| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kang Chen, Guran Y. Tetrahydroalstonine possesses protective potentials on palmitic acid stimulated SK-N-MC cells by suppression of Aβ1-42 and tau through regulation of PI3K/Akt signaling pathway. European journal of pharmacology. vol 962. 2023-12-08. PMID:38061471. |
in addition, tha significantly reduced cell apoptosis rate, down-regulated relative levels of p-jnk/jnk, bax/bcl-2, cytochrome c, active caspase-3 and caspase-3, and attenuated palmitate acid-induced aβ1-42 and tau generation. |
2023-12-08 |
2023-12-17 |
Not clear |
| Muhammed Cemil Busı, Semra Yigitaslan, Zuhal Kaltus, Nusin Harmancı, Ezgi Eroglu, Orhan Ozatık, Coskun Kay. The protective effect of taurine on cyclophosphamide-induced testicular toxicity in rats. Pakistan journal of pharmaceutical sciences. vol 36. issue 5(Special). 2023-11-27. PMID:38008966. |
tau treatment resulted in improvement in body weight gain, oxidative stress, inflammation and apoptosis, some of which were significant. |
2023-11-27 |
2023-11-28 |
rat |
| Muhammed Cemil Busı, Semra Yigitaslan, Zuhal Kaltus, Nusin Harmancı, Ezgi Eroglu, Orhan Ozatık, Coskun Kay. The protective effect of taurine on cyclophosphamide-induced testicular toxicity in rats. Pakistan journal of pharmaceutical sciences. vol 36. issue 5(Special). 2023-11-27. PMID:38008966. |
it was concluded that tau may prevent and/or treat the testicular toxicity by ameloirating oxidative stress, inflammation and apoptosis. |
2023-11-27 |
2023-11-28 |
rat |
| Diana I Salikhova, Angelika V Timofeeva, Victoria V Golovicheva, Timur Kh Fatkhudinov, Yulia A Shevtsova, Anna G Soboleva, Ivan S Fedorov, Kirill V Goryunov, Alexander S Dyakonov, Victoria O Mokrousova, Margarita O Shedenkova, Andrey V Elchaninov, Oleg V Makhnach, Sergey I Kutsev, Vladimir P Chekhonin, Denis N Silachev, Dmitry V Goldshtei. Extracellular vesicles of human glial cells exert neuroprotective effects via brain miRNA modulation in a rat model of traumatic brain injury. Scientific reports. vol 13. issue 1. 2023-11-24. PMID:37989873. |
modulation of microrna pools might contribute to the observed decrease in the number of astrocytes that inhibit neurorecovery processes while enhancing neuroplasticity by decreasing phosphorylated tau forms, preventing inflammation and apoptosis associated with secondary damage to brain tissue. |
2023-11-24 |
2023-11-28 |
human |
| Christy Hung, Rickie Patan. Elevated 4R tau contributes to endolysosomal dysfunction and neurodegeneration in VCP-related frontotemporal dementia. Brain : a journal of neurology. 2023-10-26. PMID:37882537. |
in summary, our findings demonstrate that tau hyperphosphorylation, endolysosomal dysfunction, lysosomal membrane rupture, endoplasmic reticulum stress and apoptosis are driven by a pathogenic increase in 4r tau. |
2023-10-26 |
2023-11-08 |
human |
| Deborah K Sokol, Debomoy K Lahir. Neurodevelopmental disorders and microcephaly: how apoptosis, the cell cycle, tau and amyloid-β precursor protein APPly. Frontiers in molecular neuroscience. vol 16. 2023-10-09. PMID:37808474. |
neurodevelopmental disorders and microcephaly: how apoptosis, the cell cycle, tau and amyloid-β precursor protein apply. |
2023-10-09 |
2023-10-15 |
Not clear |
| Ngoc-Han Thi Nguyen, Ji Hun Kim, Su-Min Lee, Byung-Kwan Cho, Yang-Hoon Kim, Jiho Mi. Inhibition of Tau Phosphorylation and Aβ Accumulation by S. cerevisiae-derived Vacuoles in LPS-Induced SH-SY5Y Cells. Journal of biotechnology. 2023-09-30. PMID:37777088. |
neurodegenerative diseases, such as alzheimer's disease (ad), are characterized by the accumulation of intracellular tau and amyloid beta (aβ) proteins, which lead to neuroinflammation and neuronal apoptosis. |
2023-09-30 |
2023-10-07 |
Not clear |
| Min Ji Go, Jong Min Kim, Hyo Lim Lee, Tae Yoon Kim, Seung Gyum Joo, Ju Hui Kim, Han Su Lee, Dae-Ok Kim, Ho Jin He. Anti-Amnesia-like Effect of International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37762386. |
treatment with krpbe suppressed aβ accumulation and phosphorylation of tau and reduced the expression level of bax/bcl-2 ratio and caspase 3, improving oxidative stress-induced apoptosis. |
2023-09-28 |
2023-10-07 |
mouse |
| Khadga Raj Aran, G D Gupta, Shamsher Sing. Cladribine Induces Apoptosis, Neuroinflammation, Mitochondrial Oxidative Stress, Tau Phosphorylation and Aβ (1-42) Pathway in the Hippocampus: An In vivo Approach. Journal of chemical neuroanatomy. 2023-09-14. PMID:37708945. |
cladribine induces apoptosis, neuroinflammation, mitochondrial oxidative stress, tau phosphorylation and aβ (1-42) pathway in the hippocampus: an in vivo approach. |
2023-09-14 |
2023-10-07 |
rat |
| Khadga Raj Aran, G D Gupta, Shamsher Sing. Cladribine Induces Apoptosis, Neuroinflammation, Mitochondrial Oxidative Stress, Tau Phosphorylation and Aβ (1-42) Pathway in the Hippocampus: An In vivo Approach. Journal of chemical neuroanatomy. 2023-09-14. PMID:37708945. |
the study was designed to validate an animal model of cladribine administration to rats through mitochondrial oxidative stress, inflammation, apoptosis, tau phosphorylation, and amyloid-β (1-42) accumulation. |
2023-09-14 |
2023-10-07 |
rat |
| Lovedeep Singh, Rajbir Bhatt. Signaling Pathways Involved in the Neuroprotective Effect of Osthole: Evidence and Mechanisms. Molecular neurobiology. 2023-09-08. PMID:37682453. |
activation of wnt by osthole, in turn, regulates downstream gsk-1β to inhibit tau phosphorylation and β-catenin degradation to prevent neuronal apoptosis. |
2023-09-08 |
2023-10-07 |
human |
| Yaoyao Ren, Shengtao Q. Constituent isoflavones of Puerariae radix as a potential neuroprotector in cognitive impairment: Evidence from preclinical studies. Ageing research reviews. 2023-08-24. PMID:37619620. |
these isoflavones prevent aβ aggregation, inhibit tau hyperphosphorylation, increase cholinergic neurotransmitter levels, reduce neuroinflammation and oxidative stress, improve synaptic plasticity, promote nerve regeneration, and prevent apoptosis. |
2023-08-24 |
2023-09-07 |
Not clear |
| Mengyao Shan, Yunfan Bai, Xiaoxue Fang, Xintian Lan, Yegang Zhang, Yiming Cao, Difu Zhu, Haoming Lu. American Ginseng for the Treatment of Alzheimer's Disease: A Review. Molecules (Basel, Switzerland). vol 28. issue 15. 2023-08-12. PMID:37570686. |
it has been reported that ginsenosides can inhibit amyloid β-protein (aβ) production and deposition, tau phosphorylation, apoptosis and cytotoxicity, as well as possess anti-oxidant and anti-inflammatory properties, thus suppressing the progression of ad. |
2023-08-12 |
2023-08-16 |
Not clear |
| Ashini Singh, Niraj Kumar Sing. Pre-clinical Evidence-based Neuroprotective Potential of Naringin against Alzheimer's Disease-like Pathology: A Comprehensive Review. Current pharmaceutical biotechnology. 2023-08-01. PMID:37526460. |
naringin reduces deposition of aβ, hyperphosphorylation of tau protein, cholinergic dysfunction, oxidative stress burden, mitochondrial toxicity, the activity of glutamate receptors, and apoptosis of the neuronal cells. |
2023-08-01 |
2023-08-14 |
Not clear |
| Kaiming Guo, Wenting Huang, Kun Chen, Pengkai Huang, Wenshuo Peng, Ruiqing Shi, Tao He, Mulan Zhang, Hao Wang, Jian Hu, Xinshi Wang, Yangping Shentu, Huiqin Xu, Li Li. Fibroblast growth factor 10 ameliorates neurodegeneration in mouse and cellular models of Alzheimer's disease via reducing tau hyperphosphorylation and neuronal apoptosis. Aging cell. 2023-07-28. PMID:37503695. |
fibroblast growth factor 10 ameliorates neurodegeneration in mouse and cellular models of alzheimer's disease via reducing tau hyperphosphorylation and neuronal apoptosis. |
2023-07-28 |
2023-08-14 |
mouse |
| Kaiming Guo, Wenting Huang, Kun Chen, Pengkai Huang, Wenshuo Peng, Ruiqing Shi, Tao He, Mulan Zhang, Hao Wang, Jian Hu, Xinshi Wang, Yangping Shentu, Huiqin Xu, Li Li. Fibroblast growth factor 10 ameliorates neurodegeneration in mouse and cellular models of Alzheimer's disease via reducing tau hyperphosphorylation and neuronal apoptosis. Aging cell. 2023-07-28. PMID:37503695. |
additionally, fgf10 treatment reduced tau hyperphosphorylation and neuronal apoptosis, thereby mitigating neuronal cell damage and synaptic deficits in the cortex and hippocampus of 3xtg-ad mice, as well as appswe-transfected ht22 cells. |
2023-07-28 |
2023-08-14 |
mouse |
| Kaiming Guo, Wenting Huang, Kun Chen, Pengkai Huang, Wenshuo Peng, Ruiqing Shi, Tao He, Mulan Zhang, Hao Wang, Jian Hu, Xinshi Wang, Yangping Shentu, Huiqin Xu, Li Li. Fibroblast growth factor 10 ameliorates neurodegeneration in mouse and cellular models of Alzheimer's disease via reducing tau hyperphosphorylation and neuronal apoptosis. Aging cell. 2023-07-28. PMID:37503695. |
similarly, endogenous fgf10 overexpression ameliorated tau hyperphosphorylation and neuronal apoptosis in the cortex and hippocampus of 3xtg-ad mice. |
2023-07-28 |
2023-08-14 |
mouse |
| Wei Zhang, Yating Shi, Mingti Lv, Yimin Zhang, Wei Ren, Ruling Shi, Hecheng Wang, Linlin Sha. Physalin B Reduces Tau Phosphorylation and Cell Apoptosis in HEK293 Cells by Activating FoxO1. Current molecular pharmacology. 2023-07-25. PMID:37489791. |
physalin b reduces tau phosphorylation and cell apoptosis in hek293 cells by activating foxo1. |
2023-07-25 |
2023-08-14 |
Not clear |
| A S Oreshko, A Ya Rodnyy, D V Bazovkina, V S Naumenk. Effects of central administration of the human Tau protein on the Bdnf, Trkb, p75, Mapt, Bax and Bcl-2 genes expression in the mouse brain. Vavilovskii zhurnal genetiki i selektsii. vol 27. issue 4. 2023-07-19. PMID:37465194. |
it was found that five days after administration of the protein into the fourth lateral ventricle, significant changes occurred in the expression of the genes involved in apoptosis and neurogenesis regulation, e. g., a notable decrease in the mrna level of the gene encoding the most important neurotrophic factor bdnf (brain-derived neurotrophic factor) was observed in the frontal cortex which could play an important role in neurodegeneration caused by pathological tau protein aggregation. |
2023-07-19 |
2023-08-14 |
mouse |
| Yao Zhang, Wenxuan Jia. Signal Pathways and Intestinal Flora through Trimethylamine N-oxide in Alzheimer's Disease. Current protein & peptide science. 2023-07-18. PMID:37461349. |
tmao can increase the expression of aβ and the hyperphosphorylation of tau protein, regulate the signal pathways of nlrp3/asc/caspase1, sirt1/p53/p21/rb, perk/eif2α/er-stress, sirt3-sod2-mtros, txnip-nlpr3, and perk/akt/mtor, and stimulate the inflammation, apoptosis, endoplasmic reticulum stress, and the ros. |
2023-07-18 |
2023-08-14 |
Not clear |