| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ashley Pandolfi, Robert F Stanley, Yiting Yu, Boris Bartholdy, Gopichand Pendurti, Kira Gritsman, Jacqueline Boultwood, Jonathan Chernoff, Amit Verma, Ulrich Steid. PAK1 is a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome. Blood. vol 126. issue 9. 2015-11-23. PMID:26170031. |
inhibition of pak1 induces differentiation and apoptosis of aml cells through downregulation of the myc oncogene and a core network of myc target genes. |
2015-11-23 |
2023-08-13 |
human |
| Xin Li, Xin A Zhang, Wei Xie, Xiaoqing Li, Shiang Huan. MYC-mediated synthetic lethality for treatment of hematological malignancies. Current cancer drug targets. vol 15. issue 1. 2015-11-17. PMID:25564254. |
myc overexpression sensitized cells to trailand dr5-agonist-induced apoptosis. |
2015-11-17 |
2023-08-13 |
mouse |
| Chen-Feng Qi, Yong-Soo Kim, Shao Xiang, Ziedulla Abdullaev, Ted A Torrey, Siegfried Janz, Alexander L Kovalchuk, Jiafang Sun, Delin Chen, William C Cho, Wei Gu, Herbert C Mors. Characterization of ARF-BP1/HUWE1 interactions with CTCF, MYC, ARF and p53 in MYC-driven B cell neoplasms. International journal of molecular sciences. vol 13. issue 5. 2015-11-03. PMID:22754359. |
myc provides a constitutive proliferative signal but can also initiate arf-dependent activation of p53 and apoptosis. |
2015-11-03 |
2023-08-12 |
Not clear |
| Yufei Teng, Hoi Kin Wong, Vishal Jhanji, Jian Huan Chen, Alvin Lerrmann Young, Mingzhi Zhang, Kwong Wai Choy, Jodhbir Singh Mehta, Chi Pui Pang, Gary Hin-Fai Ya. Signature microRNAs in human cornea limbal epithelium. Functional & integrative genomics. vol 15. issue 3. 2015-09-24. PMID:25487418. |
by ingenuity systems (ipa®) analysis, these micrornas could cooperatively regulate cell growth and apoptosis via tumor necrosis factor activation and myc repression. |
2015-09-24 |
2023-08-13 |
human |
| Kennosuke Karube, Elias Camp. MYC alterations in diffuse large B-cell lymphomas. Seminars in hematology. vol 52. issue 2. 2015-09-21. PMID:25805589. |
myc is a transcription factor associated with numerous physiological functions, including apoptosis, and strong oncogenic potential. |
2015-09-21 |
2023-08-13 |
Not clear |
| Jason M Link, Peter J Hurli. The activities of MYC, MNT and the MAX-interactome in lymphocyte proliferation and oncogenesis. Biochimica et biophysica acta. vol 1849. issue 5. 2015-08-28. PMID:24731854. |
myc upregulation simultaneously sensitizes cells to apoptosis and activated lymphocytes and lymphoma cells have pro-survival attributes that allow myc-driven proliferation to prevail. |
2015-08-28 |
2023-08-13 |
Not clear |
| Daniel Diolaiti, Lisa McFerrin, Patrick A Carroll, Robert N Eisenma. Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis. Biochimica et biophysica acta. vol 1849. issue 5. 2015-08-28. PMID:24857747. |
under both normal and pathological conditions myc regulates multiple aspects of cellular physiology including proliferation, differentiation, apoptosis, growth and metabolism by controlling the expression of thousands of genes. |
2015-08-28 |
2023-08-13 |
human |
| Melanie Winkle, Anke van den Berg, Masoumeh Tayari, Jantine Sietzema, Martijn Terpstra, Gertrud Kortman, Debora de Jong, Lydia Visser, Arjan Diepstra, Klaas Kok, Joost Kluive. Long noncoding RNAs as a novel component of the Myc transcriptional network. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 29. issue 6. 2015-08-24. PMID:25690653. |
myc is a well-known transcription factor with important roles in cell cycle, apoptosis, and cellular transformation. |
2015-08-24 |
2023-08-13 |
Not clear |
| Katrin E Wiese, Heidi M Haikala, Björn von Eyss, Elmar Wolf, Cyril Esnault, Andreas Rosenwald, Richard Treisman, Juha Klefström, Martin Eiler. Repression of SRF target genes is critical for Myc-dependent apoptosis of epithelial cells. The EMBO journal. vol 34. issue 11. 2015-08-12. PMID:25896507. |
here, we show that induction of apoptosis by myc in breast epithelial cells requires association of myc with miz1. |
2015-08-12 |
2023-08-13 |
Not clear |
| Katrin E Wiese, Heidi M Haikala, Björn von Eyss, Elmar Wolf, Cyril Esnault, Andreas Rosenwald, Richard Treisman, Juha Klefström, Martin Eiler. Repression of SRF target genes is critical for Myc-dependent apoptosis of epithelial cells. The EMBO journal. vol 34. issue 11. 2015-08-12. PMID:25896507. |
restoring srf activity antagonizes myc repression of srf target genes, attenuates myc-induced apoptosis, and reverts a myc-dependent decrease in akt phosphorylation and activity, a well-characterized suppressor of myc-induced apoptosis. |
2015-08-12 |
2023-08-13 |
Not clear |
| Rajeev Mishra, Takayoshi Watanabe, Makoto T Kimura, Nobuko Koshikawa, Maki Ikeda, Shota Uekusa, Hiroyuki Kawashima, Xiaofei Wang, Jun Igarashi, Diptiman Choudhury, Carla Grandori, Christopher J Kemp, Miki Ohira, Narendra K Verma, Yujin Kobayashi, Jin Takeuchi, Tsugumichi Koshinaga, Norimichi Nemoto, Noboru Fukuda, Masayoshi Soma, Takeshi Kusafuka, Kyoko Fujiwara, Hiroki Nagas. Identification of a novel E-box binding pyrrole-imidazole polyamide inhibiting MYC-driven cell proliferation. Cancer science. vol 106. issue 4. 2015-08-04. PMID:25611295. |
the myc transcription factor plays a crucial role in the regulation of cell cycle progression, apoptosis, angiogenesis, and cellular transformation. |
2015-08-04 |
2023-08-13 |
human |
| Huihua Liao, Zhou Wu, Xingduan Huang, Zhiqing Qiu, Huien W. N‑Myc downstream‑regulated gene 2 suppresses proliferation and induces oncosis of OS‑RC‑2 human renal cancer cells. Molecular medicine reports. vol 11. issue 2. 2015-07-30. PMID:25373306. |
v‑myc avian myelocytomatosis viral oncogene homolog (myc) regulates cell proliferation, differentiation and apoptosis in several types of cancer. |
2015-07-30 |
2023-08-13 |
human |
| Linka Xie, Olga Ritz, Frank Leithäuser, Hanfeng Guan, Johanna Färbinger, Clarissa D Weitzer, Franziska Gehringer, Silke Bruederlein, Karlheinz Holzmann, Marion J Vogel, Peter Möller, Thomas Wirth, Alexey Ushmoro. FOXO1 downregulation contributes to the oncogenic program of primary mediastinal B-cell lymphoma. Oncotarget. vol 5. issue 14. 2015-06-05. PMID:24977668. |
foxo1 activation in the foxo1-negative med-b1 cell line led to growth arrest and apoptosis, which was accompanied by repression of myc and bcl2l1/bclxl. |
2015-06-05 |
2023-08-13 |
Not clear |
| Nathiya Muthalagu, Melissa R Junttila, Katrin E Wiese, Elmar Wolf, Jennifer Morton, Barbara Bauer, Gerard I Evan, Martin Eilers, Daniel J Murph. BIM is the primary mediator of MYC-induced apoptosis in multiple solid tissues. Cell reports. vol 8. issue 5. 2015-05-28. PMID:25176652. |
sensitization of cells to apoptosis limits myc's oncogenic potential. |
2015-05-28 |
2023-08-13 |
human |
| Nathiya Muthalagu, Melissa R Junttila, Katrin E Wiese, Elmar Wolf, Jennifer Morton, Barbara Bauer, Gerard I Evan, Martin Eilers, Daniel J Murph. BIM is the primary mediator of MYC-induced apoptosis in multiple solid tissues. Cell reports. vol 8. issue 5. 2015-05-28. PMID:25176652. |
however, the mechanism through which myc induces apoptosis is controversial. |
2015-05-28 |
2023-08-13 |
human |
| Stephen R Han. MYC cofactors: molecular switches controlling diverse biological outcomes. Cold Spring Harbor perspectives in medicine. vol 4. issue 9. 2015-05-19. PMID:24939054. |
the transcription factor myc has fundamental roles in proliferation, apoptosis, tumorigenesis, and stem cell pluripotency. |
2015-05-19 |
2023-08-13 |
Not clear |
| Stephen R Han. MYC cofactors: molecular switches controlling diverse biological outcomes. Cold Spring Harbor perspectives in medicine. vol 4. issue 9. 2015-05-19. PMID:24939054. |
in this perspective, the major myc cofactors that regulate the various transcriptional activities of myc, including canonical and noncanonical transactivation and transcriptional repression, will be reviewed and a model of how these transcriptional mechanisms control myc-mediated proliferation, apoptosis, and tumorigenesis will be presented. |
2015-05-19 |
2023-08-13 |
Not clear |
| Fengfeng Wang, Lawrence W C Chan, William C S Cho, Petrus Tang, Jun Yu, Chi-Ren Shyu, Nancy B Y Tsui, S C Cesar Wong, Parco M Siu, S P Yip, Benjamin Y M Yun. Novel approach for coexpression analysis of E2F1-3 and MYC target genes in chronic myelogenous leukemia. BioMed research international. vol 2014. 2015-05-14. PMID:25180182. |
since genes regulated by e2f1-3 or myc are related to cell proliferation and apoptosis, we wonder if there exists difference in the coexpression patterns of genes regulated concurrently by e2f1-3 and myc between the normal and the cml states. |
2015-05-14 |
2023-08-13 |
Not clear |
| Juan M Caraballo, Juan C Acosta, Miguel A Cortés, Marta Albajar, M Teresa Gómez-Casares, Ana Batlle-López, M Angeles Cuadrado, Arantza Onaindia, Gabriel Bretones, Javier Llorca, Miguel A Piris, Dolors Colomer, Javier Leó. High p27 protein levels in chronic lymphocytic leukemia are associated to low Myc and Skp2 expression, confer resistance to apoptosis and antagonize Myc effects on cell cycle. Oncotarget. vol 5. issue 13. 2015-05-12. PMID:25051361. |
high p27 protein levels in chronic lymphocytic leukemia are associated to low myc and skp2 expression, confer resistance to apoptosis and antagonize myc effects on cell cycle. |
2015-05-12 |
2023-08-13 |
human |
| Jelena Vjetrovic, Pattabhiraman Shankaranarayanan, Marco A Mendoza-Parra, Hinrich Gronemeye. Senescence-secreted factors activate Myc and sensitize pretransformed cells to TRAIL-induced apoptosis. Aging cell. vol 13. issue 3. 2015-03-30. PMID:24589226. |
senescence-secreted factors activate myc and sensitize pretransformed cells to trail-induced apoptosis. |
2015-03-30 |
2023-08-12 |
Not clear |