| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kei Terasaki, Yasuyuki Gen, Naoto Iwai, Tomohiro Soda, Tomoko Kitaichi, Osamu Dohi, Hiroyoshi Taketani, Yuya Seko, Atsushi Umemura, Taichiro Nishikawa, Kanji Yamaguchi, Michihisa Moriguchi, Hideyuki Konishi, Yuji Naito, Yoshito Itoh, Kohichiroh Yasu. SOX2 enhances cell survival and induces resistance to apoptosis under serum starvation conditions through the AKT/GSK-3β signaling pathway in esophageal squamous cell carcinoma. Oncology letters. vol 21. issue 4. 2021-03-16. PMID:33717266. |
sox2 enhances cell survival and induces resistance to apoptosis under serum starvation conditions through the akt/gsk-3β signaling pathway in esophageal squamous cell carcinoma. |
2021-03-16 |
2023-08-13 |
human |
| Harish Potu, Malathi Kandarpa, Luke F Peterson, Alison Durham, Nicholas J Donato, Moshe Talpa. Downregulation of SOX2 by inhibition of Usp9X induces apoptosis in melanoma. Oncotarget. vol 12. issue 3. 2021-02-23. PMID:33613844. |
downregulation of sox2 by inhibition of usp9x induces apoptosis in melanoma. |
2021-02-23 |
2023-08-13 |
Not clear |
| Emílio Pereira de Brito Neto, Evelyze Pinheiro Dos Reis, Jurandy Mauro Penitente-Filho, José Carlos Montes, Karine Assis Costa, Susana Amaral Teixeira, Walmir Silva, Rogério Pinho, José Domingos Guimarães, Eduardo Paulino da Costa, Marcos Soares Lopes, Simone Eliza Facioni Guimarãe. Expression of apoptosis and myogenesis related genes during prenatal life in two divergent breeds of pigs. Theriogenology. vol 145. 2021-01-07. PMID:32004820. |
expression of apoptosis and myogenesis related genes (bax, bcl2, fgf4, ihh, hhip, shh, sox2, wnt1 and wnt4) were evaluated by quantitative real time pcr. |
2021-01-07 |
2023-08-13 |
Not clear |
| Islam M Saadeldin, Fariba Moulavi, Ayman Abdel-Aziz Swelum, Sokhangouy Saiede Khorshid, Hossini-Fahraji Hamid, Sayyed Morteza Hossein. Vitrification of camel oocytes transiently impacts mitochondrial functions without affecting the developmental potential after intracytoplasmic sperm injection and parthenogenetic activation. Environmental science and pollution research international. vol 27. issue 35. 2020-11-25. PMID:33029771. |
at the molecular level, vitrification reduced mrna expression of many genes, including those related to mitochondrial function (tfam, mt-co1, mfn1, atp1a1, nrf1), pluripotency (sox2 and pou5f1), and apoptosis (p53 and bax). |
2020-11-25 |
2023-08-13 |
Not clear |
| Guowei Li, Tao Chen, Yingxian Zhu, Xiaoyu Xiao, Juyuan Bu, Zongwen Huan. MiR-103 alleviates autophagy and apoptosis by regulating SOX2 in LPS-injured PC12 cells and SCI rats. Iranian journal of basic medical sciences. vol 21. issue 3. 2020-10-01. PMID:29511496. |
mir-103 alleviates autophagy and apoptosis by regulating sox2 in lps-injured pc12 cells and sci rats. |
2020-10-01 |
2023-08-13 |
rat |
| Peng Liu, Hailin Tang, Cailu Song, Jin Wang, Bo Chen, Xiaojia Huang, Xiaoqing Pei, Longzhong Li. SOX2 Promotes Cell Proliferation and Metastasis in Triple Negative Breast Cancer. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:30186173. |
moreover, inhibition of sox2 suppressed cell proliferation and invasion, induced cell apoptosis |
2020-10-01 |
2023-08-13 |
mouse |
| Lisnawati Rachmadi, Nurjati Chairani Siregar, Mpu Kanoko, Andrijono Andrijono, Saptawati Bardosono, Dwi Anita Suryandari, Sri Mutya Sekarutami, Bethy Suryawathy Hernow. Role of Cancer Stem Cell, Apoptotic Factor, DNA Repair, and Telomerase Toward Radiation Therapy Response in Stage IIIB Cervical Cancer. Oman medical journal. vol 34. issue 3. 2020-09-28. PMID:31110630. |
we sought to identify the role of sox2 and oct4 as cancer stem cell markers and their effects on apoptosis (via caspase 3), dna repair (chk1) and telomerase (htert) in conferring resistance to radiotherapy. |
2020-09-28 |
2023-08-13 |
Not clear |
| Bin Wang, Jiali Dong, Huiwen Xiao, Yuan Li, Yuxiao Jin, Ming Cui, Shu-Qin Zhang, Sai-Jun Fa. Metformin fights against radiation-induced early developmental toxicity. The Science of the total environment. vol 732. 2020-06-15. PMID:32438158. |
in addition, met degraded inflammatory reaction, hinders apoptosis response, and reprograms the development-related genes expression, such as sox2, sox3, sox19a and p53, in zebrafish embryos following radiation challenge. |
2020-06-15 |
2023-08-13 |
zebrafish |
| Xing Li, Wenhuan Bu, Lin Meng, Xinchen Liu, Shuangshuang Wang, Liming Jiang, Meisi Ren, Yu Fan, Hongchen Su. CXCL12/CXCR4 pathway orchestrates CSC-like properties by CAF recruited tumor associated macrophage in OSCC. Experimental cell research. vol 378. issue 2. 2020-05-26. PMID:30857971. |
these csc-like cells significantly expressed higher sox2, oct4, and nanog genes, were stronger positive for cd44 and cd105, increased cell proliferation with less apoptosis, enhanced cell migration, and were resistant to chemotherapy drug, vineristine. |
2020-05-26 |
2023-08-13 |
human |
| D S Kutilin, T G Airapetova, P A Anistratov, S P Pyltsin, I A Leiman, N S Karnaukhov, O I Ki. Copy Number Variation in Tumor Cells and Extracellular DNA in Patients with Lung Adenocarcinoma. Bulletin of experimental biology and medicine. vol 167. issue 6. 2020-04-27. PMID:31655998. |
changed copy numbers were detected for genes responsible for apoptosis regulation (bax, p53, and casp3), proliferation (sox2), dna reparation (xrcc1), oxidative phosphorylation (hv2), egfr signaling pathway (grb2, sos1, mapk1, stat1, and braf), and for mir3678 gene in lung tumor cells and extracellular dna. |
2020-04-27 |
2023-08-13 |
Not clear |
| Huapeng Zhang, Gongquan Li, Guanghui Chen, Yi Zhang, Jie Pan, Hongwei Tang, Jie Li, Wenzhi Guo, Shuijun Zhan. Targeting Mcl-1 inhibits survival and self-renewal of hepatocellular cancer stem-like cells. Clinics and research in hepatology and gastroenterology. vol 43. issue 3. 2020-04-20. PMID:30528319. |
inhibition of mcl-1 by specific inhibitors s63845 or a-1210477 hindered secondary sphere formation, triggered apoptosis signaling and reduced the level of stem cell transcription factor nanog, sox2 and klf4 in hcc spheroids cells. |
2020-04-20 |
2023-08-13 |
Not clear |
| Gang Liu, Biao Wang, Shubin Li, Qin Jin, Yanfeng Da. Human breast cancer decellularized scaffolds promote epithelial-to-mesenchymal transitions and stemness of breast cancer cells in vitro. Journal of cellular physiology. vol 234. issue 6. 2020-04-13. PMID:30478896. |
when treated with 5-fluorouracil, the expressions of stem cell markers, including oct4, sox2, and cd49f, were maximally maintained in the recellularized scaffold with decreased apoptosis rates compared with monolayer cells. |
2020-04-13 |
2023-08-13 |
human |
| Chao He, Chao Liu, Lei Wang, Yangbai Sun, Yuhang Jiang, Yongqiang Ha. Histone methyltransferase NSD2 regulates apoptosis and chemosensitivity in osteosarcoma. Cell death & disease. vol 10. issue 2. 2020-04-06. PMID:30683853. |
the results of chromatin immunoprecipitation quantitative polymerase chain reaction (chip-qpcr) assays indicated that nsd2 knockdown leads to decreased h3k36me2 modification at bcl2 and sox2 loci, thus inhibiting the transcription of these two genes that are closely correlated with apoptosis, csc properties and chemosensitivity in os cells. |
2020-04-06 |
2023-08-13 |
Not clear |
| Chao He, Chao Liu, Lei Wang, Yangbai Sun, Yuhang Jiang, Yongqiang Ha. Histone methyltransferase NSD2 regulates apoptosis and chemosensitivity in osteosarcoma. Cell death & disease. vol 10. issue 2. 2020-04-06. PMID:30683853. |
nsd2 regulates the expression of the apoptosis regulatory proteins bcl2 and sox2 through the erk and akt pathways. |
2020-04-06 |
2023-08-13 |
Not clear |
| Xueyan Zhang, Fang Hu, Changhui Li, Xiaoxuan Zheng, Bo Zhang, Huimin Wang, Guangyu Tao, Jianlin Xu, Yanwei Zhang, Baohui Ha. OCT4&SOX2-specific cytotoxic T lymphocytes plus programmed cell death protein 1 inhibitor presented with synergistic effect on killing lung cancer stem-like cells in vitro and treating drug-resistant lung cancer mice in vivo. Journal of cellular physiology. vol 234. issue 5. 2020-03-30. PMID:30382588. |
in vivo, tumor volume and tumor weight were decreased, while tumor necrosis and tumor apoptosis were increased in oct4&sox2 ctls group than cmv pp65 ctls group and control group, and in oct4&sox2 ctls + pd-1 inhibitor group than oct4&sox2 ctls group and pd-1 inhibitor group. |
2020-03-30 |
2023-08-13 |
mouse |
| Bahareh Ramezankhani, Masoumeh F Taha, Arash Javer. Vitamin C counteracts miR-302/367-induced reprogramming of human breast cancer cells and restores their invasive and proliferative capacity. Journal of cellular physiology. vol 234. issue 3. 2020-01-09. PMID:30191953. |
overexpression of mir-302/367 cluster in mda-mb-231 and sk-br-3 breast cancer cells upregulated expression of mir-302/367 members and also some core pluripotency factors including oct4a, sox2 and nanog, induced mesenchymal to epithelial transition, suppressed invasion, proliferation, and induced apoptosis in the both cell lines. |
2020-01-09 |
2023-08-13 |
mouse |
| Sercan Ergun, Serdar Oztuzc. Computational analysis of 3'UTR region of CASP3 with respect to miRSNPs and SNPs in targetting miRNAs. Computational biology and chemistry. vol 53PB. 2019-11-20. PMID:25462332. |
besides, mir-4802-3p targets three other apoptosis related genes, xiap, il1a and sox2. |
2019-11-20 |
2023-08-13 |
Not clear |
| Nadir Kocak, Filiz Ozen, Ibrahim Halil Yildirim, Yagmur Dura. Fentanyl Inhibits Tumorigenesis from Human Breast Stem Cells by Inducing Apoptosis Asian Pacific journal of cancer prevention : APJCP. vol 18. issue 3. 2019-11-20. PMID:28441707. |
gene expression analysis was performed by quantitative real-time pcr assay for the oct4,sox2 and nanog genes as stem cell markers and bax, bcl2, and p53 genes as apoptosis markers. |
2019-11-20 |
2023-08-13 |
human |
| Huijuan Zeng, Lulu Wang, Jingjie Wang, Tao Chen, Hanjun Li, Kai Zhang, Jing Chen, Shuang Zhen, Dilihumaer Tuluhong, Jieshou Li, Shaohua Wan. microRNA-129-5p suppresses Adriamycin resistance in breast cancer by targeting SOX2. Archives of biochemistry and biophysics. vol 651. 2019-06-24. PMID:29802821. |
the upregulation of mir-129-5p decreased the ic50 concentration of adriamycin and invasion and promoted the apoptosis of mda-mb-231/adr cells in the presence of adriamycin, whereas the upregulation of sex-determining region y-box 2 (sox2) reversed these effects. |
2019-06-24 |
2023-08-13 |
Not clear |
| Yang Wang, Hua-Jun Sun, Rong-Gui Li, Xiao-Mei Wang, Zhi-Qiang Cheng, Nan Lo. Reprogramming factors induce proliferation and inhibit apoptosis of melanoma cells by changing the expression of particular genes. Molecular medicine reports. vol 19. issue 2. 2019-05-24. PMID:30569122. |
the present study was conducted to investigate the effect of the four yamanaka reprogramming factors, namely oct4, sox2, klf4 and c‑myc (oskm), on the proliferation and apoptosis of melanoma cells, and to identify the responsible molecular signals. |
2019-05-24 |
2023-08-13 |
mouse |