| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ruopeng Feng, Shixin Zhou, Yinan Liu, Daijun Song, Zhilin Luan, Xin Dai, Yang Li, Na Tang, Jinhua Wen, Lingsong L. Sox2 protects neural stem cells from apoptosis via up-regulating survivin expression. The Biochemical journal. vol 450. issue 3. 2013-04-17. PMID:23301561. |
furthermore, cell apoptosis owing to knockdown of sox2 can be rescued by ectopically expressing survivin in nscs as well as in the mouse brain, as demonstrated by an in utero-injection approach. |
2013-04-17 |
2023-08-12 |
mouse |
| Gerald Thie. How Sox2 maintains neural stem cell identity. The Biochemical journal. vol 450. issue 3. 2013-04-17. PMID:23445224. |
the regulation of survivin expression by sox2 explains why the reduction of the sox2 concentration in neural stem cells is accompanied by a reduced proliferation of the cells and an induction of apoptosis. |
2013-04-17 |
2023-08-12 |
Not clear |
| Tian Tian, Yajie Zhang, Shouyu Wang, Jianwei Zhou, Shan X. Sox2 enhances the tumorigenicity and chemoresistance of cancer stem-like cells derived from gastric cancer. Journal of biomedical research. vol 26. issue 5. 2013-04-05. PMID:23554769. |
importantly, downregulation of sox2 with sirna obviously reduced spheroid colony formation and doxorubicin efflux, as well as increased apoptosis rate in sphere cells in vitro and suppressed tumorigenicity in vivo. |
2013-04-05 |
2023-08-12 |
human |
| Cathy Lee, Abbas Fotovati, Joanna Triscott, James Chen, Chitra Venugopal, Ash Singhal, Christopher Dunham, John M Kerr, Maite Verreault, Stephen Yip, Hiroaki Wakimoto, Chris Jones, Aarthi Jayanthan, Aru Narendran, Sheila K Singh, Sandra E Dun. Polo-like kinase 1 inhibition kills glioblastoma multiforme brain tumor cells in part through loss of SOX2 and delays tumor progression in mice. Stem cells (Dayton, Ohio). vol 30. issue 6. 2012-11-29. PMID:22415968. |
plk1 inhibition suppressed growth, caused g(2) /m arrest, induced apoptosis, and reduced the expression of sox2, a marker of neural stem cells, in sf188 cells. |
2012-11-29 |
2023-08-12 |
mouse |
| D Drakulic, A Krstic, M Stevanovi. Establishment and initial characterization of SOX2-overexpressing NT2/D1 cell clones. Genetics and molecular research : GMR. vol 11. issue 2. 2012-09-27. PMID:22653585. |
sox2 overexpression did not increase the population of cells undergoing apoptosis. |
2012-09-27 |
2023-08-12 |
Not clear |
| F Lin, P Lin, D Zhao, Y Chen, L Xiao, W Qin, D Li, H Chen, B Zhao, H Zou, X Zheng, X Y. Sox2 targets cyclinE, p27 and survivin to regulate androgen-independent human prostate cancer cell proliferation and apoptosis. Cell proliferation. vol 45. issue 3. 2012-06-04. PMID:22469032. |
sox2 targets cycline, p27 and survivin to regulate androgen-independent human prostate cancer cell proliferation and apoptosis. |
2012-06-04 |
2023-08-12 |
human |
| F Lin, P Lin, D Zhao, Y Chen, L Xiao, W Qin, D Li, H Chen, B Zhao, H Zou, X Zheng, X Y. Sox2 targets cyclinE, p27 and survivin to regulate androgen-independent human prostate cancer cell proliferation and apoptosis. Cell proliferation. vol 45. issue 3. 2012-06-04. PMID:22469032. |
in this study, we have evaluated the effects and potential mechanisms of sox2 on cell proliferation and apoptosis, and investigated effects of tgf-α on expression of sox2 on androgen-independent human prostate cancer cells. |
2012-06-04 |
2023-08-12 |
human |
| Hong-Ying Zhen, Qi-Hua He, Yong-Zhan Zhen, Shu-Ling Wang, Yi-Nan Liu, Wei-Hua Wu, Xiao-Yan Zhang, Ai-Li Lu, Li She. Inhibition of mouse embryonic carcinoma cell growth by lidamycin through down-regulation of embryonic stem cell-like genes Oct4, Sox2 and Myc. Investigational new drugs. vol 29. issue 6. 2012-01-23. PMID:20596749. |
in this study we demonstrated that inhibition of mouse embryonic carcinoma (ec) cell growth using ldm at low concentrations can be attributed to a loss of the cell's self-renewal capability but not to apoptosis or cell death, which can be correlated to the down-regulation of embryonic stem (es) cell-like genes oct4, sox2 and c-myc. |
2012-01-23 |
2023-08-12 |
mouse |
| Xianpei Jia, Xuefei Li, Yingxi Xu, Shu Zhang, Wenjun Mou, Yanhua Liu, Yin Liu, Dan Lv, Cheng-Hu Liu, Xiaoyue Tan, Rong Xiang, Na L. SOX2 promotes tumorigenesis and increases the anti-apoptotic property of human prostate cancer cell. Journal of molecular cell biology. vol 3. issue 4. 2011-12-02. PMID:21415100. |
we further investigated sox2's function in cell growth and apoptosis process by using a human prostate cancer cell line du145 with sox2 overexpression or down-regulation. |
2011-12-02 |
2023-08-12 |
mouse |
| Xianpei Jia, Xuefei Li, Yingxi Xu, Shu Zhang, Wenjun Mou, Yanhua Liu, Yin Liu, Dan Lv, Cheng-Hu Liu, Xiaoyue Tan, Rong Xiang, Na L. SOX2 promotes tumorigenesis and increases the anti-apoptotic property of human prostate cancer cell. Journal of molecular cell biology. vol 3. issue 4. 2011-12-02. PMID:21415100. |
to our knowledge, this study is the first to investigate sox2's function in tumorigenesis and apoptosis of human prostate cancer and to elucidate its regulatory effect on the activity of store-operated ca(2+) channels. |
2011-12-02 |
2023-08-12 |
mouse |
| Flavio Cimadamore, Katherine Fishwick, Elena Giusto, Ksenia Gnedeva, Giulio Cattarossi, Amber Miller, Stefano Pluchino, Laurence M Brill, Marianne Bronner-Fraser, Alexey V Terskik. Human ESC-derived neural crest model reveals a key role for SOX2 in sensory neurogenesis. Cell stem cell. vol 8. issue 5. 2011-10-03. PMID:21549328. |
sox2 downregulation was sufficient to induce emt and resulted in massive apoptosis when neuronal differentiation was induced. |
2011-10-03 |
2023-08-12 |
mouse |
| Hui Sun, Shaojun Zhan. Arsenic trioxide regulates the apoptosis of glioma cell and glioma stem cell via down-regulation of stem cell marker Sox2. Biochemical and biophysical research communications. vol 410. issue 3. 2011-09-16. PMID:21703238. |
arsenic trioxide regulates the apoptosis of glioma cell and glioma stem cell via down-regulation of stem cell marker sox2. |
2011-09-16 |
2023-08-12 |
Not clear |
| Hui Sun, Shaojun Zhan. Arsenic trioxide regulates the apoptosis of glioma cell and glioma stem cell via down-regulation of stem cell marker Sox2. Biochemical and biophysical research communications. vol 410. issue 3. 2011-09-16. PMID:21703238. |
here, we found that the expression of sox2 at transcriptional level was decreased during as(2)o(3)-induced glioma cell apoptosis. |
2011-09-16 |
2023-08-12 |
Not clear |
| Hui Sun, Shaojun Zhan. Arsenic trioxide regulates the apoptosis of glioma cell and glioma stem cell via down-regulation of stem cell marker Sox2. Biochemical and biophysical research communications. vol 410. issue 3. 2011-09-16. PMID:21703238. |
furthermore, as(2)o(3) inhibited the self-renewal of glioma stem cells, and efficiently induces the apoptosis of glioma stem cells, at least, partly through down-regulation of sox2. |
2011-09-16 |
2023-08-12 |
Not clear |
| Takeshi Otsubo, Yoshimitsu Akiyama, Yutaka Hashimoto, Shu Shimada, Kentaro Goto, Yasuhito Yuas. MicroRNA-126 inhibits SOX2 expression and contributes to gastric carcinogenesis. PloS one. vol 6. issue 1. 2011-08-02. PMID:21304604. |
previously, we demonstrated that sox2 plays important roles in growth inhibition through cell cycle arrest and apoptosis, and that sox2 expression is frequently down-regulated in gastric cancers. |
2011-08-02 |
2023-08-12 |
Not clear |
| Maria Ferletta, Demet Caglayan, Liza Mokvist, Yiwen Jiang, Marianne Kastemar, Lene Uhrbom, Bengt Westermar. Forced expression of Sox21 inhibits Sox2 and induces apoptosis in human glioma cells. International journal of cancer. vol 129. issue 1. 2011-07-04. PMID:20824710. |
forced expression of sox21 inhibits sox2 and induces apoptosis in human glioma cells. |
2011-07-04 |
2023-08-12 |
human |
| Maria Ferletta, Demet Caglayan, Liza Mokvist, Yiwen Jiang, Marianne Kastemar, Lene Uhrbom, Bengt Westermar. Forced expression of Sox21 inhibits Sox2 and induces apoptosis in human glioma cells. International journal of cancer. vol 129. issue 1. 2011-07-04. PMID:20824710. |
reduction of sox2 expression by using sirna against sox2 or by overexpressing sox21 using a tetracycline-regulated expression system (tet-on) caused decreased gfap expression and a reduction in cell number due to induction of apoptosis. |
2011-07-04 |
2023-08-12 |
human |
| Kristine Salmina, Eriks Jankevics, Anda Huna, Dmitry Perminov, Ilze Radovica, Tetyana Klymenko, Andrey Ivanov, Elina Jascenko, Harry Scherthan, Mark Cragg, Jekaterina Erenpreis. Up-regulation of the embryonic self-renewal network through reversible polyploidy in irradiated p53-mutant tumour cells. Experimental cell research. vol 316. issue 13. 2010-07-29. PMID:20457152. |
these polyploid tumour cells resist apoptosis, overcome cellular senescence and undergo bi- and multi-polar divisions transmitting the up-regulated oct4, nanog and sox2 self-renewal cassette to their descendents. |
2010-07-29 |
2023-08-12 |
Not clear |
| T Otsubo, Y Akiyama, K Yanagihara, Y Yuas. SOX2 is frequently downregulated in gastric cancers and inhibits cell growth through cell-cycle arrest and apoptosis. British journal of cancer. vol 98. issue 4. 2008-04-22. PMID:18268498. |
sox2 is frequently downregulated in gastric cancers and inhibits cell growth through cell-cycle arrest and apoptosis. |
2008-04-22 |
2023-08-12 |
human |
| T Otsubo, Y Akiyama, K Yanagihara, Y Yuas. SOX2 is frequently downregulated in gastric cancers and inhibits cell growth through cell-cycle arrest and apoptosis. British journal of cancer. vol 98. issue 4. 2008-04-22. PMID:18268498. |
hence, sox2 plays important roles in growth inhibition through cell-cycle arrest and apoptosis in gastric epithelial cells, and the loss of sox2 expression may be related to gastric carcinogenesis and poor prognosis. |
2008-04-22 |
2023-08-12 |
human |