| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stephen R Han. MYC cofactors: molecular switches controlling diverse biological outcomes. Cold Spring Harbor perspectives in medicine. vol 4. issue 9. 2015-05-19. PMID:24939054. |
in this perspective, the major myc cofactors that regulate the various transcriptional activities of myc, including canonical and noncanonical transactivation and transcriptional repression, will be reviewed and a model of how these transcriptional mechanisms control myc-mediated proliferation, apoptosis, and tumorigenesis will be presented. |
2015-05-19 |
2023-08-13 |
Not clear |
| Fengfeng Wang, Lawrence W C Chan, William C S Cho, Petrus Tang, Jun Yu, Chi-Ren Shyu, Nancy B Y Tsui, S C Cesar Wong, Parco M Siu, S P Yip, Benjamin Y M Yun. Novel approach for coexpression analysis of E2F1-3 and MYC target genes in chronic myelogenous leukemia. BioMed research international. vol 2014. 2015-05-14. PMID:25180182. |
since genes regulated by e2f1-3 or myc are related to cell proliferation and apoptosis, we wonder if there exists difference in the coexpression patterns of genes regulated concurrently by e2f1-3 and myc between the normal and the cml states. |
2015-05-14 |
2023-08-13 |
Not clear |
| Juan M Caraballo, Juan C Acosta, Miguel A Cortés, Marta Albajar, M Teresa Gómez-Casares, Ana Batlle-López, M Angeles Cuadrado, Arantza Onaindia, Gabriel Bretones, Javier Llorca, Miguel A Piris, Dolors Colomer, Javier Leó. High p27 protein levels in chronic lymphocytic leukemia are associated to low Myc and Skp2 expression, confer resistance to apoptosis and antagonize Myc effects on cell cycle. Oncotarget. vol 5. issue 13. 2015-05-12. PMID:25051361. |
high p27 protein levels in chronic lymphocytic leukemia are associated to low myc and skp2 expression, confer resistance to apoptosis and antagonize myc effects on cell cycle. |
2015-05-12 |
2023-08-13 |
human |
| Jelena Vjetrovic, Pattabhiraman Shankaranarayanan, Marco A Mendoza-Parra, Hinrich Gronemeye. Senescence-secreted factors activate Myc and sensitize pretransformed cells to TRAIL-induced apoptosis. Aging cell. vol 13. issue 3. 2015-03-30. PMID:24589226. |
senescence-secreted factors activate myc and sensitize pretransformed cells to trail-induced apoptosis. |
2015-03-30 |
2023-08-12 |
Not clear |
| Jelena Vjetrovic, Pattabhiraman Shankaranarayanan, Marco A Mendoza-Parra, Hinrich Gronemeye. Senescence-secreted factors activate Myc and sensitize pretransformed cells to TRAIL-induced apoptosis. Aging cell. vol 13. issue 3. 2015-03-30. PMID:24589226. |
senescent cell-induced myc silenced its target gene cflar, encoding the apoptosis inhibitor flipl , thus leading to the acquisition of trail sensitivity. |
2015-03-30 |
2023-08-12 |
Not clear |
| Benedikt Bauer, Reiner Siebert, Arne Traulse. Cancer initiation with epistatic interactions between driver and passenger mutations. Journal of theoretical biology. vol 358. 2015-03-30. PMID:24859427. |
in this tumor, the hallmark mutation leads to deregulation of the myc oncogene which increases the rate of apoptosis, but also the proliferation rate of cells. |
2015-03-30 |
2023-08-13 |
Not clear |
| Steven B McMaho. MYC and the control of apoptosis. Cold Spring Harbor perspectives in medicine. vol 4. issue 7. 2015-03-30. PMID:24985130. |
myc and the control of apoptosis. |
2015-03-30 |
2023-08-13 |
Not clear |
| Steven B McMaho. MYC and the control of apoptosis. Cold Spring Harbor perspectives in medicine. vol 4. issue 7. 2015-03-30. PMID:24985130. |
at first glance it might seem counterintuitive that myc is also among the most robust agents of programmed cell death (apoptosis) in mammalian cells. |
2015-03-30 |
2023-08-13 |
Not clear |
| Kostyantyn Krysan, Rebecca Kusko, Tristan Grogan, James O'Hearn, Karen L Reckamp, Tonya C Walser, Edward B Garon, Marc E Lenburg, Sherven Sharma, Avrum E Spira, David Elashoff, Steven M Dubinet. PGE2-driven expression of c-Myc and oncomiR-17-92 contributes to apoptosis resistance in NSCLC. Molecular cancer research : MCR. vol 12. issue 5. 2015-02-27. PMID:24469837. |
here, prostaglandin e2 (pge2) exposure rapidly upregulates the expression of the myc gene followed by the elevation of mir-17-92 levels, which in turn suppresses pten expression, thus enhancing apoptosis resistance in non-small cell lung cancer (nsclc) cells. |
2015-02-27 |
2023-08-12 |
human |
| Alberto Izzotti, Roumen Balansky, Francesco D'Agostini, Mariagrazia Longobardi, Cristina Cartiglia, Rosanna T Micale, Sebastiano La Maestra, Anna Camoirano, Gancho Ganchev, Marietta Iltcheva, Vernon E Steele, Silvio De Flor. Modulation by metformin of molecular and histopathological alterations in the lung of cigarette smoke-exposed mice. Cancer medicine. vol 3. issue 3. 2015-02-12. PMID:24683044. |
modulation by metformin of 42 of 1281 pulmonary micrornas in smoke-free mice highlighted a variety of mechanisms, including modulation of ampk, stress response, inflammation, nfκb, tlr9, tgf, p53, cell cycle, apoptosis, antioxidant pathways, ras, myc, dicer, angiogenesis, stem cell recruitment, and angiogenesis. |
2015-02-12 |
2023-08-12 |
mouse |
| Matthias Wirth, Natasa Stojanovic, Jan Christian, Mariel C Paul, Roland H Stauber, Roland M Schmid, Georg Häcker, Oliver H Krämer, Dieter Saur, Günter Schneide. MYC and EGR1 synergize to trigger tumor cell death by controlling NOXA and BIM transcription upon treatment with the proteasome inhibitor bortezomib. Nucleic acids research. vol 42. issue 16. 2015-01-20. PMID:25147211. |
however, myc can also induce apoptosis and this function of myc warrants further clarification. |
2015-01-20 |
2023-08-13 |
Not clear |
| Matthias Wirth, Natasa Stojanovic, Jan Christian, Mariel C Paul, Roland H Stauber, Roland M Schmid, Georg Häcker, Oliver H Krämer, Dieter Saur, Günter Schneide. MYC and EGR1 synergize to trigger tumor cell death by controlling NOXA and BIM transcription upon treatment with the proteasome inhibitor bortezomib. Nucleic acids research. vol 42. issue 16. 2015-01-20. PMID:25147211. |
we report here that a clinically relevant proteasome inhibitor significantly increases myc protein levels and that endogenous myc is necessary for the induction of apoptosis. |
2015-01-20 |
2023-08-13 |
Not clear |
| Meital Gabay, Yulin Li, Dean W Felshe. MYC activation is a hallmark of cancer initiation and maintenance. Cold Spring Harbor perspectives in medicine. vol 4. issue 6. 2015-01-09. PMID:24890832. |
myc activation alone in many normal cells is restrained from causing tumorigenesis through multiple genetic and epigenetically controlled checkpoint mechanisms, including proliferative arrest, apoptosis, and cellular senescence. |
2015-01-09 |
2023-08-13 |
human |
| Meital Gabay, Yulin Li, Dean W Felshe. MYC activation is a hallmark of cancer initiation and maintenance. Cold Spring Harbor perspectives in medicine. vol 4. issue 6. 2015-01-09. PMID:24890832. |
provocatively, brief or even partial suppression of myc back to its physiological levels of activation can result in the restoration of intrinsic checkpoint mechanisms, resulting in acute and sustained tumor regression, associated with tumor cells undergoing proliferative arrest, differentiation, senescence, and apoptosis, as well as remodeling of the tumor microenvironment, recruitment of an immune response, and shutdown of angiogenesis. |
2015-01-09 |
2023-08-13 |
human |
| T J Phesse, K B Myant, A M Cole, R A Ridgway, H Pearson, V Muncan, G R van den Brink, K H Vousden, R Sears, L T Vassilev, A R Clarke, O J Sanso. Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo. Cell death and differentiation. vol 21. issue 6. 2014-12-30. PMID:24583641. |
we also identify the importance of myc during dna damage-induced apoptosis in several other tissues, including the thymus and spleen, using systemic deletion of c-myc throughout the adult mouse. |
2014-12-30 |
2023-08-12 |
mouse |
| Walter Wittmann, Thomas Schimmang, Lena Gunhag. Progressive effects of N-myc deficiency on proliferation, neurogenesis, and morphogenesis in the olfactory epithelium. Developmental neurobiology. vol 74. issue 6. 2014-12-22. PMID:24376126. |
n-myc belongs to the myc proto-oncogene family, which is involved in numerous cellular processes such as proliferation, growth, apoptosis, and differentiation. |
2014-12-22 |
2023-08-12 |
mouse |
| Fionnuala Morrish, David Hockenber. MYC and mitochondrial biogenesis. Cold Spring Harbor perspectives in medicine. vol 4. issue 5. 2014-12-18. PMID:24789872. |
as an oncogene, myc also presents intriguing questions about the role of its mitochondrial targets in cancer-related phenotypes, such as the warburg effect and myc-dependent apoptosis. |
2014-12-18 |
2023-08-13 |
Not clear |
| b' A Moros, V Rodr\\xc3\\xadguez, I Saborit-Villarroya, A Montraveta, P Balsas, P Sandy, A Mart\\xc3\\xadnez, A Wiestner, E Normant, E Campo, P P\\xc3\\xa9rez-Gal\\xc3\\xa1n, D Colomer, G Rou\\xc3\\xa. Synergistic antitumor activity of lenalidomide with the BET bromodomain inhibitor CPI203 in bortezomib-resistant mantle cell lymphoma. Leukemia. vol 28. issue 10. 2014-12-03. PMID:24721791.' |
in mice, addition of cpi203 to lenalidomide therapy further decreased tumor burden, involving simultaneous myc and irf4 downregulation and apoptosis induction. |
2014-12-03 |
2023-08-13 |
mouse |
| Kay Kotkamp, Esther Kur, Björn Wendik, Bożena K Polok, Shifra Ben-Dor, Daria Onichtchouk, Wolfgang Drieve. Pou5f1/Oct4 promotes cell survival via direct activation of mych expression during zebrafish gastrulation. PloS one. vol 9. issue 3. 2014-11-25. PMID:24643012. |
myc proteins control cell proliferation, cell cycle progression, and apoptosis, and play important roles in cancer as well in establishment of pluripotency. |
2014-11-25 |
2023-08-12 |
zebrafish |
| Kay Kotkamp, Esther Kur, Björn Wendik, Bożena K Polok, Shifra Ben-Dor, Daria Onichtchouk, Wolfgang Drieve. Pou5f1/Oct4 promotes cell survival via direct activation of mych expression during zebrafish gastrulation. PloS one. vol 9. issue 3. 2014-11-25. PMID:24643012. |
however, mych knockdown alone did not induce early apoptosis, suggesting potentially redundant action of several early expressed myc genes, or combination of several pathways affected in mzspg. |
2014-11-25 |
2023-08-12 |
zebrafish |