| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lou Zhong, Siyuan Sun, Jiahai Shi, Fei Cao, Xiao Han, Zhong Che. MicroRNA-125a-5p plays a role as a tumor suppressor in lung carcinoma cells by directly targeting STAT3. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 39. issue 6. 2017-07-18. PMID:28631574. |
taken together, mir-125a-5p inhibited the proliferation and invasion of lung cancer cells and facilitated lung cancer cell apoptosis through suppressing stat3. |
2017-07-18 |
2023-08-13 |
human |
| Hiroe Nakamura, Ayumi Taguchi, Kei Kawana, Akira Kawata, Mitsuyo Yoshida, Asaha Fujimoto, Juri Ogishima, Masakazu Sato, Tomoko Inoue, Haruka Nishida, Hitomi Furuya, Kensuke Tomio, Satoko Eguchi, Mayuyo Mori-Uchino, Aki Yamashita, Katsuyuki Adachi, Takahide Arimoto, Osamu Wada-Hiraike, Katsutoshi Oda, Takeshi Nagamatsu, Yutaka Osuga, Tomoyuki Fuji. STAT3 activity regulates sensitivity to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in cervical cancer cells. International journal of oncology. vol 49. issue 5. 2017-07-13. PMID:27599897. |
stat3 activity regulates sensitivity to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in cervical cancer cells. |
2017-07-13 |
2023-08-13 |
human |
| Hiroe Nakamura, Ayumi Taguchi, Kei Kawana, Akira Kawata, Mitsuyo Yoshida, Asaha Fujimoto, Juri Ogishima, Masakazu Sato, Tomoko Inoue, Haruka Nishida, Hitomi Furuya, Kensuke Tomio, Satoko Eguchi, Mayuyo Mori-Uchino, Aki Yamashita, Katsuyuki Adachi, Takahide Arimoto, Osamu Wada-Hiraike, Katsutoshi Oda, Takeshi Nagamatsu, Yutaka Osuga, Tomoyuki Fuji. STAT3 activity regulates sensitivity to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in cervical cancer cells. International journal of oncology. vol 49. issue 5. 2017-07-13. PMID:27599897. |
signal transducer and activator of transcription 3 (stat3) is a hub molecule that shifts the cellular fate to apoptosis or survival in response to cellular stresses. |
2017-07-13 |
2023-08-13 |
human |
| Hiroe Nakamura, Ayumi Taguchi, Kei Kawana, Akira Kawata, Mitsuyo Yoshida, Asaha Fujimoto, Juri Ogishima, Masakazu Sato, Tomoko Inoue, Haruka Nishida, Hitomi Furuya, Kensuke Tomio, Satoko Eguchi, Mayuyo Mori-Uchino, Aki Yamashita, Katsuyuki Adachi, Takahide Arimoto, Osamu Wada-Hiraike, Katsutoshi Oda, Takeshi Nagamatsu, Yutaka Osuga, Tomoyuki Fuji. STAT3 activity regulates sensitivity to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in cervical cancer cells. International journal of oncology. vol 49. issue 5. 2017-07-13. PMID:27599897. |
however, the contribution of stat3 activity to trail-induced apoptosis in cervical cancer remains unknown. |
2017-07-13 |
2023-08-13 |
human |
| Hiroe Nakamura, Ayumi Taguchi, Kei Kawana, Akira Kawata, Mitsuyo Yoshida, Asaha Fujimoto, Juri Ogishima, Masakazu Sato, Tomoko Inoue, Haruka Nishida, Hitomi Furuya, Kensuke Tomio, Satoko Eguchi, Mayuyo Mori-Uchino, Aki Yamashita, Katsuyuki Adachi, Takahide Arimoto, Osamu Wada-Hiraike, Katsutoshi Oda, Takeshi Nagamatsu, Yutaka Osuga, Tomoyuki Fuji. STAT3 activity regulates sensitivity to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in cervical cancer cells. International journal of oncology. vol 49. issue 5. 2017-07-13. PMID:27599897. |
we then inhibited stat3 expression in the siha cell line using sirna against stat3 and suppressed stat3 activity using a stat3 inhibitor; both these treatments sensitized trail-induced apoptosis in the siha cell line. |
2017-07-13 |
2023-08-13 |
human |
| Hiroe Nakamura, Ayumi Taguchi, Kei Kawana, Akira Kawata, Mitsuyo Yoshida, Asaha Fujimoto, Juri Ogishima, Masakazu Sato, Tomoko Inoue, Haruka Nishida, Hitomi Furuya, Kensuke Tomio, Satoko Eguchi, Mayuyo Mori-Uchino, Aki Yamashita, Katsuyuki Adachi, Takahide Arimoto, Osamu Wada-Hiraike, Katsutoshi Oda, Takeshi Nagamatsu, Yutaka Osuga, Tomoyuki Fuji. STAT3 activity regulates sensitivity to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in cervical cancer cells. International journal of oncology. vol 49. issue 5. 2017-07-13. PMID:27599897. |
accompanied by stat3 inactivation, tm pretreatment significantly enhanced trail-induced apoptosis. |
2017-07-13 |
2023-08-13 |
human |
| Hiroe Nakamura, Ayumi Taguchi, Kei Kawana, Akira Kawata, Mitsuyo Yoshida, Asaha Fujimoto, Juri Ogishima, Masakazu Sato, Tomoko Inoue, Haruka Nishida, Hitomi Furuya, Kensuke Tomio, Satoko Eguchi, Mayuyo Mori-Uchino, Aki Yamashita, Katsuyuki Adachi, Takahide Arimoto, Osamu Wada-Hiraike, Katsutoshi Oda, Takeshi Nagamatsu, Yutaka Osuga, Tomoyuki Fuji. STAT3 activity regulates sensitivity to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in cervical cancer cells. International journal of oncology. vol 49. issue 5. 2017-07-13. PMID:27599897. |
we therefore concluded that trail-induced apoptosis was regulated by stat3 in response to trail stimulation. |
2017-07-13 |
2023-08-13 |
human |
| Uri Rozovski, David M Harris, Ping Li, Zhiming Liu, Ji Yuan Wu, Srdana Grgurevic, Stefan Faderl, Alessandra Ferrajoli, William G Wierda, Matthew Martinez, Srdan Verstovsek, Michael J Keating, Zeev Estro. At High Levels, Constitutively Activated STAT3 Induces Apoptosis of Chronic Lymphocytic Leukemia Cells. Journal of immunology (Baltimore, Md. : 1950). vol 196. issue 10. 2017-06-30. PMID:27076684. |
at high levels, constitutively activated stat3 induces apoptosis of chronic lymphocytic leukemia cells. |
2017-06-30 |
2023-08-13 |
Not clear |
| Uri Rozovski, David M Harris, Ping Li, Zhiming Liu, Ji Yuan Wu, Srdana Grgurevic, Stefan Faderl, Alessandra Ferrajoli, William G Wierda, Matthew Martinez, Srdan Verstovsek, Michael J Keating, Zeev Estro. At High Levels, Constitutively Activated STAT3 Induces Apoptosis of Chronic Lymphocytic Leukemia Cells. Journal of immunology (Baltimore, Md. : 1950). vol 196. issue 10. 2017-06-30. PMID:27076684. |
although we previously found that stat3 protects cll cells from apoptosis, stat3 levels were significantly higher in cells from patients with high counts than in cells from patients with low counts. |
2017-06-30 |
2023-08-13 |
Not clear |
| Uri Rozovski, David M Harris, Ping Li, Zhiming Liu, Ji Yuan Wu, Srdana Grgurevic, Stefan Faderl, Alessandra Ferrajoli, William G Wierda, Matthew Martinez, Srdan Verstovsek, Michael J Keating, Zeev Estro. At High Levels, Constitutively Activated STAT3 Induces Apoptosis of Chronic Lymphocytic Leukemia Cells. Journal of immunology (Baltimore, Md. : 1950). vol 196. issue 10. 2017-06-30. PMID:27076684. |
using chromatin immunoprecipitation and emsa, we found that stat3 binds with low affinity to the caspase-3 promoter, suggesting that at high levels, stat3 activates proapoptotic mechanisms and induces apoptosis in cll cells. |
2017-06-30 |
2023-08-13 |
Not clear |
| Xiaolong Zhang, Xiaoyi Wu, Fangling Zhang, Shouyong Mo, Yuanyuan Lu, Wei Wei, Xiaoling Chen, Linhua Lan, Bin Lu, Yongzhang Li. Paclitaxel induces apoptosis of esophageal squamous cell carcinoma cells by downregulating STAT3 phosphorylation at Ser727. Oncology reports. vol 37. issue 4. 2017-06-29. PMID:28350087. |
paclitaxel induces apoptosis of esophageal squamous cell carcinoma cells by downregulating stat3 phosphorylation at ser727. |
2017-06-29 |
2023-08-13 |
human |
| Xiaolong Zhang, Xiaoyi Wu, Fangling Zhang, Shouyong Mo, Yuanyuan Lu, Wei Wei, Xiaoling Chen, Linhua Lan, Bin Lu, Yongzhang Li. Paclitaxel induces apoptosis of esophageal squamous cell carcinoma cells by downregulating STAT3 phosphorylation at Ser727. Oncology reports. vol 37. issue 4. 2017-06-29. PMID:28350087. |
in this study, we found that paclitaxel-induced apoptosis by increasing the relevant apoptosis protein expression and the release of cytochrome c via downregulation of signal transducer and activator of transcription 3 (stat3) and phospho-stat3 (ser727). |
2017-06-29 |
2023-08-13 |
human |
| Xiaolong Zhang, Xiaoyi Wu, Fangling Zhang, Shouyong Mo, Yuanyuan Lu, Wei Wei, Xiaoling Chen, Linhua Lan, Bin Lu, Yongzhang Li. Paclitaxel induces apoptosis of esophageal squamous cell carcinoma cells by downregulating STAT3 phosphorylation at Ser727. Oncology reports. vol 37. issue 4. 2017-06-29. PMID:28350087. |
in conclusion, our findings reveal that paclitaxel induced apoptosis in both ec-1 and eca-109 cells through the reduction of stat3 and phospho‑stat3 (ser727) level, and suggest that paclitaxel may be of therapeutic potential in the treatment of escc through the induction of mitochondrial apoptosis in escc cells. |
2017-06-29 |
2023-08-13 |
human |
| Meng-Hsuan Cheng, Yun-Hong Wong, Chia-Ming Chang, Chun-Chien Yang, Shih-Hua Chen, Chun-Lung Yuan, Hsiao-Mei Kuo, Chun-Yuh Yang, Hui-Fen Chi. B1, a novel HDAC inhibitor, induces apoptosis through the regulation of STAT3 and NF-κB. International journal of molecular medicine. vol 39. issue 5. 2017-06-29. PMID:28393178. |
b1, a novel hdac inhibitor, induces apoptosis through the regulation of stat3 and nf-κb. |
2017-06-29 |
2023-08-13 |
human |
| Jia-Hua Feng, Kyoko Nakagawa-Goto, Kuo-Hsiung Lee, Lie-Fen Shyu. A Novel Plant Sesquiterpene Lactone Derivative, DETD-35, Suppresses BRAFV600E Mutant Melanoma Growth and Overcomes Acquired Vemurafenib Resistance in Mice. Molecular cancer therapeutics. vol 15. issue 6. 2017-06-27. PMID:27048951. |
mechanistic studies suggested that detd-35 overcame acquired vemurafenib resistance at least in part through deregulating mek-erk, akt, and stat3 signaling pathways and promoting apoptosis of cancer cells. |
2017-06-27 |
2023-08-13 |
mouse |
| Sheng-An Su, Du Yang, Wei Zhu, Zhejun Cai, Na Zhang, Lina Zhao, Jian-An Wang, Meixiang Xian. Interleukin-17A mediates cardiomyocyte apoptosis through Stat3-iNOS pathway. Biochimica et biophysica acta. vol 1863. issue 11. 2017-06-26. PMID:27566322. |
in the present study, an in-vitro model of cardiomyocyte apoptosis induced by il-17a stimulation was employed and the roles of inos and stat3 involved were investigated. |
2017-06-26 |
2023-08-13 |
mouse |
| Sheng-An Su, Du Yang, Wei Zhu, Zhejun Cai, Na Zhang, Lina Zhao, Jian-An Wang, Meixiang Xian. Interleukin-17A mediates cardiomyocyte apoptosis through Stat3-iNOS pathway. Biochimica et biophysica acta. vol 1863. issue 11. 2017-06-26. PMID:27566322. |
consistent with these data, silencing of stat3 in fact can aggravate il-17a-triggered cardiomyocyte apoptosis. |
2017-06-26 |
2023-08-13 |
mouse |
| Sheng-An Su, Du Yang, Wei Zhu, Zhejun Cai, Na Zhang, Lina Zhao, Jian-An Wang, Meixiang Xian. Interleukin-17A mediates cardiomyocyte apoptosis through Stat3-iNOS pathway. Biochimica et biophysica acta. vol 1863. issue 11. 2017-06-26. PMID:27566322. |
finally, using an in vivo myocardial ischemia/reperfusion injury model, we verified that stat3 inhibition increased inos expression and exacerbated cardiomyocyte apoptosis. |
2017-06-26 |
2023-08-13 |
mouse |
| Sheng-An Su, Du Yang, Wei Zhu, Zhejun Cai, Na Zhang, Lina Zhao, Jian-An Wang, Meixiang Xian. Interleukin-17A mediates cardiomyocyte apoptosis through Stat3-iNOS pathway. Biochimica et biophysica acta. vol 1863. issue 11. 2017-06-26. PMID:27566322. |
thus, our data strongly support the notion that stat3 plays a compensatory anti-apoptotic role in il-17a/inos-mediated cardiomyocyte apoptosis via inhibiting inos transcription, providing a novel molecular mechanism of apoptosis regulation and complicated interactions between il-17a/inos and il-17a/stat3 signalings. |
2017-06-26 |
2023-08-13 |
mouse |
| Xiaojuan Wu, Yang Cao, Hui Xiao, Chenglong Li, Jiayuh Li. Bazedoxifene as a Novel GP130 Inhibitor for Pancreatic Cancer Therapy. Molecular cancer therapeutics. vol 15. issue 11. 2017-06-15. PMID:27535971. |
here, we observed bazedoxifene inhibited stat3 phosphorylation and stat3 dna binding, induced apoptosis, and suppressed tumor growth in pancreatic cancer cells with persistent il6/gp130/stat3 signaling in vitro and in vivo in addition, il6, but not infγ, rescued bazedoxifene-mediated reduction of cell viability. |
2017-06-15 |
2023-08-13 |
mouse |