| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiuli Ding, Jiadong Chi, Xue Yang, Jian Hao, Chang Liu, Cuihong Zhu, Xiaodong Wang, Xiaohui Liu, Yangyang Niu, Wei Ji, Dan Chen, Xiongzhi W. Cucurbitacin B synergistically enhances the apoptosis-inducing effect of arsenic trioxide by inhibiting STAT3 phosphorylation in lymphoma Ramos cells. Leukemia & lymphoma. vol 58. issue 10. 2019-04-26. PMID:28278714. |
dramatically, cucurbitacin b (cub), an effective component of the dichloromethane extraction from trichosanthes kirilowii maxim, synergistically eliminated the apoptosis resistance of burkitt's lymphoma ramos cells to ato by inhibiting the phosphorylation of stat3, followed in turn by downregulation of bcl-2 and upregulation of bax. |
2019-04-26 |
2023-08-13 |
Not clear |
| Gaowu Hu, Wei Pen, Ming Wan. TRIM14 Promotes Breast Cancer Cell Proliferation by Inhibiting Apoptosis. Oncology research. vol 27. issue 4. 2019-04-23. PMID:29562956. |
additionally, cryptotanshinone, a stat3 inhibitor, inhibited cell proliferation but increased cell apoptosis in the bt474 and mda-mb-231 cell lines. |
2019-04-23 |
2023-08-13 |
human |
| Naveen A Mallangada, Joselin M Vargas, Swaroopa Thomas, Matthew G DiGiovanni, Brandon M Vaeth, Matthew D Nemesure, Ruixue Wang, Joseph F LaComb, Jennie L Williams, Lorne M Golub, Francis Johnson, Gerardo G Mackenzi. A novel tricarbonylmethane agent (CMC2.24) reduces human pancreatic tumor growth in mice by targeting Ras. Molecular carcinogenesis. vol 57. issue 9. 2019-04-22. PMID:29683208. |
in addition, downstream of erk, cmc2.24 inhibited stat3 phosphorylation levels at the serine 727 residue, enhanced the levels of superoxide anion in mitochondria, and induced intrinsic apoptosis as shown by the release of cytochrome c from the mitochondria to the cytosol and the further cleavage of caspase 9 in pc cells. |
2019-04-22 |
2023-08-13 |
mouse |
| You Lang Zhou, Luzhong Zhang, Zhou Zhou, Wei Liu, Yang Lu, Shumin He, Yajuan Cui, Yongwei Qin, Minhui Hu. Antibody Modified Nanoparticle-Mediated Delivery of miR-124 Regulates Apoptosis via Repression the Stat3 Signal in Mycobacterial-Infected Microglia. Journal of biomedical nanotechnology. vol 14. issue 12. 2019-04-16. PMID:30305225. |
antibody modified nanoparticle-mediated delivery of mir-124 regulates apoptosis via repression the stat3 signal in mycobacterial-infected microglia. |
2019-04-16 |
2023-08-13 |
Not clear |
| Fatemeh Khaki-Khatibi, Marjan Ghorbani, Mehdi Sabzichi, Fatemeh Ramezani, Jamal Mohammadia. Adjuvant therapy with stattic enriches the anti-proliferative effect of doxorubicin in human ZR-75-1 breast cancer cells via arresting cell cycle and inducing apoptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 109. 2019-03-28. PMID:30551374. |
cell viability was investigated by mtt assay, the percentage of apoptosis by dapi staining, and annexin v. real time-pcr was applied to find out the correlation between mechanistic roles of the stat3 pathway and apoptotic signal in the modulation of bcl-2 and bax gene expressions axis. |
2019-03-28 |
2023-08-13 |
human |
| Maria L Valle, Janine Dworshak, Ashok Sharma, Ahmed S Ibrahim, Mohamed Al-Shabrawey, Shruti Sharm. Inhibition of interleukin-6 trans-signaling prevents inflammation and endothelial barrier disruption in retinal endothelial cells. Experimental eye research. vol 178. 2019-03-25. PMID:30240585. |
il-6 trans-signaling activation caused a significant increase in stat3 phosphorylation, expression of adhesion molecules, ros production and apoptosis in hrecs whereas a significant decrease in mitochondrial membrane potential and no production was observed in il-6 trans-signaling activated cells. |
2019-03-25 |
2023-08-13 |
human |
| Qi Yang, Wenyu Chen, Yufeng Xu, Xiaodong Lv, Ming Zhang, Hao Jian. Polyphyllin I modulates MALAT1/STAT3 signaling to induce apoptosis in gefitinib-resistant non-small cell lung cancer. Toxicology and applied pharmacology. vol 356. 2019-03-21. PMID:30076870. |
these findings suggest that, in vitro and in vivo, pp i inhibits the viability and induces apoptosis of gefitinib-resistant nsclc by down-regulating malat1 and inactivating stat3 signaling pathway. |
2019-03-21 |
2023-08-13 |
Not clear |
| Rubashruti Kanna, Gaurav Choudhary, Nandini Ramachandra, Ulrich Steidl, Amit Verma, Aditi Shastr. STAT3 inhibition as a therapeutic strategy for leukemia. Leukemia & lymphoma. vol 59. issue 9. 2019-03-18. PMID:29164994. |
stat3 is an important transcription factor that regulates cell growth, proliferation, and inhibits apoptosis. |
2019-03-18 |
2023-08-13 |
Not clear |
| Wuguo Li, Qing Zhang, Kaotan Chen, Zhenhua Sima, Jingli Liu, Qiang Yu, Jiawei Li. 2-Ethoxystypandrone, a novel small-molecule STAT3 signaling inhibitor from Polygonum cuspidatum, inhibits cell growth and induces apoptosis of HCC cells and HCC Cancer stem cells. BMC complementary and alternative medicine. vol 19. issue 1. 2019-03-18. PMID:30709346. |
2-ethoxystypandrone, a novel small-molecule stat3 signaling inhibitor from polygonum cuspidatum, inhibits cell growth and induces apoptosis of hcc cells and hcc cancer stem cells. |
2019-03-18 |
2023-08-13 |
Not clear |
| Haiyan Ma, Dan Yan, Yina Wang, Wei Shi, Tianshu Liu, Chongqiang Zhao, Shengqi Huo, Jialin Duan, Jingwen Tao, Maocai Zhai, Pengcheng Luo, Junyi Guo, Lei Tian, Lulu Mageta, David Jou, Cuntai Zhang, Chenglong Li, Jiayuh Lin, Jiagao Lv, Sheng Li, Li Li. Bazedoxifene exhibits growth suppressive activity by targeting interleukin-6/glycoprotein 130/signal transducer and activator of transcription 3 signaling in hepatocellular carcinoma. Cancer science. vol 110. issue 3. 2019-03-08. PMID:30648776. |
our data showed that baz inhibited stat3 phosphorylation (p-stat3) and expression of stat3 downstream genes, inducing apoptosis in liver cancer cells. |
2019-03-08 |
2023-08-13 |
mouse |
| Amara Maryam, Tahir Mehmood, He Zhang, Yongming Li, Muhammad Khan, Tonghui M. Alantolactone induces apoptosis, promotes STAT3 glutathionylation and enhances chemosensitivity of A549 lung adenocarcinoma cells to doxorubicin via oxidative stress. Scientific reports. vol 7. issue 1. 2019-03-06. PMID:28740138. |
alantolactone induces apoptosis, promotes stat3 glutathionylation and enhances chemosensitivity of a549 lung adenocarcinoma cells to doxorubicin via oxidative stress. |
2019-03-06 |
2023-08-13 |
Not clear |
| Amara Maryam, Tahir Mehmood, He Zhang, Yongming Li, Muhammad Khan, Tonghui M. Alantolactone induces apoptosis, promotes STAT3 glutathionylation and enhances chemosensitivity of A549 lung adenocarcinoma cells to doxorubicin via oxidative stress. Scientific reports. vol 7. issue 1. 2019-03-06. PMID:28740138. |
taken together; alt induces oxidative stress-dependent apoptosis, inhibits stat3 activation and augments doxorubicin toxicity in a549 lung cancer cells. |
2019-03-06 |
2023-08-13 |
Not clear |
| In-Hyoung Yang, Won Jung, Lee-Han Kim, Ji-Ae Shin, Nam-Pyo Cho, Seong Doo Hong, Kyoung-Ok Hong, Sung-Dae Ch. Nitidine chloride represses Mcl-1 protein via lysosomal degradation in oral squamous cell carcinoma. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. vol 47. issue 9. 2019-03-06. PMID:29924888. |
we have shown previously that nitidine chloride (nc) induces apoptosis via inhibition of signal transducer and activator of transcription 3 (stat3). |
2019-03-06 |
2023-08-13 |
mouse |
| Kalpana Deepa Priya Dorayappan, Ross Wanner, John J Wallbillich, Uksha Saini, Roman Zingarelli, Adrian A Suarez, David E Cohn, Karuppaiyah Selvendira. Hypoxia-induced exosomes contribute to a more aggressive and chemoresistant ovarian cancer phenotype: a novel mechanism linking STAT3/Rab proteins. Oncogene. vol 37. issue 28. 2019-02-25. PMID:29636548. |
blocking exosome release by known inhibitor amiloride or stat3 inhibitor and treating with cisplatin resulted in a significant increase in apoptosis, decreased colony formation, and proliferation. |
2019-02-25 |
2023-08-13 |
mouse |
| Wei Chen, Ping Li, Yi Liu, Yu Yang, Xueting Ye, Fangyi Zhang, Hang Huan. Isoalantolactone induces apoptosis through ROS-mediated ER stress and inhibition of STAT3 in prostate cancer cells. Journal of experimental & clinical cancer research : CR. vol 37. issue 1. 2019-02-20. PMID:30541589. |
isoalantolactone induces apoptosis through ros-mediated er stress and inhibition of stat3 in prostate cancer cells. |
2019-02-20 |
2023-08-13 |
Not clear |
| Feeling YuTing Chen, Eliza Gaylord, Nancy McNamara, Sarah Kno. Deciphering Molecular and Phenotypic Changes Associated with Early Autoimmune Disease in the Aire-Deficient Mouse Model of Sjögren's Syndrome. International journal of molecular sciences. vol 19. issue 11. 2019-02-18. PMID:30453645. |
activated stat3, a blocker of apoptosis, was restricted to the ductal system and also increased with damage, highlighting its potential as a promoter of ductal cell survival. |
2019-02-18 |
2023-08-13 |
mouse |
| Jing Gao, Junling Chen, Mingjun Cai, Haijiao Xu, Junguang Jiang, Ti Tong, Hongda Wan. Clustered localization of STAT3 during the cell cycle detected by super-resolution fluorescence microscopy. Methods and applications in fluorescence. vol 5. issue 2. 2019-02-13. PMID:28367831. |
signal transducer and activator of transcription 3 (stat3) plays a key role in various cellular processes such as cell proliferation, differentiation, apoptosis and immune responses. |
2019-02-13 |
2023-08-13 |
Not clear |
| Mirae Park, Joo Weon Lim, Hyeyoung Ki. Docoxahexaenoic Acid Induces Apoptosis of Pancreatic Cancer Cells by Suppressing Activation of STAT3 and NF-κB. Nutrients. vol 10. issue 11. 2019-02-13. PMID:30400136. |
docoxahexaenoic acid induces apoptosis of pancreatic cancer cells by suppressing activation of stat3 and nf-κb. |
2019-02-13 |
2023-08-13 |
Not clear |
| Mirae Park, Joo Weon Lim, Hyeyoung Ki. Docoxahexaenoic Acid Induces Apoptosis of Pancreatic Cancer Cells by Suppressing Activation of STAT3 and NF-κB. Nutrients. vol 10. issue 11. 2019-02-13. PMID:30400136. |
since the activation of stat3 and nf-κb mediates the expression of survival genes cyclin d1 and survivin, dha induced apoptosis by suppressing the stat3/nf-κb-cyclin d1/survivin axis. |
2019-02-13 |
2023-08-13 |
Not clear |
| Ying Liu, Xinhua Wang, Shuang Zeng, Xiane Zhang, Jimin Zhao, Xiaoyan Zhang, Xinhuan Chen, Wanjing Yang, Yili Yang, Ziming Dong, Jingyu Zhu, Xin Xu, Fang Tia. The natural polyphenol curcumin induces apoptosis by suppressing STAT3 signaling in esophageal squamous cell carcinoma. Journal of experimental & clinical cancer research : CR. vol 37. issue 1. 2019-02-12. PMID:30518397. |
the natural polyphenol curcumin induces apoptosis by suppressing stat3 signaling in esophageal squamous cell carcinoma. |
2019-02-12 |
2023-08-13 |
Not clear |