| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lin Fu, Jinlong Shi, Kai Hu, Jijun Wang, Weidong Wang, Xiaoyan K. Mitogen-activated protein kinase binding protein 1 (MAPKBP1) is an unfavorable prognostic biomarker in cytogenetically normal acute myeloid leukemia. Oncotarget. vol 6. issue 10. 2016-05-20. PMID:25924238. |
gene-expression profiling revealed that some important oncogenes, including mycn, myb, cdk6 and ccnd2, etc, were up-regulated, while cell signalling pathways leading to apoptosis, antigen processing, and natural killer cell-mediated cytotoxicity were down-regulated in mapkbp1high patients with cn-aml. |
2016-05-20 |
2023-08-13 |
Not clear |
| Sagar Uttarkar, Sandeep Dukare, Bertan Bopp, Michael Goblirsch, Joachim Jose, Karl-Heinz Klempnaue. Naphthol AS-E Phosphate Inhibits the Activity of the Transcription Factor Myb by Blocking the Interaction with the KIX Domain of the Coactivator p300. Molecular cancer therapeutics. vol 14. issue 6. 2016-04-12. PMID:25740244. |
by using several human leukemia cell lines, we demonstrate that naphthol as-e phosphate suppresses the expression of myb target genes and induces myeloid differentiation and apoptosis. |
2016-04-12 |
2023-08-13 |
human |
| Yanhan Dong, Qian Zhao, Xinyu Liu, Xiaofang Zhang, Zhongqiang Qi, Haifeng Zhang, Xiaobo Zheng, Zhengguang Zhan. MoMyb1 is required for asexual development and tissue-specific infection in the rice blast fungus Magnaporthe oryzae. BMC microbiology. vol 15. 2016-01-05. PMID:25885817. |
myb proteins are involved in cell proliferation, differentiation and apoptosis, and have crucial roles in telomeres. |
2016-01-05 |
2023-08-13 |
Not clear |
| L Zhao, P Ye, T J Gond. The MYB proto-oncogene suppresses monocytic differentiation of acute myeloid leukemia cells via transcriptional activation of its target gene GFI1. Oncogene. vol 33. issue 35. 2015-04-14. PMID:24121275. |
although it is clear that myb can promote proliferation, suppress apoptosis and block differentiation, the identities of the myb target genes that mediate these effects have only been partially elucidated. |
2015-04-14 |
2023-08-12 |
human |
| Duohui Jing, Vivek A Bhadri, Dominik Beck, Julie A I Thoms, Nurul A Yakob, Jason W H Wong, Kathy Knezevic, John E Pimanda, Richard B Loc. Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells. Blood. vol 125. issue 2. 2015-03-11. PMID:25336632. |
sustained myb expression in resistant pdxs resulted in maintenance of bcl2 expression and inhibition of apoptosis. |
2015-03-11 |
2023-08-13 |
Not clear |
| Hiroshi Maruyama, Yosuke Ishitsuka, Yasuhiro Fujisawa, Junichi Furuta, Mitsuru Sekido, Yasuhiro Kawach. B-Myb enhances proliferation and suppresses differentiation of keratinocytes in three-dimensional cell culture. Archives of dermatological research. vol 306. issue 4. 2015-01-10. PMID:24515894. |
b-myb (mybl2) is a member of the myb gene family of transcription factors involved in the control of cell growth, differentiation, and apoptosis. |
2015-01-10 |
2023-08-12 |
human |
| Ping Ye, Liang Zhao, Crystal McGirr, Thomas J Gond. MYB down-regulation enhances sensitivity of U937 myeloid leukemia cells to the histone deacetylase inhibitor LBH589 in vitro and in vivo. Cancer letters. vol 343. issue 1. 2014-02-20. PMID:24075958. |
myb knockdown inhibited proliferation and induced apoptosis in u937 and k562 cells in vitro, and also sensitized both to the pro-apoptotic effect of lbh589. |
2014-02-20 |
2023-08-12 |
mouse |
| Ping Ye, Liang Zhao, Thomas J Gond. The MYB oncogene can suppress apoptosis in acute myeloid leukemia cells by transcriptional repression of DRAK2 expression. Leukemia research. vol 37. issue 5. 2013-06-07. PMID:23398943. |
the myb oncogene can suppress apoptosis in acute myeloid leukemia cells by transcriptional repression of drak2 expression. |
2013-06-07 |
2023-08-12 |
Not clear |
| Ping Ye, Liang Zhao, Thomas J Gond. The MYB oncogene can suppress apoptosis in acute myeloid leukemia cells by transcriptional repression of DRAK2 expression. Leukemia research. vol 37. issue 5. 2013-06-07. PMID:23398943. |
rna interference-mediated suppression of myb expression promoted apoptosis in the aml cell line u937, without affecting expression of the anti-apoptotic myb target bcl2. |
2013-06-07 |
2023-08-12 |
Not clear |
| Ping Ye, Liang Zhao, Thomas J Gond. The MYB oncogene can suppress apoptosis in acute myeloid leukemia cells by transcriptional repression of DRAK2 expression. Leukemia research. vol 37. issue 5. 2013-06-07. PMID:23398943. |
moreover, rna interference-mediated suppression of drak2 in u937 cells alleviated apoptosis induced by myb down-regulation. |
2013-06-07 |
2023-08-12 |
Not clear |
| Ping Ye, Liang Zhao, Thomas J Gond. The MYB oncogene can suppress apoptosis in acute myeloid leukemia cells by transcriptional repression of DRAK2 expression. Leukemia research. vol 37. issue 5. 2013-06-07. PMID:23398943. |
together, these findings identify a novel mechanism by which myb suppresses apoptosis in an aml model cell line. |
2013-06-07 |
2023-08-12 |
Not clear |
| Sanjeev K Srivastava, Arun Bhardwaj, Seema Singh, Sumit Arora, Steven McClellan, William E Grizzle, Eddie Reed, Ajay P Sing. Myb overexpression overrides androgen depletion-induced cell cycle arrest and apoptosis in prostate cancer cells, and confers aggressive malignant traits: potential role in castration resistance. Carcinogenesis. vol 33. issue 6. 2012-09-17. PMID:22431717. |
myb overexpression overrides androgen depletion-induced cell cycle arrest and apoptosis in prostate cancer cells, and confers aggressive malignant traits: potential role in castration resistance. |
2012-09-17 |
2023-08-12 |
Not clear |
| Yvette Drabsch, Ramsay G Robert, Thomas J Gond. MYB suppresses differentiation and apoptosis of human breast cancer cells. Breast cancer research : BCR. vol 12. issue 4. 2011-03-01. PMID:20659323. |
myb suppresses differentiation and apoptosis of human breast cancer cells. |
2011-03-01 |
2023-08-12 |
human |
| Göran Stenman, Mattias K Andersson, Ywonne André. New tricks from an old oncogene: gene fusion and copy number alterations of MYB in human cancer. Cell cycle (Georgetown, Tex.). vol 9. issue 15. 2010-12-01. PMID:20647765. |
deletion of these target sites may disrupt the repression of myb, leading to overexpression of myb-nfib transcripts and protein and to transcriptional activation of critical myb target genes associated with apoptosis, cell cycle control, cell growth/angiogenesis and cell adhesion. |
2010-12-01 |
2023-08-12 |
human |
| Marta Persson, Ywonne Andrén, Joachim Mark, Hugo M Horlings, Fredrik Persson, Göran Stenma. Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 44. 2009-12-07. PMID:19841262. |
we suggest that deletion of these target sites may disrupt repression of myb leading to overexpression of myb-nfib transcripts and protein and to activation of critical myb targets, including genes associated with apoptosis, cell cycle control, cell growth/angiogenesis, and cell adhesion. |
2009-12-07 |
2023-08-12 |
human |
| Jung-Chang Lee, Manju Sharma, Young-Hee Lee, Nan-Hee Lee, Sun-Young Kim, Ji-Soo Yun, Sang-Yun Nam, Pyoung-Han Hwang, Eun-Chung Jhee, Ho-Keun Y. Pax9 mediated cell survival in oral squamous carcinoma cell enhanced by c-myb. Cell biochemistry and function. vol 26. issue 8. 2009-01-23. PMID:18979497. |
transducing c-myb cells with adenovirus c-myb (ad/c-myb) were induced cell growth and inhibited apoptosis, but dominant-negative myb cells (ad/dn-myb) were not affected. |
2009-01-23 |
2023-08-12 |
Not clear |
| Hanna T Gazda, Alvin T Kho, Despina Sanoudou, Jan M Zaucha, Isaac S Kohane, Colin A Sieff, Alan H Begg. Defective ribosomal protein gene expression alters transcription, translation, apoptosis, and oncogenic pathways in Diamond-Blackfan anemia. Stem cells (Dayton, Ohio). vol 24. issue 9. 2006-10-06. PMID:16741228. |
apoptosis genes, such as tnfrsf10b and fas, transcriptional control genes, including the erythropoietic transcription factor myb (encoding c-myb), and translational genes were greatly dysregulated, mostly in diseased erythroid cells. |
2006-10-06 |
2023-08-12 |
mouse |
| Jodi K Lutwyche, Rebecca A Keough, Julie Hunter, Leeanne S Coles, Thomas J Gond. DNA binding-independent transcriptional activation of the vascular endothelial growth factor gene (VEGF) by the Myb oncoprotein. Biochemical and biophysical research communications. vol 344. issue 4. 2006-07-19. PMID:16650815. |
myb is a key transcription factor that can regulate proliferation, differentiation, and apoptosis, predominantly in the haemopoietic system. |
2006-07-19 |
2023-08-12 |
Not clear |
| Siau-Min Fung, Gary Ramsay, Alisa L Katze. MYB and CBP: physiological relevance of a biochemical interaction. Mechanisms of development. vol 120. issue 6. 2004-05-03. PMID:12834870. |
drosophila melanogaster possesses a single gene, dm myb, that is closely related to the vertebrate family of myb genes, which encode transcription factors involved in regulatory decisions affecting cell proliferation, differentiation and apoptosis. |
2004-05-03 |
2023-08-12 |
drosophila_melanogaster |
| Carrie A Fitzpatrick, Nikolai V Sharkov, Gary Ramsay, Alisa L Katze. Drosophila myb exerts opposing effects on S phase, promoting proliferation and suppressing endoreduplication. Development (Cambridge, England). vol 129. issue 19. 2002-11-08. PMID:12223407. |
drosophila melanogaster possesses a single gene, dm myb, that is closely related to the vertebrate family of myb genes, which encode transcription factors that are involved in regulatory decisions affecting cell proliferation, differentiation and apoptosis. |
2002-11-08 |
2023-08-12 |
drosophila_melanogaster |