| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lara C Mario, Jéssica Borghesi, Wilson T Crivellari-Damasceno, Phelipe O Favaron, Ana Claudia O Carreira, Sonia E A L Will, Durvanei A Maria, Maria A Miglin. Egg and fourth instar larvae gut of Aedes aegypti as a source of stem cells. Tissue & cell. vol 48. issue 5. 2017-03-22. PMID:27401144. |
embryonated eggs expressed markers involved with pluripotency (sox2 and oct 3/4), mesenchymal cells (vimentin and stro-1), neural cells (nestin), and cellular death by apoptosis (caspase 3). |
2017-03-22 |
2023-08-13 |
Not clear |
| Lili Du, Wen Sun, Huili Zhang, Dunjin Che. BDE-209 inhibits pluripotent genes expression and induces apoptosis in human embryonic stem cells. Journal of applied toxicology : JAT. vol 36. issue 5. 2016-12-23. PMID:26206603. |
our data showed that bde-209 exposure (1, 10 and 100 nm) reduced the expression of pluripotent genes such as oct4, sox2 and nanog and induced human embryonic stem cells (hescs) apoptosis. |
2016-12-23 |
2023-08-13 |
human |
| Wei-Wei Wang, Lin Lu, Tian-Hao Bao, Hong-Miao Zhang, Jing Yuan, Wei Miao, Shu-Fen Wang, Zhi-Cheng Xia. Scutellarin Alleviates Behavioral Deficits in a Mouse Model of Multiple Sclerosis, Possibly Through Protecting Neural Stem Cells. Journal of molecular neuroscience : MN. vol 58. issue 2. 2016-11-08. PMID:26514969. |
in the scutellarin-treated group, rotarod testing at the end of the treatment showed significant improvement of motor function (increased time to fall); myelin basic protein (mbp) staining of the corpus callosum revealed decreased demyelination; tunel staining followed by nestin or sox2 staining revealed increased number of nscs and decreased rate of nsc apoptosis in the subventricular zone (svz) of the lateral ventricles (lv). |
2016-11-08 |
2023-08-13 |
mouse |
| Chongmin Ren, Tingting Ren, Kang Yang, Shidong Wang, Xing Bao, Fan Zhang, Wei Gu. Inhibition of SOX2 induces cell apoptosis and G1/S arrest in Ewing's sarcoma through the PI3K/Akt pathway. Journal of experimental & clinical cancer research : CR. vol 35. 2016-10-13. PMID:26969300. |
inhibition of sox2 induces cell apoptosis and g1/s arrest in ewing's sarcoma through the pi3k/akt pathway. |
2016-10-13 |
2023-08-13 |
Not clear |
| Huijie Guo, Chuanlan Liu, Liuqi Yang, Lihua Dong, Li Wang, Qiaoping Wang, Haiyan Li, Jie Zhang, Ping Lin, Xiujie Wan. Morusin inhibits glioblastoma stem cell growth in vitro and in vivo through stemness attenuation, adipocyte transdifferentiation, and apoptosis induction. Molecular carcinogenesis. vol 55. issue 1. 2016-05-24. PMID:25557841. |
human gscs were enriched under nonadhesive culture system, and characterized through neurosphere formation, toluidine blue staining, immunofluorescence staining, western blotting analysis of stemness markers of cd133, nestin, sox2 and oct4, and tumorigenecity in vivo; the growth inhibition effect of morusin on human gscs in vitro and in vivo were tested by cell cytotoxicity, neurosphere formation inhibition, adipogenic differentiation, apoptosis induction, and tumor growth inhibition in vivo assays. |
2016-05-24 |
2023-08-13 |
human |
| Yang Li, Kangdong Chen, Lei Li, Rui Li, Juxin Zhang, Wu Re. Overexpression of SOX2 is involved in paclitaxel resistance of ovarian cancer via the PI3K/Akt pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 12. 2016-04-26. PMID:26159849. |
sox2 silencing significantly potentiated apoptosis induced by paclitaxel in skov3-tr with sox2 knockdown compared to skov3-tr transfected with control small interfering rna (sirna). |
2016-04-26 |
2023-08-13 |
human |
| Seung-Eun Lee, Jeremiah Ji-Man Moon, Eun-Young Kim, Se-Pill Par. Stem Cell-Derived Bioactive Materials Accelerate Development of Porcine In Vitro-Fertilized Embryos. Cellular reprogramming. vol 17. issue 3. 2016-03-10. PMID:26053518. |
the relative expression of reprogramming-related transcription factor (pou5f1, sox2, dppa5, and cdh1), antioxidant (prdx5), and apoptosis (bcl2l1 and birc5) genes also increased in two types of bms compared to the control. |
2016-03-10 |
2023-08-13 |
human |
| Volodymyr Petrenko, Jevgenia Mihhailova, Patrick Salmon, Jozsef Z Kis. Apoptotic neurons induce proliferative responses of progenitor cells in the postnatal neocortex. Experimental neurology. vol 273. 2016-02-18. PMID:26291762. |
in addition, we found that induced apoptosis triggered a massive proliferation of undifferentiated progenitor cell pool including sox2 as well as ng2 cells. |
2016-02-18 |
2023-08-13 |
Not clear |
| S Michael Rothenberg, Kyle Concannon, Sarah Cullen, Gaylor Boulay, Alexa B Turke, Anthony C Faber, Elizabeth L Lockerman, Miguel N Rivera, Jeffrey A Engelman, Shyamala Maheswaran, Daniel A Habe. Inhibition of mutant EGFR in lung cancer cells triggers SOX2-FOXO6-dependent survival pathways. eLife. vol 4. 2015-12-14. PMID:25686219. |
suppression of sox2 sensitizes cells to erlotinib-mediated apoptosis, ultimately decreasing the emergence of acquired resistance, whereas its ectopic expression reduces drug-induced cell death. |
2015-12-14 |
2023-08-13 |
Not clear |
| Ning Yang, Yan Wang, Lian Hui, Xiaotian Li, Xuejun Jian. Silencing SOX2 Expression by RNA Interference Inhibits Proliferation, Invasion and Metastasis, and Induces Apoptosis through MAP4K4/JNK Signaling Pathway in Human Laryngeal Cancer TU212 Cells. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 63. issue 9. 2015-11-06. PMID:26001828. |
silencing sox2 expression by rna interference inhibits proliferation, invasion and metastasis, and induces apoptosis through map4k4/jnk signaling pathway in human laryngeal cancer tu212 cells. |
2015-11-06 |
2023-08-13 |
human |
| Ning Yang, Yan Wang, Lian Hui, Xiaotian Li, Xuejun Jian. Silencing SOX2 Expression by RNA Interference Inhibits Proliferation, Invasion and Metastasis, and Induces Apoptosis through MAP4K4/JNK Signaling Pathway in Human Laryngeal Cancer TU212 Cells. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 63. issue 9. 2015-11-06. PMID:26001828. |
sry (sex determining region y)-box 2 (sox2) plays an important role in tumor cell metastasis and apoptosis. |
2015-11-06 |
2023-08-13 |
human |
| Ning Yang, Yan Wang, Lian Hui, Xiaotian Li, Xuejun Jian. Silencing SOX2 Expression by RNA Interference Inhibits Proliferation, Invasion and Metastasis, and Induces Apoptosis through MAP4K4/JNK Signaling Pathway in Human Laryngeal Cancer TU212 Cells. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 63. issue 9. 2015-11-06. PMID:26001828. |
our study aimed to investigate the silencing effects of sox2 expression using rna interference (rnai) on various biological processes in laryngeal cancer tu212 cells, including proliferation, apoptosis, invasion and metastasis. |
2015-11-06 |
2023-08-13 |
human |
| Ning Yang, Yan Wang, Lian Hui, Xiaotian Li, Xuejun Jian. Silencing SOX2 Expression by RNA Interference Inhibits Proliferation, Invasion and Metastasis, and Induces Apoptosis through MAP4K4/JNK Signaling Pathway in Human Laryngeal Cancer TU212 Cells. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 63. issue 9. 2015-11-06. PMID:26001828. |
we found that silencing sox2 decreased the proliferation, migration, and invasion of tu212 cells, and induced apoptosis. |
2015-11-06 |
2023-08-13 |
human |
| Eui-Ju Hong, Yeoul Choi, Hyun Yang, Hee Young Kang, Changhwan Ahn, Eui-Bae Jeun. Establishment of a rapid drug screening system based on embryonic stem cells. Environmental toxicology and pharmacology. vol 39. issue 1. 2015-11-04. PMID:25546121. |
following impairment of apoptosis, differentiation-related markers including un-differentiation (sox2), endoderm (hnf4), mesoderm (bmp4), and ectoderm (pax6) also fluctuated by treatment with pharmaceutical compounds. |
2015-11-04 |
2023-08-13 |
mouse |
| Chunfang Zhao, Ya Li, Ming Zhang, Yi Yang, Li Chan. miR-126 inhibits cell proliferation and induces cell apoptosis of hepatocellular carcinoma cells partially by targeting Sox2. Human cell. vol 28. issue 2. 2015-11-02. PMID:25585946. |
mir-126 inhibits cell proliferation and induces cell apoptosis of hepatocellular carcinoma cells partially by targeting sox2. |
2015-11-02 |
2023-08-13 |
human |
| Chen Chen, Fanrong Meng, Haisu Wan, Qinghua Zho. [Interaction between microRNAs and OCT4]. Zhongguo fei ai za zhi = Chinese journal of lung cancer. vol 18. issue 1. 2015-09-11. PMID:25603874. |
several mirnas have been demonstrated to regulate stemness factors such as oct4, nanog, sox2 and klf4 in cancer cells, thereby modulating the proliferation, apoptosis, differentiation, drug resistance and immunity of cancer cells. |
2015-09-11 |
2023-08-13 |
Not clear |
| Zhiqiang Zhao, Jun-qiang Yin, Man-si Wu, Guohui Song, Xian-biao Xie, Changye Zou, Qinglian Tang, Yuanzhong Wu, Jinchang Lu, Yongqian Wang, Jin Wang, Tiebang Kang, Qiang Jia, Jingnan She. Dihydromyricetin activates AMP-activated protein kinase and P38(MAPK) exerting antitumor potential in osteosarcoma. Cancer prevention research (Philadelphia, Pa.). vol 7. issue 9. 2015-07-21. PMID:24894198. |
we found that dihydromyricetin induced increased p21 expression and g2-m cell-cycle arrest, caused dna damage, activated atm-chk2-h2ax signaling pathways, and induced apoptosis in osteosarcoma cells as well as decreasing the sphere formation capability by downregulating sox2 expression. |
2015-07-21 |
2023-08-13 |
Not clear |
| Qiang Sun, Jidong Li, Guojing Wang, Yu Xi. Role of the embryonic protein SOX2 in cholangiocarcinoma. Cell biochemistry and biophysics. vol 70. issue 2. 2015-07-02. PMID:24906237. |
in vitro experiments showed that overexpression of sox2 in cells was associated with increased cell proliferation, suppressed cell apoptosis, as well as enhanced cell migration and invasion. |
2015-07-02 |
2023-08-13 |
Not clear |
| Dong Li, Li-Nan Zhao, Xiu-Lan Zheng, Ping Lin, Feng Lin, Yue Li, Hai-Feng Zou, Rong-Jun Cui, Hui Chen, Xiao-Guang Y. Sox2 is involved in paclitaxel resistance of the prostate cancer cell line PC-3 via the PI3K/Akt pathway. Molecular medicine reports. vol 10. issue 6. 2015-06-19. PMID:25310235. |
in the present study, using mtt, clone formation, cell cycle and apoptosis assays, over-expression of sox2 was demonstrated to enhance the paclitaxel (pac) resistance of the pc-3 prostate cancer cell line, promoting cell proliferation and exhibiting an anti‑apoptotic effect. |
2015-06-19 |
2023-08-13 |
Not clear |
| Dong Li, Li-Nan Zhao, Xiu-Lan Zheng, Ping Lin, Feng Lin, Yue Li, Hai-Feng Zou, Rong-Jun Cui, Hui Chen, Xiao-Guang Y. Sox2 is involved in paclitaxel resistance of the prostate cancer cell line PC-3 via the PI3K/Akt pathway. Molecular medicine reports. vol 10. issue 6. 2015-06-19. PMID:25310235. |
western blot analysis revealed that the phosphoinositide 3-kinase/akt signaling pathway was activated in cells overexpressing sox2, and by targeting cyclin e and survivin, sox2 promoted g1/s phase transition and prevented apoptosis under pac treatment. |
2015-06-19 |
2023-08-13 |
Not clear |