| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrey V Markov, Marina A Zenkova, Evgeniya B Logashenk. Modulation of Tumour-Related Signaling Pathways by Natural Pentacyclic Triterpenoids and their Semisynthetic Derivatives. Current medicinal chemistry. vol 24. issue 13. 2017-09-08. PMID:28078994. |
among the most relevant mechanisms involved are cell cycle arrest, apoptosis and autophagy triggered by the effect of triterpenoids on tgf-β and her cell surface receptors and the downstream pi3kakt- mtor and ikk/nf-kb signaling axis, stat3 pathway and mapk cascades. |
2017-09-08 |
2023-08-13 |
Not clear |
| Jaya Srivastava, John DiGiovann. Non-canonical Stat3 signaling in cancer. Molecular carcinogenesis. vol 55. issue 12. 2017-09-05. PMID:26649644. |
stat3 is a member of the signal transducers and activators of transcription family and is a known regulator of essential biologic processes including angiogenesis, apoptosis, cell cycle progression, and cell migration. |
2017-09-05 |
2023-08-13 |
Not clear |
| R Bharti, G Dey, P K Ojha, S Rajput, S K Jaganathan, R Sen, M Manda. Diacerein-mediated inhibition of IL-6/IL-6R signaling induces apoptotic effects on breast cancer. Oncogene. vol 35. issue 30. 2017-09-01. PMID:26616855. |
the in vivo antitumor effect was correlated with decreased proliferation (ki-67), increased apoptosis (tunel) and inhibition of il-6/il-6r-mediated stat3, mapk and akt pathway in tumor remnants. |
2017-09-01 |
2023-08-13 |
Not clear |
| G Wang, Y Yu, C Sun, T Liu, T Liang, L Zhan, X Lin, X-H Fen. STAT3 selectively interacts with Smad3 to antagonize TGF-β signalling. Oncogene. vol 35. issue 33. 2017-08-30. PMID:26616859. |
depletion of stat3 promotes tgf-β-mediated transcriptional and physiological responses, including cell cycle arrest, apoptosis and epithelial-to-mesenchymal transition. |
2017-08-30 |
2023-08-13 |
Not clear |
| Nathan De Beule, Kim De Veirman, Ken Maes, Elke De Bruyne, Eline Menu, Karine Breckpot, Hendrik De Raeve, Rian Van Rampelbergh, Jo A Van Ginderachter, Rik Schots, Els Van Valckenborgh, Karin Vanderkerke. Tumour-associated macrophage-mediated survival of myeloma cells through STAT3 activation. The Journal of pathology. vol 241. issue 4. 2017-08-29. PMID:27976373. |
the pro-survival effect was associated with activation of the stat3 pathway in 5t33mm cells, less cleavage of caspase-3, and thus less apoptosis. |
2017-08-29 |
2023-08-13 |
Not clear |
| Wei Li, Hongxiu Zhang, Mingxiu Nie, Yanlei Tian, Xu Chen, Ceshi Chen, Haijun Chen, Rong Li. Ursolic acid derivative FZU-03,010 inhibits STAT3 and induces cell cycle arrest and apoptosis in renal and breast cancer cells. Acta biochimica et biophysica Sinica. vol 49. issue 4. 2017-08-29. PMID:28338932. |
ursolic acid derivative fzu-03,010 inhibits stat3 and induces cell cycle arrest and apoptosis in renal and breast cancer cells. |
2017-08-29 |
2023-08-13 |
Not clear |
| Schafiq Nabhani, Cyrill Schipp, Hagit Miskin, Carina Levin, Sergey Postovsky, Tal Dujovny, Ariel Koren, Dan Harlev, Anne-Marie Bis, Franziska Auer, Baerbel Keller, Klaus Warnatz, Michael Gombert, Sebastian Ginzel, Arndt Borkhardt, Polina Stepensky, Ute Fische. STAT3 gain-of-function mutations associated with autoimmune lymphoproliferative syndrome like disease deregulate lymphocyte apoptosis and can be targeted by BH3 mimetic compounds. Clinical immunology (Orlando, Fla.). vol 181. 2017-08-28. PMID:28579554. |
stat3 gain-of-function mutations associated with autoimmune lymphoproliferative syndrome like disease deregulate lymphocyte apoptosis and can be targeted by bh3 mimetic compounds. |
2017-08-28 |
2023-08-13 |
Not clear |
| Schafiq Nabhani, Cyrill Schipp, Hagit Miskin, Carina Levin, Sergey Postovsky, Tal Dujovny, Ariel Koren, Dan Harlev, Anne-Marie Bis, Franziska Auer, Baerbel Keller, Klaus Warnatz, Michael Gombert, Sebastian Ginzel, Arndt Borkhardt, Polina Stepensky, Ute Fische. STAT3 gain-of-function mutations associated with autoimmune lymphoproliferative syndrome like disease deregulate lymphocyte apoptosis and can be targeted by BH3 mimetic compounds. Clinical immunology (Orlando, Fla.). vol 181. 2017-08-28. PMID:28579554. |
hyperactivity of stat3, a known repressor of fas, was associated with decreased fas-mediated apoptosis, mimicking alps caused by fas mutations. |
2017-08-28 |
2023-08-13 |
Not clear |
| Xing-Hua Liao, Yuan Xiang, Cheng-Xi Yu, Jia-Peng Li, Hui Li, Qi Nie, Peng Hu, Jun Zhou, Tong-Cun Zhan. STAT3 is required for MiR-17-5p-mediated sensitization to chemotherapy-induced apoptosis in breast cancer cells. Oncotarget. vol 8. issue 9. 2017-08-24. PMID:28178652. |
stat3 is required for mir-17-5p-mediated sensitization to chemotherapy-induced apoptosis in breast cancer cells. |
2017-08-24 |
2023-08-13 |
Not clear |
| Xing-Hua Liao, Yuan Xiang, Cheng-Xi Yu, Jia-Peng Li, Hui Li, Qi Nie, Peng Hu, Jun Zhou, Tong-Cun Zhan. STAT3 is required for MiR-17-5p-mediated sensitization to chemotherapy-induced apoptosis in breast cancer cells. Oncotarget. vol 8. issue 9. 2017-08-24. PMID:28178652. |
on the other hand, mir-17-5p induced apoptosis in breast cancer cells, and overexpression of mir-17-5p sensitized mcf-7 cells to paclitaxel-induced apoptosis via stat3. |
2017-08-24 |
2023-08-13 |
Not clear |
| Xing-Hua Liao, Yuan Xiang, Cheng-Xi Yu, Jia-Peng Li, Hui Li, Qi Nie, Peng Hu, Jun Zhou, Tong-Cun Zhan. STAT3 is required for MiR-17-5p-mediated sensitization to chemotherapy-induced apoptosis in breast cancer cells. Oncotarget. vol 8. issue 9. 2017-08-24. PMID:28178652. |
overexpression of stat3 in mcf-7 cells decreased paclitaxel-induced apoptosis, but stat3 knockout abolished the mir-17-5p-induced increases in apoptosis. |
2017-08-24 |
2023-08-13 |
Not clear |
| Xing-Hua Liao, Yuan Xiang, Cheng-Xi Yu, Jia-Peng Li, Hui Li, Qi Nie, Peng Hu, Jun Zhou, Tong-Cun Zhan. STAT3 is required for MiR-17-5p-mediated sensitization to chemotherapy-induced apoptosis in breast cancer cells. Oncotarget. vol 8. issue 9. 2017-08-24. PMID:28178652. |
finally, mir-17-5p promoted apoptosis by increasing p53 expression, which was inhibited by stat3. |
2017-08-24 |
2023-08-13 |
Not clear |
| Xing-Hua Liao, Yuan Xiang, Cheng-Xi Yu, Jia-Peng Li, Hui Li, Qi Nie, Peng Hu, Jun Zhou, Tong-Cun Zhan. STAT3 is required for MiR-17-5p-mediated sensitization to chemotherapy-induced apoptosis in breast cancer cells. Oncotarget. vol 8. issue 9. 2017-08-24. PMID:28178652. |
these results demonstrate a novel pathway via which mir-17-5p inhibits stat3 and increases p53 expression to promote apoptosis in breast cancer cells. |
2017-08-24 |
2023-08-13 |
Not clear |
| Ji Ma, Shaofeng Shui, Xinwei Han, Dong Guo, Tengfei Li, Lei Ya. microRNA-200a silencing protects neural stem cells against cerebral ischemia/reperfusion injury. PloS one. vol 12. issue 2. 2017-08-21. PMID:28222148. |
the changes in cell viability, apoptosis, migration, the expression of c-myc, and the phosphorylation of stat1, stat3 and mapk were respectively assessed. |
2017-08-21 |
2023-08-13 |
Not clear |
| Dongqing Zuo, Zifei Zhou, Hongsheng Wang, Tao Zhang, Jie Zang, Fei Yin, Wei Sun, Jiepeng Chen, Lili Duan, Jing Xu, Zhuoying Wang, Chongren Wang, Binhui Lin, Zeze Fu, Yuxin Liao, Suoyuan Li, Mengxiong Sun, Yingqi Hua, Longpo Zheng, Zhengdong Ca. Alternol, a natural compound, exerts an anti-tumour effect on osteosarcoma by modulating of STAT3 and ROS/MAPK signalling pathways. Journal of cellular and molecular medicine. vol 21. issue 2. 2017-07-31. PMID:27624867. |
taken together, our results reveal that alternol suppresses cell proliferation, migration and induces apoptosis, cell cycle arrest by modulating of ros-dependent mapk and stat3 signalling pathways in human os cells. |
2017-07-31 |
2023-08-13 |
mouse |
| Tao Zhang, Suoyuan Li, Jingjie Li, Fei Yin, Yingqi Hua, Zhouying Wang, Binhui Lin, Hongsheng Wang, Dongqing Zou, Zifei Zhou, Jing Xu, Chengqing Yi, Zhengdong Ca. Natural product pectolinarigenin inhibits osteosarcoma growth and metastasis via SHP-1-mediated STAT3 signaling inhibition. Cell death & disease. vol 7. issue 10. 2017-07-31. PMID:27735939. |
we also found pectolinarigenin significantly suppressed osteosarcoma cell proliferation, induced apoptosis and reduced the level of stat3 downstream proteins cyclin d1, survivin, b-cell lymphoma 2 (bcl-2), b-cell lymphoma extra-large (bcl-xl) and myeloid cell leukemia 1 (mcl-1). |
2017-07-31 |
2023-08-13 |
Not clear |
| Jiawei Shou, Liangkun You, Junlin Yao, Jiansheng Xie, Jing Jing, Zhao Jing, Liming Jiang, Xinbing Sui, Hongming Pan, Weidong Ha. Cyclosporine A sensitizes human non-small cell lung cancer cells to gefitinib through inhibition of STAT3. Cancer letters. vol 379. issue 1. 2017-07-26. PMID:27264264. |
mechanistically, csa promoted gefitinib-induced apoptosis through inhibition of the stat3 pathway. |
2017-07-26 |
2023-08-13 |
human |
| Jiawei Shou, Liangkun You, Junlin Yao, Jiansheng Xie, Jing Jing, Zhao Jing, Liming Jiang, Xinbing Sui, Hongming Pan, Weidong Ha. Cyclosporine A sensitizes human non-small cell lung cancer cells to gefitinib through inhibition of STAT3. Cancer letters. vol 379. issue 1. 2017-07-26. PMID:27264264. |
similar with the function of csa, sirnas against stat3 also enhanced gefitinib-induced apoptosis in multiple lung cancer cells. |
2017-07-26 |
2023-08-13 |
human |
| Zhiwei Zhou, Xijian Lu, Jin Wang, Jia Xiao, Jing Liu, Feiyue Xin. microRNA let-7c is essential for the anisomycin-elicited apoptosis in Jurkat T cells by linking JNK1/2 to AP-1/STAT1/STAT3 signaling. Scientific reports. vol 6. 2017-07-18. PMID:27087117. |
the let-7c over-expression and the addition of its mimics facilitated the activation of ap-1, stat1 and bim by linking jnk1/2 to ap-1/stat1, but rather inhibited the activation of stat3 and bcl-xl by connecting jnk1/2 to stat3, followed by the augmented apoptosis in the cells. |
2017-07-18 |
2023-08-13 |
human |
| Zhiwei Zhou, Xijian Lu, Jin Wang, Jia Xiao, Jing Liu, Feiyue Xin. microRNA let-7c is essential for the anisomycin-elicited apoptosis in Jurkat T cells by linking JNK1/2 to AP-1/STAT1/STAT3 signaling. Scientific reports. vol 6. 2017-07-18. PMID:27087117. |
the let-7c deficiency reduced the ap-1, stat1 and bim activities, and enhanced the stat3 and bcl-xl, alleviating the anisomycin-induced apoptosis. |
2017-07-18 |
2023-08-13 |
human |