| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yinfei Tan, Eleonora Sementino, Jianming Pei, Yuwaraj Kadariya, Timothy K Ito, Joseph R Test. Co-targeting of Akt and Myc inhibits viability of lymphoma cells from Lck-Dlx5 mice. Cancer biology & therapy. vol 16. issue 4. 2016-01-20. PMID:25793663. |
in contrast, the specific myc inhibitor 10058-f4 caused apoptosis, and when combined with bez235 (≥0.5 µm), an enhanced effect on apoptosis was consistently observed. |
2016-01-20 |
2023-08-13 |
mouse |
| Alper Yetil, Benedict Anchang, Arvin M Gouw, Stacey J Adam, Tahera Zabuawala, Ramya Parameswaran, Jan van Riggelen, Sylvia Plevritis, Dean W Felshe. p19ARF is a critical mediator of both cellular senescence and an innate immune response associated with MYC inactivation in mouse model of acute leukemia. Oncotarget. vol 6. issue 6. 2016-01-12. PMID:25784651. |
addiction to myc is a consequence of both cell-autonomous mechanisms, such as proliferative arrest, cellular senescence, and apoptosis, as well as non-cell autonomous mechanisms, such as shutdown of angiogenesis, and recruitment of immune effectors. |
2016-01-12 |
2023-08-13 |
mouse |
| Xin Li, Xin A Zhang, Xiaoqing Li, Wei Xie, Shiang Huan. MYC-mediated synthetic lethality for treating tumors. Current cancer drug targets. vol 15. issue 2. 2016-01-04. PMID:25553514. |
elevated myc levels lead to dna damage, senescence, and apoptosis. |
2016-01-04 |
2023-08-13 |
mouse |
| Manpreet Kalkat, Pak-Kei Chan, Amanda R Wasylishen, Tharan Srikumar, Sam S Kim, Romina Ponzielli, David P Bazett-Jones, Brian Raught, Linda Z Pen. Identification of c-MYC SUMOylation by mass spectrometry. PloS one. vol 9. issue 12. 2015-12-17. PMID:25522242. |
abrogation of signaling through this residue by substitution with arginine (k326r) has no obvious effects on myc half-life, intracellular localization, transcriptional targets, nor on the biological effects of myc overexpression in two different cell systems assessed for soft agar colony formation, proliferation, and apoptosis. |
2015-12-17 |
2023-08-13 |
Not clear |
| Ashley Pandolfi, Robert F Stanley, Yiting Yu, Boris Bartholdy, Gopichand Pendurti, Kira Gritsman, Jacqueline Boultwood, Jonathan Chernoff, Amit Verma, Ulrich Steid. PAK1 is a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome. Blood. vol 126. issue 9. 2015-11-23. PMID:26170031. |
inhibition of pak1 induces differentiation and apoptosis of aml cells through downregulation of the myc oncogene and a core network of myc target genes. |
2015-11-23 |
2023-08-13 |
human |
| Xin Li, Xin A Zhang, Wei Xie, Xiaoqing Li, Shiang Huan. MYC-mediated synthetic lethality for treatment of hematological malignancies. Current cancer drug targets. vol 15. issue 1. 2015-11-17. PMID:25564254. |
myc overexpression sensitized cells to trailand dr5-agonist-induced apoptosis. |
2015-11-17 |
2023-08-13 |
mouse |
| Chen-Feng Qi, Yong-Soo Kim, Shao Xiang, Ziedulla Abdullaev, Ted A Torrey, Siegfried Janz, Alexander L Kovalchuk, Jiafang Sun, Delin Chen, William C Cho, Wei Gu, Herbert C Mors. Characterization of ARF-BP1/HUWE1 interactions with CTCF, MYC, ARF and p53 in MYC-driven B cell neoplasms. International journal of molecular sciences. vol 13. issue 5. 2015-11-03. PMID:22754359. |
myc provides a constitutive proliferative signal but can also initiate arf-dependent activation of p53 and apoptosis. |
2015-11-03 |
2023-08-12 |
Not clear |
| Yufei Teng, Hoi Kin Wong, Vishal Jhanji, Jian Huan Chen, Alvin Lerrmann Young, Mingzhi Zhang, Kwong Wai Choy, Jodhbir Singh Mehta, Chi Pui Pang, Gary Hin-Fai Ya. Signature microRNAs in human cornea limbal epithelium. Functional & integrative genomics. vol 15. issue 3. 2015-09-24. PMID:25487418. |
by ingenuity systems (ipa®) analysis, these micrornas could cooperatively regulate cell growth and apoptosis via tumor necrosis factor activation and myc repression. |
2015-09-24 |
2023-08-13 |
human |
| Kennosuke Karube, Elias Camp. MYC alterations in diffuse large B-cell lymphomas. Seminars in hematology. vol 52. issue 2. 2015-09-21. PMID:25805589. |
myc is a transcription factor associated with numerous physiological functions, including apoptosis, and strong oncogenic potential. |
2015-09-21 |
2023-08-13 |
Not clear |
| Jason M Link, Peter J Hurli. The activities of MYC, MNT and the MAX-interactome in lymphocyte proliferation and oncogenesis. Biochimica et biophysica acta. vol 1849. issue 5. 2015-08-28. PMID:24731854. |
myc upregulation simultaneously sensitizes cells to apoptosis and activated lymphocytes and lymphoma cells have pro-survival attributes that allow myc-driven proliferation to prevail. |
2015-08-28 |
2023-08-13 |
Not clear |
| Daniel Diolaiti, Lisa McFerrin, Patrick A Carroll, Robert N Eisenma. Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis. Biochimica et biophysica acta. vol 1849. issue 5. 2015-08-28. PMID:24857747. |
under both normal and pathological conditions myc regulates multiple aspects of cellular physiology including proliferation, differentiation, apoptosis, growth and metabolism by controlling the expression of thousands of genes. |
2015-08-28 |
2023-08-13 |
human |
| Melanie Winkle, Anke van den Berg, Masoumeh Tayari, Jantine Sietzema, Martijn Terpstra, Gertrud Kortman, Debora de Jong, Lydia Visser, Arjan Diepstra, Klaas Kok, Joost Kluive. Long noncoding RNAs as a novel component of the Myc transcriptional network. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 29. issue 6. 2015-08-24. PMID:25690653. |
myc is a well-known transcription factor with important roles in cell cycle, apoptosis, and cellular transformation. |
2015-08-24 |
2023-08-13 |
Not clear |
| Katrin E Wiese, Heidi M Haikala, Björn von Eyss, Elmar Wolf, Cyril Esnault, Andreas Rosenwald, Richard Treisman, Juha Klefström, Martin Eiler. Repression of SRF target genes is critical for Myc-dependent apoptosis of epithelial cells. The EMBO journal. vol 34. issue 11. 2015-08-12. PMID:25896507. |
here, we show that induction of apoptosis by myc in breast epithelial cells requires association of myc with miz1. |
2015-08-12 |
2023-08-13 |
Not clear |
| Katrin E Wiese, Heidi M Haikala, Björn von Eyss, Elmar Wolf, Cyril Esnault, Andreas Rosenwald, Richard Treisman, Juha Klefström, Martin Eiler. Repression of SRF target genes is critical for Myc-dependent apoptosis of epithelial cells. The EMBO journal. vol 34. issue 11. 2015-08-12. PMID:25896507. |
restoring srf activity antagonizes myc repression of srf target genes, attenuates myc-induced apoptosis, and reverts a myc-dependent decrease in akt phosphorylation and activity, a well-characterized suppressor of myc-induced apoptosis. |
2015-08-12 |
2023-08-13 |
Not clear |
| Rajeev Mishra, Takayoshi Watanabe, Makoto T Kimura, Nobuko Koshikawa, Maki Ikeda, Shota Uekusa, Hiroyuki Kawashima, Xiaofei Wang, Jun Igarashi, Diptiman Choudhury, Carla Grandori, Christopher J Kemp, Miki Ohira, Narendra K Verma, Yujin Kobayashi, Jin Takeuchi, Tsugumichi Koshinaga, Norimichi Nemoto, Noboru Fukuda, Masayoshi Soma, Takeshi Kusafuka, Kyoko Fujiwara, Hiroki Nagas. Identification of a novel E-box binding pyrrole-imidazole polyamide inhibiting MYC-driven cell proliferation. Cancer science. vol 106. issue 4. 2015-08-04. PMID:25611295. |
the myc transcription factor plays a crucial role in the regulation of cell cycle progression, apoptosis, angiogenesis, and cellular transformation. |
2015-08-04 |
2023-08-13 |
human |
| Huihua Liao, Zhou Wu, Xingduan Huang, Zhiqing Qiu, Huien W. N‑Myc downstream‑regulated gene 2 suppresses proliferation and induces oncosis of OS‑RC‑2 human renal cancer cells. Molecular medicine reports. vol 11. issue 2. 2015-07-30. PMID:25373306. |
v‑myc avian myelocytomatosis viral oncogene homolog (myc) regulates cell proliferation, differentiation and apoptosis in several types of cancer. |
2015-07-30 |
2023-08-13 |
human |
| Linka Xie, Olga Ritz, Frank Leithäuser, Hanfeng Guan, Johanna Färbinger, Clarissa D Weitzer, Franziska Gehringer, Silke Bruederlein, Karlheinz Holzmann, Marion J Vogel, Peter Möller, Thomas Wirth, Alexey Ushmoro. FOXO1 downregulation contributes to the oncogenic program of primary mediastinal B-cell lymphoma. Oncotarget. vol 5. issue 14. 2015-06-05. PMID:24977668. |
foxo1 activation in the foxo1-negative med-b1 cell line led to growth arrest and apoptosis, which was accompanied by repression of myc and bcl2l1/bclxl. |
2015-06-05 |
2023-08-13 |
Not clear |
| Nathiya Muthalagu, Melissa R Junttila, Katrin E Wiese, Elmar Wolf, Jennifer Morton, Barbara Bauer, Gerard I Evan, Martin Eilers, Daniel J Murph. BIM is the primary mediator of MYC-induced apoptosis in multiple solid tissues. Cell reports. vol 8. issue 5. 2015-05-28. PMID:25176652. |
sensitization of cells to apoptosis limits myc's oncogenic potential. |
2015-05-28 |
2023-08-13 |
human |
| Nathiya Muthalagu, Melissa R Junttila, Katrin E Wiese, Elmar Wolf, Jennifer Morton, Barbara Bauer, Gerard I Evan, Martin Eilers, Daniel J Murph. BIM is the primary mediator of MYC-induced apoptosis in multiple solid tissues. Cell reports. vol 8. issue 5. 2015-05-28. PMID:25176652. |
however, the mechanism through which myc induces apoptosis is controversial. |
2015-05-28 |
2023-08-13 |
human |
| Stephen R Han. MYC cofactors: molecular switches controlling diverse biological outcomes. Cold Spring Harbor perspectives in medicine. vol 4. issue 9. 2015-05-19. PMID:24939054. |
the transcription factor myc has fundamental roles in proliferation, apoptosis, tumorigenesis, and stem cell pluripotency. |
2015-05-19 |
2023-08-13 |
Not clear |