| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Simran Chauhan, Tapan Behl, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Sumeet Gupta, Mohammed Albratty, Asim Najmi, Abdulkarim M Meraya, Hassan A Alhazm. Understanding the Intricate Role of Exosomes in Pathogenesis of Alzheimer's Disease. Neurotoxicity research. 2022-12-23. PMID:36564606. |
exosomes are known to spread toxic hyperphosphorylated tau and amyloid-β between the cells and are linked to the loss of neurons by inducing apoptosis. |
2022-12-23 |
2023-08-14 |
human |
| Desh Deepak Singh, Ali A Shati, Mohammad Y Alfaifi, Serag Eldin I Elbehairi, Ihn Han, Eun-Ha Choi, Dharmendra K Yada. Development of Dementia in Type 2 Diabetes Patients: Mechanisms of Insulin Resistance and Antidiabetic Drug Development. Cells. vol 11. issue 23. 2022-12-11. PMID:36497027. |
brain cells becoming resistant to insulin leads to elevated blood glucose levels, impaired synaptic plasticity, microglial overactivation, mitochondrial dysfunction, neuronal apoptosis, nutrient deprivation, tau (tubulin-associated unit) phosphorylation, and cholinergic dysfunction. |
2022-12-11 |
2023-08-14 |
Not clear |
| Desh Deepak Singh, Ali A Shati, Mohammad Y Alfaifi, Serag Eldin I Elbehairi, Ihn Han, Eun-Ha Choi, Dharmendra K Yada. Development of Dementia in Type 2 Diabetes Patients: Mechanisms of Insulin Resistance and Antidiabetic Drug Development. Cells. vol 11. issue 23. 2022-12-11. PMID:36497027. |
we discuss the pathological and physiological mechanisms behind the association between type 2 diabetes mellitus and dementia, such as insulin resistance, insulin signaling, and sporadic forms of dementia; the relationship between insulin receptor activation and tau phosphorylation; dementia and mrna expression and downregulation of related receptors; neural modulation due to insulin secretion and glucose homeostasis; and neuronal apoptosis due to insulin resistance and type 2 diabetes mellitus. |
2022-12-11 |
2023-08-14 |
Not clear |
| b' Antonella Calderaro, Giuseppe Tancredi Patan\\xc3\\xa8, Ester Tellone, Davide Barreca, Silvana Ficarra, Francesco Misiti, Giuseppina Lagan\\xc3\\xa. The Neuroprotective Potentiality of Flavonoids on Alzheimer\'s Disease. International journal of molecular sciences. vol 23. issue 23. 2022-12-11. PMID:36499159.' |
the flavonoids' mechanism of action in ad involved the inhibition of acetylcholinesterase, butyrylcholinesterase, tau protein aggregation, β-secretase, oxidative stress, inflammation, and apoptosis through modulation of signaling pathways which are implicated in cognitive and neuroprotective functions, such as erk, pi3-kinase/akt, nfkb, mapks, and endogenous antioxidant enzymatic systems. |
2022-12-11 |
2023-08-14 |
human |
| Marine Denechaud, Sarah Geurs, Thomas Comptdaer, Séverine Bégard, Alejandro Garcia-Núñez, Louis-Adrien Pechereau, Thomas Bouillet, Yannick Vermeiren, Peter P De Deyn, Romain Perbet, Vincent Deramecourt, Claude-Alain Maurage, Michiel Vanderhaegen, Sebastiaan Vanuytven, Bruno Lefebvre, Elke Bogaert, Nicole Déglon, Thierry Voet, Morvane Colin, Luc Buée, Bart Dermaut, Marie-Christine Gala. Tau promotes oxidative stress-associated cycling neurons in S phase as a pro-survival mechanism: possible implication for Alzheimer's disease. Progress in neurobiology. 2022-12-08. PMID:36481386. |
tau downregulation in murine neurons revealed an essential role for tau to promote cell cycle progression to s phase and prevent apoptosis in response to oxidative stress. |
2022-12-08 |
2023-08-14 |
Not clear |
| Yu-Shen Yang, Shi-Ling He, Wei-Can Chen, Cong-Mei Wang, Qiao-Mei Huang, Yan-Chuan Shi, Shu Lin, He-Fan H. Recent progress on the role of non-coding RNA in postoperative cognitive dysfunction. Frontiers in cellular neuroscience. vol 16. 2022-10-31. PMID:36313620. |
the pathogenesis of pocd mainly includes neuroinflammation, neuronal apoptosis, oxidative stress, accumulation of aβ, and tau hyperphosphorylation; however, the exact mechanism remains unclear. |
2022-10-31 |
2023-08-14 |
Not clear |
| Yueh-Ting Tsai, Shung-Te Kao, Chin-Yi Chen. Medicinal Herbs and Their Derived Ingredients Protect against Cognitive Decline in In Vivo Models of Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232612. |
this review delineates how in in vivo models mhdis suppress aβ deposition by downregulating β- and γ-secretase activities; inhibit oxidative stress by enhancing the antioxidant activities and reducing lipid peroxidation; prevent tau hyperphosphorylation by upregulating protein phosphatase 2a expression and downregulating glycogen synthase kinase-3β expression; reduce inflammatory mediators partly by upregulating brain-derived neurotrophic factor/extracellular signal-regulated protein kinase 1/2-mediated signaling and downregulating p38 mitogen-activated protein kinase (p38 mapk)/c-jun n-terminal kinase (jnk)-mediated signaling; attenuate synaptic dysfunction by increasing presynaptic protein, postsynaptic protein, and acetylcholine levels and preventing acetylcholinesterase activity; and protect against neuronal apoptosis mainly by upregulating akt/cyclic amp response element-binding protein/b-cell lymphoma 2 (bcl-2)-mediated anti-apoptotic signaling and downregulating p38 mapk/jnk/bcl-2-associated x protein (bax)/caspase-3-, bax/apoptosis-inducing factor-, c/ebp homologous protein/glucose-regulated protein 78-, and autophagy-mediated apoptotic signaling. |
2022-10-14 |
2023-08-14 |
Not clear |
| Yueh-Ting Tsai, Shung-Te Kao, Chin-Yi Chen. Medicinal Herbs and Their Derived Ingredients Protect against Cognitive Decline in In Vivo Models of Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232612. |
therefore, mhdis listed in this review protect against aβ-induced cognitive decline by inhibiting aβ accumulation, oxidative stress, tau hyperphosphorylation, inflammation, synaptic damage, and neuronal apoptosis in the cortex and hippocampus during the early and late ad phases. |
2022-10-14 |
2023-08-14 |
Not clear |
| Fulin Guan, Qichang Gao, Xinghua Dai, Lei Li, Rui Bao, Jiaao G. LncRNA RP11-59J16.2 aggravates apoptosis and increases tau phosphorylation by targeting MCM2 in AD. Frontiers in genetics. vol 13. 2022-09-12. PMID:36092938. |
lncrna rp11-59j16.2 aggravates apoptosis and increases tau phosphorylation by targeting mcm2 in ad. |
2022-09-12 |
2023-08-14 |
Not clear |
| Xiangxiang Zhu, Zilei Zhang, Xin Yang, Longkai Qi, Yinrui Guo, Xiaocui Tang, Yizhen Xie, Diling Che. Improvement of extraction from Hericium erinaceus on the gut-brain axis in AD-like mice. Brain research. 2022-08-07. PMID:35934088. |
in this study, results showed the extractions of hericium erinaceus can ameliorate the learning and memory abilities significantly, reduce the swelling of brain tissues, neuronal apoptosis, and down-regulate the expression of alzheimer's disease intracellular markers including tau and aβ1-42. |
2022-08-07 |
2023-08-14 |
mouse |
| Tania Arora, Vikash Prashar, Randeep Singh, Tushar Singh Barwal, Harish Changotra, Arti Sharma, Jyoti Parkas. Dysregulated miRNAs in Progression and Pathogenesis of Alzheimer's Disease. Molecular neurobiology. 2022-07-22. PMID:35867206. |
alzheimer's disease (ad) is a progressive degeneration of neurons due to the accumulation of amyloid-β peptide (aβ) and hyper-phosphorylation of tau protein in the neuronal milieu leading to increased oxidative stress and apoptosis. |
2022-07-22 |
2023-08-14 |
human |
| Vanesa Carmona Mata, Joshua Goldber. Morin and isoquercitrin protect against ischemic neuronal injury by modulating signaling pathways and stimulating mitochondrial biogenesis. Nutritional neuroscience. 2022-07-20. PMID:35857717. |
the search for the etiology of alzheimer's disease has revealed dysregulation of amyloid protein precursors, β-secretase, mitophagy, apoptosis, and tau protein genes after ischemic brain injury. |
2022-07-20 |
2023-08-14 |
Not clear |
| Tianlin Jiang, Jiahua Wang, Chao Li, Guiyun Cao, Xiaohong Wan. Prohibitins: A Key Link between Mitochondria and Nervous System Diseases. Oxidative medicine and cellular longevity. vol 2022. 2022-07-18. PMID:35847581. |
phbs can prevent apoptosis, inflammation, mitochondrial dysfunction, and autophagy in neurological disorders through different molecules and pathways, such as opa-1, pink1/parkin, il6/stat3, tau, no, lc3, and tdp43. |
2022-07-18 |
2023-08-14 |
Not clear |
| Cui Yang, Qiu Yang, Yang Xiang, Xian-Rong Zeng, Jun Xiao, Wei-Dong L. The neuroprotective effects of oxygen therapy in Alzheimer's disease: a narrative review. Neural regeneration research. vol 18. issue 1. 2022-07-08. PMID:35799509. |
increasing evidence also suggests that oxygen therapy may improve many pathological aspects of ad including amyloid-beta metabolism, tau phosphorylation, neuroinflammation, neuronal apoptosis, oxidative stress, neurotrophic factors, mitochondrial function, cerebral blood volume, and protein synthesis. |
2022-07-08 |
2023-08-14 |
Not clear |
| Lin Wang, Bi-Qiang Zhou, Ying-Hong Li, Qian-Qian Jiang, Wei-Hong Cong, Ke-Ji Chen, Xiao-Min Wen, Zheng-Zhi W. Lactoferrin modification of berberine nanoliposomes enhances the neuroprotective effects in a mouse model of Alzheimer's disease. Neural regeneration research. vol 18. issue 1. 2022-07-08. PMID:35799547. |
previous studies have shown that berberine has neuroprotective effects against alzheimer's disease, including antagonizing tau phosphorylation, and inhibiting acetylcholinesterase activity and neural cell apoptosis. |
2022-07-08 |
2023-08-14 |
mouse |
| Lin Wang, Bi-Qiang Zhou, Ying-Hong Li, Qian-Qian Jiang, Wei-Hong Cong, Ke-Ji Chen, Xiao-Min Wen, Zheng-Zhi W. Lactoferrin modification of berberine nanoliposomes enhances the neuroprotective effects in a mouse model of Alzheimer's disease. Neural regeneration research. vol 18. issue 1. 2022-07-08. PMID:35799547. |
lactoferrin-modified berberine nanoliposomes inhibited acetylcholinesterase activity and apoptosis in the hippocampus, reduced tau over-phosphorylation in the cerebral cortex, and improved mouse behavior. |
2022-07-08 |
2023-08-14 |
mouse |
| Junhao Huang, Zhiwei Xu, Hongshu Chen, Yiyou Lin, Jiale Wei, Sichen Wang, Hongxia Yu, Shuo Huang, Yehui Zhang, Changyu Li, Xiaojie Zho. Shen Qi Wan Ameliorates Learning and Memory Impairment Induced by STZ in AD Rats through PI3K/AKT Pathway. Brain sciences. vol 12. issue 6. 2022-06-24. PMID:35741643. |
expression levels of neun and proteins related to tau and apoptosis were measured using immunohistochemistry and western blotting, respectively. |
2022-06-24 |
2023-08-14 |
rat |
| Junhao Huang, Zhiwei Xu, Hongshu Chen, Yiyou Lin, Jiale Wei, Sichen Wang, Hongxia Yu, Shuo Huang, Yehui Zhang, Changyu Li, Xiaojie Zho. Shen Qi Wan Ameliorates Learning and Memory Impairment Induced by STZ in AD Rats through PI3K/AKT Pathway. Brain sciences. vol 12. issue 6. 2022-06-24. PMID:35741643. |
we found that sqw treatment significantly alleviated learning and memory impairment, pathological damage, and apoptosis in rats, as evidenced by an increased level of neun and bcl-2, and decreased phosphorylation of tau, bax, and caspase-3 protein expression. |
2022-06-24 |
2023-08-14 |
rat |
| Sarha A L Queiroz, Alyne M M Ton, Thiago M C Pereira, Bianca P Campagnaro, Larissa Martinelli, Aitor Picos, Manuel Campos-Toimil, Elisardo C Vasque. The Gut Microbiota-Brain Axis: A New Frontier on Neuropsychiatric Disorders. Frontiers in psychiatry. vol 13. 2022-06-20. PMID:35722583. |
ad involves oxidative stress, neuroinflammation and accelerated apoptosis, accompanied by deposition of amyloid-β peptide plaques and tau protein-based neurofibrillary tangles in the central nervous system. |
2022-06-20 |
2023-08-14 |
Not clear |
| Xiaohui Ma, Linlin Liu, Jing Men. Retraction notice to "MicroRNA-125b promotes neurons cell apoptosis and tau phosphorylation in Alzheimer's disease" [Neurosci. Lett. 661 (2017) 57-62]. Neuroscience letters. vol 783. 2022-06-12. PMID:35691149. |
retraction notice to "microrna-125b promotes neurons cell apoptosis and tau phosphorylation in alzheimer's disease" [neurosci. |
2022-06-12 |
2023-08-14 |
Not clear |