| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Zajac-Kay. Myc oncogene: a key component in cell cycle regulation and its implication for lung cancer. Lung cancer (Amsterdam, Netherlands). vol 34 Suppl 2. 2002-02-05. PMID:11720740. |
the myc gene family which includes c-myc, n-myc and l-myc, are transcription factors that play a role in cell proliferation, apoptosis and in the development of human tumors. |
2002-02-05 |
2023-08-12 |
human |
| J Miethe, C Schwartz, K Wottrich, D Wenning, K H Klempnaue. Crosstalk between Myc and activating transcription factor 2 (ATF2): Myc prolongs the half-life and induces phosphorylation of ATF2. Oncogene. vol 20. issue 56. 2002-01-16. PMID:11781825. |
myc is a key regulator of cell growth, differentiation and apoptosis, and affects cell fate decisions by activating as well as by inhibiting the expression of cellular genes. |
2002-01-16 |
2023-08-12 |
Not clear |
| L Tiberio, J A Maier, L Schiaffonat. Down-modulation of c-myc expression by phorbol ester protects CEM T leukaemia cells from starvation-induced apoptosis: role of ornithine decarboxylase and polyamines. Cell death and differentiation. vol 8. issue 10. 2001-12-11. PMID:11598794. |
myc is a transcriptional activator whose deregulated expression not only promotes proliferation but also induces or sensitizes cells to apoptosis. |
2001-12-11 |
2023-08-12 |
Not clear |
| C M Eischen, M F Roussel, S J Korsmeyer, J L Clevelan. Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis. Molecular and cellular biology. vol 21. issue 22. 2001-12-04. PMID:11604501. |
here we report that the proapoptotic bcl-2 family member bax also mediates apoptosis triggered by myc and inhibits myc-induced lymphomagenesis. |
2001-12-04 |
2023-08-12 |
mouse |
| R J Rounbehler, R Schneider-Broussard, C J Conti, D G Johnso. Myc lacks E2F1's ability to suppress skin carcinogenesis. Oncogene. vol 20. issue 38. 2001-09-27. PMID:11536046. |
myc and e2f1 can each stimulate proliferation, induce apoptosis, and contribute to oncogenic transformation. |
2001-09-27 |
2023-08-12 |
mouse |
| R J Rounbehler, R Schneider-Broussard, C J Conti, D G Johnso. Myc lacks E2F1's ability to suppress skin carcinogenesis. Oncogene. vol 20. issue 38. 2001-09-27. PMID:11536046. |
in addition, k5 myc and k5 e2f1 transgenic mice both display aberrant, p53-dependent apoptosis in the epidermis. |
2001-09-27 |
2023-08-12 |
mouse |
| N Thiriet, S Jayanthi, M McCoy, B Ladenheim, J L Cade. Methamphetamine increases expression of the apoptotic c-myc and L-myc genes in the mouse brain. Brain research. Molecular brain research. vol 90. issue 2. 2001-09-13. PMID:11406298. |
to clarify the possible mechanisms by which the recreational drug, methamphetamine (meth), induces apoptosis, we investigated its effects on the expression of myc apoptotic genes. |
2001-09-13 |
2023-08-12 |
mouse |
| G Leone, R Sears, E Huang, R Rempel, F Nuckolls, C H Park, P Giangrande, L Wu, H I Saavedra, S J Field, M A Thompson, H Yang, Y Fujiwara, M E Greenberg, S Orkin, C Smith, J R Nevin. Myc requires distinct E2F activities to induce S phase and apoptosis. Molecular cell. vol 8. issue 1. 2001-09-13. PMID:11511364. |
myc requires distinct e2f activities to induce s phase and apoptosis. |
2001-09-13 |
2023-08-12 |
mouse |
| G Leone, R Sears, E Huang, R Rempel, F Nuckolls, C H Park, P Giangrande, L Wu, H I Saavedra, S J Field, M A Thompson, H Yang, Y Fujiwara, M E Greenberg, S Orkin, C Smith, J R Nevin. Myc requires distinct E2F activities to induce S phase and apoptosis. Molecular cell. vol 8. issue 1. 2001-09-13. PMID:11511364. |
in contrast, the ability of myc to induce apoptosis is markedly reduced in cells deleted for e2f1 but not e2f2 or e2f3. |
2001-09-13 |
2023-08-12 |
mouse |
| M Henriksson, G Selivanova, M Lindström, K G Wima. Inactivation of Myc-induced p53-dependent apoptosis in human tumors. Apoptosis : an international journal on programmed cell death. vol 6. issue 1-2. 2001-09-06. PMID:11321036. |
however, myc can also trigger cell death by apoptosis. |
2001-09-06 |
2023-08-12 |
human |
| Y H Chung, J Youn, Y Choi, D J Paik, Y J Ch. Requirement of de novo protein synthesis for aminopterin-induced apoptosis in a mouse myeloma cell line. Immunology letters. vol 77. issue 3. 2001-09-06. PMID:11410244. |
taken together, these results suggest that cells deficient in the salvage pathway of purine biosynthesis are susceptible to aminopterin-induced apoptosis that requires de novo synthesis of proapoptotic factors, including myc oncoprotein. |
2001-09-06 |
2023-08-12 |
mouse |
| M Soriani, N A Williams, T R Hirs. Escherichia coli enterotoxin B subunit triggers apoptosis of CD8(+) T cells by activating transcription factor c-myc. Infection and immunity. vol 69. issue 8. 2001-08-23. PMID:11447169. |
preincubation with c-myc antisense oligodeoxynucleotides demonstrated that myc expression was necessary for etxb-mediated apoptosis. |
2001-08-23 |
2023-08-12 |
Not clear |
| M Soriani, N A Williams, T R Hirs. Escherichia coli enterotoxin B subunit triggers apoptosis of CD8(+) T cells by activating transcription factor c-myc. Infection and immunity. vol 69. issue 8. 2001-08-23. PMID:11447169. |
when cd8(+) t cells were pretreated with inhibitors of ikappabalpha turnover and nf-kappab translocation, this resulted in a marked reduction in both etxb-induced apoptosis and myc expression. |
2001-08-23 |
2023-08-12 |
Not clear |
| X Yin, M F Landay, W Han, E S Levitan, S C Watkins, R M Levenson, D L Farkas, E V Prochowni. Dynamic in vivo interactions among Myc network members. Oncogene. vol 20. issue 34. 2001-08-23. PMID:11498788. |
members of the myc oncoprotein network (c-myc, max, and mad) play important roles in proliferation, differentiation, and apoptosis. |
2001-08-23 |
2023-08-12 |
Not clear |
| C M Eischen, D Woo, M F Roussel, J L Clevelan. Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis. Molecular and cellular biology. vol 21. issue 15. 2001-08-16. PMID:11438662. |
enforced bcl-2 expression inhibits myc-induced apoptosis and cooperates with myc in transformation. |
2001-08-16 |
2023-08-12 |
mouse |
| G A Cornwall, R Collis, Q Xiao, N Hsia, S R Han. B-Myc, a proximal caput epididymal protein, is dependent on androgens and testicular factors for expression. Biology of reproduction. vol 64. issue 6. 2001-08-02. PMID:11369584. |
the myc family of transcriptional regulators carries out critical roles in the control of cellular proliferation, differentiation, apoptosis, and tumorigenesis. |
2001-08-02 |
2023-08-12 |
Not clear |
| M Wert, S Kennedy, H C Palfrey, N Ha. Myc drives apoptosis in PC12 cells in the absence of Max. Oncogene. vol 20. issue 28. 2001-08-02. PMID:11439337. |
myc drives apoptosis in pc12 cells in the absence of max. |
2001-08-02 |
2023-08-12 |
Not clear |
| M Wert, S Kennedy, H C Palfrey, N Ha. Myc drives apoptosis in PC12 cells in the absence of Max. Oncogene. vol 20. issue 28. 2001-08-02. PMID:11439337. |
induction of myc activity resulted in a threefold increase in apoptosis after 5 days when cells were maintained in 1% serum. |
2001-08-02 |
2023-08-12 |
Not clear |
| M Wert, S Kennedy, H C Palfrey, N Ha. Myc drives apoptosis in PC12 cells in the absence of Max. Oncogene. vol 20. issue 28. 2001-08-02. PMID:11439337. |
these results show that myc can induce apoptosis in pc12 cells in a max-independent manner and that alternate signaling pathways exist to mediate cell survival. |
2001-08-02 |
2023-08-12 |
Not clear |
| E L Soucie, M G Annis, J Sedivy, J Filmus, B Leber, D W Andrews, L Z Pen. Myc potentiates apoptosis by stimulating Bax activity at the mitochondria. Molecular and cellular biology. vol 21. issue 14. 2001-07-26. PMID:11416148. |
myc potentiates apoptosis by stimulating bax activity at the mitochondria. |
2001-07-26 |
2023-08-12 |
Not clear |