| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ting Yang, Sijuan Tian, Yaohui Wang, Jing Ji, Juan Zha. Antitumor activity of pachymic acid in cervical cancer through inducing endoplasmic reticulum stress, mitochondrial dysfunction, and activating the AMPK pathway. Environmental toxicology. 2022-05-07. PMID:35524978. |
finally, we subcutaneously implanted hela cells into female nude mice and treated them with pachymic acid (50 mg/kg) for 3 weeks (5 days/week), and observed in pachymic acid induced xenograft mice, tumor growth was suppressed, cell apoptosis, er-related gene expression, and ros levels in tumor tissues were increased. |
2022-05-07 |
2023-08-13 |
mouse |
| Liling Jiang, Chuangyu Wen, Huan Zhou, Aochu Liu, Haichuan Zhang, Xinmei Chen, Wa Ding, Jinbao Liu, Xianping Sh. Cyclin-dependent kinase 7/9 inhibitor SNS-032 induces apoptosis in diffuse large B-cell lymphoma cells. Cancer biology & therapy. vol 23. issue 1. 2022-03-25. PMID:35332847. |
we report that sns-032 induced growth inhibition and cell apoptosis in both dlbcl cells in vitro, and inhibited the growth of both dlbcl xenografts in nude mice. |
2022-03-25 |
2023-08-13 |
mouse |
| Xiumei He, Yueyue Fen. MicroRNA hsa-miR-657 promotes retinoblastoma malignancy by inhibiting peroxisome proliferator-activated receptor alpha expression. Anti-cancer drugs. 2022-03-24. PMID:35324527. |
cell proliferation, apoptosis, and migration were measured in retinoblastoma cell lines, and xenografting experiments were performed using nude mice. |
2022-03-24 |
2023-08-13 |
mouse |
| Rong-Dan Lu, Zhe Huang, Jia-Min Lu, Hai-Qiang Zhang, Yong-Fu Sha. [Effect of Circular RNA hsa_circ_0067582 on the Proliferation and Invasion Ability of Gastric Cancer Cells]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 44. issue 1. 2022-03-18. PMID:35300769. |
methods after hsa_circ_0067582 overexpression (oe-circ_0067582) plasmid was transfected into ags and sgc-7901 cells,the cell viability,proliferation,invasion ability,and apoptosis were detected by cck-8,colony formation and edu assays,transwell assay,and flow cytometry,respectively.western blotting was employed to detect the expression levels of proteins related to the cell apoptosis and epithelial-mesenchymal transition(emt).the effect of oe-circ_0067582 on the growth of sgc-7901 cells in nude mice was observed.bioinformatics tools were used to predict the binding target mirna of hsa_circ_0067582,and the competing endogenous rna(cerna)regulatory network was established.finally,functional enrichment was performed to analyze the biological functions of the target genes of the predicted mirna. |
2022-03-18 |
2023-08-13 |
mouse |
| Jiao Zhang, Man-Yuan Li, Xiao Lu, Quan-Xing Liu, Dong Zhou, Gui-Xue Yang, Xiao-Qing Liu, Hong Zheng, Ji-Gang Da. CWHM-1008 Induces Apoptosis and Protective Autophagy through the Akt/mTOR Axis in LUAD Cells. Journal of oncology. vol 2021. 2022-01-31. PMID:35096055. |
moreover, cwhm-1008 significantly inhibited the growth and induced apoptosis of a549 cell in nude mice in vivo. |
2022-01-31 |
2023-08-13 |
mouse |
| Quan Jin, Jianmu Li, Fan Yang, Lingling Feng, Xin D. Circular RNA circKIF2A Contributes to the Progression of Neuroblastoma Through Regulating PRPS1 Expression by Sponging miR-377-3p. Biochemical genetics. 2022-01-18. PMID:35039981. |
functionally, the silencing of circkif2a inhibited cell proliferation, migration, invasion, and glycolysis, boosted apoptosis in neuroblastoma cells in vitro, and blocked the growth of subcutaneously transplanted tumors in nude mice. |
2022-01-18 |
2023-08-13 |
mouse |
| Changyu Zhu, Xiaolei Jiang, Hua Xiao, Jianmei Gua. Tumor-derived extracellular vesicles inhibit HGF/c-Met and EGF/EGFR pathways to accelerate the radiosensitivity of nasopharyngeal carcinoma cells via microRNA-142-5p delivery. Cell death discovery. vol 8. issue 1. 2022-01-11. PMID:35013115. |
npc xenotransplantation models in nude mice were also established by subcutaneous injection of 5-8fr cells to determine apoptosis, tumorigenicity, and radiosensitivity in nude mice. |
2022-01-11 |
2023-08-13 |
mouse |
| Changyu Zhu, Xiaolei Jiang, Hua Xiao, Jianmei Gua. Tumor-derived extracellular vesicles inhibit HGF/c-Met and EGF/EGFR pathways to accelerate the radiosensitivity of nasopharyngeal carcinoma cells via microRNA-142-5p delivery. Cell death discovery. vol 8. issue 1. 2022-01-11. PMID:35013115. |
furthermore, evs-mir-142-5p inhibited growth and radioresistance and accelerated the apoptosis of radiotherapy-resistant npc cells in nude mice by inhibiting the hgf/c-met and egf/egfr pathways. |
2022-01-11 |
2023-08-13 |
mouse |
| Wen-Hui Huang, Qing Yang, Chuan Zhan. eIF4A3-induced circWAC promotes breast cancer progression through mediating miR-599/E2F3 axis. The Kaohsiung journal of medical sciences. 2022-01-06. PMID:34989110. |
cell proliferation, migration, invasion, apoptosis, glycolysis, and tumorigenesis in nude mice were assessed to analyze the role of circwac/microrna-599 (mir-599)/e2f transcription factor 3 (e2f3) axis in bc. |
2022-01-06 |
2023-08-13 |
mouse |
| Yan Long, Yong-Rong Wu, Yin-Mei Guo, Xin-Jun Luo, Xian-Fu Li, Tian-Tian Huang, Zhen Huang, Zhuo Liu, Zheng-Jia Chen, Qing Zhou, Xue-Fei Tia. [Xihuang Pills and its main components inhibit PI3K/Akt/mTOR signaling pathways and promote the apoptosis of prostate cancer cells in PC-3 tumor-bearing mice]. Zhonghua nan ke xue = National journal of andrology. vol 27. issue 4. 2021-12-16. PMID:34914218. |
to evaluate the effects of xihuang pills (xhp) and its main components on pi3k, akt and mtor signaling pathways and cell apoptosis of castration-resistant human pca pc-3 cell subcutaneously transplanted tumors in nude mice. |
2021-12-16 |
2023-08-13 |
mouse |
| RongXin Xiao, Hong Wang, Biao Yan. MicroRNA-98-5p modulates cervical cancer progression via controlling PI3K/AKT pathway. Bioengineered. vol 12. issue 2. 2021-12-13. PMID:34895048. |
reverse transcription quantitative polymerase chain reaction was applied to detect mir-98-5p expression in cc tissues and cell lines; cell counting kit-8 and edu analysis were performed for checking cell proliferation, flow cytometry for cell apoptosis, transwell for cell invasion and migration, western blot for proliferation-related proteins ki67 and proliferating cell nuclear antigen expression, apoptosis-related proteins bcl-2 and bax expression, epithelial-mesenchymal transition (emt)-related proteins snail, matrix metalloproteinase-3, e-cadherin and n-cadherin expression, as well as pi3k/akt pathway-related proteins pten, pi3k as well as akt expression levels, and the nude mouse tumor xenograft experiment was applied to verify |
2021-12-13 |
2023-08-13 |
mouse |
| Yangqian Shi, Lingyu Meng, Chunliang Zhang, Fengmin Zhang, Yong Fan. Extracellular vesicles of Lacticaseibacillus paracasei PC-H1 induce colorectal cancer cells apoptosis via PDK1/AKT/Bcl-2 signaling pathway. Microbiological research. vol 255. 2021-12-09. PMID:34839170. |
lpevs inhibited the growth of crc xenograft in nude mice and promoted tumor apoptosis in vivo. |
2021-12-09 |
2023-08-13 |
mouse |
| Yancheng Zhong, Lanqin Cao, Haotian Ma, Qian Wang, Pingpin Wei, Juan Yang, Yuqing Mo, Lihua Cao, Cijun Shuai, Shuping Pen. Lin28A Regulates Stem-like Properties of Ovarian Cancer Cells by Enriching RAN and HSBP1 mRNA and Up-regulating its Protein Expression. International journal of biological sciences. vol 16. issue 11. 2021-11-10. PMID:32398961. |
and after knocking down of ran or hsbp1 in lin28a highly expressed oc cells, the survival and invasion of oc cells and tumor size of oc xenograft in nude mice were markedly inhibited and apoptosis was increased. |
2021-11-10 |
2023-08-13 |
mouse |
| Xiaoping Pan, Xiaolv Hong, Sumei Li, Ping Meng, Feng Xia. METTL3 promotes adriamycin resistance in MCF-7 breast cancer cells by accelerating pri-microRNA-221-3p maturation in a m6A-dependent manner. Experimental & molecular medicine. vol 53. issue 1. 2021-11-08. PMID:33420414. |
cultured adr-resistant mcf-7 cells were assayed for their half maximal inhibitory concentration (ic50) values and apoptosis using an mtt assay and annexin v-fitc/pi-labeled flow cytometry, and the cells were then xenografted into nude mice. |
2021-11-08 |
2023-08-13 |
mouse |
| Su Cui, Chun-Lu Yang, Dong-Yi Che. LncRNA EWSAT1 Regulates the Tumorigenesis of NSCLC as a ceRNA by Modulating miR-330-5p/ITGA5 Axis. Biochemical genetics. vol 59. issue 6. 2021-10-28. PMID:33928467. |
in addition, xenograft models were also constructed on nude mice to detect the tumor volume and weight, and the expression of ki67 and apoptosis in xenograft tumor were evaluated. |
2021-10-28 |
2023-08-13 |
mouse |
| Surajit Karmakar, Subhasree Roy Choudhury, Naren L Banik, Swapan K Ra. Induction of Mitochondrial Pathways and Endoplasmic Reticulum Stress for Increasing Apoptosis in Ectopic and Orthotopic Neuroblastoma Xenografts. Journal of cancer therapy. vol 2. issue 2. 2021-10-21. PMID:22468231. |
we evaluated synergistic efficacy of n-(4-hydroxyphenyl) retinamide (4-hpr) and genistein (gst) for induction of apoptosis in human malignant neuroblastoma sh-sy5y and sk-n-be2 cells in culture and activation of multiple pathways for increasing apoptosis in ectopic and orthotopic neuroblastoma xenografts in nude mice. |
2021-10-21 |
2023-08-12 |
mouse |
| Surajit Karmakar, Subhasree Roy Choudhury, Naren L Banik, Swapan K Ra. Induction of Mitochondrial Pathways and Endoplasmic Reticulum Stress for Increasing Apoptosis in Ectopic and Orthotopic Neuroblastoma Xenografts. Journal of cancer therapy. vol 2. issue 2. 2021-10-21. PMID:22468231. |
collectively, synergistic effects of 4-hpr and gst induced mitochondrial pathways and also er stress for increasing apoptosis in ectopic and orthotopic neuroblastoma xenografts in nude mice. |
2021-10-21 |
2023-08-12 |
mouse |
| Zhao Liu, Abhik Bandyopadhyay, Robert W Nichols, Long Wang, Andrew P Hinck, Shui Wang, Lu-Zhe Su. Blockade of Autocrine TGF-β Signaling Inhibits Stem Cell Phenotype, Survival, and Metastasis of Murine Breast Cancer Cells. Journal of stem cell research & therapy. vol 2. issue 1. 2021-10-21. PMID:23482850. |
when xenografted in athymic nude mice, the dnrii cells were also found to undergo apoptosis and induced significantly lower lung metastasis burden than the control cells even though they formed similar size of xenograft tumors. |
2021-10-21 |
2023-08-12 |
mouse |
| Xiao-Lin Wang, Shi-Chun Lu, Chao Sun, Wei-Guo Jin, Yi-Wei Fan, Yu-Sheng Shu, Hong-Can Shi, Ling-Feng Mi. Tripartite motif protein 11 (TRIM11), an oncogene for human lung cancer via the DUSP6-mediated ERK1/2 signaling pathway. Cancer biology & therapy. vol 22. issue 4. 2021-10-15. PMID:33970779. |
our data confirmed the anti-cancer effect of sitrim11 in human lung cancer by demonstrating inhibition of cancer cell proliferation, induction of apoptosis, prevention of 2-nbdg uptake, suppression of ld production, and prevention of lung cancer cell (a549) tumorigenicity in nude mice. |
2021-10-15 |
2023-08-13 |
mouse |
| Chen-Hua Dong, Tao Jiang, Hang Yin, Hu Song, Yi Zhang, Hao Geng, Pei-Cong Shi, Yi-Xin Xu, Hong Gao, Lian-Yu Liu, Lei Zhou, Zhao-Hui Zhang, Jun Son. LMNB2 promotes the progression of colorectal cancer by silencing p21 expression. Cell death & disease. vol 12. issue 4. 2021-10-13. PMID:33782407. |
functional analysis, including cck8 cell proliferation test, edu proliferation test, colony formation analysis, nude mouse xenograft, cell cycle, and apoptosis analysis showed that lmnb2 significantly promotes cell proliferation by promoting cell cycle progression in vivo and in vitro. |
2021-10-13 |
2023-08-13 |
mouse |