| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Srimanta Patra, Amruta Singh, Prakash P Praharaj, Nitish K Mohanta, Mrutyunjay Jena, Birija S Patro, Ali Abusharha, Shankargouda Patil, Sujit K Bhuti. SIRT1 inhibits mitochondrial hyperfusion associated mito-bulb formation to sensitize oral cancer cells for apoptosis in a mtROS-dependent signalling pathway. Cell death & disease. vol 14. issue 11. 2023-11-10. PMID:37949849. |
in this setting, sirt1 knockdown hinders apoptosis activation in ga-primed oral cancer cells. |
2023-11-10 |
2023-11-20 |
Not clear |
| Srimanta Patra, Amruta Singh, Prakash P Praharaj, Nitish K Mohanta, Mrutyunjay Jena, Birija S Patro, Ali Abusharha, Shankargouda Patil, Sujit K Bhuti. SIRT1 inhibits mitochondrial hyperfusion associated mito-bulb formation to sensitize oral cancer cells for apoptosis in a mtROS-dependent signalling pathway. Cell death & disease. vol 14. issue 11. 2023-11-10. PMID:37949849. |
similarly, sirt1 overexpression in the cddp resistance oral cancer-derived polyploid giant cancer cells (pgccs) re-sensitizes the cells to apoptosis. |
2023-11-10 |
2023-11-20 |
Not clear |
| Yanjun Zeng, Gang Xu, Congrui Feng, Danyan Cai, Sizhi Wu, Yuanling Liu, Yuluo Chen, Wei M. Klotho inhibits the activation of NLRP3 inflammasome to alleviate lipopolysaccharide-induced inflammatory injury in A549 cells and restore mitochondrial function through SIRT1/Nrf2 signaling pathway. The Chinese journal of physiology. vol 66. issue 5. 2023-11-06. PMID:37929344. |
however, ex527, a sirt1 inhibitor, attenuated the klotho effect to suppress viability and mitochondrial function and promoted apoptosis, inflammatory response, and oxidative stress of a549 cells. |
2023-11-06 |
2023-11-08 |
Not clear |
| Nahla E El-Ashmawy, Eman G Khedr, Naglaa F Khedr, Samar A El-Adaw. Emerging therapeutic strategy for mitigating cancer progression through inhibition of sirtuin-1 and epithelial-mesenchymal transition. Pathology, research and practice. vol 251. 2023-11-05. PMID:37925819. |
sirtuin-1 (sirt1) is a histone deacetylase that is important for signaling, cell persistence, and apoptosis. |
2023-11-05 |
2023-11-08 |
Not clear |
| Cheng Teng, Jingtao Wu, Zhao Zhang, Jinquan Wang, Ye Yang, Chengji Dong, Long Wu, Zhen Lin, Yuezheng Hu, Jing Wang, Xiaolei Zhang, Zhongke Li. Fucoxanthin ameliorates endoplasmic reticulum stress and inhibits apoptosis and alleviates intervertebral disc degeneration in rats by upregulating Sirt1. Phytotherapy research : PTR. 2023-11-02. PMID:37918392. |
fucoxanthin ameliorates endoplasmic reticulum stress and inhibits apoptosis and alleviates intervertebral disc degeneration in rats by upregulating sirt1. |
2023-11-02 |
2023-11-08 |
rat |
| Cheng Teng, Jingtao Wu, Zhao Zhang, Jinquan Wang, Ye Yang, Chengji Dong, Long Wu, Zhen Lin, Yuezheng Hu, Jing Wang, Xiaolei Zhang, Zhongke Li. Fucoxanthin ameliorates endoplasmic reticulum stress and inhibits apoptosis and alleviates intervertebral disc degeneration in rats by upregulating Sirt1. Phytotherapy research : PTR. 2023-11-02. PMID:37918392. |
after the use of fx, the expression of sirt1 was up-regulated, the activation of perk-eif2α-atf4-chop was decreased, and apoptosis and ecm degradation were decreased. |
2023-11-02 |
2023-11-08 |
rat |
| Nahid Najafi, Samira Barangi, Zahra Moosavi, Seyed Hamid Aghaee-Bakhtiari, Soghra Mehri, Gholamreza Karim. Melatonin Attenuates Arsenic-Induced Neurotoxicity in Rats Through the Regulation of miR-34a/miR-144 in Sirt1/Nrf2 Pathway. Biological trace element research. 2023-10-18. PMID:37853305. |
besides, the levels of apoptosis (caspase 3, bax/bcl2 ratio) and autophagy markers (sirt1, beclin-1, and lc3 ii/i ratio) as well as the expression of mir-144 and mir-34a in cortex tissue were determined. |
2023-10-18 |
2023-11-08 |
rat |
| Reem S Alruhaimi, Emad H M Hassanein, May N Bin-Jumah, Ayman M Mahmou. Cadmium-induced lung injury is associated with oxidative stress, apoptosis, and altered SIRT1 and Nrf2/HO-1 signaling; protective role of the melatonin agonist agomelatine. Naunyn-Schmiedeberg's archives of pharmacology. 2023-10-11. PMID:37819390. |
cadmium-induced lung injury is associated with oxidative stress, apoptosis, and altered sirt1 and nrf2/ho-1 signaling; protective role of the melatonin agonist agomelatine. |
2023-10-11 |
2023-10-15 |
rat |
| Hyeon Hee Kwon, Chi-Hoon Ahn, Hyo-Jung Lee, Deok Yong Sim, Ji Eon Park, Su-Yeon Park, Bonglee Kim, Bum-Sang Shim, Sung-Hoon Ki. The Apoptotic and Anti-Warburg Effects of Brassinin in PC-3 Cells via Reactive Oxygen Species Production and the Inhibition of the c-Myc, SIRT1, and β-Catenin Signaling Axis. International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37762214. |
taken together, these findings support evidence that brassinin induces apoptosis via the ros-mediated inhibition of sirt1, c-myc, β-catenin, and glycolysis proteins as a potent anticancer candidate. |
2023-09-28 |
2023-10-07 |
Not clear |
| Zilin Liu, Jun Huang, Xuezhong Wang, Shuang Deng, Jianlin Zhou, Ziheng Gong, Xuyang Li, Yanjie Wang, Jian Yang, Yong H. Dapagliflozin suppress endoplasmic reticulum stress mediated apoptosis of chondrocytes by activating Sirt1. Chemico-biological interactions. 2023-09-23. PMID:37741535. |
dapagliflozin suppress endoplasmic reticulum stress mediated apoptosis of chondrocytes by activating sirt1. |
2023-09-23 |
2023-10-07 |
Not clear |
| Atta Ullah, Muhammad Waqas, Sobia Ahsan Halim, Muhammad Daud, Afnan Jan, Ajmal Khan, Ahmed Al-Harras. Sirtuin 1 inhibition: a promising avenue to suppress cancer progression through small inhibitors design. Journal of biomolecular structure & dynamics. 2023-09-04. PMID:37661778. |
by raising p53 acetylation, encouraging apoptosis, and reducing cell proliferation, inhibiting sirt1's catalytic domain, which interacts with p53, shows potential as a cancer treatment. |
2023-09-04 |
2023-09-07 |
Not clear |
| Yunpeng Luo, Na Hu, Yang Zhao, Jian Lai, Xi Luo, Jingchen Li. Resveratrol‑mediated activation of SIRT1 inhibits the PERK‑eIF2α‑ATF4 pathway and mitigates bupivacaine‑induced neurotoxicity in PC12 cells. Experimental and therapeutic medicine. vol 26. issue 3. 2023-08-21. PMID:37602306. |
however, it remains unknown whether the activation of sirt1 by rsv is able to attenuate bup-induced er stress and apoptosis. |
2023-08-21 |
2023-09-07 |
Not clear |
| Yunpeng Luo, Na Hu, Yang Zhao, Jian Lai, Xi Luo, Jingchen Li. Resveratrol‑mediated activation of SIRT1 inhibits the PERK‑eIF2α‑ATF4 pathway and mitigates bupivacaine‑induced neurotoxicity in PC12 cells. Experimental and therapeutic medicine. vol 26. issue 3. 2023-08-21. PMID:37602306. |
the results revealed that bup induced cell apoptosis and decreased cell viability, accompanied by the downregulation of sirt1. |
2023-08-21 |
2023-09-07 |
Not clear |
| Yunpeng Luo, Na Hu, Yang Zhao, Jian Lai, Xi Luo, Jingchen Li. Resveratrol‑mediated activation of SIRT1 inhibits the PERK‑eIF2α‑ATF4 pathway and mitigates bupivacaine‑induced neurotoxicity in PC12 cells. Experimental and therapeutic medicine. vol 26. issue 3. 2023-08-21. PMID:37602306. |
however, rsv restored sirt1 protein expression, downregulated the expression of the pro-apoptotic protein bax, upregulated the expression of the anti-apoptotic protein bcl-2, decreased the apoptosis rate of the cells and increased cell viability. |
2023-08-21 |
2023-09-07 |
Not clear |
| Yunpeng Luo, Na Hu, Yang Zhao, Jian Lai, Xi Luo, Jingchen Li. Resveratrol‑mediated activation of SIRT1 inhibits the PERK‑eIF2α‑ATF4 pathway and mitigates bupivacaine‑induced neurotoxicity in PC12 cells. Experimental and therapeutic medicine. vol 26. issue 3. 2023-08-21. PMID:37602306. |
these results indicate that the activation of sirt1 by rsv alleviates bup-induced pc12 cell er stress and apoptosis via regulation of the perk-eif2α-atf4 pathway. |
2023-08-21 |
2023-09-07 |
Not clear |
| Yu Xia, Shanshan Li, Xixi Wang, Bing Zhao, Shasha Chen, Qihang Jiang, Shiwen Xu, Shu L. Astilbin targeted Sirt1 to inhibit acetylation of Nrf2 to alleviate grass carp hepatocyte apoptosis caused by PCB126-induced mitochondrial kinetic and metabolism dysfunctions. Fish & shellfish immunology. 2023-08-19. PMID:37597642. |
astilbin targeted sirt1 to inhibit acetylation of nrf2 to alleviate grass carp hepatocyte apoptosis caused by pcb126-induced mitochondrial kinetic and metabolism dysfunctions. |
2023-08-19 |
2023-09-07 |
cat |
| Yu Xia, Shanshan Li, Xixi Wang, Bing Zhao, Shasha Chen, Qihang Jiang, Shiwen Xu, Shu L. Astilbin targeted Sirt1 to inhibit acetylation of Nrf2 to alleviate grass carp hepatocyte apoptosis caused by PCB126-induced mitochondrial kinetic and metabolism dysfunctions. Fish & shellfish immunology. 2023-08-19. PMID:37597642. |
our findings revealed that pcb126 exposure resulted in a decrease in expression levels of sirt1, factors related to mitochondrial fusion (opa1, mfn1, and mfn2), antioxidant (cat, sod1, and sod2), energy metabolism (pkm2, idh, and sdh) and anti-apoptosis (bcl-2), and an increase in expression levels of nrf2 acetylation, mitochondrial fission (drp1), factors that promote apoptosis (cytc, bax, cas9, and cas3) in l8824 cells. |
2023-08-19 |
2023-09-07 |
cat |
| Yu Xia, Shanshan Li, Xixi Wang, Bing Zhao, Shasha Chen, Qihang Jiang, Shiwen Xu, Shu L. Astilbin targeted Sirt1 to inhibit acetylation of Nrf2 to alleviate grass carp hepatocyte apoptosis caused by PCB126-induced mitochondrial kinetic and metabolism dysfunctions. Fish & shellfish immunology. 2023-08-19. PMID:37597642. |
in summary, our findings suggested that astilbin promoted the deacetylation of nrf2 by interacting with sirt1, thereby alleviating pcb126-induced mitochondrial apoptosis mediated by mitochondrial dynamics imbalance and energy metabolism disorder through the inhibition of oxidative stress in l8824 cells. |
2023-08-19 |
2023-09-07 |
cat |
| Auwal Abdullahi, Thomson W L Wong, Shamay S M N. Putative role of non-invasive vagus nerve stimulation in cancer pathology and immunotherapy: Can this be a hidden treasure, especially for the elderly? Cancer medicine. 2023-08-17. PMID:37587897. |
the vns does this by reducing oxidative stress via silent information regulator 1 (sirt1); inhibiting inflammation via both hypothalamic-pituitary-axis (hpa) and the release of corticosteroid from the adrenal gland, and cholinergic anti-inflammatory pathway (cap), and increasing vagal activity which helps in the regulation of cell proliferation, differentiation, apoptosis, and metabolism, and increase chance of survival. |
2023-08-17 |
2023-09-07 |
Not clear |
| Xiang Xu, Caifeng Li, Junping Zou, Liang Li. MiR-34a targets SIRT1 to reduce p53 deacetylation and promote sevoflurane inhalation anesthesia-induced neuronal autophagy and apoptosis in neonatal mice. Experimental neurology. 2023-07-19. PMID:37467842. |
mir-34a targets sirt1 to reduce p53 deacetylation and promote sevoflurane inhalation anesthesia-induced neuronal autophagy and apoptosis in neonatal mice. |
2023-07-19 |
2023-08-14 |
mouse |