| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vlasta Lungova, Jamie M Verheyden, John Herriges, Xin Sun, Susan L Thibeaul. Ontogeny of the mouse vocal fold epithelium. Developmental biology. vol 399. issue 2. 2015-05-08. PMID:25601450. |
the illustration of these morphogenetic events is substantiated by dynamic changes in cell proliferation and apoptosis, as well as the expression pattern of key transcription factors, foxa2, sox2 and nkx2-1 that specify and pattern the foregut endoderm. |
2015-05-08 |
2023-08-13 |
mouse |
| Yu-Ting Chou, Chih-Chan Lee, Shih-Hsin Hsiao, Sey-En Lin, Sheng-Chieh Lin, Chih-Hung Chung, Chi-Hsiu Chung, Yu-Rong Kao, Yuan-Hung Wang, Chien-Tsun Chen, Yau-Huei Wei, Cheng-Wen W. The emerging role of SOX2 in cell proliferation and survival and its crosstalk with oncogenic signaling in lung cancer. Stem cells (Dayton, Ohio). vol 31. issue 12. 2015-01-15. PMID:23940081. |
sox2 expression promoted chemoresistance, and silencing of sox2 perturbed mitochondrial function, causing marked apoptosis and autophagy. |
2015-01-15 |
2023-08-12 |
mouse |
| Yu-Ting Chou, Chih-Chan Lee, Shih-Hsin Hsiao, Sey-En Lin, Sheng-Chieh Lin, Chih-Hung Chung, Chi-Hsiu Chung, Yu-Rong Kao, Yuan-Hung Wang, Chien-Tsun Chen, Yau-Huei Wei, Cheng-Wen W. The emerging role of SOX2 in cell proliferation and survival and its crosstalk with oncogenic signaling in lung cancer. Stem cells (Dayton, Ohio). vol 31. issue 12. 2015-01-15. PMID:23940081. |
sox2 induced bcl2l1, the ectopic expression of which rescued the effects of sox2 silencing on apoptosis, autophagy, and mitochondrial function. |
2015-01-15 |
2023-08-12 |
mouse |
| Ade Kallas, Martin Pook, Annika Trei, Toivo Maimet. Assessment of the Potential of CDK2 Inhibitor NU6140 to Influence the Expression of Pluripotency Markers NANOG, OCT4, and SOX2 in 2102Ep and H9 Cells. International journal of cell biology. vol 2014. 2014-12-05. PMID:25477962. |
both hes and hec cells responded to nu6140 treatment by induced apoptosis and a decreased expression of nanog, oct4, and sox2 in surviving cells. |
2014-12-05 |
2023-08-13 |
human |
| R Santini, S Pietrobono, S Pandolfi, V Montagnani, M D'Amico, J Y Penachioni, M C Vinci, L Borgognoni, B Stecc. SOX2 regulates self-renewal and tumorigenicity of human melanoma-initiating cells. Oncogene. vol 33. issue 38. 2014-11-12. PMID:24681955. |
sox2 silencing also inhibits cell growth and induces apoptosis in melanoma cells. |
2014-11-12 |
2023-08-12 |
human |
| Andreas Schröck, Maike Bode, Friederike Johanna Maria Göke, Petra Marion Bareiss, Rebekka Schairer, Hui Wang, Wilko Weichert, Alina Franzen, Robert Kirsten, Tobias van Bremen, Angela Queisser, Glen Kristiansen, Lynn Heasley, Friedrich Bootz, Claudia Lengerke, Sven Perne. Expression and role of the embryonic protein SOX2 in head and neck squamous cell carcinoma. Carcinogenesis. vol 35. issue 7. 2014-09-25. PMID:24743512. |
in order to investigate the functional role of sox2 in human hnscc, sox2 knockdown and overexpression in scc-25 cells were generated by lentiviral constructs and subjected to cell cycle analysis, proliferation and apoptosis assays. |
2014-09-25 |
2023-08-13 |
human |
| Ronak Eini, Hans Stoop, Ad J M Gillis, Katharina Biermann, Lambert C J Dorssers, Leendert H J Looijeng. Role of SOX2 in the etiology of embryonal carcinoma, based on analysis of the NCCIT and NT2 cell lines. PloS one. vol 9. issue 1. 2014-09-16. PMID:24404135. |
down-regulation of sox2 by targeted sirna provokes nccit cells towards apoptosis, while inhibition of oct3/4 expression induced differentiation, with retained sox2 levels. |
2014-09-16 |
2023-08-12 |
mouse |
| Ronak Eini, Hans Stoop, Ad J M Gillis, Katharina Biermann, Lambert C J Dorssers, Leendert H J Looijeng. Role of SOX2 in the etiology of embryonal carcinoma, based on analysis of the NCCIT and NT2 cell lines. PloS one. vol 9. issue 1. 2014-09-16. PMID:24404135. |
the data presented in this study are based on a single ec cell line with a sox2 amplification, with nt2 as control ec cell line, showing no profound induction of apoptosis upon sox2 downregulation. |
2014-09-16 |
2023-08-12 |
mouse |
| Katharina Hütz, Raquel Mejías-Luque, Katarina Farsakova, Manfred Ogris, Stefan Krebs, Martina Anton, Michael Vieth, Ulrich Schüller, Marlon R Schneider, Helmut Blum, Ernst Wagner, Andreas Jung, Markus Gerhar. The stem cell factor SOX2 regulates the tumorigenic potential in human gastric cancer cells. Carcinogenesis. vol 35. issue 4. 2014-05-27. PMID:24325912. |
interestingly, inhibition of sox2 reduced cell proliferation and migration, increased apoptosis and induced changes in cell cycle. |
2014-05-27 |
2023-08-12 |
human |
| Si Chen, Xuefei Li, Dan Lu, Yingxi Xu, Wenjun Mou, Lina Wang, Yanan Chen, Yanhua Liu, Xiru Li, Lu-Yuan Li, Lin Liu, Dwayne Stupack, Ralph A Reisfeld, Rong Xiang, Na L. SOX2 regulates apoptosis through MAP4K4-survivin signaling pathway in human lung cancer cells. Carcinogenesis. vol 35. issue 3. 2014-05-14. PMID:24233838. |
sox2 regulates apoptosis through map4k4-survivin signaling pathway in human lung cancer cells. |
2014-05-14 |
2023-08-12 |
human |
| Si Chen, Xuefei Li, Dan Lu, Yingxi Xu, Wenjun Mou, Lina Wang, Yanan Chen, Yanhua Liu, Xiru Li, Lu-Yuan Li, Lin Liu, Dwayne Stupack, Ralph A Reisfeld, Rong Xiang, Na L. SOX2 regulates apoptosis through MAP4K4-survivin signaling pathway in human lung cancer cells. Carcinogenesis. vol 35. issue 3. 2014-05-14. PMID:24233838. |
previous studies have implicated cancer stem cells in tumor recurrence and revealed that the stem cell gene sox2 plays an important role in the tumor cell resistance to apoptosis. |
2014-05-14 |
2023-08-12 |
human |
| Si Chen, Xuefei Li, Dan Lu, Yingxi Xu, Wenjun Mou, Lina Wang, Yanan Chen, Yanhua Liu, Xiru Li, Lu-Yuan Li, Lin Liu, Dwayne Stupack, Ralph A Reisfeld, Rong Xiang, Na L. SOX2 regulates apoptosis through MAP4K4-survivin signaling pathway in human lung cancer cells. Carcinogenesis. vol 35. issue 3. 2014-05-14. PMID:24233838. |
nonetheless, the mechanism by which sox2 regulates apoptosis signals remained undefined. |
2014-05-14 |
2023-08-12 |
human |
| Si Chen, Xuefei Li, Dan Lu, Yingxi Xu, Wenjun Mou, Lina Wang, Yanan Chen, Yanhua Liu, Xiru Li, Lu-Yuan Li, Lin Liu, Dwayne Stupack, Ralph A Reisfeld, Rong Xiang, Na L. SOX2 regulates apoptosis through MAP4K4-survivin signaling pathway in human lung cancer cells. Carcinogenesis. vol 35. issue 3. 2014-05-14. PMID:24233838. |
here, we demonstrated the surprising finding that silencing of the sox2 gene effectively induces apoptosis via the activation of death receptor and mitochondrial signaling pathways in human non-small cell lung cancer cells. |
2014-05-14 |
2023-08-12 |
human |
| Azucena Gomez-Cabrero, Wolfgang Wrasidlo, Ralph A Reisfel. IMD-0354 targets breast cancer stem cells: a novel approach for an adjuvant to chemotherapy to prevent multidrug resistance in a murine model. PloS one. vol 8. issue 8. 2014-03-31. PMID:24014113. |
decrease of stem-like gene expression of oct4, nanog and sox2, and apoptosis resistance related to the survivin gene also was observed after treatment with this compound. |
2014-03-31 |
2023-08-12 |
mouse |
| Poornima Bhat-Nakshatri, Chirayu P Goswami, Sunil Badve, George W Sledge, Harikrishna Nakshatr. Identification of FDA-approved drugs targeting breast cancer stem cells along with biomarkers of sensitivity. Scientific reports. vol 3. 2014-02-14. PMID:23982413. |
atra reduced mammosphere-forming ability of a subset of breast cancer cells, which correlated with induction of apoptosis, reduced expression of sox2 but elevated expression of its antagonist cdx2. |
2014-02-14 |
2023-08-12 |
Not clear |
| Yasuyuki Gen, Kohichiroh Yasui, Taichiro Nishikawa, Toshikazu Yoshikaw. SOX2 promotes tumor growth of esophageal squamous cell carcinoma through the AKT/mammalian target of rapamycin complex 1 signaling pathway. Cancer science. vol 104. issue 7. 2014-02-06. PMID:23510069. |
ly294002 suppressed the ability of sox2 to enhance tumor growth of escc by reducing cell proliferation, but not by enhancing apoptosis. |
2014-02-06 |
2023-08-12 |
mouse |
| C Hage, V Rausch, N Giese, T Giese, F Schönsiegel, S Labsch, C Nwaeburu, J Mattern, J Gladkich, I Her. The novel c-Met inhibitor cabozantinib overcomes gemcitabine resistance and stem cell signaling in pancreatic cancer. Cell death & disease. vol 4. 2013-10-23. PMID:23661005. |
in primary, csc-enriched spheroidal cultures cabozantinib downregulated csc markers sox2, c-met and cd133 and induced apoptosis. |
2013-10-23 |
2023-08-12 |
Not clear |
| Juan Li, Lutao Du, Yongmei Yang, Chuanxin Wang, Hui Liu, Lili Wang, Xin Zhang, Wei Li, Guixi Zheng, Zhaogang Don. MiR-429 is an independent prognostic factor in colorectal cancer and exerts its anti-apoptotic function by targeting SOX2. Cancer letters. vol 329. issue 1. 2013-04-24. PMID:23111103. |
functionally, mir-429 overexpression suppressed cell apoptosis by directly targeting sox2 in ht-29 cells. |
2013-04-24 |
2023-08-12 |
human |
| Ruopeng Feng, Shixin Zhou, Yinan Liu, Daijun Song, Zhilin Luan, Xin Dai, Yang Li, Na Tang, Jinhua Wen, Lingsong L. Sox2 protects neural stem cells from apoptosis via up-regulating survivin expression. The Biochemical journal. vol 450. issue 3. 2013-04-17. PMID:23301561. |
sox2 protects neural stem cells from apoptosis via up-regulating survivin expression. |
2013-04-17 |
2023-08-12 |
mouse |
| Ruopeng Feng, Shixin Zhou, Yinan Liu, Daijun Song, Zhilin Luan, Xin Dai, Yang Li, Na Tang, Jinhua Wen, Lingsong L. Sox2 protects neural stem cells from apoptosis via up-regulating survivin expression. The Biochemical journal. vol 450. issue 3. 2013-04-17. PMID:23301561. |
although overexpression of sox2 elevates survivin expression, knockdown of sox2 results in a decrease in survivin expression, thereby initiating the mitochondria-dependent apoptosis related to caspase 9 activation. |
2013-04-17 |
2023-08-12 |
mouse |