. issue 1. 2024-02-01. PMID:38302810. |
the hallmark pathology of ad includes formation of β-amyloid (aβ) oligomers and tau hyperphosphorylation in the brain, which induces neuroinflammation, oxidative stress, synaptic dysfunction, and neuronal apoptosis. |
2024-02-01 |
2024-02-04 |
Not clear |
| Weam W Ibrahim, Rabab H Sayed, Mohamed F Abdelhameed, Enayat A Omara, Mahmoud I Nassar, Noha F Abdelkader, Mohamed A Farag, Abdelsamed I Elshamy, Sherif M Afif. Neuroprotective potential of Erigeron bonariensis ethanolic extract against ovariectomized/D-galactose-induced memory impairments in female rats in relation to its metabolite fingerprint as revealed using UPLC/MS. Inflammopharmacology. 2024-01-31. PMID:38294617. |
moreover, e. bonariensis extract mitigated ovx/d-gal-induced aβ aggregation, tau hyperphosphorylation, ache activity, neuroinflammation (nf-κbp65, tnf-α, il-1β), and apoptosis (cytc, bax). |
2024-01-31 |
2024-02-02 |
rat |
| Ryszard Pluta, Stanisław J Czuczwa. Ischemia-Reperfusion Programming of Alzheimer's Disease-Related Genes-A New Perspective on Brain Neurodegeneration after Cardiac Arrest. International journal of molecular sciences. vol 25. issue 2. 2024-01-27. PMID:38279289. |
we present the latest data on the dysregulation of genes related to the metabolism of the amyloid protein precursor, tau protein, autophagy, mitophagy, apoptosis, and amyloid and tau protein transport genes. |
2024-01-27 |
2024-01-29 |
Not clear |
| Jun-Fei Zhang, Zhi-Ting Fang, Jun-Ning Zhao, Gong-Ping Liu, Xin Shen, Gao-Feng Jiang, Qian Li. Acetylated tau exacerbates apoptosis by disturbing mitochondrial dynamics in HEK293 cells. Journal of neurochemistry. 2024-01-26. PMID:38275215. |
acetylated tau exacerbates apoptosis by disturbing mitochondrial dynamics in hek293 cells. |
2024-01-26 |
2024-01-28 |
human |
| Wei Ma, Kui Lu, Hua-Min Liang, Jin-Yuan Zhan. Synapsin 1 Ameliorates Cognitive Impairment and Neuroinflammation in Rats with Alzheimer's Disease: An Experimental and Bioinformatics Study. Current Alzheimer research. 2024-01-12. PMID:38213171. |
alzheimer's disease (ad) is a persistent neuropathological injury that manifests via neuronal/synaptic death, age spot development, tau hyperphosphorylation, neuroinflammation, and apoptosis. |
2024-01-12 |
2024-01-14 |
rat |
| Tao Zhang, Byeong Mo Kim, Tae Ho Le. Death-associated protein kinase 1 as a therapeutic target for Alzheimer's disease. Translational neurodegeneration. vol 13. issue 1. 2024-01-09. PMID:38195518. |
we have established an upstream effect of dapk1 on aβ and tau pathologies and neuronal apoptosis through kinase-mediated protein phosphorylation, supporting a causal role of dapk1 in the pathophysiology of ad. |
2024-01-09 |
2024-01-13 |
Not clear |
| Yeok Boo Chang, Eun-Jin Jung, Hyung Joo Suh, Hyeon-Son Cho. Protective Effects of Whey Protein Hydrolysate, Treadmill Exercise, and Their Combination against Scopolamine-Induced Cognitive Deficit in Mice. Foods (Basel, Switzerland). vol 12. issue 24. 2023-12-23. PMID:38137233. |
exercise and wph also exerted neuroprotective effects by inhibiting the hyperphosphorylation of tau proteins, enhancing the expression of the brain-derived neurotrophic factor, and inhibiting apoptosis by reducing the bax/bcl2 ratio in conjunction with the downregulation of the mitogen-activated protein kinase pathway. |
2023-12-23 |
2023-12-25 |
mouse |
| Ling Lei, Yong Luo, Dongkun Kang, Fumin Yang, Dongli Meng, Jian-Zhi Wang, Rong Liu, Xiaochuan Wang, Hong-Lian L. Gypenoside IX restores Akt/GSK-3β pathway and alleviates Alzheimer's disease-like neuropathology and cognitive deficits. Aging. vol 15. 2023-12-14. PMID:38095632. |
in the current study, we used staurosporine (stp), an inducer of apoptosis and causing tau hyperphosphorylation, to mimic ad models, and explored the role and mechanism of gypenoside ix (one of the extracts of gynostemma, gp for short name in our experiments) in stp treated primary hippocampal neurons and rats. |
2023-12-14 |
2023-12-17 |
rat |
| Ling Lei, Yong Luo, Dongkun Kang, Fumin Yang, Dongli Meng, Jian-Zhi Wang, Rong Liu, Xiaochuan Wang, Hong-Lian L. Gypenoside IX restores Akt/GSK-3β pathway and alleviates Alzheimer's disease-like neuropathology and cognitive deficits. Aging. vol 15. 2023-12-14. PMID:38095632. |
we found stp not only increased apoptosis and tau hyperphosphorylation, but also significantly increased aβ production, resulting in synaptic dysfunction and cognitive decline in mimic ad models by stp. |
2023-12-14 |
2023-12-17 |
rat |
| Dongdong Zhao, Deqi Yin, Xinxin Wang, Yanxi Li, Miao He, Jianmin Hu, Lin Shumei, Jiancheng Yan. Taurine alleviates high-fat-high-glucose-induced pancreatic islet β-cell oxidative stress and apoptosis in rat. Heliyon. vol 9. issue 12. 2023-12-11. PMID:38076203. |
in conclusion, this experiment confirmed that tau could alleviate the oxidative stress and apoptosis induced by the hfhg diet in rat pancreatic β-cells. |
2023-12-11 |
2023-12-17 |
rat |