| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yongda Yuan, Haiyuan Teng, Tianshu Zhang, Dongsheng Wang, Haotian Gu, Weiguang L. Toxicological effects induced by two carbamates on earthworms (Eisenia fetida): Acute toxicity, arrested regeneration and underlying mechanisms. Ecotoxicology and environmental safety. vol 269. 2023-12-14. PMID:38096595. |
moreover, severely retarded posterior renewal of amputated earthworms was noticed in meb and feb treatments relative to the control group, with pronouncedly compromised morphology, dwindling segments and elevated cell apoptosis of blastema tissues, which were mediated by the rising sox2 and decreasing tctp levels. |
2023-12-14 |
2023-12-17 |
Not clear |
| Yangyi Chen, Yongge Chen, Weixian Li. Chaperonin containing TCP1 subunit 6A may activate Notch and Wnt pathways to facilitate the malignant behaviors and cancer stemness in oral squamous cell carcinoma. Cancer biology & therapy. vol 25. issue 1. 2023-12-12. PMID:38084868. |
in scc-15 and hsc-3 cells, cct6a overexpression increased cell proliferation, invasion, sphere formation, cd133, and sox2 expression, but decreased cell apoptosis; on the contrary, cct6a knockout exhibited an opposite effect on the above indexes. |
2023-12-12 |
2023-12-17 |
Not clear |
| Ilaria Roato, Giacomo Baima, Clarissa Orrico, Alessandro Mosca Balma, Daniela Alotto, Federica Romano, Riccardo Ferracini, Mario Aimetti, Federico Mussan. Senescent Markers Expressed by Periodontal Ligament-Derived Stem Cells (PDLSCs) Harvested from Patients with Periodontitis Can Be Rejuvenated by RG108. Biomedicines. vol 11. issue 9. 2023-09-28. PMID:37760976. |
rg108 did not affect the proliferation and apoptosis of pdlscs, and it showed little effect on hpdlscs, while a significant reduction of both p16 and p21 was detected along with an increase of sox2 and oct4 in ppdlscs after treatment at 100 μm rg108. |
2023-09-28 |
2023-10-07 |
Not clear |
| I V Arutyunyan, A G Soboleva, E A Kovtunov, A M Kosyreva, V V Kudelkina, A I Alekseeva, A V Elchaninov, E D Jumaniyazova, D V Goldshtein, G B Bolshakova, T Kh Fatkhudino. Gene Expression Profile of 3D Spheroids in Comparison with 2D Cell Cultures and Tissue Strains of Diffuse High-Grade Gliomas. Bulletin of experimental biology and medicine. 2023-09-28. PMID:37770789. |
using real time pcr, we evaluated the expression of gfap, cd44, pten, s100b, vegfa, hif1a, sox2, melk, gdnf, and mgmt genes playing an important role in the progression of gliomas and regulating tumor cell proliferation, adhesion, invasion, plasticity, apoptosis, dna repair, and recruitment of tumor-associated cells. |
2023-09-28 |
2023-10-07 |
Not clear |
| Wanlin Zhu, Bin Ye, Shangwen Yang, Youming L. USP10 promotes intrahepatic cholangiocarcinoma cell survival and stemness via SNAI1 deubiquitination. Journal of molecular histology. 2023-09-27. PMID:37755617. |
usp10 knockdown in rbe cells inhibited cell proliferation, promoted cell apoptosis and decreased the diameter of the formed spheres and the expression levels of cd44, epcam, oct4 and sox2. |
2023-09-27 |
2023-10-07 |
mouse |
| Swayamsiddha Kar, Niharika, Ankan Roy, Samir Kumar Patr. Overexpression of SOX2 Gene by Histone Modifications: SOX2 Enhances Human Prostate and Breast Cancer Progression by Prevention of Apoptosis and Enhancing Cell Proliferation. Oncology. 2023-08-07. PMID:37549026. |
overexpression of sox2 gene by histone modifications: sox2 enhances human prostate and breast cancer progression by prevention of apoptosis and enhancing cell proliferation. |
2023-08-07 |
2023-08-14 |
human |
| Aaron A Mehus, Madison Jones, Mason Trahan, Kaija Kinnunen, Kaitlyn Berwald, Becker Lindner, Sarmad Al-Marsoummi, Xu Dong Zhou, Scott H Garrett, Donald A Sens, Mary Ann Sens, Seema Somj. Pevonedistat Inhibits SOX2 Expression and Sphere Formation but Also Drives the Induction of Terminal Differentiation Markers and Apoptosis within Arsenite-Transformed Urothelial Cells. International journal of molecular sciences. vol 24. issue 11. 2023-06-11. PMID:37298099. |
pevonedistat inhibits sox2 expression and sphere formation but also drives the induction of terminal differentiation markers and apoptosis within arsenite-transformed urothelial cells. |
2023-06-11 |
2023-08-14 |
Not clear |
| K V Aleksandrova, I I Suvorov. Evaluation of the Effectiveness of Various Autophagy Inhibitors in A549 Cancer Stem Cells. Acta naturae. vol 15. issue 1. 2023-05-08. PMID:37153502. |
the obtained results demonstrate that autophagy inhibition by autophinib downregulates the expression of the sox2 protein in a549 cells, and that this downregulation correlates with a pronounced induction of apoptosis. |
2023-05-08 |
2023-08-14 |
human |
| Zhibin Xiao, Xiajing Zhang, Guangyao Li, Li Sun, Jiangjing Li, Ziwei Jing, Qingya Qiu, Guangxiang He, Changjun Gao, Xude Su. Tibial fracture surgery in elderly mice caused postoperative neurocognitive disorder via SOX2OT lncRNA in the hippocampus. Molecular brain. vol 16. issue 1. 2023-04-25. PMID:37098623. |
sox2ot knockdown reduced apoptosis, inhibited oxidative stress, suppressed mitochondrial hyperdivision, attenuated surgery-induced cognitive dysfunction, and promoted downstream sox2 expression in elderly mice. |
2023-04-25 |
2023-08-14 |
mouse |
| Zhongqiu Tan, Lifeng Zhao, Shiqing Huang, Qiulan Jiang, Yantao Wei, Junyun Long Wu, Zhiwen Zhang, Yepeng L. Small peptide LINC00511-133aa encoded by LINC00511 regulates breast cancer cell invasion and stemness through the Wnt/β-catenin pathway. Molecular and cellular probes. 2023-04-17. PMID:37068562. |
cell proliferation, invasion, and apoptosis were evaluated using cck8, apoptotic, wound healing, and transwell invasion assays, while the characteristic changes of tumor stem cells were detected through sphere-forming assay and western blot analyses of the stemness markers oct4, nanog, and sox2. |
2023-04-17 |
2023-08-14 |
Not clear |
| Tieqi Li, Gehou Zhang, Wei Li, Jian Xiao, Zheng Zhou, Guolin Tan, Jingang A. MicroRNA-101-3p inhibits nasopharyngeal carcinoma cell proliferation and cisplatin resistance through ZIC5 down-regulation by targeting SOX2. Biological chemistry. 2023-02-08. PMID:36752150. |
sox2 had a binding site on zic5, and sox2 promoted proliferation, migration, and cisplatin resistance and inhibited cell apoptosis by up-regulating zic5. mechanistically, mir-101-3p was decreased in cisplatin-resistant npc cells and negatively targeted sox2. |
2023-02-08 |
2023-08-14 |
mouse |
| Zhenzhen Wei, Ziyuan Wang, Qiong Chai, Zan Li, Mengjie Zhang, Yuli Zhang, Lu Zhang, Qingfeng Tang, Huirong Zhu, Hua Su. Exosomes derived from MDR cells induce cetuximab resistance in CRC via PI3K/AKT signaling‑mediated Sox2 and PD‑L1 expression. Experimental and therapeutic medicine. vol 25. issue 2. 2023-02-06. PMID:36741914. |
furthermore, exosomes derived from crc/mdr cells decreased sensitivity to cetuximab via the activation of pi3k/akt signaling, which promoted sox2 and programmed death-ligand 1 (pd-l1) mrna and protein expression according to reverse transcription-quantitative pcr, western blotting and immunohistochemistry analyses, as well as apoptosis resistance both |
2023-02-06 |
2023-08-14 |
human |
| L N Ding, Y Y Yu, C J Ma, C J Lei, H B Zhan. SOX2-associated signaling pathways regulate biological phenotypes of cancers. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 160. 2023-02-04. PMID:36738502. |
in addition, sox2 also regulates the proliferation, apoptosis, invasion, migration, ferroptosis and drug resistance of cancer cells. |
2023-02-04 |
2023-08-14 |
Not clear |
| Xueying Ma, Yizhe Dai, Tiantong Qiu, Xin Chen, Peng Xiao, Wenhua L. Effects of acute exposure to amisulbrom on retinal development in zebrafish (Danio rerio) embryos. Environmental science and pollution research international. 2023-01-30. PMID:36715803. |
compared with the control group, amisulbrom-treated zebrafish embryos displayed phenotypic microphthalmia, dysregulation of gene transcription levels (alcama, prox1a, sox2, vsx1, rho, bluops, rdops, uvops, and grops) related to the retinal cell layer differentiation, and increased retinal apoptosis. |
2023-01-30 |
2023-08-14 |
zebrafish |
| Xue-Qin Chen, Ling-Lan Li, Guo-Tao Fu, Li-Xin Han, Rui-Peng Wu, Yong-Min Xiong, Chuan-Dao Shi, Qi-Ling Liu, Rong-Qiang Zhan. [Expression and Regulatory Mechanism of Autophagy-related Genes in Synovial Tissues of Patients with Rheumatoid Arthritis]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 44. issue 6. 2023-01-09. PMID:36621784. |
objective to investigate the expression regulation of autophagy-related genes(atg)and the mechanism of autophagy in rheumatoid arthritis(ra).methods the differentially expressed genes(deg)of ra were identified from gse55235 and gse55457,on the basis of which the differentially expressed autophagy-related genes(de-atg)were selected from the human autophagy database.string 11.0 and genemania were used to establish protein-protein interaction networks.further,the transcription factor-gene-mirna co-expression network was established via networkanalyst and cytoscape.finally,receiver operating characteristic(roc)curve and drugbank were employed to evaluate the efficacy of the predicted biomarkers and the performance of drugs targeting de-atg.graphpad prism 8.2.1 and r 4.0.3 were used for statistical analysis and graphics.results a total of 485 deg were enriched in signaling pathways such as t cell activation,hormone regulation,osteoclast differentiation,ra,and chemokines.eleven de-atg regulated the expression of runx1,tp53,sox2,and hsa-mir-155-5p in synovial tissues of ra patients and were involved in the response to environmental factors such as 2,3,7,8-tetrachlorodibenzodioxin and silicon dioxide.the roc curve analysis identified the de-atg with good sensitivity and specificity,such as myc,mapk8,cdkn1a,and tnfsf10,which can be used to distinguish certain phenotypes and serve as novel biomarkers for ra.conclusions in ra,down-regulated de-atg expression may promote apoptosis and lysis of chondrocytes.the identified novel biomarkers provides new ideas and methods for diagnosing and treating ra.the establishment of transcription factor-mirna-gene co-expression network provides direct evidence for dissecting synovial inflammation and articular cartilage destruction. |
2023-01-09 |
2023-08-14 |
human |
| Gang Ye, Man-Li Hu, Ling Xia. Foxa2-mediated lncRNA SOX2OT up-regulation alleviates oxidative stress and apoptosis of renal tubular epithelial cells by promoting SIRT1 expression in diabetic nephropathy. Nephrology (Carlton, Vic.). 2022-12-28. PMID:36576135. |
we intend to investigate the function and related mechanisms of lncrna sox2 overlapping transcript (sox2ot) in high glucose (hg)-induced oxidative stress and apoptosis of renal tubular epithelial cells (rtecs). |
2022-12-28 |
2023-08-14 |
Not clear |
| Chia-Hung Hsu, Pei-Wei Weng, Ming-Yao Chen, Chi-Tai Yeh, Syahru Agung Setiawan, Vijesh Kumar Yadav, Alexander T H Wu, David T W Tzeng, Jian-Xian Gong, Zhen Yang, Yew-Min Tzen. Therapeutic targeting of hepatocellular carcinoma cells with antrocinol, a novel, dual-specificity, small-molecule inhibitor of the KRAS and ERK oncogenic signaling pathways. Chemico-biological interactions. 2022-12-24. PMID:36565974. |
additionally, antrocinol-induced apoptosis in the huh7 cell line, inhibited the formation of tumorspheres, and suppressed the expression of cancer stem cell markers cd133, klf4, cd44, oct4, sox2, and c-myc. |
2022-12-24 |
2023-08-14 |
mouse |
| Neda Rajabi, Fateme Mohammadnejad, Mohammad Amin Doustvandi, Mahdi Abdoli Shadbad, Mohammad Amini, Habib Tajalli, Ahad Mokhtarzadeh, Elham Baghbani, Nicola Silvestris, Behzad Baradara. Photodynamic therapy with zinc phthalocyanine enhances the anti-cancer effect of tamoxifen in breast cancer cell line: Promising combination treatment against triple-negative breast cancer? Photodiagnosis and photodynamic therapy. 2022-11-27. PMID:36436735. |
based on our results, monotherapies with ta and znpc-pdt can remarkably increase cell cytotoxicity effects, stimulate apoptosis via downregulating bcl-2 and upregulating caspase-3 and caspase-9, inhibit migration via downregulating snail1 and zeb1, and suppress clonogenicity via downregulating sox2 and cd44 in mda-mb-231 cells. |
2022-11-27 |
2023-08-14 |
Not clear |
| Deliang Cheng, Lijun Zhang, Xiaoju Lian. SIRT1 targeted by miR-211-5p regulated proliferation and apoptosis of Dex-treated growth plate chondrocytes via mediating SOX2. Clinical and experimental pharmacology & physiology. 2022-09-10. PMID:36086922. |
sirt1 targeted by mir-211-5p regulated proliferation and apoptosis of dex-treated growth plate chondrocytes via mediating sox2. |
2022-09-10 |
2023-08-14 |
Not clear |
| Xiaoxue Xi, Tianyue Cao, Yonghong Qian, Huiling Wang, Songwen Ju, Youguo Chen, Ting Chen, Jian Yang, Biaoquan Liang, Shunyu Ho. CDC20 is a novel biomarker for improved clinical predictions in epithelial ovarian cancer. American journal of cancer research. vol 12. issue 7. 2022-08-15. PMID:35968331. |
short hairpin rna (shrna) was used to silence cdc20 to explore its effects on eoc cell proliferation, apoptosis and sry-related hmg-box 2 (sox2) expression. |
2022-08-15 |
2023-08-14 |
Not clear |