| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M A Gregory, Q Xiao, G A Cornwall, B Lutterbach, S R Han. B-Myc is preferentially expressed in hormonally-controlled tissues and inhibits cellular proliferation. Oncogene. vol 19. issue 42. 2000-11-09. PMID:11039906. |
the myc family of genes plays an important role in several cellular processes including proliferation, apoptosis, differentiation, and transformation. |
2000-11-09 |
2023-08-12 |
mouse |
| M Landay, S K Oster, F Khosravi, L E Grove, X Yin, J Sedivy, L Z Penn, E V Prochowni. Promotion of growth and apoptosis in c-myc nullizygous fibroblasts by other members of the myc oncoprotein family. Cell death and differentiation. vol 7. issue 8. 2000-10-20. PMID:10918443. |
promotion of growth and apoptosis in c-myc nullizygous fibroblasts by other members of the myc oncoprotein family. |
2000-10-20 |
2023-08-12 |
Not clear |
| A Pajic, D Spitkovsky, B Christoph, B Kempkes, M Schuhmacher, M S Staege, M Brielmeier, J Ellwart, F Kohlhuber, G W Bornkamm, A Polack, D Eic. Cell cycle activation by c-myc in a burkitt lymphoma model cell line. International journal of cancer. vol 87. issue 6. 2000-09-07. PMID:10956386. |
re-expression of myc activates the cell cycle without inducing apoptosis. |
2000-09-07 |
2023-08-12 |
human |
| E R Cameron, J Morton, C J Johnston, J Irvine, M Bell, D E Onions, J C Neil, M Campbell, K Blyt. Fas-independent apoptosis in T-cell tumours induced by the CD2-myc transgene. Cell death and differentiation. vol 7. issue 1. 2000-06-12. PMID:10713723. |
depending on the cellular context, the myc oncoprotein is capable of promoting cell proliferation or death by apoptosis. |
2000-06-12 |
2023-08-12 |
mouse |
| E R Cameron, J Morton, C J Johnston, J Irvine, M Bell, D E Onions, J C Neil, M Campbell, K Blyt. Fas-independent apoptosis in T-cell tumours induced by the CD2-myc transgene. Cell death and differentiation. vol 7. issue 1. 2000-06-12. PMID:10713723. |
the pathways by which myc induces apoptosis are as yet poorly characterised although recent observations on rat fibroblasts over-expressing myc have demonstrated a requirement for the fas pathway. |
2000-06-12 |
2023-08-12 |
mouse |
| E R Cameron, J Morton, C J Johnston, J Irvine, M Bell, D E Onions, J C Neil, M Campbell, K Blyt. Fas-independent apoptosis in T-cell tumours induced by the CD2-myc transgene. Cell death and differentiation. vol 7. issue 1. 2000-06-12. PMID:10713723. |
further, tumour cell lines derived from mice expressing a regulatable form of myc showed inducible apoptosis at similar rates regardless of their lpr genotype. |
2000-06-12 |
2023-08-12 |
mouse |
| D Ewert, J Duhadawa. Inhibition of apoptosis by Marek's disease viruses. Acta virologica. vol 43. issue 2-3. 2000-05-12. PMID:10696433. |
these findings suggest that because the sb-1 strain persists in the alv-infected cells, it may augment lymphoid leukosis by inhibiting apoptosis and providing a survival advantage to the b cells which have a deregulated myc proto-oncogene. |
2000-05-12 |
2023-08-12 |
Not clear |
| I S Ayene, E J Bernhard, W G McKenna, R J Muschel, R E Krisch, C J Koc. DNA as an important target in radiation-induced apoptosis of MYC and MYC plus RAS transfected rat embryo fibroblasts. International journal of radiation biology. vol 76. issue 3. 2000-05-02. PMID:10757314. |
dna as an important target in radiation-induced apoptosis of myc and myc plus ras transfected rat embryo fibroblasts. |
2000-05-02 |
2023-08-12 |
rat |
| I S Ayene, E J Bernhard, W G McKenna, R J Muschel, R E Krisch, C J Koc. DNA as an important target in radiation-induced apoptosis of MYC and MYC plus RAS transfected rat embryo fibroblasts. International journal of radiation biology. vol 76. issue 3. 2000-05-02. PMID:10757314. |
this study uses a radiation chemistry approach to determine if dna is an important target for radiation-induced apoptosis of myc (mr4) and myc plus ras (3.7) transfected rat embryo fibroblast cell lines. |
2000-05-02 |
2023-08-12 |
rat |
| H A Coller, C Grandori, P Tamayo, T Colbert, E S Lander, R N Eisenman, T R Golu. Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 7. 2000-04-24. PMID:10737792. |
a possible mechanism for myc-mediated apoptosis was revealed by identification of the tumor necrosis factor receptor associated protein trap1 as a myc target. |
2000-04-24 |
2023-08-12 |
human |
| S Pelengaris, B Rudolph, T Littlewoo. Action of Myc in vivo - proliferation and apoptosis. Current opinion in genetics & development. vol 10. issue 1. 2000-03-31. PMID:10679391. |
action of myc in vivo - proliferation and apoptosis. |
2000-03-31 |
2023-08-12 |
mouse |
| S Pelengaris, B Rudolph, T Littlewoo. Action of Myc in vivo - proliferation and apoptosis. Current opinion in genetics & development. vol 10. issue 1. 2000-03-31. PMID:10679391. |
recent experiments employing transgenic mice that express an ectopically regulatable myc gene or protein have begun to elucidate the role of the balance between proliferation and apoptosis in myc-induced carcinogenesis. |
2000-03-31 |
2023-08-12 |
mouse |
| A Tan, P Bitterman, N Sonenberg, M Peterson, V Polunovsk. Inhibition of Myc-dependent apoptosis by eukaryotic translation initiation factor 4E requires cyclin D1. Oncogene. vol 19. issue 11. 2000-03-31. PMID:10723135. |
ectopically expressed eukaryotic translation initiation factor 4e (eif4e) stimulates cell proliferation, suppresses apoptosis in growth factor restricted cells, and induces malignant transformation in primary rodent fibroblasts when coexpressed with protooncogene myc. |
2000-03-31 |
2023-08-12 |
rat |
| K Blyth, M Stewart, M Bell, C James, G Evan, J C Neil, E R Camero. Sensitivity to myc-induced apoptosis is retained in spontaneous and transplanted lymphomas of CD2-mycER mice. Oncogene. vol 19. issue 6. 2000-03-16. PMID:10698495. |
activation of the myc oncoprotein resulted in both proliferation and apoptosis in vivo. |
2000-03-16 |
2023-08-12 |
mouse |
| K Blyth, M Stewart, M Bell, C James, G Evan, J C Neil, E R Camero. Sensitivity to myc-induced apoptosis is retained in spontaneous and transplanted lymphomas of CD2-mycER mice. Oncogene. vol 19. issue 6. 2000-03-16. PMID:10698495. |
in conclusion, lymphomas arising in cd2-mycer mice retain the capacity to undergo apoptosis in response to myc activation and show no phenotypic evidence of the presence of an active dominant inhibitor. |
2000-03-16 |
2023-08-12 |
mouse |
| V J Heath, D A Gillespie, D H Crouc. Inhibition of the terminal stages of adipocyte differentiation by cMyc. Experimental cell research. vol 254. issue 1. 2000-02-24. PMID:10623469. |
the nuclear oncoprotein myc is a pivotal regulator of several important biological processes, including cellular proliferation, differentiation, and apoptosis. |
2000-02-24 |
2023-08-12 |
Not clear |
| M Tsuneoka, E Mekad. Ras/MEK signaling suppresses Myc-dependent apoptosis in cells transformed by c-myc and activated ras. Oncogene. vol 19. issue 1. 2000-02-07. PMID:10644986. |
overexpression of chicken bcl-xl suppressed apoptosis under serum-limiting conditions, but not apoptosis initiated by ras/mek inhibition in cells transformed by myc and activated ras. |
2000-02-07 |
2023-08-12 |
chicken |
| D Bannasch, I Weis, M Schwa. Nmi protein interacts with regions that differ between MycN and Myc and is localized in the cytoplasm of neuroblastoma cells in contrast to nuclear MycN. Oncogene. vol 18. issue 48. 2000-01-06. PMID:10597290. |
myc family proteins play an important role in cellular processes such as proliferation, differentiation, apoptosis and transformation. |
2000-01-06 |
2023-08-12 |
Not clear |
| K Noguchi, C Kitanaka, H Yamana, A Kokubu, T Mochizuki, Y Kuchin. Regulation of c-Myc through phosphorylation at Ser-62 and Ser-71 by c-Jun N-terminal kinase. The Journal of biological chemistry. vol 274. issue 46. 2000-01-03. PMID:10551811. |
however, signal pathways regulating the function of myc proteins during apoptosis are unknown. |
2000-01-03 |
2023-08-12 |
Not clear |
| N Rubio, C Torre. Interferon-gamma induces proliferation but not apoptosis in murine astrocytes through the differential expression of the myc proto-oncogene family. Brain research. Molecular brain research. vol 71. issue 1. 1999-12-22. PMID:10407192. |
interferon-gamma induces proliferation but not apoptosis in murine astrocytes through the differential expression of the myc proto-oncogene family. |
1999-12-22 |
2023-08-12 |
mouse |