| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kathryn E Reynolds, Eileen Huang, Monica Sabbineni, Eliza Wiseman, Nadeem Murtaza, Desmond Ahuja, Matt Napier, Kathryn M Murphy, Karun K Singh, Angela L Scot. Purinergic Signalling Mediates Aberrant Excitability of Developing Neuronal Circuits in the Fmr1 Knockout Mouse Model. Molecular neurobiology. 2024-04-23. PMID:38652351. |
here, we found that conditioned media from primary fmr1 ko astrocytes was sufficient to enhance neurite extension and complexity of both wildtype and fmr1 ko neurons to a similar degree as utp-mediated outgrowth. |
2024-04-23 |
2024-04-26 |
mouse |
| Gabriel A Hoppock, Evan G Buettmann, Joseph A Denisco, Galen M Goldscheitter, Sebastian N Condyles, Otto J Juhl, Michael A Friedman, Yue Zhang, Henry J Donahu. Connexin 43 and Cell Culture Substrate Differentially Regulate OCY454 Osteocytic Differentiation and Signaling to Primary Bone Cells. American journal of physiology. Cell physiology. 2023-08-21. PMID:37602413. |
conditioned media from cx43 ko cells promoted increased osteoblastogenesis and increased osteoclastogenesis, with maximal effects from 3d cultured cx43 ko cells. |
2023-08-21 |
2023-09-07 |
Not clear |
| Gabriel A Hoppock, Evan G Buettmann, Joseph A Denisco, Galen M Goldscheitter, Sebastian N Condyles, Otto J Juhl, Michael A Friedman, Yue Zhang, Henry J Donahu. Connexin 43 and Cell Culture Substrate Differentially Regulate OCY454 Osteocytic Differentiation and Signaling to Primary Bone Cells. bioRxiv : the preprint server for biology. 2023-07-10. PMID:37425674. |
conditioned media from cx43 ko cells promoted increased osteoblastogenesis and increased osteoclastogenesis, with maximal effects from 3d cultured cx43 ko cells. |
2023-07-10 |
2023-08-14 |
Not clear |
| Leandro Val Sayson, Hyun Jun Lee, Darlene Mae Ortiz, Mikyung Kim, Raly James Perez Custodio, Chae Hyeon Lee, Yong Sup Lee, Jae Hoon Cheong, Hee Jin Ki. The differential vulnerabilities of Per2 knockout mice to the addictive properties of methamphetamine and cocaine. Progress in neuro-psychopharmacology & biological psychiatry. 2023-05-04. PMID:37141987. |
in this study, the responses of wt and per2 ko mice to various psychostimulants via intravenous self-administration were determined, along with their behaviors in meth- or cocaine (coc)-induced conditioned place preference and spontaneous locomotion in the open-field test. |
2023-05-04 |
2023-08-14 |
mouse |
| Nicola Wheelan, Jonathan R Seckl, Joyce L W Ya. 11β-Hydroxysteroid dehydrogenase 1 deficiency prevents PTSD-like memory in young adult mice. Psychoneuroendocrinology. vol 146. 2022-10-02. PMID:36183622. |
in contrast, young hsd1 ko mice fear conditioned with stress showed normal fear memory (i.e., increased fear response to conditioning context), as observed in wt mice fear conditioned alone. |
2022-10-02 |
2023-08-14 |
mouse |
| Nicola Wheelan, Jonathan R Seckl, Joyce L W Ya. 11β-Hydroxysteroid dehydrogenase 1 deficiency prevents PTSD-like memory in young adult mice. Psychoneuroendocrinology. vol 146. 2022-10-02. PMID:36183622. |
while aged hsd1 ko mice fear conditioned with stress also displayed normal contextual fear memory, the fear response to the 'safe' tone remained. |
2022-10-02 |
2023-08-14 |
mouse |
| Samantha L Regan, Chiho Sugimoto, Hannah E Dawson, Michael T Williams, Charles V Vorhee. Latrophilin-3 heterozygous versus homozygous mutations in Sprague Dawley rats: Effects on egocentric and allocentric memory and locomotor activity. Genes, brain, and behavior. 2022-08-19. PMID:35985692. |
ko and het rats had egocentric (cwm) and spatial deficits (mwm), increased startle response, and ko rats showed less conditioned freezing on contextual and cued memory; there were no effects on working memory (rwm) or passive avoidance. |
2022-08-19 |
2023-08-14 |
human |
| Meng Fan, Weikuan Sun, Xiaofan Gu, Shanshan Lu, Qiang Shen, Xuan Liu, Xiongwen Zhan. The critical role of STAT3 in biogenesis of tumor-derived exosomes with potency of inducing cancer cachexia in vitro and in vivo. Oncogene. 2022-01-16. PMID:35034093. |
the genetic manipulation of stat3 expression, stat3 knockout (ko) or overexpression (oe), significantly affected the exosome biogenesis and also the potency of c26 conditioned medium (cm) in inducing muscle atrophy and lipolysis in vitro. |
2022-01-16 |
2023-08-13 |
mouse |
| Anthony Sclafani, Karen Ackrof. Fat preference deficits and experience-induced recovery in, global taste-deficient Trpm5 and Calhm1 knockout mice. Physiology & behavior. 2022-01-09. PMID:34998826. |
the same ko mice preferred all fat concentrations in a second test series, which is attributed to a postoral fat conditioned attraction to the non-taste flavor qualities of the intralipid, although they consumed less fat than the wt mice. |
2022-01-09 |
2023-08-13 |
mouse |
| Tomohisa Mori, Naoki Uzawa, Daiki Masukawa, Shigeto Hirayama, Yoshiyuki Iwase, Mayuna Hokazono, Yuya Udagawa, Tsutomu Suzuk. Enhancement of the rewarding effects of 3,4-methylenedioxymethamphetamine in orexin knockout mice. Behavioural brain research. vol 396. 2021-11-09. PMID:32653557. |
in the present study, conditioned place preferences induced by methamphetamine and methylphenidate were not altered in orexin ko mice. |
2021-11-09 |
2023-08-13 |
mouse |
| Tomohisa Mori, Naoki Uzawa, Daiki Masukawa, Shigeto Hirayama, Yoshiyuki Iwase, Mayuna Hokazono, Yuya Udagawa, Tsutomu Suzuk. Enhancement of the rewarding effects of 3,4-methylenedioxymethamphetamine in orexin knockout mice. Behavioural brain research. vol 396. 2021-11-09. PMID:32653557. |
interestingly, we found that mdma induced a conditioned place preference in orexin ko mice, but not in wild type (wt) mice. |
2021-11-09 |
2023-08-13 |
mouse |
| Samantha L Regan, Emily M Pitzer, Jillian R Hufgard, Chiho Sugimoto, Michael T Williams, Charles V Vorhee. A novel role for the ADHD risk gene latrophilin-3 in learning and memory in Lphn3 knockout rats. Neurobiology of disease. vol 158. 2021-10-14. PMID:34352385. |
ko rats were impaired in egocentric l&m in the cincinnati water maze, spatial l&m and cognitive flexibility in the morris water maze (mwm), with no effects on conditioned freezing, novel object recognition, or temporal order recognition. |
2021-10-14 |
2023-08-13 |
mouse |
| Yamila I Rodriguez, Ludmila E Campos, Melina G Castro, Nadia Bannoud, Ada G Blidner, Verónica P Filippa, Diego O Croci, Gabriel A Rabinovich, Sergio E Alvare. Tumor Necrosis Factor Receptor-1 (p55) Deficiency Attenuates Tumor Growth and Intratumoral Angiogenesis and Stimulates CD8 Cells. vol 9. issue 11. 2021-06-16. PMID:33202705. |
although no evidence of spontaneous metastases was observed, conditioned media obtained from tnfr1 ko tumors increased tumor cell migration. |
2021-06-16 |
2023-08-13 |
mouse |
| José Wojnacki, Sébastien Nola, Philippe Bun, Béatrice Cholley, Francesca Filippini, Mary T Pressé, Joanna Lipecka, Sin Man Lam, Julie N'guyen, Axelle Simon, Amine Ouslimani, Guanghou Shui, Claudio Marcelo Fader, Maria Isabel Colombo, Ida Chiara Guerrera, Thierry Gall. Role of VAMP7-Dependent Secretion of Reticulon 3 in Neurite Growth. Cell reports. vol 33. issue 12. 2021-05-24. PMID:33357422. |
treatment of neuronal cells with atg5 or vamp7 ko conditioned medium does not recapitulate the effect of these kos on neurite growth. |
2021-05-24 |
2023-08-13 |
Not clear |
| Soomaayeh Heysieattalab, Ka-Hung Lee, Yan Liu, Yubin Wang, Michael R Foy, Xiaoning Bi, Michel Baudr. Impaired cerebellar plasticity and eye-blink conditioning in calpain-1 knock-out mice. Neurobiology of learning and memory. vol 170. 2021-04-12. PMID:30735788. |
however, after 5 days of training, the percentage of conditioned responses (crs) between calpain-1 ko and wt mice was identical. |
2021-04-12 |
2023-08-13 |
mouse |
| Kuisheng Sun, Feng Wang, Lin Ma, Xiaofan Ren, Chun Zhang, Weifang Rong, Tao Su. Genetic knockout of the G protein-coupled estrogen receptor 1 facilitates the acquisition of morphine-induced conditioned place preference and aversion in mice. Biochemical and biophysical research communications. vol 525. issue 4. 2020-12-28. PMID:32184017. |
our study used gper1 knockout (gper1 ko) and wild-type (wt) mice to compare the sensitivity differences of morphine- and sucrose-induced conditioned place preference (cpp) and naloxone-induced conditioned place aversion (cpa), and differences in dopamine (da) content in the nucleus accumbens (nac) were determined by high performance liquid chromatography (hplc). |
2020-12-28 |
2023-08-13 |
mouse |
| Alexander Tishchenko, Daniel D Azorín, Laia Vidal-Brime, María José Muñoz, Pol Jiménez Arenas, Christopher Pearce, Henrique Girao, Santiago Ramón Y Cajal, Trond Aase. Cx43 and Associated Cell Signaling Pathways Regulate Tunneling Nanotubes in Breast Cancer Cells. Cancers. vol 12. issue 10. 2020-11-03. PMID:33003486. |
notably, secreted factors present in conditioned medium stimulated tnts more potently when derived from cx43-expressing cells than from ko cells. |
2020-11-03 |
2023-08-13 |
Not clear |
| Harumi Nakao, Yasushi Kishimoto, Kouichi Hashimoto, Kazuo Kitamura, Miwako Yamasaki, Kazuki Nakao, Masahiko Watanabe, Masanobu Kano, Yutaka Kirino, Atsu Aib. mGluR1 in cerebellar Purkinje cells is essential for the formation but not expression of associative eyeblink memory. Scientific reports. vol 9. issue 1. 2020-10-13. PMID:31089195. |
global mglur1 knock-out (ko) mice show a significantly lower percentage of conditioned response (cr%) than wild-type mice in eyeblink conditioning, and the impaired cr% is restored by the introduction of mglur1 in pcs. |
2020-10-13 |
2023-08-13 |
mouse |
| Ignacio M Larrayoz, Hilda Ferrero, Eva Martisova, Francisco J Gil-Bea, María J Ramírez, Alfredo Martíne. Adrenomedullin Contributes to Age-Related Memory Loss in Mice and Is Elevated in Aging Human Brains. Frontiers in molecular neuroscience. vol 10. 2020-10-01. PMID:29187812. |
mice lacking neuronal am and pamp (knockout, ko) and their wild type (wt) littermates were subjected, at different ages, to the novel object recognition test and the contextual fear conditioned test. |
2020-10-01 |
2023-08-13 |
mouse |
| Raquel Pascua-Maestro, Esperanza González, Concepción Lillo, Maria D Ganfornina, Juan Manuel Falcón-Pérez, Diego Sanche. Extracellular Vesicles Secreted by Astroglial Cells Transport Apolipoprotein D to Neurons and Mediate Neuronal Survival Upon Oxidative Stress. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:30687015. |
indeed, we demonstrate that conditioned media derived from apod-knock-out (ko) astrocytes exert only a partial autocrine protection from oxidative stress (os) challenges, and that evs are required for apod-positive astrocytic cell line derived medium to exert full neuroprotection. |
2020-10-01 |
2023-08-13 |
human |