| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J N Rashida Gnanaprakasam, John William Sherman, Ruoning Wan. MYC and HIF in shaping immune response and immune metabolism. Cytokine & growth factor reviews. vol 35. 2018-03-19. PMID:28363691. |
beyond several key signaling kinase cascades, the hypoxia inducible factor 1 (hif-1) and the proto-oncogene myc, act alone or in concert, to coordinate t cell metabolic reprogramming, cell proliferation, functional differentiation and apoptosis, enabling a robust t cell-mediated adaptive immune response. |
2018-03-19 |
2023-08-13 |
Not clear |
| Amanda R Oran, Clare M Adams, Xiao-Yong Zhang, Victoria J Gennaro, Harla K Pfeiffer, Hestia S Mellert, Hans E Seidel, Kirsten Mascioli, Jordan Kaplan, Mahmoud R Gaballa, Chen Shen, Isidore Rigoutsos, Michael P King, Justin L Cotney, Jamie J Arnold, Suresh D Sharma, Ubaldo E Martinez-Outschoorn, Christopher R Vakoc, Lewis A Chodosh, James E Thompson, James E Bradner, Craig E Cameron, Gerald S Shadel, Christine M Eischen, Steven B McMaho. Multi-focal control of mitochondrial gene expression by oncogenic MYC provides potential therapeutic targets in cancer. Oncotarget. vol 7. issue 45. 2018-03-16. PMID:27590350. |
we further demonstrate that inhibition of this newly defined myc effector pathway causes robust and selective tumor cell apoptosis, via an acute, checkpoint-like mechanism linked to aberrant electron transport chain complex assembly and mitochondrial reactive oxygen species (ros) production. |
2018-03-16 |
2023-08-13 |
mouse |
| Jiuhong Huang, Yu Feng, Xinhong Chen, Wenzhe Li, Lei Xu. Myc inhibits JNK-mediated cell death in vivo. Apoptosis : an international journal on programmed cell death. vol 22. issue 4. 2018-03-06. PMID:28150056. |
the proto-oncogene myc is well known for its roles in promoting cell growth, proliferation and apoptosis. |
2018-03-06 |
2023-08-13 |
human |
| Jiuhong Huang, Yu Feng, Xinhong Chen, Wenzhe Li, Lei Xu. Myc inhibits JNK-mediated cell death in vivo. Apoptosis : an international journal on programmed cell death. vol 22. issue 4. 2018-03-06. PMID:28150056. |
thus, besides its well-studied apoptosis promoting function, myc also antagonizes jnk-mediated cell death in drosophila, and this function is likely conserved from fly to human. |
2018-03-06 |
2023-08-13 |
human |
| Morihiro Okada, Thomas C Miller, Luan Wen, Yun-Bo Sh. A balance of Mad and Myc expression dictates larval cell apoptosis and adult stem cell development during Xenopus intestinal metamorphosis. Cell death & disease. vol 8. issue 5. 2018-02-16. PMID:28492553. |
a balance of mad and myc expression dictates larval cell apoptosis and adult stem cell development during xenopus intestinal metamorphosis. |
2018-02-16 |
2023-08-13 |
xenopus_laevis |
| Aleksandra Dakic, Kyle DiVito, Shuang Fang, Frank Suprynowicz, Anirudh Gaur, Xin Li, Nancy Palechor-Ceron, Vera Simic, Sujata Choudhury, Songtao Yu, Cynthia M Simbulan-Rosenthal, Dean Rosenthal, Richard Schlegel, Xuefeng Li. ROCK inhibitor reduces Myc-induced apoptosis and mediates immortalization of human keratinocytes. Oncotarget. vol 7. issue 41. 2018-02-12. PMID:27556514. |
since we previously postulated that e7 and the rock inhibitor, y-27632, were members of the same functional pathway in cell immortalization, we tested whether y-27632 would inhibit apoptosis induced by the over-expression of myc. |
2018-02-12 |
2023-08-13 |
human |
| Aleksandra Dakic, Kyle DiVito, Shuang Fang, Frank Suprynowicz, Anirudh Gaur, Xin Li, Nancy Palechor-Ceron, Vera Simic, Sujata Choudhury, Songtao Yu, Cynthia M Simbulan-Rosenthal, Dean Rosenthal, Richard Schlegel, Xuefeng Li. ROCK inhibitor reduces Myc-induced apoptosis and mediates immortalization of human keratinocytes. Oncotarget. vol 7. issue 41. 2018-02-12. PMID:27556514. |
most important, y-27632 cooperated with myc to immortalize keratinocytes efficiently, indicating that apoptosis is a major barrier to myc-induced immortalization of keratinocytes. |
2018-02-12 |
2023-08-13 |
human |
| Ting Zhang, Hua Qian, Cui Hu, Hui Lu, Ji-Bing Li, Ya-Fen Wu, Wei L. MiR-26a Mediates Ultraviolet B-Induced Apoptosis by Targeting Histone Methyltransferase EZH2 Depending on Myc Expression. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 43. issue 3. 2017-12-26. PMID:28977801. |
mir-26a mediates ultraviolet b-induced apoptosis by targeting histone methyltransferase ezh2 depending on myc expression. |
2017-12-26 |
2023-08-13 |
Not clear |
| Yulin Li, Anja Deutzmann, Peter S Choi, Alice C Fan, Dean W Felshe. BIM mediates oncogene inactivation-induced apoptosis in multiple transgenic mouse models of acute lymphoblastic leukemia. Oncotarget. vol 7. issue 19. 2017-12-11. PMID:27095570. |
overexpression of mir-17-92 blocked the induction of apoptosis upon oncogene inactivation in the myc and ras-driven but not in the bcr-abl-driven all leukemia. |
2017-12-11 |
2023-08-13 |
mouse |
| Luana D'Artista, Andrea Bisso, Andrea Piontini, Mirko Doni, Alessandro Verrecchia, Theresia R Kress, Marco J Morelli, Giannino Del Sal, Bruno Amati, Stefano Campane. Pin1 is required for sustained B cell proliferation upon oncogenic activation of Myc. Oncotarget. vol 7. issue 16. 2017-12-04. PMID:26943576. |
in both pin1-deficient b-cells and mefs, the proliferative response to oncogenic myc was selectively impaired, with no alterations in myc-induced apoptosis or mitogen-induced cell cycle entry. |
2017-12-04 |
2023-08-13 |
mouse |
| Vamsidhar Velcheti, Tomas Radivoyevitch, Yogen Saunthararaja. Higher-Level Pathway Objectives of Epigenetic Therapy: A Solution to the p53 Problem in Cancer. American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting. vol 37. 2017-11-29. PMID:28561650. |
outside of this core, apoptosis and differentiation programs, which dominantly antagonize myc to terminate cell division, necessarily differ between cancer and normal cells, as apoptosis is suppressed by biallelic inactivation of the master regulator of apoptosis, p53, or its cofactor p16/cdkn2a in approximately 80% of cancers. |
2017-11-29 |
2023-08-13 |
Not clear |
| C David Wood, Hildegonda Veenstra, Sarika Khasnis, Andrea Gunnell, Helen M Webb, Claire Shannon-Lowe, Simon Andrews, Cameron S Osborne, Michelle J Wes. MYC activation and BCL2L11 silencing by a tumour virus through the large-scale reconfiguration of enhancer-promoter hubs. eLife. vol 5. 2017-10-31. PMID:27490482. |
lymphomagenesis in the presence of deregulated myc requires suppression of myc-driven apoptosis, often through downregulation of the pro-apoptotic bcl2l11 gene (bim). |
2017-10-31 |
2023-08-13 |
Not clear |
| V Selvarajan, M Osato, G S S Nah, J Yan, T-H Chung, D C-C Voon, Y Ito, M F Ham, M Salto-Tellez, N Shimizu, S-N Choo, S Fan, W-J Chng, S-B N. RUNX3 is oncogenic in natural killer/T-cell lymphoma and is transcriptionally regulated by MYC. Leukemia. vol 31. issue 10. 2017-10-24. PMID:28119527. |
treatment with a small-molecule myc inhibitor (jq1) caused significant downregulation of myc and runx3, leading to apoptosis in nktl cells. |
2017-10-24 |
2023-08-13 |
Not clear |
| Ang Luo, Xuan Zhang, Liya Fu, Zhengmao Zhu, Jin-Tang Don. Zinc finger factor ZNF121 is a MYC-interacting protein functionally affecting MYC and cell proliferation in epithelial cells. Journal of genetics and genomics = Yi chuan xue bao. vol 43. issue 12. 2017-10-17. PMID:27988300. |
myc is a potent oncoprotein that modulates multiple cellular processes including proliferation, apoptosis, differentiation, stemness, senescence, and migration. |
2017-10-17 |
2023-08-13 |
human |
| Joshua R Porter, Brian E Fisher, Laura Baranello, Julia C Liu, Diane M Kambach, Zuqin Nie, Woo Seuk Koh, Ji Luo, Jayne M Stommel, David Levens, Eric Batchelo. Global Inhibition with Specific Activation: How p53 and MYC Redistribute the Transcriptome in the DNA Double-Strand Break Response. Molecular cell. vol 67. issue 6. 2017-10-12. PMID:28867293. |
reducing myc during the dna damage response was important for cell-fate regulation, as counteracting myc repression reduced cell-cycle arrest and elevated apoptosis. |
2017-10-12 |
2023-08-13 |
Not clear |
| Ko-Jen Li, Cheng-Han Wu, Chieh-Yu Shen, Yu-Min Kuo, Chia-Li Yu, Song-Chou Hsie. Membrane Transfer from Mononuclear Cells to Polymorphonuclear Neutrophils Transduces Cell Survival and Activation Signals in the Recipient Cells via Anti-Extrinsic Apoptotic and MAP Kinase Signaling Pathways. PloS one. vol 11. issue 6. 2017-08-18. PMID:27258015. |
total membrane transfer from cd4+ t to pmns delayed pmn apoptosis by suppressing the extrinsic apoptotic molecules, bax, myc and caspase 8. |
2017-08-18 |
2023-08-13 |
human |
| Tomohiro Aoki, Kazuyuki Shimada, Akihiko Sakamoto, Keiki Sugimoto, Takanobu Morishita, Yuki Kojima, Satoko Shimada, Seiichi Kato, Chisako Iriyama, Shunsuke Kuno, Yasuhiko Harada, Akihiro Tomita, Fumihiko Hayakawa, Hitoshi Kiyo. Emetine elicits apoptosis of intractable B-cell lymphoma cells with MYC rearrangement through inhibition of glycolytic metabolism. Oncotarget. vol 8. issue 8. 2017-08-18. PMID:28055963. |
emetine elicits apoptosis of intractable b-cell lymphoma cells with myc rearrangement through inhibition of glycolytic metabolism. |
2017-08-18 |
2023-08-13 |
Not clear |
| Debangana Chakravorty, Tanmoy Jana, Sukhen Das Mandal, Anuradha Seth, Anubrata Bhattacharya, Sudipto Sah. MYCbase: a database of functional sites and biochemical properties of Myc in both normal and cancer cells. BMC bioinformatics. vol 18. issue 1. 2017-08-10. PMID:28454513. |
myc is an essential gene having multiple functions such as in cell growth, differentiation, apoptosis, genomic stability, angiogenesis, and disease biology. |
2017-08-10 |
2023-08-13 |
Not clear |
| Simon J Hogg, Andrea Newbold, Stephin J Vervoort, Leonie A Cluse, Benjamin P Martin, Gareth P Gregory, Marcus Lefebure, Eva Vidacs, Richard W Tothill, James E Bradner, Jake Shortt, Ricky W Johnston. BET Inhibition Induces Apoptosis in Aggressive B-Cell Lymphoma via Epigenetic Regulation of BCL-2 Family Members. Molecular cancer therapeutics. vol 15. issue 9. 2017-06-29. PMID:27406984. |
using the eμ-myc model of b-cell lymphoma, we demonstrate that bet inhibition with jq1 is a potent inducer of p53-independent apoptosis that occurs in the absence of effects on myc gene expression. |
2017-06-29 |
2023-08-13 |
Not clear |
| Kaiming Sun, Ruzanna Atoyan, Mylissa A Borek, Steven Dellarocca, Maria Elena S Samson, Anna W Ma, Guang-Xin Xu, Troy Patterson, David P Tuck, Jaye L Viner, Ali Fattaey, Jing Wan. Dual HDAC and PI3K Inhibitor CUDC-907 Downregulates MYC and Suppresses Growth of MYC-dependent Cancers. Molecular cancer therapeutics. vol 16. issue 2. 2017-06-29. PMID:27980108. |
in this study, we demonstrated that hdac and pi3k inhibition synergistically downregulates myc protein levels and induces apoptosis in "double-hit" (dh) diffuse large b-cell lymphoma (dlbcl) cells. |
2017-06-29 |
2023-08-13 |
human |