| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Rudolph, R Saffrich, J Zwicker, B Henglein, R Müller, W Ansorge, M Eiler. Activation of cyclin-dependent kinases by Myc mediates induction of cyclin A, but not apoptosis. The EMBO journal. vol 15. issue 12. 1996-08-27. PMID:8670807. |
in contrast, neither microinjection of cdk inhibitors nor chemical inhibition of cdk2 affected the ability of myc to induce apoptosis in serum-starved cells. |
1996-08-27 |
2023-08-12 |
Not clear |
| B Rudolph, R Saffrich, J Zwicker, B Henglein, R Müller, W Ansorge, M Eiler. Activation of cyclin-dependent kinases by Myc mediates induction of cyclin A, but not apoptosis. The EMBO journal. vol 15. issue 12. 1996-08-27. PMID:8670807. |
further, in isoleucine-deprived cells, myc induces apoptosis without altering cdk activity. |
1996-08-27 |
2023-08-12 |
Not clear |
| B Rudolph, R Saffrich, J Zwicker, B Henglein, R Müller, W Ansorge, M Eiler. Activation of cyclin-dependent kinases by Myc mediates induction of cyclin A, but not apoptosis. The EMBO journal. vol 15. issue 12. 1996-08-27. PMID:8670807. |
we conclude that myc acts upstream of cdks in stimulating cell proliferation and also that activation of cdks and induction of apoptosis are largely independent events that occur in response to induction of myc. |
1996-08-27 |
2023-08-12 |
Not clear |
| E J Uhlmann, C D'Sa-Eipper, T Subramanian, A J Wagner, N Hay, G Chinnadura. Deletion of a nonconserved region of Bcl-2 confers a novel gain of function: suppression of apoptosis with concomitant cell proliferation. Cancer research. vol 56. issue 11. 1996-07-30. PMID:8653686. |
here, we report that a deletion of a nonconserved region of human bcl-2 (residues 51-85) confers a novel gain of function that not only suppresses apoptosis induced by the tumor suppressor protein p53 and the myc oncoprotein but also permits continued cell proliferation. |
1996-07-30 |
2023-08-12 |
human |
| W G McKenna, E J Bernhard, D A Markiewicz, M S Rudoltz, A Maity, R J Musche. Regulation of radiation-induced apoptosis in oncogene-transfected fibroblasts: influence of H-ras on the G2 delay. Oncogene. vol 12. issue 2. 1996-03-01. PMID:8570201. |
we have studied the relationship of apoptosis induction to effects on the g2 phase cell cycle in a series of rat embryo cells transformed by rash plus myc or immortalized by myc alone. |
1996-03-01 |
2023-08-12 |
rat |
| R Fulton, R Gallagher, D Crouch, J C Nei. Apparent uncoupling of oncogenicity from fibroblast transformation and apoptosis in a mutant myc gene transduced by feline leukemia virus. Journal of virology. vol 70. issue 2. 1996-02-22. PMID:8551576. |
apparent uncoupling of oncogenicity from fibroblast transformation and apoptosis in a mutant myc gene transduced by feline leukemia virus. |
1996-02-22 |
2023-08-12 |
chicken |
| M S Topp, C A Papadimitriou, F Eitelbach, E Oelmann, B Koehler, D Oberberg, Z Von Marschall, B Reufi, H Stein, E Thie. Antiproliferative effect of human interleukin-4 in human cancer cell lines: studies on the mechanism. Leukemia & lymphoma. vol 19. issue 3-4. 1996-02-08. PMID:8535226. |
studies of possible mechanisms involved in the antiproliferative effect of rhil-4 showed that rhil-4 does not induce apoptosis or modulation of the transcription factor c myc in the responsive nsclc cell lines. |
1996-02-08 |
2023-08-12 |
mouse |
| A Basu, J S Clin. Oncogenic transformation alters cisplatin-induced apoptosis in rat embryo fibroblasts. International journal of cancer. vol 63. issue 4. 1995-12-28. PMID:7591272. |
over-expression of myc, but not ras, src or mos, induced apoptosis in r6 cells. |
1995-12-28 |
2023-08-12 |
mouse |
| C C Ling, M Guo, C H Chen, T Delohere. Radiation-induced apoptosis: effects of cell age and dose fractionation. Cancer research. vol 55. issue 22. 1995-12-15. PMID:7585576. |
the cell cycle dependence of radiation-induced apoptosis was measured using mitotically synchronized rec:myc(ch1) and rat1:mycb cells. |
1995-12-15 |
2023-08-12 |
Not clear |
| C C Ling, M Guo, C H Chen, T Delohere. Radiation-induced apoptosis: effects of cell age and dose fractionation. Cancer research. vol 55. issue 22. 1995-12-15. PMID:7585576. |
in contrast, the inverse split-dose effect for apoptosis is absent for rec:myc(ch1), due presumably to the radiation-induced g1 delay. |
1995-12-15 |
2023-08-12 |
Not clear |
| C C Ling, M Guo, C H Chen, T Delohere. Radiation-induced apoptosis: effects of cell age and dose fractionation. Cancer research. vol 55. issue 22. 1995-12-15. PMID:7585576. |
parallel split-dose experiments, but using clonogenic survival as end points, show recovery for rec:myc(ch1) cells but not for rat1:mycb cells, reflecting the influence of split-dose, radiation-induced apoptosis. |
1995-12-15 |
2023-08-12 |
Not clear |
| A J Watso. Review article: manipulation of cell death--the development of novel strategies for the treatment of gastrointestinal disease. Alimentary pharmacology & therapeutics. vol 9. issue 3. 1995-10-05. PMID:7654884. |
mutations or deletions of p53, bcl-2 and myc prevents the appropriate deletion of malignant cells and causes resistance to anti-cancer drugs which act by the induction of apoptosis. |
1995-10-05 |
2023-08-12 |
Not clear |
| S R Han. Methionine deprivation regulates the translation of functionally-distinct c-Myc proteins. Advances in experimental medicine and biology. vol 375. 1995-09-21. PMID:7645422. |
numerous reports have demonstrated a fundamental and diverse role for the myc gene in cellular events, including proliferation, differentiation and apoptosis (cole 1986; spencer and groudine 1991; askew et al. |
1995-09-21 |
2023-08-12 |
Not clear |
| H Naora, T Nishida, Y Shindo, M Adachi, H Naor. Association of nbl gene expression and glucocorticoid-induced apoptosis in mouse thymus in vivo. Immunology. vol 85. issue 1. 1995-09-11. PMID:7635523. |
in contrast, expression of myc, which is believed to be involved in apoptosis in other cell systems, declined as thymic apoptosis increased. |
1995-09-11 |
2023-08-12 |
mouse |
| A E Milner, R J Grand, C D Gregor. Effects of interferon-alpha on human B cells: repression of apoptosis and prevention of cell growth are independent responses of Burkitt lymphoma lines. International journal of cancer. vol 61. issue 3. 1995-06-01. PMID:7729947. |
analysis of c-myc protein levels confirmed previous observations that repression of apoptosis in ifn-alpha-rescuable bl cells was associated with an early inhibition of myc that was followed by a return to high-level expression. |
1995-06-01 |
2023-08-12 |
human |
| S Gaubatz, A Imhof, R Dosch, O Werner, P Mitchell, R Buettner, M Eiler. Transcriptional activation by Myc is under negative control by the transcription factor AP-2. The EMBO journal. vol 14. issue 7. 1995-05-30. PMID:7729426. |
the transcriptional activation function of myc is required for its ability to induce cell cycle progression, cellular transformation and apoptosis. |
1995-05-30 |
2023-08-12 |
Not clear |
| D R Green, A Mahboubi, W Nishioka, S Oja, F Echeverri, Y Shi, J Glynn, Y Yang, J Ashwell, R Bissonnett. Promotion and inhibition of activation-induced apoptosis in T-cell hybridomas by oncogenes and related signals. Immunological reviews. vol 142. 1995-05-04. PMID:7698799. |
thus, both myc and max play roles in activation-induced apoptosis, presumably via control of gene expression. |
1995-05-04 |
2023-08-12 |
Not clear |
| A Asai, Y Miyagi, H Hashimoto, S H Lee, K Mishima, A Sugiyama, H Tanaka, T Mochizuki, T Yasuda, Y Kuchin. Modulation of tumor immunogenicity of rat glioma cells by s-Myc expression: eradication of rat gliomas in vivo. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 5. issue 11. 1995-03-16. PMID:7848917. |
the myc family proteins represented by c-myc are thought to play a crucial role in cellular proliferation, differentiation, transformation, and apoptosis. |
1995-03-16 |
2023-08-12 |
human |
| A J Wagner, J M Kokontis, N Ha. Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1. Genes & development. vol 8. issue 23. 1995-01-17. PMID:7995520. |
by introducing a conditionally active myc allele into primary embryo fibroblasts null for p53, and into fibroblasts without endogenous p53 expression but ectopically expressing a temperature-sensitive p53 allele, we show that expression of wild-type p53 is required for susceptibility to myc-mediated apoptosis. |
1995-01-17 |
2023-08-12 |
Not clear |
| C C Ling, C H Chen, W X L. Apoptosis induced at different dose rates: implication for the shoulder region of cell survival curves. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. vol 32. issue 2. 1994-12-29. PMID:7972906. |
apoptosis is induced by radiation, administered at different dose rates of 3-60 gy/h, in rat embryo cells transfected with a c-myc oncogene (rec:myc(ch1)) or with a c-ha-ras oncogene (rec:ras(ch1)). |
1994-12-29 |
2023-08-12 |
rat |