| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Haiqiong Chen, Miaoqing Liu, Qiyao Li, Pingjiang Zhou, Jie Huang, Qiqi Zhu, Zhongrong Li, Ren-Shan G. Exposure to dipentyl phthalate in utero disrupts the adrenal cortex function of adult male rats by inhibiting SIRT1/PGC-1α and inducing AMPK phosphorylation. Environmental toxicology. 2023-01-30. PMID:36715143. |
in conclusion, in utero exposure to dpep disrupts adrenocortical function of the adult male offspring by (1) increasing ampk phosphorylation and decreasing akt1 phosphorylation and sirt1 levels, (2) reducing adrenocorticotropic hormone levels, and (3) possibly inducing oxidative stress and apoptosis. |
2023-01-30 |
2023-08-14 |
rat |
| Samira Barangi, A Wallace Hayes, Gholamreza Karim. The role of lncRNAs/miRNAs/Sirt1 axis in myocardial and cerebral injury. Cell cycle (Georgetown, Tex.). 2023-01-27. PMID:36703306. |
sirtuins, especially sirt1, have a critical function in regulating a variety of physiological processes such as oxidative stress, inflammation, apoptosis, and autophagy. |
2023-01-27 |
2023-08-14 |
Not clear |
| Liqun Xu, Xiaoyan Zhang, Gaozhi Li, Lijun Zhang, Shu Zhang, Fei Shi, Zebing H. Inhibition of SIRT1 by miR-138-5p provides a mechanism for inhibiting osteoblast proliferation and promoting apoptosis under simulated microgravity. Life sciences in space research. vol 36. 2023-01-22. PMID:36682830. |
inhibition of sirt1 by mir-138-5p provides a mechanism for inhibiting osteoblast proliferation and promoting apoptosis under simulated microgravity. |
2023-01-22 |
2023-08-14 |
Not clear |
| Liqun Xu, Xiaoyan Zhang, Gaozhi Li, Lijun Zhang, Shu Zhang, Fei Shi, Zebing H. Inhibition of SIRT1 by miR-138-5p provides a mechanism for inhibiting osteoblast proliferation and promoting apoptosis under simulated microgravity. Life sciences in space research. vol 36. 2023-01-22. PMID:36682830. |
our study further showed that sirtuin 1 (sirt1) was downregulated and negatively correlated with the expression of mir-138-5p under simulated microgravity, which indicated that mir-138-5p inhibited osteoblast proliferation and promoted osteoblast apoptosis by targeting sirt1. |
2023-01-22 |
2023-08-14 |
Not clear |
| Wenping Xiong, Dongming Li, Yu Feng, Chenguang Jia, Xiangyu Zhang, Zheng Li. CircLPAR1 Promotes Neuroinflammation and Oxidative Stress in APP/PS1 Mice by Inhibiting SIRT1/Nrf-2/HO-1 Axis Through Destabilizing GDF-15 mRNA. Molecular neurobiology. 2023-01-16. PMID:36646968. |
moreover, the protective effect of circlpar1 knockdown against aβ-induced apoptosis was abolished by gdf-15 knockdown, and sirt1 overexpression could counteract this effect of gdf-15 knockdown. |
2023-01-16 |
2023-08-14 |
mouse |
| Zhongxuan Ma, Dingding Feng, Wenjuan Rui, Zhiqing Wan. Baicalin attenuates chronic unpredictable mild stress-induced hippocampal neuronal apoptosis through regulating SIRT1/PARP1 signaling pathway. Behavioural brain research. 2023-01-15. PMID:36642102. |
meanwhile, ba significantly increased the protein level of sirt1, sirt1 inhibitor (ex-527) treatment reversed the effect of ba on reducing the protein level of parp1 and neuronal apoptosis in cums-induced mice. |
2023-01-15 |
2023-08-14 |
mouse |
| Yan Xue, Wenwen Fu, Ping Yu, Yuangeng Li, Xiaofeng Yu, Huali Xu, Dayun Su. Ginsenoside Rc Alleviates Myocardial Ischemia-Reperfusion Injury by Reducing Mitochondrial Oxidative Stress and Apoptosis: Role of SIRT1 Activation. Journal of agricultural and food chemistry. 2023-01-10. PMID:36626267. |
ginsenoside rc alleviates myocardial ischemia-reperfusion injury by reducing mitochondrial oxidative stress and apoptosis: role of sirt1 activation. |
2023-01-10 |
2023-08-14 |
Not clear |
| Fangzi Ke, Hongyun Wang, Jiaqing Geng, Fang Fang, Xiaoqi Jing, Chengzhi Fang, Bing-Hong Zhan. MiR-155 promotes inflammation and apoptosis via targeting SIRT1 in hypoxic-ischemic brain damage. Experimental neurology. 2023-01-07. PMID:36608839. |
mir-155 promotes inflammation and apoptosis via targeting sirt1 in hypoxic-ischemic brain damage. |
2023-01-07 |
2023-08-14 |
rat |
| Fangzi Ke, Hongyun Wang, Jiaqing Geng, Fang Fang, Xiaoqi Jing, Chengzhi Fang, Bing-Hong Zhan. MiR-155 promotes inflammation and apoptosis via targeting SIRT1 in hypoxic-ischemic brain damage. Experimental neurology. 2023-01-07. PMID:36608839. |
we found that mir-155 promoted inflammation and apoptosis via targeting sirt1 and negatively regulated its expression levels in oxygen-glucose deprivation/reoxygenation (ogd/r) in an in vitro model. |
2023-01-07 |
2023-08-14 |
rat |
| Fangzi Ke, Hongyun Wang, Jiaqing Geng, Fang Fang, Xiaoqi Jing, Chengzhi Fang, Bing-Hong Zhan. MiR-155 promotes inflammation and apoptosis via targeting SIRT1 in hypoxic-ischemic brain damage. Experimental neurology. 2023-01-07. PMID:36608839. |
silencing of sirt1 reversed the effects of mir-155 inhibitor on apoptosis and the nf-κb pathway in ogd/r-treated pc12 cells and microglia (bv2) cells. |
2023-01-07 |
2023-08-14 |
rat |
| Gaber El-Saber Batiha, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Engy Elekhnaw. SIRT1 pathway in Parkinson's disease: a faraway snapshot but so close. Inflammopharmacology. 2022-12-29. PMID:36580159. |
thus, sirt1 and sirt1 activators play a crucial role in the mitigation of pd neuropathology through the amelioration of oxidative stress, inflammatory disorders, mitochondrial dysfunction, apoptosis, and inflammatory signaling pathways. |
2022-12-29 |
2023-08-14 |
Not clear |
| Gang Ye, Man-Li Hu, Ling Xia. Foxa2-mediated lncRNA SOX2OT up-regulation alleviates oxidative stress and apoptosis of renal tubular epithelial cells by promoting SIRT1 expression in diabetic nephropathy. Nephrology (Carlton, Vic.). 2022-12-28. PMID:36576135. |
foxa2-mediated lncrna sox2ot up-regulation alleviates oxidative stress and apoptosis of renal tubular epithelial cells by promoting sirt1 expression in diabetic nephropathy. |
2022-12-28 |
2023-08-14 |
Not clear |
| Qiang Tu, Lingling Xu, Hufei Zhang, Yumin Qiu, Zhefu Liu, Bing Dong, Jun Ta. Andrographolide improves the dysfunction of endothelial progenitor cells from angiotensin II-induced hypertensive mice through SIRT1 signaling. Biochemical and biophysical research communications. vol 642. 2022-12-21. PMID:36543019. |
mechanistically, agp up-regulated sirt1 expression, decreased the bax/bcl-2 ratio and the expression level of cleaved caspase-3, thus inhibiting the apoptosis of ang ii induced epcs. |
2022-12-21 |
2023-08-14 |
mouse |
| Yingying Liu, Yanzhen Tan, Guojie Cao, Lei Shi, Yujie Song, Wenju Shan, Miao Zhang, Panpan Li, Haitao Zhou, Bing Zhang, Yang Sun, Wei Y. Bergenin alleviates myocardial ischemia-reperfusion injury via SIRT1 signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 158. 2022-12-20. PMID:36538860. |
here, we hypothesized that bergenin attenuated mi/r-induced apoptosis and reactive oxygen species (ros) production via sirt1. |
2022-12-20 |
2023-08-14 |
mouse |
| Yingying Liu, Yanzhen Tan, Guojie Cao, Lei Shi, Yujie Song, Wenju Shan, Miao Zhang, Panpan Li, Haitao Zhou, Bing Zhang, Yang Sun, Wei Y. Bergenin alleviates myocardial ischemia-reperfusion injury via SIRT1 signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 158. 2022-12-20. PMID:36538860. |
intriguingly, bergenin remarkably decreased apoptosis in cardiac tissue accompanied by sirt1 upregulation following mi/r injury. |
2022-12-20 |
2023-08-14 |
mouse |
| Yingying Liu, Yanzhen Tan, Guojie Cao, Lei Shi, Yujie Song, Wenju Shan, Miao Zhang, Panpan Li, Haitao Zhou, Bing Zhang, Yang Sun, Wei Y. Bergenin alleviates myocardial ischemia-reperfusion injury via SIRT1 signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 158. 2022-12-20. PMID:36538860. |
further studies showed that inhibiting sirt1 blocked bergenin's beneficial impact against apoptosis following si/r injury through excessive oxidative stress and depression of the bcl2 to bax ratio. |
2022-12-20 |
2023-08-14 |
mouse |
| Yingying Liu, Yanzhen Tan, Guojie Cao, Lei Shi, Yujie Song, Wenju Shan, Miao Zhang, Panpan Li, Haitao Zhou, Bing Zhang, Yang Sun, Wei Y. Bergenin alleviates myocardial ischemia-reperfusion injury via SIRT1 signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 158. 2022-12-20. PMID:36538860. |
collectively, these findings indicate that bergenin alleviates mi/r injury by ameliorating myocardial apoptosis and oxidative damage via the sirt1 signaling pathway. |
2022-12-20 |
2023-08-14 |
mouse |
| Maisa Siddiq Abduh, Reem S Alruhaimi, Haifa A Alqhtani, Omnia E Hussein, Mohammad H Abukhalil, Emadeldin M Kamel, Ayman M Mahmou. Rosmarinic acid mitigates chlorpyrifos-induced oxidative stress, inflammation, and kidney injury in rats by modulating SIRT1 and Nrf2/HO-1 signaling. Life sciences. 2022-12-15. PMID:36521549. |
in conclusion, ra prevented cpf nephrotoxicity by attenuating oxidative stress, inflammation, and apoptosis and upregulating sirt1 and nrf2/ho-1 signaling. |
2022-12-15 |
2023-08-14 |
rat |
| Shih-Ya Tseng, Hsien-Yuan Chang, Yi-Heng Li, Ting-Hsing Cha. Effects of Cilostazol on Angiogenesis in Diabetes through Adiponectin/Adiponectin Receptors/Sirtuin1 Signaling Pathway. International journal of molecular sciences. vol 23. issue 23. 2022-12-11. PMID:36499166. |
by sequential knockdown of adipors, sirt1, and ampk, our data demonstrated that cilostazol prevented apoptosis and stimulated proliferation, chemotactic motility, and capillary-like tube formation in hg-treated huvecs through the adipors/sirt1/ampk signaling pathway. |
2022-12-11 |
2023-08-14 |
mouse |
| Yang Deng, Junqing Zou, Ye Hong, Qiang Peng, Xinxin Fu, Rui Duan, Jie Chen, Xiangliang Che. Higher Circulating Trimethylamine N-Oxide Aggravates Cognitive Impairment Probably via Downregulating Hippocampal SIRT1 in Vascular Dementia Rats. Cells. vol 11. issue 22. 2022-11-26. PMID:36429082. |
our findings suggest that tmao increases oxidative stress-induced neuroinflammation and apoptosis by inhibiting the sirt1 pathway, thereby exacerbating cognitive dysfunction and neuropathological changes in vad rats. |
2022-11-26 |
2023-08-14 |
rat |