| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiang Xu, Caifeng Li, Junping Zou, Liang Li. MiR-34a targets SIRT1 to reduce p53 deacetylation and promote sevoflurane inhalation anesthesia-induced neuronal autophagy and apoptosis in neonatal mice. Experimental neurology. 2023-07-19. PMID:37467842. |
this study is to investigate the function of mir-34a and interactions between mir-34a, sirt1, and p53 in sevoflurane-induced neuronal apoptosis and autophagy in neonatal mice. |
2023-07-19 |
2023-08-14 |
mouse |
| Xiang Xu, Caifeng Li, Junping Zou, Liang Li. MiR-34a targets SIRT1 to reduce p53 deacetylation and promote sevoflurane inhalation anesthesia-induced neuronal autophagy and apoptosis in neonatal mice. Experimental neurology. 2023-07-19. PMID:37467842. |
mir-34a promotes sevoflurane-stimulated neuronal apoptosis and autophagy in neonatal mice by inhibiting sirt1 expression and subsequent p53 deacetylation. |
2023-07-19 |
2023-08-14 |
mouse |
| Kentaro Kadono, Hidenobu Kojima, Siyuan Yao, Shoichi Kageyama, Kojiro Nakamura, Hirofumi Hirao, Takahiro Ito, Kenneth Dery, Douglas Farmer, Fady Kaldas, Xiaoling Li, Jerzy Kupiec-Weglinsk. SIRT1 Regulates Hepatocyte Programmed Cell Death via GSDME - IL18 Axis in Human and Mouse Liver Transplantation. Research square. 2023-07-18. PMID:37461687. |
hepatocyte sirt1 deficiency upregulated apoptosis and gsdme-mediated programmed cell death, which in turn deteriorated the hepatocellular function and shortened olt survival. |
2023-07-18 |
2023-08-14 |
mouse |
| Kentaro Kadono, Hidenobu Kojima, Siyuan Yao, Shoichi Kageyama, Kojiro Nakamura, Hirofumi Hirao, Takahiro Ito, Kenneth Dery, Douglas Farmer, Fady Kaldas, Xiaoling Li, Jerzy Kupiec-Weglinsk. SIRT1 Regulates Hepatocyte Programmed Cell Death via GSDME - IL18 Axis in Human and Mouse Liver Transplantation. Research square. 2023-07-18. PMID:37461687. |
hepatocyte sirt1 signaling regulated anti-apoptotic bcl-2/xiap proteins, suppressed cold stress-triggered apoptosis, and mitigated gsdme licensing to release il18. |
2023-07-18 |
2023-08-14 |
mouse |
| A Nemmar, S Beegam, N E Zaaba, O Elzaki, A Pathan, B H Al. Waterpipe smoke inhalation induces lung injury and aortic endothelial dysfunction in mice. Physiological research. vol 72. issue 3. 2023-07-14. PMID:37449747. |
in conclusion, our study provided evidence that wps inhalation triggers lung injury and endothelial inflammation, oxidative stress and apoptosis which were associated with nuclear factor-kappab activation and sirt1 down-regulation. |
2023-07-14 |
2023-08-14 |
mouse |
| Xingyu Zhou, Yueqi Qiu, Kui Mu, Yaping L. Decreased SIRT1 protein may promote HMGB1 translocation in the keratinocytes of patients with cutaneous lupus erythematosus. Indian journal of dermatology, venereology and leprology. 2023-07-12. PMID:37436013. |
conclusion sirt1 may inhibit hmgb1 translocation by hmgb1 deacetylation which inhibited the apoptosis of keratinocytes induced by uvb. |
2023-07-12 |
2023-08-14 |
Not clear |
| Feiying Wu, Xinyu Xia, Ting Lei, Huiying Du, Hui Hua, Wei Liu, Bin Xu, Tianyao Yan. Inhibition of SIRT1 promotes ultraviolet B induced cataract via downregulation of the KEAP1/NFE2L2 signaling pathway. Journal of photochemistry and photobiology. B, Biology. vol 245. 2023-07-12. PMID:37437439. |
due to continuous exposure to ultraviolet b(uvb) radiation, eye lenses are constantly subjected to oxidative stress that induces lens epithelial cell (lec) apoptosis, which has been associated with the inactivation of sirtuin1 (sirt1). |
2023-07-12 |
2023-08-14 |
rat |
| Feiying Wu, Xinyu Xia, Ting Lei, Huiying Du, Hui Hua, Wei Liu, Bin Xu, Tianyao Yan. Inhibition of SIRT1 promotes ultraviolet B induced cataract via downregulation of the KEAP1/NFE2L2 signaling pathway. Journal of photochemistry and photobiology. B, Biology. vol 245. 2023-07-12. PMID:37437439. |
the in vivo findings revealed that uvb radiation exposure decreased sirt1 and nfe2l2 levels, upregulated keap1 expression, led to an oxidative/antioxidative imbalance and increased lec apoptosis in the eye lens. |
2023-07-12 |
2023-08-14 |
rat |
| Faiza Alam, Maheen Shahid, Sumaira Riffat, Ihsan Nazurah Zulkipli, Fatima Syed, Mussarat Ashraf, Rehana Rehma. SIRT1 and antioxidants in infertile females: Exploration of the role of vitamin D. PloS one. vol 18. issue 7. 2023-07-11. PMID:37428803. |
sirt1 and antioxidants in infertile females: exploration of the role of vitamin d. deficiency of silent information regulator 1 (sirt1) can trigger inflammation, mitochondrial malfunctioning, and apoptosis through the hypothalamic-pituitary-ovarian axis, producing poor quality oocytes, leading to infertility. |
2023-07-11 |
2023-08-14 |
Not clear |
| Yajun Cui, Weidong Zhang, Panpan Yang, Siqi Zhu, Shenglei Luo, Minqi L. Menaquinone-4 prevents medication-related osteonecrosis of the jaw through the SIRT1 signaling-mediated inhibition of cellular metabolic stresses-induced osteoblast apoptosis. Free radical biology & medicine. 2023-06-26. PMID:37364692. |
menaquinone-4 prevents medication-related osteonecrosis of the jaw through the sirt1 signaling-mediated inhibition of cellular metabolic stresses-induced osteoblast apoptosis. |
2023-06-26 |
2023-08-14 |
Not clear |
| Guang Li, Chunxiao Hu, Yan Liu, Huiqing Li. Ligustilide, a novel SIRT1 agonist, alleviates lipopolysaccharide-induced acute lung injury through deacetylation of NICD. International immunopharmacology. vol 121. 2023-06-16. PMID:37327514. |
and in sirt1 knockout mice with ali, lig pretreatment also lost its effects on inflammation, apoptosis, and oxidative stress during ali. |
2023-06-16 |
2023-08-14 |
mouse |
| Xiaomei Chen, Chongyi Li, Rui Zeng, Ling Qiu, Jianhang Huang, Ning Wang, Xia Ren, Xingwu Lin. Propofol Regulates HIF-1 α Effect of Expression of Targeted SIRT1 Signal pathway on Kidney Renal Clear Cell Carcinoma. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 3. 2023-06-11. PMID:37300675. |
it was concluded that propofol can inhibit the sirt1 signal pathway by up-regulating the level of hif-1α in kirc, which can significantly decrease the proliferation and invasion ability of kirc cells, induce apoptosis and increase the release of intracellular inflammatory factors. |
2023-06-11 |
2023-08-14 |
human |
| Bao-Feng Song, Bo-Jun Li, Jin-Zhu Ning, Yu-Qi Xia, Ze-Hua Ye, Tian-Hui Yuan, Xin-Zhou Yan, Lei Li, Xiang-Jun Zhou, Ting Rao, Wei Li, Fan Chen. Overexpression of sirtuin 1 attenuates calcium oxalate-induced kidney injury by promoting macrophage polarization. International immunopharmacology. vol 121. 2023-06-10. PMID:37301123. |
macrophages overexpressing sirt1 differentiated towards the anti-inflammatory m2 phenotype, significantly inhibiting apoptosis and alleviating injury in the kidneys of mice with hyperoxaluria. |
2023-06-10 |
2023-08-14 |
mouse |
| Bao-Feng Song, Bo-Jun Li, Jin-Zhu Ning, Yu-Qi Xia, Ze-Hua Ye, Tian-Hui Yuan, Xin-Zhou Yan, Lei Li, Xiang-Jun Zhou, Ting Rao, Wei Li, Fan Chen. Overexpression of sirtuin 1 attenuates calcium oxalate-induced kidney injury by promoting macrophage polarization. International immunopharmacology. vol 121. 2023-06-10. PMID:37301123. |
our results suggest that sirt1 promotes macrophage polarization towards the m2 phenotype by repressing the notch signaling pathway, which reduces caox crystal deposition, apoptosis, and damage in the kidney. |
2023-06-10 |
2023-08-14 |
mouse |
| Kaihui Xie, Qiaoli Yang, Zunqiang Yan, Xiaoli Gao, Xiaoyu Huang, Pengfei Wang, Jie Li, Jiyou Li, Zike Wang, Yi Gao, Shuangbao Gu. Overexpression of SIRT1 alleviates oxidative damage and barrier dysfunction in CPB2 toxin-infected IPEC-J2 cells. Microbial pathogenesis. 2023-06-05. PMID:37276895. |
the results indicated that overexpression of sirt1 suppressed reactive oxygen species (ros) generates, the expression tumor necrosis factor-α (tnf-α), interleukin (il)-6 and bax, nuclear factor-kappa b (nf-κb p65), phospho (p)-nf-kb p65 and lactate dehydrogenase (ldh) activity and apoptosis in cpb2 toxin-treated ipec-j2 cells, and increased il-10, mitochondrial membrane potential (ΔΨm), bcl-2, claudin1 and occludin levels and cell viability. |
2023-06-05 |
2023-08-14 |
Not clear |
| Mohamed F Balaha, Ahmed A Alamer, Alaa A Eisa, Hashim M Aljohan. Shikonin Alleviates Gentamicin-Induced Renal Injury in Rats by Targeting Renal Endocytosis, SIRT1/Nrf2/HO-1, TLR-4/NF-κB/MAPK, and PI3K/Akt Cascades. Antibiotics (Basel, Switzerland). vol 12. issue 5. 2023-05-27. PMID:37237729. |
these potentials could be attributed to the modulation of the renal sirt1/nrf2/ho-1, tlr-4/nf-κb/mapk, and pi3k/akt cascades, which enhanced the renal antioxidant system and suppressed renal inflammation and apoptosis, as indicated by enhancements of sirt1, nrf2, ho-1, gsh, sod, tac, iκb-α, bcl-2, pi3k, and akt levels and mrna expressions, with reduction of tlr-4, nf-κb, mapk, il-1β, tnf-α, mda, inos, no, cytochrome c, caspase-3, bax levels, and bax/bcl-2 ratio. |
2023-05-27 |
2023-08-14 |
rat |
| Cheng Huang, Zi-Jun Lin, Jui-Chieh Chen, Hao-Jun Zheng, Yu-Heng Lai, Hsiu-Chen Huan. α-Viniferin-Induced Apoptosis through Downregulation of SIRT1 in Non-Small Cell Lung Cancer Cells. Pharmaceuticals (Basel, Switzerland). vol 16. issue 5. 2023-05-27. PMID:37242510. |
α-viniferin-induced apoptosis through downregulation of sirt1 in non-small cell lung cancer cells. |
2023-05-27 |
2023-08-14 |
mouse |
| Zhonghua Zhang, Cong Liu, Xiaoming Zhou, Xin Zhan. The Critical Role of Sirt1 in Subarachnoid Hemorrhages: Mechanism and Therapeutic Considerations. Brain sciences. vol 13. issue 4. 2023-05-16. PMID:37190639. |
a growing number of studies have demonstrated that sirt1 activation may exert positive effects on sahs by regulating inflammation, oxidative stress, apoptosis, autophagy, and ferroptosis. |
2023-05-16 |
2023-08-14 |
Not clear |
| Na-Rae Joo, Sang-Ah Park, Jung-Hwan Park, Sang-Muk O. TOPK inhibits TNF-α-induced granulosa cell apoptosis via regulation of SIRT1/p53. Biochemical and biophysical research communications. vol 664. 2023-05-06. PMID:37148702. |
in addition, sirt1 inhibition augmented acetylation of p53 or expression of puma and noxa in response to tnf-α, leading to cov434 cell apoptosis. |
2023-05-06 |
2023-08-14 |
human |
| Jian Li, Yang Cao, Lin-Na Li, Xin Chu, Yan-Song Wang, Jia-Jun Cai, Jin Zhao, Song Ma, Gang Li, Zhong-Kai Fa. Neuroprotective Effects of Oxymatrine via Triggering Autophagy and Inhibiting Apoptosis Following Spinal Cord Injury in Rats. Molecular neurobiology. 2023-04-28. PMID:37115405. |
omt significantly enhanced autophagy activity, inhibited apoptosis in neurons, and increased sirt1 and p-ampk expression levels. |
2023-04-28 |
2023-08-14 |
rat |