| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chengfa Zhao, Junsong Shi, Rong Zhou, Xiaoyan He, Huaqiang Yang, Zhenfang W. DZNep and UNC0642 enhance in vitro developmental competence of cloned pig embryos. Reproduction (Cambridge, England). vol 157. issue 4. 2019-04-16. PMID:30730848. |
we found that (1) treatment with 10 nm dznep or 5 nm unc0642 for 24 h after activation had the best promoting effect on the development of cloned embryos (blastocyst rate 10.32% vs 18.08% for dznep, and 10.44% vs 18.14% for unc0642); (2) 10 nm dznep and 5 nm unc0642 significantly decreased the levels of h3k27me3 and h3k9me2, respectively, at the 2-cell, 4-cell and blastocyst stages; (3) the apoptosis level was lower in the treatment groups than in untreated control; and (4) the transcriptional expression of epigenetic genes (ezh2, glp, g9a, setdb1, setdb2, suv39h1 and suv39h2) was decreased and pluripotency genes (nanog, pou5f1, sox2 and bmp4) was increased in treatment groups compared with control. |
2019-04-16 |
2023-08-13 |
Not clear |
| Yeo-Jin Son, Seung-Eun Lee, Yun-Gwi Park, Sang-Gi Jeong, Min-Young Shin, Eun-Young Kim, Se-Pill Par. Fibroblast Growth Factor 10 Enhances the Developmental Efficiency of Somatic Cell Nuclear Transfer Embryos by Accelerating the Kinetics of Cleavage During In Vitro Maturation. Cellular reprogramming. vol 20. issue 3. 2019-04-15. PMID:29708768. |
the messenger rna (mrna) expression of genes involved in apoptosis (baculoviral inhibitor of apoptosis repeat containing 5 [birc5] and caspase 3 [casp3]) and development (octamer-binding transcription factor 4 [pou5f1] and sex determining region y box 2 [sox2]) increased after 10 f treatment. |
2019-04-15 |
2023-08-13 |
Not clear |
| Xuesong Zhang, Jianfeng Shao, Xinyan Li, Lihua Cui, Zhengbing Ta. Docetaxel promotes cell apoptosis and decreases SOX2 expression in CD133‑expressing hepatocellular carcinoma stem cells by suppressing the PI3K/AKT signaling pathway. Oncology reports. vol 41. issue 2. 2019-02-04. PMID:30483804. |
docetaxel promotes cell apoptosis and decreases sox2 expression in cd133‑expressing hepatocellular carcinoma stem cells by suppressing the pi3k/akt signaling pathway. |
2019-02-04 |
2023-08-13 |
human |
| Xuesong Zhang, Jianfeng Shao, Xinyan Li, Lihua Cui, Zhengbing Ta. Docetaxel promotes cell apoptosis and decreases SOX2 expression in CD133‑expressing hepatocellular carcinoma stem cells by suppressing the PI3K/AKT signaling pathway. Oncology reports. vol 41. issue 2. 2019-02-04. PMID:30483804. |
therefore, the present study aimed to determine the effects of docetaxel on cell apoptosis and sox2 expression in cultured human hcc stem cells. |
2019-02-04 |
2023-08-13 |
human |
| Xuesong Zhang, Jianfeng Shao, Xinyan Li, Lihua Cui, Zhengbing Ta. Docetaxel promotes cell apoptosis and decreases SOX2 expression in CD133‑expressing hepatocellular carcinoma stem cells by suppressing the PI3K/AKT signaling pathway. Oncology reports. vol 41. issue 2. 2019-02-04. PMID:30483804. |
the present study collectively indicated that docetaxel promoted apoptosis and upregulated sox2 expression of human hcc stem cells through the suppression of the pi3k/akt signaling pathway. |
2019-02-04 |
2023-08-13 |
human |
| Levon M Khachigia. The Yin and Yang of YY1 in tumor growth and suppression. International journal of cancer. vol 143. issue 3. 2019-01-01. PMID:29322514. |
on the other hand, tumor suppressor roles of yy1 appear to involve yy1 stimulation of tumor suppressor brca1, increased bax transcription and apoptosis involving cytochrome c release and caspase-3/-7 cleavage, induction of heme oxygenase-1, inhibition of prb phosphorylation and p21 binding to cyclin d1 and cdk4, reduced expression of long noncoding rna of sox2 overlapping transcript, and muc4/erbb2/p38/mef2c-dependent downregulation of mmp-10. |
2019-01-01 |
2023-08-13 |
Not clear |
| Joanna Romanek, Jolanta Opiela, Daniel Lipiński, Zdzisław Smorą. Effect of High Hydrostatic Pressure Applied Before Cryopreservation on the Survival Rate and Quality of Porcine Mesenchymal Stem Cells After Thawing. Animal biotechnology. vol 29. issue 4. 2018-12-26. PMID:29144199. |
the aim of the present study was to examine the effects of varied high hydrostatic pressure (hhp) values on survival rate, proliferation rate, cell multipotency (transcript expression of sox2, c-myc, and rex1) and apoptosis (expression of phosphatidylserine (ps), survivin at the rna level and bax at the protein level) of porcine mesenchymal stem cells (mscs). |
2018-12-26 |
2023-08-13 |
Not clear |
| Swayamsiddha Kar, Dipta Sengupta, Moonmoon Deb, Nibedita Pradhan, Samir Kumar Patr. SOX2 function and Hedgehog signaling pathway are co-conspirators in promoting androgen independent prostate cancer. Biochimica et biophysica acta. Molecular basis of disease. vol 1863. issue 1. 2018-12-11. PMID:27816521. |
sox2 was expressed in all the three cell lines and its inhibition reduced cell proliferation and induced apoptosis. |
2018-12-11 |
2023-08-13 |
human |
| Nadir Koçak, Hüseyin Dönmez, İbrahim Halil Yildiri. Effects of melatonin on apoptosis and cell differentiation in MCF-7 derived cancer stem cells. Cellular and molecular biology (Noisy-le-Grand, France). vol 64. issue 12. 2018-12-11. PMID:30301504. |
expression of genes related to apoptosis (bax and bcl2) and self-renewal and differentiation (oct4, sox2, and nanog) analyzed after the sorting of cancer stem cells from mcf-7 cells. |
2018-12-11 |
2023-08-13 |
Not clear |
| Zhiren Zhang, Yunqing Cao, Yanhui Zhai, Xiaoling Ma, Xinglan An, Sheng Zhang, Ziyi L. MicroRNA-29b regulates DNA methylation by targeting Dnmt3a/3b and Tet1/2/3 in porcine early embryo development. Development, growth & differentiation. vol 60. issue 4. 2018-10-11. PMID:29878317. |
in addition, the pluripotency genes nanog and sox2 were significantly downregulated, and the apoptosis genes bax and casp3 were upregulated, but anti-apoptosis gene bcl-2 was downregulated in blastocysts. |
2018-10-11 |
2023-08-13 |
Not clear |
| Bruno S F Souza, Gabriela L A Sampaio, Ciro S Pereira, Gubio S Campos, Silvia I Sardi, Luiz A R Freitas, Claudio P Figueira, Bruno D Paredes, Carolina K V Nonaka, Carine M Azevedo, Vinicius P C Rocha, Antonio C Bandeira, Rosalia Mendez-Otero, Ricardo Ribeiro Dos Santos, Milena B P Soare. Zika virus infection induces mitosis abnormalities and apoptotic cell death of human neural progenitor cells. Scientific reports. vol 6. 2018-07-09. PMID:28008958. |
induction of apoptosis of sox2 |
2018-07-09 |
2023-08-13 |
human |
| Anita Thyagarajan, Jeremiah Saylae, Ravi P Sah. Acetylsalicylic acid inhibits the growth of melanoma tumors via SOX2-dependent-PAF-R-independent signaling pathway. Oncotarget. vol 8. issue 30. 2018-04-23. PMID:28636992. |
interestingly, modulation of sox2 expression by pgf2α agonists and upregulation by fibroblast growth factor 1 (fgf-1) rescued melanoma cells from asa-induced decreased survival and increased apoptosis. |
2018-04-23 |
2023-08-13 |
mouse |
| Hassan Nazari, Abolfazl Shirazi, Naser Shams-Esfandabadi, Azita Afzali, Ebrahim Ahmad. The effect of amniotic membrane stem cells as donor nucleus on gene expression in reconstructed bovine oocytes. The International journal of developmental biology. vol 60. issue 4-6. 2018-01-31. PMID:27389982. |
the expression pattern of genes involved in self-renewal and pluripotency (pou5f1, sox2, nanog), imprinting (igf2, igf2r), dna methylation (dnmt1, dnmt3a), histone deacetylation (hdac2), and apoptosis (bax, bcl2) were evaluated in nt and ivf derived embryos. |
2018-01-31 |
2023-08-13 |
cattle |
| Taeho Kwon, Yesol Bak, Young-Ho Park, Gyu-Beom Jang, Jeong-Seok Nam, Jeong Eun Yoo, Young Nyun Park, In Seon Bak, Jin-Man Kim, Do-Young Yoon, Dae-Yeul Y. Peroxiredoxin II Is Essential for Maintaining Stemness by Redox Regulation in Liver Cancer Cells. Stem cells (Dayton, Ohio). vol 34. issue 5. 2017-12-04. PMID:26866938. |
downregulation of prx ii in huh7 cells with treatment of sirna reduced expression of epcam and cd133 as well as sox2 in accordance with increased ros and apoptosis, which were reversed in huh7-hprx ii cells. |
2017-12-04 |
2023-08-13 |
Not clear |
| Huixiao Dong, Xiuzhen Hao, Benliang Cui, Meiling Gu. MiR-429 suppresses glioblastoma multiforme by targeting SOX2. Cell biochemistry and function. vol 35. issue 5. 2017-08-15. PMID:28749077. |
enforced expression of mir-429 inhibits gbm cells proliferation, induces apoptosis and suppresses invasion and leads to the downregulation of the sox2 protein. |
2017-08-15 |
2023-08-13 |
Not clear |
| Xuan Li, Yan-Kui Wang, Zhi-Qiang Song, Zhi-Qiang Du, Cai-Xia Yan. Dimethyl Sulfoxide Perturbs Cell Cycle Progression and Spindle Organization in Porcine Meiotic Oocytes. PloS one. vol 11. issue 6. 2017-07-24. PMID:27348312. |
3% dmso treatment did not affect expression of genes involved in spindle organization (bub1 and mad2) and apoptosis (nf-κb, pten, bcl2, caspase3 and caspase9), however, it significantly decreased expression levels of pluripotency genes (oct4, sox2 and lin28) in mature oocytes. |
2017-07-24 |
2023-08-13 |
mouse |
| Jinxi He, Juan Shi, Kangjian Zhang, Jing Xue, Jing Li, Jiali Yang, Juan Chen, Jun Wei, Hong Ren, Xiaoming Li. Sox2 inhibits Wnt-β-catenin signaling and metastatic potency of cisplatin-resistant lung adenocarcinoma cells. Molecular medicine reports. vol 15. issue 4. 2017-05-22. PMID:28259951. |
notably, knockdown sox2 using short hairpin rna led to an enhanced susceptibility of a549 and a549/ddp cells to cisplatin, along with increased cell apoptosis. |
2017-05-22 |
2023-08-13 |
Not clear |
| Feng Zhong, Xinsheng Cheng, Shibo Sun, Jie Zho. Transcriptional activation of PD-L1 by Sox2 contributes to the proliferation of hepatocellular carcinoma cells. Oncology reports. vol 37. issue 5. 2017-05-08. PMID:28339084. |
knockdown of sox2 reduced the cell proliferation ability and induces apoptosis of hcc cells, suggesting the function of sox2 in regulating both the cell proliferation and apoptosis. |
2017-05-08 |
2023-08-13 |
Not clear |
| Chang-Nim Im, Hye Hyeon Yun, Jeong-Hwa Le. Heat Shock Factor 1 Depletion Sensitizes A172 Glioblastoma Cells to Temozolomide via Suppression of Cancer Stem Cell-Like Properties. International journal of molecular sciences. vol 18. issue 2. 2017-04-20. PMID:28241425. |
when hsf1 or bis knockdown was combined with temozolomide (tmz) treatment, a standard drug used in glioblastoma therapy, apoptosis increased, as measured by an increase in poly (adp-ribose) polymerase (parp) cleavage, whereas cancer stem-like properties, such as colony-forming activity and sox2 protein expression, decreased. |
2017-04-20 |
2023-08-13 |
Not clear |
| Katia Cortese, Antonio Daga, Massimiliano Monticone, Sara Tavella, Alessia Stefanelli, Cinzia Aiello, Angela Bisio, Grazia Bellese, Patrizio Castagnol. Carnosic acid induces proteasomal degradation of Cyclin B1, RB and SOX2 along with cell growth arrest and apoptosis in GBM cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 23. issue 7. 2017-04-07. PMID:27235706. |
carnosic acid induces proteasomal degradation of cyclin b1, rb and sox2 along with cell growth arrest and apoptosis in gbm cells. |
2017-04-07 |
2023-08-13 |
Not clear |