| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Hayashi, K Nomata, C C Chang, R J Ruch, J E Trosk. Cooperative effects of v-myc and c-Ha-ras oncogenes on gap junctional intercellular communication and tumorigenicity in rat liver epithelial cells. Cancer letters. vol 128. issue 2. 1998-08-06. PMID:9683275. |
the objective of this study was to isolate and partially characterize several rat liver epithelial cell clones containing myc, ras and myc/ras oncogenes in order to study their roles in apoptosis and to test the hypothesis that gap junctional intercellular communication is necessary for apoptosis in solid tissues and that the loss of junctional communication leads to tumorigenesis. |
1998-08-06 |
2023-08-12 |
rat |
| G N Filippova, A Lindblom, L J Meincke, E M Klenova, P E Neiman, S J Collins, N A Doggett, V V Lobanenko. A widely expressed transcription factor with multiple DNA sequence specificity, CTCF, is localized at chromosome segment 16q22.1 within one of the smallest regions of overlap for common deletions in breast and prostate cancers. Genes, chromosomes & cancer. vol 22. issue 1. 1998-07-22. PMID:9591631. |
the cellular protooncogene myc encodes a nuclear transcription factor that is involved in regulating important cellular functions, including cell cycle progression, differentiation, and apoptosis. |
1998-07-22 |
2023-08-12 |
human |
| I Savini, I D'Angelo, M Annicchiarico-Petruzzelli, L Bellincampi, G Melino, L Aviglian. Ascorbic acid recycling in N-myc amplified human neuroblastoma cells. Anticancer research. vol 18. issue 2A. 1998-06-18. PMID:9615725. |
the present data may explain the ability of the tumor to progress or regress through mechanisms involving both myc oncogene and apoptosis. |
1998-06-18 |
2023-08-12 |
human |
| E B Thompso. The many roles of c-Myc in apoptosis. Annual review of physiology. vol 60. 1998-06-12. PMID:9558477. |
understanding the kinetic and quantitative relationships that determine how and what genes c-myc regulates is essential to understanding how myc is involved in apoptosis. |
1998-06-12 |
2023-08-12 |
Not clear |
| P Steiner, B Rudolph, D Müller, M Eiler. The functions of Myc in cell cycle progression and apoptosis. Progress in cell cycle research. vol 2. 1998-05-13. PMID:9552384. |
the functions of myc in cell cycle progression and apoptosis. |
1998-05-13 |
2023-08-12 |
Not clear |
| P Steiner, B Rudolph, D Müller, M Eiler. The functions of Myc in cell cycle progression and apoptosis. Progress in cell cycle research. vol 2. 1998-05-13. PMID:9552384. |
myc also induces cells to undergo apoptosis, and the relationship between myc-induced cell cycle entry and apoptosis is discussed. |
1998-05-13 |
2023-08-12 |
Not clear |
| C Quéva, P J Hurlin, K P Foley, R N Eisenma. Sequential expression of the MAD family of transcriptional repressors during differentiation and development. Oncogene. vol 16. issue 8. 1998-04-02. PMID:9519870. |
members of the myc proto-oncogene family encode transcription factors that function in multiple aspects of cell behavior, including proliferation, differentiation, transformation and apoptosis. |
1998-04-02 |
2023-08-12 |
mouse |
| P Bellosta, Q Zhang, S P Goff, C Basilic. Signaling through the ARK tyrosine kinase receptor protects from apoptosis in the absence of growth stimulation. Oncogene. vol 15. issue 20. 1997-12-29. PMID:9395235. |
interestingly ark signaling protects from apoptosis induced by serum deprivation, myc overexpression, or by tnf alpha but not from u.v. |
1997-12-29 |
2023-08-12 |
mouse |
| K Haas, C Johannes, C Geisen, T Schmidt, H Karsunky, S Blass-Kampmann, G Obe, T Mörö. Malignant transformation by cyclin E and Ha-Ras correlates with lower sensitivity towards induction of cell death but requires functional Myc and CDK4. Oncogene. vol 15. issue 21. 1997-12-29. PMID:9399649. |
cyclin e/ha-ras transformed cells are highly tumorigenic in synergeneic rats, are able to form colonies in soft agar and show protection towards apoptosis upon serum starvation or dna damage compared to cells transformed by the combination of myc, cyclin d1 or sv40 large t-antigen and ha-ras. |
1997-12-29 |
2023-08-12 |
rat |
| S Kagaya, C Kitanaka, K Noguchi, T Mochizuki, A Sugiyama, A Asai, N Yasuhara, Y Eguchi, Y Tsujimoto, Y Kuchin. A functional role for death proteases in s-Myc- and c-Myc-mediated apoptosis. Molecular and cellular biology. vol 17. issue 11. 1997-11-21. PMID:9343438. |
however, it remains unknown whether these apoptotic proteases are generally involved in apoptosis triggered by other stimuli such as myc and p53. |
1997-11-21 |
2023-08-12 |
Not clear |
| K Yu, C P Ravera, Y N Chen, G McMaho. Regulation of Myc-dependent apoptosis by p53, c-Jun N-terminal kinases/stress-activated protein kinases, and Mdm-2. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 8. issue 7. 1997-08-22. PMID:9218867. |
deregulated overexpression of c-myc (myc) confers susceptibility to apoptosis in several cell types, but the molecular regulation of these processes has not been well established. |
1997-08-22 |
2023-08-12 |
human |
| K Yu, C P Ravera, Y N Chen, G McMaho. Regulation of Myc-dependent apoptosis by p53, c-Jun N-terminal kinases/stress-activated protein kinases, and Mdm-2. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 8. issue 7. 1997-08-22. PMID:9218867. |
ectopic overexpression of myc in both rat1 fibroblasts and human osteosarcoma cells causes a dramatic increase of cellular p53 mrna and protein, and this induction of p53 correlates with apoptosis triggered by withdrawal of serum. |
1997-08-22 |
2023-08-12 |
human |
| K Yu, C P Ravera, Y N Chen, G McMaho. Regulation of Myc-dependent apoptosis by p53, c-Jun N-terminal kinases/stress-activated protein kinases, and Mdm-2. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 8. issue 7. 1997-08-22. PMID:9218867. |
anticancer agents vinblastine and nocodazole also induce apoptosis in myc-transformed rat1 fibroblasts but are cytostatic to the same cells without myc overexpression. |
1997-08-22 |
2023-08-12 |
human |
| K Yu, C P Ravera, Y N Chen, G McMaho. Regulation of Myc-dependent apoptosis by p53, c-Jun N-terminal kinases/stress-activated protein kinases, and Mdm-2. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 8. issue 7. 1997-08-22. PMID:9218867. |
we demonstrate that induction of myc-dependent apoptosis in these cells is specifically associated with an activation of p46 c-jun n-terminal kinase/stress-activated protein kinase (jnk/sapk) activity, whereas this jnk/sapk activation is absent in stress-treated cells without myc overexpression. |
1997-08-22 |
2023-08-12 |
human |
| L Mauvieux, E Macintyr. [Molecular anomalies in malignant hemopathies]. Presse medicale (Paris, France : 1983). vol 26. issue 21. 1997-08-21. PMID:9239151. |
both types of anomalies involve genes controlling the cell cycle, cell differentiation or cell death (apoptosis), in particular transcription factors (for example, e2a, rara, myc) and molecules involved in signal transduction (for example ras, abl, lck). |
1997-08-21 |
2023-08-12 |
Not clear |
| W Clark, D A Gillespi. Transformation by v-Jun prevents cell cycle exit and promotes apoptosis in the absence of serum growth factors. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 8. issue 4. 1997-08-15. PMID:9101083. |
we conclude that v-jun shares the capacity of the myc, e1a, and e2f oncoproteins to promote both cell cycle progression and apoptosis under conditions of mitogen depletion. |
1997-08-15 |
2023-08-12 |
Not clear |
| S J Nass, R B Dickso. Defining a role for c-Myc in breast tumorigenesis. Breast cancer research and treatment. vol 44. issue 1. 1997-07-16. PMID:9164674. |
recent evidence indicates that myc can promote cell proliferation as well as cell death via apoptosis. |
1997-07-16 |
2023-08-12 |
human |
| S Bodis, T Hemesath, D E Fishe. Highly conserved asparagine in the basic domain of Myc is dispensable for DNA binding, transformation, and apoptosis. Biochemical and molecular medicine. vol 60. issue 2. 1997-07-07. PMID:9169089. |
highly conserved asparagine in the basic domain of myc is dispensable for dna binding, transformation, and apoptosis. |
1997-07-07 |
2023-08-12 |
Not clear |
| S Bodis, T Hemesath, D E Fishe. Highly conserved asparagine in the basic domain of Myc is dispensable for DNA binding, transformation, and apoptosis. Biochemical and molecular medicine. vol 60. issue 2. 1997-07-07. PMID:9169089. |
to test the possibility of whether the basic region of myc encodes a second biological function, the conserved asparagine in c-myc (n360) was mutated to alanine and tested for the myc-dependent functions of cellular transformation and apoptosis. |
1997-07-07 |
2023-08-12 |
Not clear |
| M Vitale, L Zamai, E Falcieri, G Zauli, P Gobbi, S Santi, C Cinti, G Webe. IMP dehydrogenase inhibitor, tiazofurin, induces apoptosis in K562 human erythroleukemia cells. Cytometry. vol 30. issue 1. 1997-06-24. PMID:9056744. |
tiazofurin, an anticancer drug which inhibits imp dehydrogenase, decreases cellular gtp concentration, induces differentiation and down-regulates ras and myc oncogene expression, caused apoptosis of k562 cells in a time- and dose-dependent fashion. |
1997-06-24 |
2023-08-12 |
human |