| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yilin Zhang, Weiqiang Yu, Xinquan Jiang, Kaige Lv, Shengjun Sun, Fuqiang Zhan. Analysis of the cytotoxicity of differentially sized titanium dioxide nanoparticles in murine MC3T3-E1 preosteoblasts. Journal of materials science. Materials in medicine. vol 22. issue 8. 2011-12-07. PMID:21681655. |
there was a significant increase in lactate dehydrogenase (ldh) release, apoptosis and mitochondrial membrane permeability following short-term exposure of the cells to tio(2) nps. |
2011-12-07 |
2023-08-12 |
Not clear |
| Yilin Zhang, Weiqiang Yu, Xinquan Jiang, Kaige Lv, Shengjun Sun, Fuqiang Zhan. Analysis of the cytotoxicity of differentially sized titanium dioxide nanoparticles in murine MC3T3-E1 preosteoblasts. Journal of materials science. Materials in medicine. vol 22. issue 8. 2011-12-07. PMID:21681655. |
compared with the 32 nm tio(2) nps, 5 nm tio(2) nps were more toxic, induced more apoptosis, increased mitochondrial membrane permeability and stimulated more gm-csf expression at a high concentration (≥100 μg/ml). |
2011-12-07 |
2023-08-12 |
Not clear |
| Shixian Huang, Jianfeng Li, Liang Han, Shuhuan Liu, Haojun Ma, Rongqin Huang, Chen Jian. Dual targeting effect of Angiopep-2-modified, DNA-loaded nanoparticles for glioma. Biomaterials. vol 32. issue 28. 2011-11-21. PMID:21700333. |
furthermore, the tunel analysis showed a more wide-extended apoptosis in the pamam-peg-angiopep/porf-trail nps treated group, compared to other groups including commercial temozolomide-treated one. |
2011-11-21 |
2023-08-12 |
mouse |
| Francelyne Marano, Salik Hussain, Fernando Rodrigues-Lima, Armelle Baeza-Squiban, Sonja Bolan. Nanoparticles: molecular targets and cell signalling. Archives of toxicology. vol 85. issue 7. 2011-10-20. PMID:20502881. |
the induction of apoptosis is also closely related to the modulation of signalling pathways induced by nps. |
2011-10-20 |
2023-08-12 |
Not clear |
| Changyan Liang, Yuebo Yang, You Ling, Yueshan Huang, Tian Li, Xiaomao L. Improved therapeutic effect of folate-decorated PLGA-PEG nanoparticles for endometrial carcinoma. Bioorganic & medicinal chemistry. vol 19. issue 13. 2011-10-17. PMID:21641806. |
the fol-targeted ptx nps showed a greater cytotoxicity against hec-1a cancer cells in vitro and in vivo, which might be induced by apoptosis. |
2011-10-17 |
2023-08-12 |
mouse |
| Renping Hu, Lei Zheng, Ting Zhang, Guodong Gao, Yaling Cui, Zhe Cheng, Jie Cheng, Mengmeng Hong, Meng Tang, Fashui Hon. Molecular mechanism of hippocampal apoptosis of mice following exposure to titanium dioxide nanoparticles. Journal of hazardous materials. vol 191. issue 1-3. 2011-09-21. PMID:21570177. |
previous studies demonstrate that the exposure to titanium dioxide nanoparticles (tio(2) nps) damages the central nervous system of mice; however, very little is known about the effects of tio(2) nps on hippocampal apoptosis or its molecular mechanism. |
2011-09-21 |
2023-08-12 |
mouse |
| Renping Hu, Lei Zheng, Ting Zhang, Guodong Gao, Yaling Cui, Zhe Cheng, Jie Cheng, Mengmeng Hong, Meng Tang, Fashui Hon. Molecular mechanism of hippocampal apoptosis of mice following exposure to titanium dioxide nanoparticles. Journal of hazardous materials. vol 191. issue 1-3. 2011-09-21. PMID:21570177. |
the present study investigated the molecular mechanism associated with hippocampal apoptosis in mice induced by intragastric administration of tio(2) nps for consecutive 60 days. |
2011-09-21 |
2023-08-12 |
mouse |
| Renping Hu, Lei Zheng, Ting Zhang, Guodong Gao, Yaling Cui, Zhe Cheng, Jie Cheng, Mengmeng Hong, Meng Tang, Fashui Hon. Molecular mechanism of hippocampal apoptosis of mice following exposure to titanium dioxide nanoparticles. Journal of hazardous materials. vol 191. issue 1-3. 2011-09-21. PMID:21570177. |
our findings indicate that tio(2) nps accumulate in the mouse hippocampus, and this accumulation, in turn, led to hippocampal apoptosis and impairment in spatial recognition memory in mice. |
2011-09-21 |
2023-08-12 |
mouse |
| Manasi Das, Fahima Dilnawaz, Sanjeeb K Saho. Targeted nutlin-3a loaded nanoparticles inhibiting p53-MDM2 interaction: novel strategy for breast cancer therapy. Nanomedicine (London, England). vol 6. issue 3. 2011-08-26. PMID:21542687. |
the objective of the present study is to prepare and characterize nutlin-3a loaded polymeric poly(lactide-co-glycolide) nanoparticles (nps) surface functionalized with transferrin ligand, to deliver the encapsulated drug in a targeted manner to its site of action and to evaluate the efficacy of the nanoformulation in terms of its cellular uptake, cell cytotoxicity, cell cycle arrest, apoptosis and activation of p53 pathway at molecular level in mcf-7 breast cancer cell line. |
2011-08-26 |
2023-08-12 |
Not clear |
| Maqusood Ahame. Toxic response of nickel nanoparticles in human lung epithelial A549 cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 25. issue 4. 2011-08-18. PMID:21376802. |
further, activity of caspase-3 enzyme, marker of apoptosis was significantly higher in treated cells with time and ni nps dosage. |
2011-08-18 |
2023-08-12 |
human |
| Sung Mook Lim, Tae Hyung Kim, Hai Hua Jiang, Chan Woong Park, Seulki Lee, Xiaoyuan Chen, Kang Choon Le. Improved biological half-life and anti-tumor activity of TNF-related apoptosis-inducing ligand (TRAIL) using PEG-exposed nanoparticles. Biomaterials. vol 32. issue 13. 2011-06-08. PMID:21306770. |
the trail-peg-np formulation efficiently suppressed tumor growth (>70%), and histological findings confirmed that nps induced significant tumor cell apoptosis without inducing liver toxicity. |
2011-06-08 |
2023-08-12 |
mouse |
| Pallab Sanpui, Arun Chattopadhyay, Siddhartha Sankar Ghos. Induction of apoptosis in cancer cells at low silver nanoparticle concentrations using chitosan nanocarrier. ACS applied materials & interfaces. vol 3. issue 2. 2011-06-07. PMID:21280584. |
we report the development of a chitosan nanocarrier (nc)-based delivery of silver nanoparticles (ag nps) to mammalian cells for induction of apoptosis at very low concentrations of the nps. |
2011-06-07 |
2023-08-12 |
human |
| Nicole M Schaeublin, Laura K Braydich-Stolle, Amanda M Schrand, John M Miller, Jim Hutchison, John J Schlager, Saber M Hussai. Surface charge of gold nanoparticles mediates mechanism of toxicity. Nanoscale. vol 3. issue 2. 2011-06-03. PMID:21229159. |
in conclusion, these results indicate that surface charge is a major determinant of how au nps impact cellular processes, with the charged nps inducing cell death through apoptosis and neutral nps leading to necrosis. |
2011-06-03 |
2023-08-12 |
human |
| Ritesh K Shukla, Ashutosh Kumar, Alok K Pandey, Shashi S Singh, Alok Dhawa. Titanium dioxide nanoparticles induce oxidative stress-mediated apoptosis in human keratinocyte cells. Journal of biomedical nanotechnology. vol 7. issue 1. 2011-06-01. PMID:21485823. |
our study demonstrates oxidative stress mediated apoptosis in human keratinocyte cells exposed to tio2 nps. |
2011-06-01 |
2023-08-12 |
human |
| Kyuri Lee, Hyukjin Lee, Kun Woo Lee, Tae Gwan Par. Optical imaging of intracellular reactive oxygen species for the assessment of the cytotoxicity of nanoparticles. Biomaterials. vol 32. issue 10. 2011-05-05. PMID:21247630. |
for various ps nps, the extent of intracellular ros was well correlated with cellular uptake, apoptosis inducing activity, and cytotoxic effect of nps. |
2011-05-05 |
2023-08-12 |
Not clear |
| Yaling Cui, Huiting Liu, Min Zhou, Yanmei Duan, Na Li, Xiaolan Gong, Renping Hu, Mengmeng Hong, Fashui Hon. Signaling pathway of inflammatory responses in the mouse liver caused by TiO2 nanoparticles. Journal of biomedical materials research. Part A. vol 96. issue 1. 2011-03-03. PMID:21105171. |
the results showed the titanium accumulation in liver, histopathological changes and hepatocytes apoptosis of mice liver, and the liver function damaged by tio(2) nps. |
2011-03-03 |
2023-08-12 |
mouse |
| Yaling Cui, Xiaolan Gong, Yanmei Duan, Na Li, Renping Hu, Huiting Liu, Mengmeng Hong, Min Zhou, Ling Wang, Han Wang, Fashui Hon. Hepatocyte apoptosis and its molecular mechanisms in mice caused by titanium dioxide nanoparticles. Journal of hazardous materials. vol 183. issue 1-3. 2010-12-28. PMID:20724067. |
while the hepatocyte apoptosis induced by tio(2) nanoparticles (nps) has been demonstrated, very little is known about the molecular mechanisms underlying this mouse liver apoptosis. |
2010-12-28 |
2023-08-12 |
mouse |
| Yaling Cui, Xiaolan Gong, Yanmei Duan, Na Li, Renping Hu, Huiting Liu, Mengmeng Hong, Min Zhou, Ling Wang, Han Wang, Fashui Hon. Hepatocyte apoptosis and its molecular mechanisms in mice caused by titanium dioxide nanoparticles. Journal of hazardous materials. vol 183. issue 1-3. 2010-12-28. PMID:20724067. |
in order to understand the hepatocyte apoptosis induced by intragastric administration of tio(2) nps for consecutive 60 days, the hepatocyte apoptosis, various oxidative stress parameters and the stress-related gene expression levels were assayed for the mouse liver. |
2010-12-28 |
2023-08-12 |
mouse |
| Yaling Cui, Xiaolan Gong, Yanmei Duan, Na Li, Renping Hu, Huiting Liu, Mengmeng Hong, Min Zhou, Ling Wang, Han Wang, Fashui Hon. Hepatocyte apoptosis and its molecular mechanisms in mice caused by titanium dioxide nanoparticles. Journal of hazardous materials. vol 183. issue 1-3. 2010-12-28. PMID:20724067. |
60 days of tio(2) nps exposure, hepatocyte apoptosis in the liver could be observed, which was followed by increased reactive oxygen species accumulation, and decreased the stress-related gene expression levels of superoxide dismutase, catalase, glutathione peroxidase, metallothionein, heat shock protein 70, glutathione s transferase, p53, and transferrin; and the significant enhancement of the cytochrome p450 1a expression level. |
2010-12-28 |
2023-08-12 |
mouse |
| Yaling Cui, Xiaolan Gong, Yanmei Duan, Na Li, Renping Hu, Huiting Liu, Mengmeng Hong, Min Zhou, Ling Wang, Han Wang, Fashui Hon. Hepatocyte apoptosis and its molecular mechanisms in mice caused by titanium dioxide nanoparticles. Journal of hazardous materials. vol 183. issue 1-3. 2010-12-28. PMID:20724067. |
it implied that hepatocyte apoptosis, oxidative stresses, and alteration of expression levels of the genes related with tio(2) nps detoxification/metabolism regulation and radical scavenging action. |
2010-12-28 |
2023-08-12 |
mouse |