| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amanda M Schrand, Mohammad F Rahman, Saber M Hussain, John J Schlager, David A Smith, Ali F Sye. Metal-based nanoparticles and their toxicity assessment. Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology. vol 2. issue 5. 2010-12-07. PMID:20681021. |
nps also interact with proteins and enzymes within mammalian cells and they can interfere with the antioxidant defense mechanism leading to reactive oxygen species generation, the initiation of an inflammatory response and perturbation and destruction of the mitochondria causing apoptosis or necrosis. |
2010-12-07 |
2023-08-12 |
Not clear |
| P Gopinath, Sonit Kumar Gogoi, Pallab Sanpui, Anumita Paul, Arun Chattopadhyay, Siddhartha Sankar Ghos. Signaling gene cascade in silver nanoparticle induced apoptosis. Colloids and surfaces. B, Biointerfaces. vol 77. issue 2. 2010-10-12. PMID:20197232. |
here, we have used rt-pcr to study the gene expression, flow cytometry analyses to probe the extent of apoptosis (facs) and atomic force microscopy (afm) to follow the cell membrane topology change induced by ag nps. |
2010-10-12 |
2023-08-12 |
Not clear |
| Hossein Azizi, Narges-Zare Mehrjardi, Ebrahim Shahbazi, Katayoun Hemmesi, Mirza Khalil Bahmani, Hossein Baharvan. Dehydroepiandrosterone stimulates neurogenesis in mouse embryonal carcinoma cell- and human embryonic stem cell-derived neural progenitors and induces dopaminergic neurons. Stem cells and development. vol 19. issue 6. 2010-09-16. PMID:19788394. |
this observation was related to the division of nps and the reduction of apoptosis. |
2010-09-16 |
2023-08-12 |
mouse |
| D M Gonçalves, S Chiasson, D Girar. Activation of human neutrophils by titanium dioxide (TiO2) nanoparticles. Toxicology in vitro : an international journal published in association with BIBRA. vol 24. issue 3. 2010-06-22. PMID:20005940. |
we also determined the effects of tio(2) on two neutrophil functions requiring a longer exposure period between nps and cells: apoptosis and cytokine production. |
2010-06-22 |
2023-08-12 |
human |
| Na Li, Yanmei Duan, Mengmeng Hong, Lei Zheng, Min Fei, Xiaoyang Zhao, Jue Wang, Yaling Cui, Huiting Liu, Jingwei Cai, Songjie Gong, Han Wang, Fashui Hon. Spleen injury and apoptotic pathway in mice caused by titanium dioxide nanoparticules. Toxicology letters. vol 195. issue 2-3. 2010-05-27. PMID:20381595. |
in order to understand the spleen injury induced by intraperitoneal injection of tio(2) nanoparticules (nps) for consecutive 45 days, the spleen pathological changes, apoptosis, the expression levels of the apoptotic genes and their proteins, and oxidative stress in the mouse spleen were investigated. |
2010-05-27 |
2023-08-12 |
mouse |
| Na Li, Yanmei Duan, Mengmeng Hong, Lei Zheng, Min Fei, Xiaoyang Zhao, Jue Wang, Yaling Cui, Huiting Liu, Jingwei Cai, Songjie Gong, Han Wang, Fashui Hon. Spleen injury and apoptotic pathway in mice caused by titanium dioxide nanoparticules. Toxicology letters. vol 195. issue 2-3. 2010-05-27. PMID:20381595. |
the results demonstrated that tio(2) nps had obvious accumulation in the mouse spleen, leading to congestion and lymph nodule proliferation of spleen tissue, and splenocyte apoptosis. |
2010-05-27 |
2023-08-12 |
mouse |
| Na Li, Yanmei Duan, Mengmeng Hong, Lei Zheng, Min Fei, Xiaoyang Zhao, Jue Wang, Yaling Cui, Huiting Liu, Jingwei Cai, Songjie Gong, Han Wang, Fashui Hon. Spleen injury and apoptotic pathway in mice caused by titanium dioxide nanoparticules. Toxicology letters. vol 195. issue 2-3. 2010-05-27. PMID:20381595. |
these findings provide strong evidence that the tio(2) nps can induce the spleen pathological changes, apoptosis, leading to the reduction of immunity of mice. |
2010-05-27 |
2023-08-12 |
mouse |
| Malkiel A Cohen, Pavel Itsykson, Benjamin E Reubinof. The role of FGF-signaling in early neural specification of human embryonic stem cells. Developmental biology. vol 340. issue 2. 2010-05-18. PMID:20149789. |
the early neuralization effect of fgf-signaling is not mediated by promoting the proliferation of existing neural precursors (nps) or prevention of their apoptosis. |
2010-05-18 |
2023-08-12 |
human |
| Ranjita Misra, Sanjeeb K Saho. Intracellular trafficking of nuclear localization signal conjugated nanoparticles for cancer therapy. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 39. issue 1-3. 2010-05-03. PMID:19961929. |
flow cytometry experiments results showed that nls conjugated nps are showing greater cell cycle (g2/m phase) blocking and apoptosis than native dox and unconjugated nps. |
2010-05-03 |
2023-08-12 |
Not clear |
| Maqusood Ahamed, Ryan Posgai, Timothy J Gorey, Mark Nielsen, Saber M Hussain, John J Row. Silver nanoparticles induced heat shock protein 70, oxidative stress and apoptosis in Drosophila melanogaster. Toxicology and applied pharmacology. vol 242. issue 3. 2010-02-18. PMID:19874832. |
our previous in vitro study demonstrated that ag nps caused dna damage and apoptosis in mouse embryonic stem cells and fibroblasts. |
2010-02-18 |
2023-08-12 |
mouse |
| Maqusood Ahamed, Ryan Posgai, Timothy J Gorey, Mark Nielsen, Saber M Hussain, John J Row. Silver nanoparticles induced heat shock protein 70, oxidative stress and apoptosis in Drosophila melanogaster. Toxicology and applied pharmacology. vol 242. issue 3. 2010-02-18. PMID:19874832. |
this study was undertaken to examine the toxic effects of well-characterized polysaccharide coated 10 nm ag nps on heat shock stress, oxidative stress, dna damage and apoptosis in drosophila melanogaster. |
2010-02-18 |
2023-08-12 |
mouse |
| Maqusood Ahamed, Ryan Posgai, Timothy J Gorey, Mark Nielsen, Saber M Hussain, John J Row. Silver nanoparticles induced heat shock protein 70, oxidative stress and apoptosis in Drosophila melanogaster. Toxicology and applied pharmacology. vol 242. issue 3. 2010-02-18. PMID:19874832. |
moreover, activities of caspase-3 and caspase-9, markers of apoptosis were significantly higher in ag nps exposed organisms. |
2010-02-18 |
2023-08-12 |
mouse |
| Maqusood Ahamed, Ryan Posgai, Timothy J Gorey, Mark Nielsen, Saber M Hussain, John J Row. Silver nanoparticles induced heat shock protein 70, oxidative stress and apoptosis in Drosophila melanogaster. Toxicology and applied pharmacology. vol 242. issue 3. 2010-02-18. PMID:19874832. |
the results indicate that ag nps in d. melanogaster induce heat shock stress, oxidative stress, dna damage and apoptosis. |
2010-02-18 |
2023-08-12 |
mouse |
| Yumei Liu, Wuqing Ouyang, Ziqiang Zhang, Xuefeng Yang, Shuyan M. [Effects of vinblastine nanoparticles on growth and apoptosis of glioma cell line C6]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 34. issue 14. 2009-12-08. PMID:19894518. |
to compare effects of vinblastine (vlb) nanoparticles (nps) and vlb physiologic saline solution on inhibiting glioma cell lines c6 growth and inducting its apoptosis. |
2009-12-08 |
2023-08-12 |
Not clear |
| Jennifer F Nyland, Jennifer J K Bai, Howard E Katz, Ellen K Silbergel. In vitro interactions between splenocytes and dansylamide dye-embedded nanoparticles detected by flow cytometry. Nanomedicine : nanotechnology, biology, and medicine. vol 5. issue 3. 2009-12-03. PMID:19523425. |
these results indicate that nps may affect cell function at concentrations below those inducing cytotoxicity or apoptosis and demonstrate a novel method to image both localization of nps and cell-level effects. |
2009-12-03 |
2023-08-12 |
Not clear |
| Rasmus Foldbjerg, Ping Olesen, Mads Hougaard, Duy Anh Dang, Hans Jürgen Hoffmann, Herman Autru. PVP-coated silver nanoparticles and silver ions induce reactive oxygen species, apoptosis and necrosis in THP-1 monocytes. Toxicology letters. vol 190. issue 2. 2009-09-28. PMID:19607894. |
by using the flowcytometric annexin v/propidium iodide (pi) assay, both ag nps and ag+ were shown to induce apoptosis and necrosis in thp-1 cells depending on dose and exposure time. |
2009-09-28 |
2023-08-12 |
human |
| Jiao Sun, Tingting Din. p53 reaction to apoptosis induced by hydroxyapatite nanoparticles in rat macrophages. Journal of biomedical materials research. Part A. vol 88. issue 3. 2009-03-16. PMID:18335527. |
the effects and mechanism of hydroxyapatite (hap) nanoparticles (nps) on the induction of cytotoxicity and apoptosis in rat macrophages was evaluated by testing the antiproliferative effect of hap nps with agar overlay and direct contact methods. |
2009-03-16 |
2023-08-12 |
rat |
| Jiao Sun, Tingting Din. p53 reaction to apoptosis induced by hydroxyapatite nanoparticles in rat macrophages. Journal of biomedical materials research. Part A. vol 88. issue 3. 2009-03-16. PMID:18335527. |
the characteristic morphological changes of apoptosis were observed in macrophages after treatment with hap nps for 24 h. furthermore, p53 mrna levels significantly increased when macrophages were incubated with 200 microg/ml hap nps (p < 0.01). |
2009-03-16 |
2023-08-12 |
rat |
| Jiao Sun, Tingting Din. p53 reaction to apoptosis induced by hydroxyapatite nanoparticles in rat macrophages. Journal of biomedical materials research. Part A. vol 88. issue 3. 2009-03-16. PMID:18335527. |
the conclusion is that hap nps can induce p53 expression through phosphorylation, which promotes downstream genes and finally results in cell apoptosis. |
2009-03-16 |
2023-08-12 |
rat |
| Dadong Guo, Chunhui Wu, Xiaomao Li, Hui Jiang, Xuemei Wang, Baoan Che. In vitro cellular uptake and cytotoxic effect of functionalized nickel nanoparticles on leukemia cancer cells. Journal of nanoscience and nanotechnology. vol 8. issue 5. 2008-08-13. PMID:18572641. |
the results of 3-(4,5-dimethylthiazol-2-yl)2,5-diphenyl-tetrazolium bromide (mtt) assay, dna fragmentation and flow cytometry studies demonstrate that the ni nps could exert cytotoxicity to leukemia k562 cells at high concentration, and subsequently induce both apoptosis and necrosis of target cancer cells, whilst it had little impact on target cells when at low concentration. |
2008-08-13 |
2023-08-12 |
Not clear |