| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E L Soucie, M G Annis, J Sedivy, J Filmus, B Leber, D W Andrews, L Z Pen. Myc potentiates apoptosis by stimulating Bax activity at the mitochondria. Molecular and cellular biology. vol 21. issue 14. 2001-07-26. PMID:11416148. |
myc expression and apoptosis were universally associated with bcl-acta and not bcl-cb5, suggesting that myc acts downstream at a point common to these distinct apoptotic signaling cascades. |
2001-07-26 |
2023-08-12 |
Not clear |
| E L Soucie, M G Annis, J Sedivy, J Filmus, B Leber, D W Andrews, L Z Pen. Myc potentiates apoptosis by stimulating Bax activity at the mitochondria. Molecular and cellular biology. vol 21. issue 14. 2001-07-26. PMID:11416148. |
during apoptosis, bax translocation to the mitochondria occurs in the presence or absence of myc expression. |
2001-07-26 |
2023-08-12 |
Not clear |
| E L Soucie, M G Annis, J Sedivy, J Filmus, B Leber, D W Andrews, L Z Pen. Myc potentiates apoptosis by stimulating Bax activity at the mitochondria. Molecular and cellular biology. vol 21. issue 14. 2001-07-26. PMID:11416148. |
reintroduction of myc into the c-myc null cells restores bax activation, cytochrome c release, and inhibition of apoptosis by bcl-2. |
2001-07-26 |
2023-08-12 |
Not clear |
| E L Soucie, M G Annis, J Sedivy, J Filmus, B Leber, D W Andrews, L Z Pen. Myc potentiates apoptosis by stimulating Bax activity at the mitochondria. Molecular and cellular biology. vol 21. issue 14. 2001-07-26. PMID:11416148. |
these results demonstrate a role for myc in the regulation of bax activation during apoptosis. |
2001-07-26 |
2023-08-12 |
Not clear |
| E L Soucie, M G Annis, J Sedivy, J Filmus, B Leber, D W Andrews, L Z Pen. Myc potentiates apoptosis by stimulating Bax activity at the mitochondria. Molecular and cellular biology. vol 21. issue 14. 2001-07-26. PMID:11416148. |
moreover, apoptosis that can be triggered in the absence of myc provides evidence that signaling pathways exist which circumvent bax activation and cytochrome c release to trigger caspase activation. |
2001-07-26 |
2023-08-12 |
Not clear |
| K A Brandvold, D L Ewert, S C Kent, P Neiman, A Ruddel. Blocked B cell differentiation and emigration support the early growth of Myc-induced lymphomas. Oncogene. vol 20. issue 25. 2001-07-12. PMID:11423972. |
the clonal expansion of these follicles allowed us to examine how myc influences cell differentiation, growth, and apoptosis in lymphoid progenitors soon after the onset of myc overexpression. |
2001-07-12 |
2023-08-12 |
Not clear |
| I D'Agnano, A Valentini, C Fornari, B Bucci, G Starace, A Felsani, G Citr. Myc down-regulation induces apoptosis in M14 melanoma cells by increasing p27(kip1) levels. Oncogene. vol 20. issue 22. 2001-07-05. PMID:11420693. |
myc down-regulation induces apoptosis in m14 melanoma cells by increasing p27(kip1) levels. |
2001-07-05 |
2023-08-12 |
Not clear |
| I D'Agnano, A Valentini, C Fornari, B Bucci, G Starace, A Felsani, G Citr. Myc down-regulation induces apoptosis in M14 melanoma cells by increasing p27(kip1) levels. Oncogene. vol 20. issue 22. 2001-07-05. PMID:11420693. |
our results indicate that down-regulation of myc protein induces a g(1) arrest and activates apoptosis by increasing p27(kip1) content in melanoma cells, that are known to be defective for the p16-cyclind/cdk4-prb g(1) checkpoint. |
2001-07-05 |
2023-08-12 |
Not clear |
| D A Gewirtz, Y M Di, J K Randolph, P T Jain, K Valerie, S Bullock, N Nath, S P Chellappa. Rb dephosphorylation and suppression of E2F activity in human breast tumor cells exposed to a pharmacological concentration of estradiol. Archives of biochemistry and biophysics. vol 388. issue 2. 2001-05-24. PMID:11368161. |
in addition to the lack of caspase-3 in mcf-7 cells, the absence of apoptosis could be related, at least in part, to the fact that estradiol promotes a rapid reduction in levels of the e2f-1 and myc proteins. |
2001-05-24 |
2023-08-12 |
human |
| D G Breckenridge, G C Shor. Regulation of apoptosis by E1A and Myc oncoproteins. Critical reviews in eukaryotic gene expression. vol 10. issue 3-4. 2001-04-26. PMID:11272469. |
regulation of apoptosis by e1a and myc oncoproteins. |
2001-04-26 |
2023-08-12 |
Not clear |
| S Balachandran, M Porosnicu, G N Barbe. Oncolytic activity of vesicular stomatitis virus is effective against tumors exhibiting aberrant p53, Ras, or myc function and involves the induction of apoptosis. Journal of virology. vol 75. issue 7. 2001-04-05. PMID:11238874. |
oncolytic activity of vesicular stomatitis virus is effective against tumors exhibiting aberrant p53, ras, or myc function and involves the induction of apoptosis. |
2001-04-05 |
2023-08-12 |
Not clear |
| C Wójci. Proteasomes in apoptosis: villains or guardians? Cellular and molecular life sciences : CMLS. vol 56. issue 11-12. 2001-02-15. PMID:11212325. |
the proteasome mediated step(s) in apoptosis is located upstream of mitochondrial changes and caspase activation, and can involve in different systems bcl-2, jun n-terminal kinase, heat shock proteins, myc, p53, polyamines and other factors. |
2001-02-15 |
2023-08-12 |
Not clear |
| C Quéva, G A McArthur, B M Iritani, R N Eisenma. Targeted deletion of the S-phase-specific Myc antagonist Mad3 sensitizes neuronal and lymphoid cells to radiation-induced apoptosis. Molecular and cellular biology. vol 21. issue 3. 2001-02-08. PMID:11154258. |
targeted deletion of the s-phase-specific myc antagonist mad3 sensitizes neuronal and lymphoid cells to radiation-induced apoptosis. |
2001-02-08 |
2023-08-12 |
mouse |
| M D Hogarty, X Liu, P M Thompson, P S White, E P Sulman, J M Maris, G M Brodeu. BIN1 inhibits colony formation and induces apoptosis in neuroblastoma cell lines with MYCN amplification. Medical and pediatric oncology. vol 35. issue 6. 2001-02-02. PMID:11107117. |
however, in many mammalian cells, deregulated expression of myc family genes (including mycn) induces apoptosis. |
2001-02-02 |
2023-08-12 |
Not clear |
| M D Hogarty, X Liu, P M Thompson, P S White, E P Sulman, J M Maris, G M Brodeu. BIN1 inhibits colony formation and induces apoptosis in neuroblastoma cell lines with MYCN amplification. Medical and pediatric oncology. vol 35. issue 6. 2001-02-02. PMID:11107117. |
we hypothesized that bin1, a myc interacting protein capable of inducing apoptosis, may be an important regulator of mycn in neuroblastoma. |
2001-02-02 |
2023-08-12 |
Not clear |
| M Schuhmacher, F Kohlhuber, M Hölzel, C Kaiser, H Burtscher, M Jarsch, G W Bornkamm, G Laux, A Polack, U H Weidle, D Eic. The transcriptional program of a human B cell line in response to Myc. Nucleic acids research. vol 29. issue 2. 2001-01-25. PMID:11139609. |
the proto-oncogene c-myc (myc) encodes a transcription factor (myc) that promotes growth, proliferation and apoptosis. |
2001-01-25 |
2023-08-12 |
human |
| F Su, C N Theodosis, R J Schneide. Role of NF-kappaB and myc proteins in apoptosis induced by hepatitis B virus HBx protein. Journal of virology. vol 75. issue 1. 2001-01-04. PMID:11119591. |
role of nf-kappab and myc proteins in apoptosis induced by hepatitis b virus hbx protein. |
2001-01-04 |
2023-08-12 |
Not clear |
| A MacLaren, W Clark, D A Gillespi. v-Jun sensitizes cells to apoptosis by a mechanism involving mitochondrial cytochrome C release. Oncogene. vol 19. issue 51. 2000-12-28. PMID:11127822. |
v-jun shares the ability of the myc, e1a, and e2f oncogenes to both sustain cell cycle progression and promote apoptosis in the absence of mitogenic stimulation. |
2000-12-28 |
2023-08-12 |
Not clear |
| H B Forrester, N Albright, C C Ling, W C Dewe. Computerized video time-lapse analysis of apoptosis of REC:Myc cells X-irradiated in different phases of the cell cycle. Radiation research. vol 154. issue 6. 2000-12-22. PMID:11096419. |
computerized video time-lapse analysis of apoptosis of rec:myc cells x-irradiated in different phases of the cell cycle. |
2000-12-22 |
2023-08-12 |
rat |
| A N Billin, A L Eilers, K L Coulter, J S Logan, D E Aye. MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. Molecular and cellular biology. vol 20. issue 23. 2000-12-19. PMID:11073985. |
max is a common dimerization partner for a family of transcription factors (myc, mad [or mxi]), and mnt [or rox] proteins) that regulate cell growth, proliferation, and apoptosis. |
2000-12-19 |
2023-08-12 |
Not clear |