| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoxue Xi, Tianyue Cao, Yonghong Qian, Huiling Wang, Songwen Ju, Youguo Chen, Ting Chen, Jian Yang, Biaoquan Liang, Shunyu Ho. CDC20 is a novel biomarker for improved clinical predictions in epithelial ovarian cancer. American journal of cancer research. vol 12. issue 7. 2022-08-15. PMID:35968331. |
short hairpin rna (shrna) was used to silence cdc20 to explore its effects on eoc cell proliferation, apoptosis and sry-related hmg-box 2 (sox2) expression. |
2022-08-15 |
2023-08-14 |
Not clear |
| Le Zhang, Sandrine Billet, Gabrielle Gonzales, Krizia Rohena-Rivera, Hayato Muranaka, Gina Chia-Yi Chu, Qian Yang, Hyung Kim, Neil A Bhowmick, Bethany Smit. Fatty Acid Signaling Impacts Prostate Cancer Lineage Plasticity in an Autocrine and Paracrine Manner. Cancers. vol 14. issue 14. 2022-07-27. PMID:35884514. |
cd36 inhibition with enzalutamide elevated apoptosis by tunel, but limited proliferation and sox2 expression compared to enzalutamide alone. |
2022-07-27 |
2023-08-14 |
mouse |
| Yi He, Salvador Alejo, Prabhakar Pitta Venkata, Jessica D Johnson, Ilanna Loeffel, Uday P Pratap, Yi Zou, Zhao Lai, Rajeshwar R Tekmal, Edward R Kost, Gangadhara R Saredd. Therapeutic Targeting of Ovarian Cancer Stem Cells Using Estrogen Receptor Beta Agonist. International journal of molecular sciences. vol 23. issue 13. 2022-07-09. PMID:35806169. |
western blot and rt-qpcr assays demonstrated the upregulation of apoptosis and cell cycle arrest genes such as fdxr, p21/cdkn1a, cleaved parp, and caspase 3, and the downregulation of stemness markers sox2, oct4, and nanog. |
2022-07-09 |
2023-08-14 |
Not clear |
| Zhicheng Wang, Shiyi Chen, Yan Zhang, Changqi Su, Yonglan Liao, Shilin Zhang, Yan Ren, Fei Ye, Changjun Zeng, Guangbin Zhou, Hong Xian, Ming Zhan. Poly(I:C) exposure during in vitro fertilization disrupts first cleavage of mouse embryos and subsequent blastocyst development. Journal of reproductive immunology. vol 151. 2022-05-07. PMID:35525084. |
moreover, cdx2 and sox2 expression was decreased while blastocyst cell apoptosis was increased. |
2022-05-07 |
2023-08-13 |
mouse |
| Sae-Bom Yoon, Geonhee Lee, Sung Bum Park, Heeyeong Cho, Jeong-O Lee, Byumseok Ko. Properties of differentiated SH-SY5Y grown on carbon-based materials. RSC advances. vol 10. issue 33. 2022-05-06. PMID:35515479. |
the data suggest that sh-sy5y cells grown on cnt surfaces show an average 20.2% increase in cell viability; 5.7% decrease in the ratio of cells undergoing apoptosis; 78.3, 43.4 and 38.1% increases in sox2, gfap and neun expression, respectively; and a 29.7% increase in mean firing rate on a multi-electrode array. |
2022-05-06 |
2023-08-13 |
Not clear |
| Xun Fang, Bereket Molla Tanga, Seonggyu Bang, Gyeonghwan Seong, Islam M Saadeldin, Ahmad Yar Qamar, Joohyun Shim, Kimyung Choi, Sanghoon Lee, Jongki Ch. Vitamin C enhances porcine cloned embryo development and improves the derivation of embryonic stem-like cells. Reproductive biology. vol 22. issue 2. 2022-03-25. PMID:35334451. |
vitamin c decreased the gene expression of apoptosis (bax) and increased the expression of genes associated with nuclear reprogramming (nanog, pou5f1, sox2, c-myc, klf4, and tead4), antioxidation (sod1), anti-apoptotic (bcl2), and trophectoderm (cdx2). |
2022-03-25 |
2023-08-13 |
Not clear |
| Diyan Chen, Gaogan Jia, Yanping Zhang, Huanyu Mao, Liping Zhao, Wenyan Li, Yan Chen, Yusu N. Sox2 overexpression alleviates noise-induced hearing loss by inhibiting inflammation-related hair cell apoptosis. Journal of neuroinflammation. vol 19. issue 1. 2022-03-01. PMID:35227273. |
sox2 overexpression alleviates noise-induced hearing loss by inhibiting inflammation-related hair cell apoptosis. |
2022-03-01 |
2023-08-13 |
Not clear |
| Tai-Yu Chen, Ji Zhou, Peng-Cheng Li, Chun-Han Tang, Ke Xu, Tao Li, Tao Re. SOX2 knockdown with siRNA reverses cisplatin resistance in NSCLC by regulating APE1 signaling. Medical oncology (Northwood, London, England). vol 39. issue 3. 2022-01-21. PMID:35059870. |
the effects of sox2 on cell viability, proliferation, and apoptosis were evaluated in vitro. |
2022-01-21 |
2023-08-13 |
Not clear |
| Tai-Yu Chen, Ji Zhou, Peng-Cheng Li, Chun-Han Tang, Ke Xu, Tao Li, Tao Re. SOX2 knockdown with siRNA reverses cisplatin resistance in NSCLC by regulating APE1 signaling. Medical oncology (Northwood, London, England). vol 39. issue 3. 2022-01-21. PMID:35059870. |
knockdown of sox2 in a549/cddp-induced apoptosis by inhibiting colony formation and decreasing viability, but overexpression of sox2 reversed these effects. |
2022-01-21 |
2023-08-13 |
Not clear |
| Tai-Yu Chen, Ji Zhou, Peng-Cheng Li, Chun-Han Tang, Ke Xu, Tao Li, Tao Re. SOX2 knockdown with siRNA reverses cisplatin resistance in NSCLC by regulating APE1 signaling. Medical oncology (Northwood, London, England). vol 39. issue 3. 2022-01-21. PMID:35059870. |
as expected, colony formation was obviously inhibited and apoptosis was strongly enhanced in a549/cddp treated with sox2 sisox2 alone or combined with cddp compared with control cells. |
2022-01-21 |
2023-08-13 |
Not clear |
| Yingbing Zhang, Ying Yang, Peipei Qiao, Xiyue Wang, Ruiluan Yu, Hongzheng Sun, Xupeng Xing, Yong Zhang, Jianmin S. CHAF1b, chromatin assembly factor-1 subunit b, is essential for mouse preimplantation embryos. International journal of biological macromolecules. 2021-12-15. PMID:34906611. |
notably, chaf1b depletion increased apoptosis and caused down-regulated expression of key regulators of cell fate specification, including oct4, cdx2, sox2, and nanog. |
2021-12-15 |
2023-08-13 |
mouse |
| Qiaoqiao Xu, Mingming Yu, Yuxia Zhou, Zhenyao Huang, Xiaomin Huang, Bo Xu, Kun Zhou, Xiaojiao Chen, Yankai Xia, Xinru Wang, Chuncheng Lu, Xiumei Ha. Effects of 2,2',4,4'-tetrabromodiphenyl ether on the development of mouse embryonic stem cells. Reproductive toxicology (Elmsford, N.Y.). vol 106. 2021-12-06. PMID:34547414. |
overall, our findings demonstrate that bde47 exposure upregulates the expression of mir-145 and mir-34a and in turn downregulates the expression of oct4, sox2 and nanog, thereby affecting apoptosis and pluripotency and causing toxicity during embryonic development. |
2021-12-06 |
2023-08-13 |
mouse |
| Xiaozhi Liu, Lei Chen, Zhongmin Jiang, Junfei Wang, Zhiguo Su, Gang Li, Shizhu Yu, Zhenlin Li. Malignant behaviorial characteristics of CD133(+/-) glioblastoma cells from a Northern Chinese population. Experimental and therapeutic medicine. vol 5. issue 1. 2021-10-21. PMID:23251243. |
a comparison of tumor subtypes demonstrated that cd133(+) glioblastoma cells had a lower incidence of cell apoptosis in the tumor tissue and higher protein expression levels of oct4, sox2, pcna, egfr, ang2, mmp2 and mmp9 compared with cd133(-) cells. |
2021-10-21 |
2023-08-12 |
mouse |
| Diba Borzabadi Farahani, Hassan Akrami, Behrouz Moradi, Kiumars Mehdizadeh, Mohammad Reza Fattah. The Effect of hsa-miR-451b Knockdown on Biological Functions of Gastric Cancer Stem-Like Cells. Biochemical genetics. vol 59. issue 5. 2021-09-28. PMID:33725258. |
first, gastric cancer stem-like cells were transfected by hsa-mir-451b inhibitor then we used real-time rt-pcr to evaluate its effect on the expression of hsa-mir-451b and two of its direct target genes, stemness markers such as klf4, sox2, cd44, oct3/4 and nanog genes and finally akt, pi3k, bcl-2, bax, casp3 and pcna genes involved in apoptosis. |
2021-09-28 |
2023-08-13 |
Not clear |
| Xin Peng, Guanming Chen, Baozhou Lv, Jiudi L. MicroRNA-148a/152 cluster restrains tumor stem cell phenotype of colon cancer via modulating CCT6A. Anti-cancer drugs. 2021-09-06. PMID:34486532. |
upregulated mir-148a/152 depressed cct6a expression and restrained invasion and migration ability, colony formation and proliferation, induced cell apoptosis, depressed oct4, nanog and sox2 mrna expression of colon cancer stem cells, and descended tumor weight and volume in nude mice. |
2021-09-06 |
2023-08-13 |
mouse |
| Fuyuki Sato, Ujjal K Bhawal, Nao Sugiyama, Shoko Osaki, Kosuke Oikawa, Yasuteru Muragak. Potential Role of DEC1 in Cervical Cancer Cells Involving Overexpression and Apoptosis. Clocks & sleep. vol 2. issue 1. 2021-07-29. PMID:33089188. |
the stem cell markers sox2 and c-myc are involved in the regulation of apoptosis and poor prognosis. |
2021-07-29 |
2023-08-13 |
human |
| Fuyuki Sato, Ujjal K Bhawal, Nao Sugiyama, Shoko Osaki, Kosuke Oikawa, Yasuteru Muragak. Potential Role of DEC1 in Cervical Cancer Cells Involving Overexpression and Apoptosis. Clocks & sleep. vol 2. issue 1. 2021-07-29. PMID:33089188. |
combination treatment of dec1 overexpression and cisplatin inhibited apoptosis and affected sox2 and c-myc expressions in hela cells. |
2021-07-29 |
2023-08-13 |
human |
| Fuyuki Sato, Ujjal K Bhawal, Nao Sugiyama, Shoko Osaki, Kosuke Oikawa, Yasuteru Muragak. Potential Role of DEC1 in Cervical Cancer Cells Involving Overexpression and Apoptosis. Clocks & sleep. vol 2. issue 1. 2021-07-29. PMID:33089188. |
meanwhile, dec2 overexpression had little effect on apoptosis and on sox2 and c-myc expressions. |
2021-07-29 |
2023-08-13 |
human |
| Fuyuki Sato, Ujjal K Bhawal, Nao Sugiyama, Shoko Osaki, Kosuke Oikawa, Yasuteru Muragak. Potential Role of DEC1 in Cervical Cancer Cells Involving Overexpression and Apoptosis. Clocks & sleep. vol 2. issue 1. 2021-07-29. PMID:33089188. |
we conclude that dec1 has anti-apoptotic effects and regulates sox2 and c-myc expressions on apoptosis. |
2021-07-29 |
2023-08-13 |
human |
| Boyang Liu, Jian Zhou, Chenyang Wang, Yajie Chi, Quantang Wei, Zhao Fu, Changlin Lian, Qiongzhen Huang, Chenxin Liao, Zhao Yang, Huijun Zeng, Ningbo Xu, Hongbo Gu. LncRNA SOX2OT promotes temozolomide resistance by elevating SOX2 expression via ALKBH5-mediated epigenetic regulation in glioblastoma. Cell death & disease. vol 11. issue 5. 2021-04-07. PMID:32439916. |
together, these results demonstrated that lncrna sox2ot inhibited cell apoptosis, promoted cell proliferation, and tmz resistance by upregulating sox2 expression, which activated the wnt5a/β-catenin signaling pathway. |
2021-04-07 |
2023-08-13 |
Not clear |