| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaodong Wang, Jin Yan, Xiaolong Ni, Sipin Hu, Mingwan Zhang, Yin Yin. Phloretin targets SIRT1 to alleviate oxidative stress, apoptosis, and inflammation in deep venous thrombosis. Toxicological research. vol 40. issue 1. 2024-01-15. PMID:38223667. |
furthermore, sirna-sirt1 transfection abolished the protective effect of phloretin against ox‑ldl‑induced dvt in huvecs, indicating that phloretin targets sirt1 to alleviate oxidative stress, cell apoptosis, and inflammation in dvt rats and huvecs. |
2024-01-15 |
2024-01-17 |
human |
| Min Huang, Junfeng Wang, Zhengrong Zhang, Xueliang Zu. ZMIZ1 Regulates Proliferation, Autophagy and Apoptosis of Colon Cancer Cells by Mediating Ubiquitin-Proteasome Degradation of SIRT1. Biochemical genetics. 2024-01-12. PMID:38214831. |
zmiz1 regulates proliferation, autophagy and apoptosis of colon cancer cells by mediating ubiquitin-proteasome degradation of sirt1. |
2024-01-12 |
2024-01-14 |
Not clear |
| Min Huang, Junfeng Wang, Zhengrong Zhang, Xueliang Zu. ZMIZ1 Regulates Proliferation, Autophagy and Apoptosis of Colon Cancer Cells by Mediating Ubiquitin-Proteasome Degradation of SIRT1. Biochemical genetics. 2024-01-12. PMID:38214831. |
knockdown or pharmacological inhibition of sirt1 neutralized the effects of zmiz knockdown on proliferation, autophagy and apoptosis in hct116 and ht29 cells. |
2024-01-12 |
2024-01-14 |
Not clear |
| Mahitab G Haggagy, Lamiaa A Ahmed, Marwa Sharaky, Mahmoud M Elhefnawi, Mervat M Omra. SIRT1 as a potential key regulator for mediating apoptosis in oropharyngeal cancer using cyclophosphamide and all-trans retinoic acid. Scientific reports. vol 14. issue 1. 2024-01-03. PMID:38167952. |
sirt1 as a potential key regulator for mediating apoptosis in oropharyngeal cancer using cyclophosphamide and all-trans retinoic acid. |
2024-01-03 |
2024-01-06 |
Not clear |
| Xiaopeng Peng, Haoyao Yuan, Guangtian Chen, Yuliang Guo, Qiuer Liang, Qiming Chen, Weidong Ca. Investigation on the effect of ulinastatin on the apoptosis of vascular smooth muscle cells in rats with aortic dissection based on the Sirt1/FoxO3a pathway. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 13. 2023-12-30. PMID:38158682. |
for this purpose a rat model of aortic dissection (ad) was constructed by giving drinking water containing 0.08% β-aminopropionitrile (bapn) to rats, he staining was used to observe the pathological changes of the aorta in ad rats; the diseased blood vessels of ad rats were taken for primary culture and passage of vsmcs, the morphology of vsmcs was observed, and vsmcs were identify with immunofluorescence staining; vsmcs were treated with culture media containing 0, 1000, 2000, 3000, 4000, 5000, 6000, 7000 u/ml ulinastatin, and mtt kit was used to determine the effect of ulinastatin on vsmc proliferation in ad rats; the vsmc of ad rats were divided into blank group (normal culture), ulinastatin group (medium containing 5000 u/ml ulinastatin), sirt1 inhibitor group (medium containing 1 μmol/l ex527), ulinastatin + sirt1 inhibitor group (medium containing 5000 u/ml ulinastatin, 1 μmol/l ex527), flow cytometry was used to detect the vsmc apoptosis in each group, wb was used to detect the expression of vsmc apoptosis-related proteins and sirt1/foxo3a pathway-related proteins in each group. |
2023-12-30 |
2024-01-05 |
rat |
| Xiaopeng Peng, Haoyao Yuan, Guangtian Chen, Yuliang Guo, Qiuer Liang, Qiming Chen, Weidong Ca. Investigation on the effect of ulinastatin on the apoptosis of vascular smooth muscle cells in rats with aortic dissection based on the Sirt1/FoxO3a pathway. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 13. 2023-12-30. PMID:38158682. |
findings suggested that the aortic wall of ad rats was thickened, and the dissection false cavity appeared; vsmc mostly presented different shapes such as triangles and stars, the immunofluorescence staining results showed that α-sma was arranged in the cytoplasm in the form of myofilaments, showing green fluorescence, and the nucleus showed blue fluorescence, and the rate of positive cells was more than 95%; various doses of ulinastatin had a certain inhibitory effect on the proliferation of vsmc, and 5000 u/ml ulinastatin had a higher proliferation inhibition rate; compared with the blank group, the vsmc apoptosis rate, caspase-3, bax protein, sirt1/foxo3a pathway related protein expression in the ulinastatin group were significantly increased, and the bcl-2 protein expression was significantly decreased (p<0.05), the vsmc apoptosis rate, caspase-3, bax protein, sirt1/foxo3a pathway related protein expression in the sirt1 inhibitor group were significantly decreased, and the bcl-2 protein expression was significantly increased (p<0.05); compared with the ulinastatin group, the vsmc apoptosis rate, caspase-3, bax protein, sirt1/foxo3a pathway related protein expression in the ulinastatin + sirt1 inhibitor group were significantly decreased, and the bcl-2 protein expression was significantly increased (p<0.05). |
2023-12-30 |
2024-01-05 |
rat |
| Jinxiao He, Fang Fan, Jingxian Li, Yi Han, Ye Song, Rong Zhang, Yang Xu, Huajie Wu, Rui Fa. SIRT1 alleviates insulin resistance and respiratory distress in late preterm rats by activating QKI5-mediated PPARγ/PI3K/AKT pathway. Cell cycle (Georgetown, Tex.). 2023-12-26. PMID:38146686. |
activation of sirt1 reversed insulin-induced reduction in cell proliferation, glucose consumption, sp-b and sp-c expression, and the activity of the pi3k/akt pathway and increase in cellular inflammation and apoptosis. |
2023-12-26 |
2023-12-28 |
rat |
| Feida Ni, Feixia Wang, Jingyi Li, Yifeng Liu, Xiao Sun, Jianpeng Chen, Jiaqun Li, Yanye Zhang, Jiani Jin, Xiaohang Ye, Mixue Tu, Jianhua Chen, Chuan Chen, Dan Zhan. BNC1 deficiency induces mitochondrial dysfunction-triggered spermatogonia apoptosis through the CREB/SIRT1/FOXO3 pathway: the therapeutic potential of nicotinamide riboside and metformin. Biology of reproduction. 2023-12-11. PMID:38079523. |
dietary supplementation with nicotinamide riboside or metformin in mutated mice increased sirt1 signaling, improved the architecture of spermatogenic tubules, inhibited apoptosis of the testis, and improved the fertility of mice with a bnc1 truncation mutation. |
2023-12-11 |
2023-12-17 |
mouse |
| Zahra Hajializadeh, Mohammad Khaksar. Cardioprotective effects of calorie restriction against inflammation and apoptosis in ovariectomized obese rats: Role of classical estrogen receptors and SIRT1. Obesity research & clinical practice. 2023-12-09. PMID:38071166. |
cardioprotective effects of calorie restriction against inflammation and apoptosis in ovariectomized obese rats: role of classical estrogen receptors and sirt1. |
2023-12-09 |
2023-12-17 |
rat |
| Yuancong Jiang, Xiaolong Miao, Zelai Wu, Weixun Xie, Li Wang, Han Liu, Weihua Gon. Targeting SIRT1 synergistically improves the antitumor effect of JQ-1 in hepatocellular carcinoma. Heliyon. vol 9. issue 11. 2023-12-04. PMID:38045194. |
in addition, jq-1 mediated ampk/p-ampk axis activation to upregulate sirt1 protein expression and enhanced autophagy to inhibit cell apoptosis. |
2023-12-04 |
2023-12-10 |
Not clear |
| Meifeng Li, Jihuan Hu, Jiazhan Zhou, Chuxin Wu, Dongming Li, Huiling Mao, Lingbao Kong, Chengyu Hu, Xiaowen X. Grass carp (Ctenopharyngodon idella) deacetylase SIRT1 targets p53 to suppress apoptosis in a KAT8 dependent or independent manner. Fish & shellfish immunology. 2023-12-03. PMID:38043873. |
grass carp (ctenopharyngodon idella) deacetylase sirt1 targets p53 to suppress apoptosis in a kat8 dependent or independent manner. |
2023-12-03 |
2023-12-10 |
Not clear |
| Meifeng Li, Jihuan Hu, Jiazhan Zhou, Chuxin Wu, Dongming Li, Huiling Mao, Lingbao Kong, Chengyu Hu, Xiaowen X. Grass carp (Ctenopharyngodon idella) deacetylase SIRT1 targets p53 to suppress apoptosis in a KAT8 dependent or independent manner. Fish & shellfish immunology. 2023-12-03. PMID:38043873. |
here, our study revealed that grass carp (ctenopharyngodon idella) sirt1 (cisirt1, mn125614.1) inhibits apoptosis through targeting p53 in a kat8-dependent or a kat8-independent manner. |
2023-12-03 |
2023-12-10 |
Not clear |
| Di Liu, Junhao Liu, Kejun Liu, Yanchao Hu, Jinming Feng, Yang Bu, Qi Wan. SIRT1 Inhibition-Induced Mitochondrial Damage Promotes GSDME-Dependent Pyroptosis in Hepatocellular Carcinoma Cells. Molecular biotechnology. 2023-12-03. PMID:38044396. |
sirt1 was upregulated in hcc tissues and cells, and a negative correlation was observed between sirt1 and gsdme-n. sirt1 silencing suppressed the proliferation, migration, and invasion of hcc cells while also promoting apoptosis and inducing mitochondrial damage. |
2023-12-03 |
2023-12-10 |
human |
| Di Liu, Junhao Liu, Kejun Liu, Yanchao Hu, Jinming Feng, Yang Bu, Qi Wan. SIRT1 Inhibition-Induced Mitochondrial Damage Promotes GSDME-Dependent Pyroptosis in Hepatocellular Carcinoma Cells. Molecular biotechnology. 2023-12-03. PMID:38044396. |
inhibition of gsdme reduced sirt1 silencing-induced cell swelling, decreased ldh release rate, and promoted apoptosis. |
2023-12-03 |
2023-12-10 |
human |
| Qian Wang, Long Bi, Jie M. [Correlation of expression of silencing information regulator 2 related enzyme 1 and tumor necrosis factor-like weak inducer of apoptosis in articular effusion and knee osteoarthritis]. Zhongguo gu shang = China journal of orthopaedics and traumatology. vol 36. issue 11. 2023-11-28. PMID:38012874. |
to analyze the correlation between the expression of silencing information regulator 2 related enzyme 1 (sirt1), tumor necrosis factor like weak inducer of apoptosis (tweak) and knee osteoarthritis. |
2023-11-28 |
2023-11-29 |
Not clear |
| Kentaro Kadono, Hidenobu Kojima, Siyuan Yao, Shoichi Kageyama, Kojiro Nakamura, Hirofumi Hirao, Takahiro Ito, Kenneth J Dery, Douglas G Farmer, Fady M Kaldas, Xiaoling Li, Jerzy W Kupiec-Weglinsk. SIRT1 regulates hepatocyte programmed cell death via GSDME - IL18 axis in human and mouse liver transplantation. Cell death & disease. vol 14. issue 11. 2023-11-25. PMID:37996424. |
indeed, hepatocyte sirt1 deficiency upregulated apoptosis and gsdme-mediated programmed cell death, deteriorating hepatocellular function and shortening olt survival. |
2023-11-25 |
2023-11-28 |
mouse |
| Kentaro Kadono, Hidenobu Kojima, Siyuan Yao, Shoichi Kageyama, Kojiro Nakamura, Hirofumi Hirao, Takahiro Ito, Kenneth J Dery, Douglas G Farmer, Fady M Kaldas, Xiaoling Li, Jerzy W Kupiec-Weglinsk. SIRT1 regulates hepatocyte programmed cell death via GSDME - IL18 axis in human and mouse liver transplantation. Cell death & disease. vol 14. issue 11. 2023-11-25. PMID:37996424. |
hepatocyte sirt1 expression regulated anti-apoptotic bcl-2/xiap proteins, suppressed cold stress-triggered apoptosis, and mitigated gsdme licensing to release il18. |
2023-11-25 |
2023-11-28 |
mouse |
| Nurul Fatihah Talib, Zunshu Zhu, Kyoung-Soo Ki. Vitamin D3 Exerts Beneficial Effects on C2C12 Myotubes through Activation of the Vitamin D Receptor (VDR)/Sirtuins (SIRT)1/3 Axis. Nutrients. vol 15. issue 22. 2023-11-25. PMID:38004107. |
in a muscle-wasting model triggered by ifn-γ/tnf-α in c2c12 myotubes, diminished vdr, sirt1, and sirt3 levels led to skeletal muscle atrophy and apoptosis. |
2023-11-25 |
2023-11-28 |
Not clear |
| Srimanta Patra, Amruta Singh, Prakash P Praharaj, Nitish K Mohanta, Mrutyunjay Jena, Birija S Patro, Ali Abusharha, Shankargouda Patil, Sujit K Bhuti. SIRT1 inhibits mitochondrial hyperfusion associated mito-bulb formation to sensitize oral cancer cells for apoptosis in a mtROS-dependent signalling pathway. Cell death & disease. vol 14. issue 11. 2023-11-10. PMID:37949849. |
sirt1 inhibits mitochondrial hyperfusion associated mito-bulb formation to sensitize oral cancer cells for apoptosis in a mtros-dependent signalling pathway. |
2023-11-10 |
2023-11-20 |
Not clear |
| Srimanta Patra, Amruta Singh, Prakash P Praharaj, Nitish K Mohanta, Mrutyunjay Jena, Birija S Patro, Ali Abusharha, Shankargouda Patil, Sujit K Bhuti. SIRT1 inhibits mitochondrial hyperfusion associated mito-bulb formation to sensitize oral cancer cells for apoptosis in a mtROS-dependent signalling pathway. Cell death & disease. vol 14. issue 11. 2023-11-10. PMID:37949849. |
further, low-dose priming with gallic acid (ga), a bio-active sirt1 activator, nullifies cddp-mediated apoptosis inhibition by suppressing mitochondrial hyperfusion. |
2023-11-10 |
2023-11-20 |
Not clear |