| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Manisha Prajapat, Harvinder Singh, Gajendra Chaudhary, Phulen Sarma, Gurjeet Kaur, Ajay Prakash Patel, Bikash Medh. A Novel Inhibitor of DKK1/LRP6 Interactions Against the Alzheimer Disease: An Insilco Approach. Bioinformatics and biology insights. vol 17. 2023-07-10. PMID:37424708. |
when this pathway is blocked, it activates gsk3 beta, leading to tau hyperphosphorylation and the apoptosis of neurons. |
2023-07-10 |
2023-08-14 |
Not clear |
| Deborah Inyang, Tasneem Saumtally, Chinelo Nonyerem Nnadi, Sharmila Devi, Po-Wah S. A Systematic Review of the Effects of Capsaicin on Alzheimer's Disease. International journal of molecular sciences. vol 24. issue 12. 2023-06-28. PMID:37373321. |
ten studies showed capsaicin attenuated tau deposition, apoptosis, and synaptic dysfunction; was only weakly effective on oxidative stress; and had conflicting effects on amyloid processing. |
2023-06-28 |
2023-08-14 |
rat |
| Zikang Hao, Kerui Liu, Lu Zhou, Ping Che. Precious but convenient means of prevention and treatment: physiological molecular mechanisms of interaction between exercise and motor factors and Alzheimer's disease. Frontiers in physiology. vol 14. 2023-06-27. PMID:37362440. |
in addition, this paper introduces a new approach to regulate the blood-brain barrier, i.e., to restore the stability of the blood-brain barrier, reduce abnormal phosphorylation of tau proteins and reduce neuronal apoptosis. |
2023-06-27 |
2023-08-14 |
human |
| Vasileios Papaliagkas, Kallirhoe Kalinderi, Patroklos Vareltzis, Despoina Moraitou, Theodora Papamitsou, Maria Chatzidimitrio. CSF Biomarkers in the Early Diagnosis of Mild Cognitive Impairment and Alzheimer's Disease. International journal of molecular sciences. vol 24. issue 10. 2023-05-27. PMID:37240322. |
proteins and molecules that reflect the pathogenesis of the disease, e.g., neurodegeneration, accumulation of abeta, hyperphosphorylation of tau protein and apoptosis may be used as biomarkers. |
2023-05-27 |
2023-08-14 |
Not clear |
| Sneha Kumari, Rishika Dhapola, Dibbanti HariKrishna Redd. Apoptosis in Alzheimer's disease: insight into the signaling pathways and therapeutic avenues. Apoptosis : an international journal on programmed cell death. 2023-05-15. PMID:37186274. |
alzheimer's disease (ad) is characterized by the accumulation of hyperphosphorylated tau and amyloid-β (aβ) protein resulting in synaptic loss and apoptosis. |
2023-05-15 |
2023-08-14 |
Not clear |
| Moxin Wu, Zhiying Chen, Min Jiang, Bing Bao, Dongling Li, Xiaoping Yin, Xueren Wang, Dan Liu, Ling-Qiang Zh. Friend or foe: role of pathological tau in neuronal death. Molecular psychiatry. 2023-03-15. PMID:36918705. |
in contrast, pathological tau always detaches from microtubules and is implicated in a series of neurological disorders that are characterized by irreversible neuronal death, such as necrosis, apoptosis, necroptosis, pyroptosis, ferroptosis, autophagy-dependent neuronal death and phagocytosis by microglia. |
2023-03-15 |
2023-08-14 |
Not clear |
| Moxin Wu, Zhiying Chen, Min Jiang, Bing Bao, Dongling Li, Xiaoping Yin, Xueren Wang, Dan Liu, Ling-Qiang Zh. Friend or foe: role of pathological tau in neuronal death. Molecular psychiatry. 2023-03-15. PMID:36918705. |
however, recent studies have also revealed that pathological tau can facilitate neuron escape from acute apoptosis, delay necroptosis through its action on granulovacuolar degeneration bodies (gvbs), and facilitate iron export from neurons to block ferroptosis. |
2023-03-15 |
2023-08-14 |
Not clear |
| Shenpan Li, Xiao Chen, Qian Sun, Xiaohu Ren, Jiacheng Zhong, Li Zhou, Hongyu Zhang, Guowei Li, Yungang Liu, Jianjun Liu, Haiyan Huan. Long term exposure of saxitoxin induced cognitive deficits and YAP1 cytoplasmic retention. Ecotoxicology and environmental safety. vol 253. 2023-02-15. PMID:36791486. |
meanwhile, stx treatment induced cell apoptosis and tau protein hyperphosphorylation. |
2023-02-15 |
2023-08-14 |
mouse |
| Zhiyou Yang, Junxin Liu, Shuai Wei, Jiahang Deng, Xinyue Feng, Shucheng Liu, Mingxin Li. A novel strategy for bioactive natural products targeting NLRP3 inflammasome in Alzheimer's disease. Frontiers in pharmacology. vol 13. 2023-01-26. PMID:36699095. |
aβ and tau pathologies induce neurite atrophy and neuronal apoptosis, leading to cognitive, language, and behavioral deficits. |
2023-01-26 |
2023-08-14 |
Not clear |
| Sk Chand Basha, Mekala Janaki Ramaiah, Jagannatha Rao Kosagishara. Untangling the Role of TREM2 in Conjugation with Microglia in Neuronal Dysfunction: A Hypothesis on a Novel Pathway in the Pathophysiology of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2023-01-23. PMID:36683512. |
the major pathophysiology of ad comprises amyloid-β (aβ), tau, oxidative stress, and apoptosis. |
2023-01-23 |
2023-08-14 |
Not clear |
| Guoliang Fang, Jiexiu Zhao, Pengfei Li, Liang Li, Tao Yu, Xingya Yang, Zihong He, Ye Tia. Long-term treadmill exercise inhibits neuronal cell apoptosis and reduces tau phosphorylation in the cerebral cortex and hippocampus of aged rats. Science bulletin. vol 62. issue 11. 2023-01-20. PMID:36659268. |
long-term treadmill exercise inhibits neuronal cell apoptosis and reduces tau phosphorylation in the cerebral cortex and hippocampus of aged rats. |
2023-01-20 |
2023-08-14 |
rat |
| Xiaoqian Peng, Hongsong Guo, Xiao Zhang, Zikang Yang, John Bosco Ruganzu, Zhuoyuan Yang, Xiangyuan Wu, Wei Bi, Shengfeng Ji, Weina Yan. TREM2 Inhibits Tau Hyperphosphorylation and Neuronal Apoptosis via the PI3K/Akt/GSK-3β Signaling Pathway In vivo and In vitro. Molecular neurobiology. 2023-01-20. PMID:36662361. |
trem2 inhibits tau hyperphosphorylation and neuronal apoptosis via the pi3k/akt/gsk-3β signaling pathway in vivo and in vitro. |
2023-01-20 |
2023-08-14 |
mouse |
| Xiaoqian Peng, Hongsong Guo, Xiao Zhang, Zikang Yang, John Bosco Ruganzu, Zhuoyuan Yang, Xiangyuan Wu, Wei Bi, Shengfeng Ji, Weina Yan. TREM2 Inhibits Tau Hyperphosphorylation and Neuronal Apoptosis via the PI3K/Akt/GSK-3β Signaling Pathway In vivo and In vitro. Molecular neurobiology. 2023-01-20. PMID:36662361. |
however, the precise signaling pathways underlying the effect of trem2 on tau pathology and neuronal apoptosis have not been fully elucidated. |
2023-01-20 |
2023-08-14 |
mouse |
| Xiaoqian Peng, Hongsong Guo, Xiao Zhang, Zikang Yang, John Bosco Ruganzu, Zhuoyuan Yang, Xiangyuan Wu, Wei Bi, Shengfeng Ji, Weina Yan. TREM2 Inhibits Tau Hyperphosphorylation and Neuronal Apoptosis via the PI3K/Akt/GSK-3β Signaling Pathway In vivo and In vitro. Molecular neurobiology. 2023-01-20. PMID:36662361. |
in the present study, upregulation of trem2 significantly inhibited tau hyperphosphorylation at ser199, ser396, and thr205, respectively, as well as prevented neuronal loss and apoptosis. |
2023-01-20 |
2023-08-14 |
mouse |
| Xiaoqian Peng, Hongsong Guo, Xiao Zhang, Zikang Yang, John Bosco Ruganzu, Zhuoyuan Yang, Xiangyuan Wu, Wei Bi, Shengfeng Ji, Weina Yan. TREM2 Inhibits Tau Hyperphosphorylation and Neuronal Apoptosis via the PI3K/Akt/GSK-3β Signaling Pathway In vivo and In vitro. Molecular neurobiology. 2023-01-20. PMID:36662361. |
in line with in vivo findings, trem2-overexpressing bv2 microglia following β-amyloid (aβ) stimulation led to a significant increase in the phosphorylation of pi3k, akt, and gsk-3β, accompanied by a decrease in tau hyperphosphorylation and apoptosis in co-cultured sh-sy5y cells. |
2023-01-20 |
2023-08-14 |
mouse |
| Xiaoqian Peng, Hongsong Guo, Xiao Zhang, Zikang Yang, John Bosco Ruganzu, Zhuoyuan Yang, Xiangyuan Wu, Wei Bi, Shengfeng Ji, Weina Yan. TREM2 Inhibits Tau Hyperphosphorylation and Neuronal Apoptosis via the PI3K/Akt/GSK-3β Signaling Pathway In vivo and In vitro. Molecular neurobiology. 2023-01-20. PMID:36662361. |
furthermore, ly294002, a specific pi3k inhibitor, was observed to abolish the beneficial effects of trem2 on tau hyperphosphorylation, neuronal apoptosis, and spatial cognitive impairments in vivo and in vitro. |
2023-01-20 |
2023-08-14 |
mouse |
| Xiaoqian Peng, Hongsong Guo, Xiao Zhang, Zikang Yang, John Bosco Ruganzu, Zhuoyuan Yang, Xiangyuan Wu, Wei Bi, Shengfeng Ji, Weina Yan. TREM2 Inhibits Tau Hyperphosphorylation and Neuronal Apoptosis via the PI3K/Akt/GSK-3β Signaling Pathway In vivo and In vitro. Molecular neurobiology. 2023-01-20. PMID:36662361. |
thus, our findings indicated that trem2 inhibits tau hyperphosphorylation and neuronal apoptosis, at least in part, by the activation of the pi3k/akt/gsk-3β signaling pathway. |
2023-01-20 |
2023-08-14 |
mouse |
| Guoqing Wang, Xiangpeng Shen, Xiangkong Song, Ningfen Wang, Xuewen Wo, Yonglei Ga. Protective mechanism of gold nanoparticles on human neural stem cells injured by β-amyloid protein through miR-21-5p/SOCS6 pathway. Neurotoxicology. vol 95. 2023-01-09. PMID:36623431. |
the results demonstrate that aunps co-treatment repressed the high expression of total tau (t-tau), phosphorylated tau (p-tau), and aβ protein, and reduced apoptosis rate of hnscs. |
2023-01-09 |
2023-08-14 |
human |
| Jiasi Yu, Dan Wu, Yanan Zhao, Linli Guo, Ping Li. Study on multi-target effects of PIMPC on Aβ/Cu Brain research. 2022-12-31. PMID:36586663. |
study on multi-target effects of pimpc on aβ/cu glycogen synthase kinase-3 (gsk-3), a key role in the pathogenesis of alzheimer's disease (ad), has been linked with the formation of β-amyloid (aβ), tubulin-associated unit (tau) protein phosphorylation and apoptosis. |
2022-12-31 |
2023-08-14 |
Not clear |
| Mohd Uzair Ali, Laiba Anwar, Mohd Humair Ali, Mohammad Kashif Iqubal, Ashif Iqubal, Sanjula Baboota, Javed Al. Signalling Pathways Involved in Microglial Activation in Alzheimer's Disease and Potential Neuroprotective Role of Phytoconstituents. CNS & neurological disorders drug targets. 2022-12-25. PMID:36567300. |
the pathophysiology of ad comprises aβ, hyperphosphorylated tau protein formation, abrupt cholinergic cascade, oxidative stress, neuronal apoptosis, and neuroinflammation. |
2022-12-25 |
2023-08-14 |
Not clear |