| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peter J Hurlin, Shala Dezfoul. Functions of myc:max in the control of cell proliferation and tumorigenesis. International review of cytology. vol 238. 2004-12-17. PMID:15364199. |
however, forced expression of myc profoundly sensitizes normal cells to apoptosis. |
2004-12-17 |
2023-08-12 |
human |
| Peter J Hurlin, Shala Dezfoul. Functions of myc:max in the control of cell proliferation and tumorigenesis. International review of cytology. vol 238. 2004-12-17. PMID:15364199. |
therefore, tumor formation caused by deregulated myc expression requires cooperating events that disrupt pathways that mediate apoptosis. |
2004-12-17 |
2023-08-12 |
human |
| M Hunter Jamerson, Michael D Johnson, Robert B Dickso. Of mice and Myc: c-Myc and mammary tumorigenesis. Journal of mammary gland biology and neoplasia. vol 9. issue 1. 2004-12-07. PMID:15082916. |
the proto-oncogene c- myc is involved in regulating proliferation and apoptosis, and its deregulation via genomic and postgenomic mechanisms, contributes to the development and progression of multiple human cancers, including those of the breast. |
2004-12-07 |
2023-08-12 |
mouse |
| Anthony Farina, Francesco Faiola, Ernest Martine. Reconstitution of an E box-binding Myc:Max complex with recombinant full-length proteins expressed in Escherichia coli. Protein expression and purification. vol 34. issue 2. 2004-11-16. PMID:15003254. |
the c-myc oncoprotein (myc) is a dna sequence-specific transcription factor that regulates transcription of a wide variety of genes involved in the control of cell growth, proliferation, differentiation, and apoptosis and its deregulated expression is implicated in many types of human cancer. |
2004-11-16 |
2023-08-12 |
human |
| Megan S Lim, Kojo S J Elenitoba-Johnso. Ubiquitin ligases in malignant lymphoma. Leukemia & lymphoma. vol 45. issue 7. 2004-11-01. PMID:15359630. |
identification and characterization of their substrates indicate that they regulate the turnover of key cell cycle proteins (p27kip1, p21cip1, p57kip2, cyclin e), tumor suppressor proteins (p53, rb), signaling kinases (src, zap70, pi-3 kinase), apoptosis regulators (bcl-2, bax, bik) and transcription factors (myc, nf-kappab, e1f1), all of which have been implicated in the pathogenesis of malignant lymphoma. |
2004-11-01 |
2023-08-12 |
Not clear |
| Jonas A Nilsson, John L Clevelan. Mnt: master regulator of the Max network. Cell cycle (Georgetown, Tex.). vol 3. issue 5. 2004-10-05. PMID:15107624. |
by removing mnt, either via conventional knockout techniques or via rna interference, cells become hyper-proliferative, susceptible to apoptosis and can be transformed by ras--all hallmarks of myc overexpression. |
2004-10-05 |
2023-08-12 |
Not clear |
| I Moreno de Alborán, E Baena, C Martinez-. c-Myc-deficient B lymphocytes are resistant to spontaneous and induced cell death. Cell death and differentiation. vol 11. issue 1. 2004-08-25. PMID:12970677. |
c-myc gene is a member of the myc family of proto-oncogenes involved in proliferation, differentiation, and apoptosis. |
2004-08-25 |
2023-08-12 |
Not clear |
| Sarah B Pierce, Cynthia Yost, Jessica S Britton, Lenora W M Loo, Erin M Flynn, Bruce A Edgar, Robert N Eisenma. dMyc is required for larval growth and endoreplication in Drosophila. Development (Cambridge, England). vol 131. issue 10. 2004-08-18. PMID:15128666. |
members of the myc family of proto-oncogenes have long been implicated in regulating proliferation, apoptosis and oncogenesis. |
2004-08-18 |
2023-08-12 |
drosophila_melanogaster |
| Emanuela Grassilli, Andrea Ballabeni, Emilia Maellaro, Barbara Del Bello, Kristian Heli. Loss of MYC confers resistance to doxorubicin-induced apoptosis by preventing the activation of multiple serine protease- and caspase-mediated pathways. The Journal of biological chemistry. vol 279. issue 20. 2004-07-21. PMID:14990581. |
loss of myc confers resistance to doxorubicin-induced apoptosis by preventing the activation of multiple serine protease- and caspase-mediated pathways. |
2004-07-21 |
2023-08-12 |
Not clear |
| Yan Wang, Ingo H Engels, Deborah A Knee, Marc Nasoff, Quinn L Deveraux, Kim C Quo. Synthetic lethal targeting of MYC by activation of the DR5 death receptor pathway. Cancer cell. vol 5. issue 5. 2004-06-28. PMID:15144957. |
here we show that agonists of the trail death receptor dr5 potently induce apoptosis in human cells overexpressing the myc oncogene, both in vitro and as tumor xenografts in vivo. |
2004-06-28 |
2023-08-12 |
human |
| Yan Wang, Ingo H Engels, Deborah A Knee, Marc Nasoff, Quinn L Deveraux, Kim C Quo. Synthetic lethal targeting of MYC by activation of the DR5 death receptor pathway. Cancer cell. vol 5. issue 5. 2004-06-28. PMID:15144957. |
these results identify a novel mechanism by which myc sensitizes cells to apoptosis and validate dr5 agonists as potential myc-selective cancer therapeutics. |
2004-06-28 |
2023-08-12 |
human |
| Alexander Egle, Alan W Harris, Philippe Bouillet, Suzanne Cor. Bim is a suppressor of Myc-induced mouse B cell leukemia. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 16. 2004-06-15. PMID:15079075. |
thus, bim is induced by myc in b cells and mediates apoptosis. |
2004-06-15 |
2023-08-12 |
mouse |
| Julie Secombe, Sarah B Pierce, Robert N Eisenma. Myc: a weapon of mass destruction. Cell. vol 117. issue 2. 2004-05-24. PMID:15084254. |
growth and proliferation potentiated by deregulated myc oncogene expression is balanced by myc-induced apoptosis. |
2004-05-24 |
2023-08-12 |
drosophila_melanogaster |
| Makoto Tsuneoka, Toshiyuki Umata, Hiroshi Kimura, Yoshiro Koda, Masayuki Nakajima, Kenichiro Kosai, Tsuyoshi Takahashi, Yoshie Takahashi, Akitsugu Yamamot. c-myc induces autophagy in rat 3Y1 fibroblast cells. Cell structure and function. vol 28. issue 3. 2004-05-13. PMID:12951440. |
a c-myc mutant lacking myc box ii induced neither apoptosis nor oncogenic transformation, but still stimulated autophagy. |
2004-05-13 |
2023-08-12 |
rat |
| Eduardo Moreno, Konrad Basle. dMyc transforms cells into super-competitors. Cell. vol 117. issue 1. 2004-05-06. PMID:15066287. |
here we use drosophila imaginal discs to mimic situations in which cells with unequal levels of myc protein are apposed and show that this invariably elicits a win/lose situation reminiscent of cell competition; cells with lower levels of dmyc are eliminated by apoptosis whereas cells with higher levels of dmyc over-proliferate. |
2004-05-06 |
2023-08-12 |
human |
| M Wilda, J Bruch, L Harder, D Rawer, A Reiter, A Borkhardt, W Woessman. Inactivation of the ARF-MDM-2-p53 pathway in sporadic Burkitt's lymphoma in children. Leukemia. vol 18. issue 3. 2004-03-24. PMID:14712292. |
however, activated myc can initiate arf-dependent activation of p53 and apoptosis as well. |
2004-03-24 |
2023-08-12 |
Not clear |
| Jonas A Nilsson, Kirsteen H Maclean, Ulrich B Keller, Helene Pendeville, Troy A Baudino, John L Clevelan. Mnt loss triggers Myc transcription targets, proliferation, apoptosis, and transformation. Molecular and cellular biology. vol 24. issue 4. 2004-03-12. PMID:14749372. |
mnt loss triggers myc transcription targets, proliferation, apoptosis, and transformation. |
2004-03-12 |
2023-08-12 |
Not clear |
| Jonas A Nilsson, Kirsteen H Maclean, Ulrich B Keller, Helene Pendeville, Troy A Baudino, John L Clevelan. Mnt loss triggers Myc transcription targets, proliferation, apoptosis, and transformation. Molecular and cellular biology. vol 24. issue 4. 2004-03-12. PMID:14749372. |
however, in normal cells myc also triggers apoptosis. |
2004-03-12 |
2023-08-12 |
Not clear |
| Jonas A Nilsson, Kirsteen H Maclean, Ulrich B Keller, Helene Pendeville, Troy A Baudino, John L Clevelan. Mnt loss triggers Myc transcription targets, proliferation, apoptosis, and transformation. Molecular and cellular biology. vol 24. issue 4. 2004-03-12. PMID:14749372. |
knockdown of mnt expression by stable retroviral rna interference triggers many targets typical of the "myc" response and provokes accelerated proliferation and apoptosis. |
2004-03-12 |
2023-08-12 |
Not clear |
| Zhongdong Huang, Jolinda A Traugh, J Michael Bisho. Negative control of the Myc protein by the stress-responsive kinase Pak2. Molecular and cellular biology. vol 24. issue 4. 2004-03-12. PMID:14749374. |
phosphorylation by pak2 inhibits the ability of myc to activate transcription, to sustain cellular proliferation, to transform nih 3t3 cells in culture, and to elicit apoptosis on serum withdrawal. |
2004-03-12 |
2023-08-12 |
Not clear |