| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Geith Maal-Bared, Mandy Yee, Erika K Harding, Martha Ghebreselassie, Michael Bergamini, Roxanne Choy, Ethan Kim, Stephanie Di Vito, Maryam Patel, Mohammadreza Amirzadeh, Taryn E Grieder, Brenda L Coles, James I Nagy, Robert P Bonin, Hendrik W Steenland, Derek van der Koo. Connexin-36-positive gap junctions in ventral tegmental area GABA neurons sustain opiate dependence. The European journal of neuroscience. 2024-04-28. PMID:38679044. |
the tegmental pedunculopontine nucleus (tpp) is necessary for opiate conditioned place preferences (cpp) in previously drug-naïve rats and mice, whereas dopaminergic (da) transmission in the nucleus accumbens (nac) is necessary for opiate cpp in opiate-dependent and withdrawn (odw) rats and mice. |
2024-04-28 |
2024-05-01 |
mouse |
| Nazanin Kahvandi, Zahra Ebrahimi, Maryam Sharifi, Seyed Asaad Karimi, Siamak Shahidi, Iraj Salehi, Rasool Haddadi, Abdolrahman Sarih. S-3,4-DCPG, a potent orthosteric agonist for the mGlu8 receptor, facilitates extinction and inhibits the reinstatement of morphine-induced conditioned place preference in male rats. Pharmacology, biochemistry, and behavior. 2024-04-23. PMID:38653345. |
the objective of this study was to examine the involvement of mglu8 receptors in the nac in the mechanisms underlying the extinction and reinstatement of conditioned place preference (cpp) induced by morphine. |
2024-04-23 |
2024-04-26 |
rat |
| Young-Jung Kim, Wun-A Kook, Shi-Xun Ma, Bo-Ram Lee, Yong-Hyun Ko, Seon-Kyung Kim, Youyoung Lee, Jae-Gyeong Lee, Sooyeun Lee, Kyeong-Man Kim, Seok-Yong Lee, Choon-Gon Jan. The novel psychoactive substance 25E-NBOMe induces reward-related behaviors via dopamine D1 receptor signaling in male rodents. Archives of pharmacal research. 2024-03-29. PMID:38551761. |
our data demonstrated that 25e-nbome induces conditioned place preference, and the dopaminergic signaling in the nac mediates these. |
2024-03-29 |
2024-04-01 |
mouse |
| Young-Jung Kim, Wun-A Kook, Shi-Xun Ma, Bo-Ram Lee, Yong-Hyun Ko, Seon-Kyung Kim, Youyoung Lee, Jae-Gyeong Lee, Sooyeun Lee, Kyeong-Man Kim, Seok-Yong Lee, Choon-Gon Jan. The novel psychoactive substance 25E-NBOMe induces reward-related behaviors via dopamine D1 receptor signaling in male rodents. Archives of pharmacal research. 2024-03-29. PMID:38551761. |
significantly, pharmacological blockade of d1dr or chemogenetic inhibition of d1dr-expressing medium spiny neurons in the nac attenuated 25e-nbome-induced conditioned place preference in male mice. |
2024-03-29 |
2024-04-01 |
mouse |
| Ziqing Huai, Bing Huang, Guanhong He, Haibo Li, Yonghui Liu, Qiumin Le, Feifei Wang, Lan Ma, Xing Li. Accumulation of NMDA receptors in accumbal neuronal ensembles mediates increased conditioned place preference for cocaine after prolonged withdrawal. Progress in neurobiology. 2024-02-24. PMID:38401668. |
here we labeled neuronal ensembles in the shell of nac (nacsh) activated by cocaine conditioned place preference (cpp) training. |
2024-02-24 |
2024-02-27 |
mouse |
| Seyedeh-Najmeh Katebi, Anahita Torkaman-Boutorabi, Esmail Riahi, Abbas Haghparas. N-acetylcysteine attenuates accumbal core neuronal activity in response to morphine in the reinstatement of morphine CPP in morphine extinguished rats. Progress in neuro-psychopharmacology & biological psychiatry. 2024-01-12. PMID:38215930. |
in this study, we aimed to explore the impact of subchronic nac administration during the extinction period and acute nac administration on the electrical activity of nacore neurons in response to a priming dose of morphine in rats subjected to extinction from morphine-induced place preference (cpp).we conducted single-unit recordings in anesthetized rats on the reinstatement day, following the establishment of morphine-induced conditioned place preference (7 mg/kg, s.c., 3 days), and subsequent drug-free extinction. |
2024-01-12 |
2024-01-15 |
rat |
| Milan D Valyear, Alexa Brown, Ghislaine Deyab, Franz R Villaruel, Soraya Lahlou, Nina Caporicci-Dinucci, Nadia Chaudhr. Augmenting glutamatergic, but not dopaminergic, activity in the nucleus accumbens shell disrupts responding to a discrete alcohol cue in an alcohol context. The European journal of neuroscience. 2024-01-08. PMID:38185906. |
when conditioned cs responding was tested by presenting the cs without alcohol, we found that augmenting glutamatergic activity in the nucleus accumbens (nac) shell by microinfusing α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) reduced responding to an alcohol cs in an alcohol, but not neutral, context. |
2024-01-08 |
2024-01-10 |
rat |
| Emanuele Claudio Latagliata, Cristina Orsini, Simona Cabib, Francesca Biagioni, Francesco Fornai, Stefano Puglisi-Allegr. Prefrontal Dopamine in Flexible Adaptation to Environmental Changes: A Game for Two Players. Biomedicines. vol 11. issue 12. 2023-12-23. PMID:38137410. |
the reviewed findings point to a role of catecholaminergic transmission in the medial prefrontal cortex (mpfc) in modulating da's availability in the nucleus accumbens (nac), as well as a role of nac da in modulating the motivational value of natural and conditioned stimuli. |
2023-12-23 |
2023-12-25 |
Not clear |
| Ingrid Reverte, Claudia Marchetti, Sara Pezza, Soami F Zenoni, Giorgia Scaringi, Laura Ferrucci, Ginevra D'Ottavio, Annabella Pignataro, Diego Andolina, Marcello Raspa, Ferdinando Scavizzi, Marco Venniro, Leslie A Ramsey, Cornelius Gross, Daniele Caprioli, Davide Ragozzin. Microglia-mediated calcium-permeable AMPAR accumulation in the nucleus accumbens drives hyperlocomotion during cocaine withdrawal. Brain, behavior, and immunity. 2023-11-15. PMID:37967660. |
here, we investigated the role of microglia in nac neuroadaptations after withdrawal from cocaine-induced conditioned place preference (cpp). |
2023-11-15 |
2023-11-20 |
Not clear |
| Xiaohui Bai, Kun Zhang, Chaopeng Ou, Yanyu Mu, Dongmei Chi, Jianxing Zhang, Jingxiu Huang, Xile Li, Yingjun Zhang, Wan Huang, Handong Ouyan. AKAP150 from nucleus accumbens dopamine D1 and D2 receptor-expressing medium spiny neurons regulates morphine withdrawal. iScience. vol 26. issue 11. 2023-11-13. PMID:37953959. |
in this study, akap150 expression in nac is upregulated in naloxone-precipitated morphine withdrawal model, and knockdown of akap150 alleviates morphine withdrawal somatic signs and improves the performance of conditioned place aversion (cpa) test. |
2023-11-13 |
2023-11-20 |
Not clear |
| Joakim W Ronström, Stephanie B Williams, Andrew Payne, Daniel J Obray, Caylor Hafen, Matthew Burris, K Scott Weber, Scott C Steffensen, Jordan T Yorgaso. Interleukin-10 enhances activity of ventral tegmental area dopamine neurons resulting in increased dopamine release. Brain, behavior, and immunity. 2023-07-15. PMID:37453452. |
intracranial il-10 enhanced nac dopamine levels in vivo and produced conditioned place aversion. |
2023-07-15 |
2023-08-14 |
Not clear |
| Jonatan Barrera-Chimal, Nathalie Henley, Michael Philip Grant, Schrodinger Cenatus, Pedro Geraldes, Vincent Pichette, Casimiro Gerarduzz. Tungsten toxicity on kidney tubular epithelial cells induces renal inflammation and M1-macrophage polarization. Cell biology and toxicology. 2023-06-27. PMID:37368165. |
these effects were not observed when raw cells were exposed to conditioned media from hk-2 cells treated with tungsten and supplemented with the antioxidant n-acetylcysteine (nac). |
2023-06-27 |
2023-08-14 |
mouse |
| Daniel R Garton, Giorgio Turconi, Vilma Iivanainen, Jaan-Olle Andresso. Opposing Spatially Segregated Function of Endogenous GDNF-RET Signaling in Cocaine Addiction. Biomolecules. vol 13. issue 5. 2023-05-27. PMID:37238631. |
similarly, after establishing cocaine-induced conditioned place preference, we studied the effect of conditionally reducing gdnf in the ventral striatum nucleus accumbens (nac), the target of mesolimbic dopaminergic innervation. |
2023-05-27 |
2023-08-14 |
Not clear |
| Daniel R Garton, Giorgio Turconi, Vilma Iivanainen, Jaan-Olle Andresso. Opposing Spatially Segregated Function of Endogenous GDNF-RET Signaling in Cocaine Addiction. Biomolecules. vol 13. issue 5. 2023-05-27. PMID:37238631. |
we find that the reduction of ret within the vta hastens cocaine-induced conditioned place preference extinction and reduces reinstatement, while the reduction of gdnf within the nac does the opposite: prolongs cocaine-induced conditioned place preference and increases preference during reinstatement. |
2023-05-27 |
2023-08-14 |
Not clear |
| Christian M Wood, Laith Alexander, Johan Alsiö, Andrea M Santangelo, Lauren McIver, Gemma J Cockcroft, Angela C Robert. Chemogenetics identifies separate area 25 brain circuits involved in anhedonia and anxiety in marmosets. Science translational medicine. vol 15. issue 690. 2023-04-05. PMID:37018416. |
activation of the neural pathway connecting the scacc-25 to the nucleus accumbens (nac) caused blunting of anticipatory arousal (a form of anhedonia) in marmosets in response to a reward-associated conditioned stimulus in an appetitive pavlovian discrimination test. |
2023-04-05 |
2023-08-14 |
human |
| Linxuan Zhang, Zehao Zeng, Xiaoyu Lu, Mengqing Li, Jiayu Yao, Guangjing Zou, Zhaorong Chen, Qian Li, Changqi Li, Fang L. CNTN1 in the Nucleus Accumbens is Involved in Methamphetamine-Induced Conditioned Place Preference in Mice. Neurotoxicity research. 2023-04-04. PMID:37014368. |
additionally, repeated meth exposure also induced conditioned place preference (cpp) in mice and upregulated the expression levels of cntn1, nr2a, nr2b, and psd95 in the nac. |
2023-04-04 |
2023-08-14 |
mouse |
| Zahra Ebrahimi, Nazanin Kahvandi, Elahe Shahriari, Alireza Komaki, Seyed Asaad Karimi, Marzieh Naderishahab, Maryam Sharifi, Abdolrahman Sarih. VU0155041, a positive allosteric modulator of mGluR4, in the nucleus accumbens facilitates extinction and inhibits the reinstatement of morphine-induced conditioned place preference in male rats. Brain research bulletin. 2023-03-30. PMID:36997034. |
here, we examined the hypothesis that the mglu4 receptor within that nac has a role in the extinction and reinstatement of morphine-induced conditioned place preference (cpp). |
2023-03-30 |
2023-08-14 |
rat |
| Parviz Dousti Kataj, Nasim Vousooghi, Mahmoud Reza Hadjighassem, Maryam Farahmandfar, Somayeh Ebrahimi-Baroug. Evaluation of the effect of mesenchymal stem cells injection in the nucleus accumbens on the morphine reinstatement behavior in a conditioned place preference model in Wistar rat: expression changes of NMDA receptor subunits and NT-3. Behavioural brain research. 2023-02-28. PMID:36854364. |
this study was designed to discover the effect of mscs injection in the nucleus accumbens (nac) on the reinstatement of behavior in morphine-induced conditioned place preference (cpp) in male rats. |
2023-02-28 |
2023-08-14 |
rat |
| Diana M Cortés-Patiño, Hans Ballesteros-Acosta, Valentyna Martin Neira, David Rikardo Pérez Contreras, Marisol R Lampre. Post-weaning social isolation increases the incentive value of nicotine-related contexts and decreases the accumulation of ΔFosB in nucleus accumbens in adolescent rats. Pharmacology, biochemistry, and behavior. 2023-02-22. PMID:36805863. |
the current study evaluated the effects of differential rearing conditions during adolescence (isolation or group rearing) on (1) conditioned place preference induced by low nicotine doses (0.1 or 0.3 mg/kg) and (2) sensitization to the locomotor effects of nicotine after sub-chronic administration (3) and accumulation of Δfosb in nucleus accumbens (nac). |
2023-02-22 |
2023-08-14 |
rat |
| Chen Yin Ou, Ying Hao Yu, Chi-Wen Wu, Anna Kozłowska, Bai-Chung Shyu, Andrew Chih Wei Huan. Neuronal activity of the medial prefrontal cortex, nucleus accumbens, and basolateral amygdala in conditioned taste aversion and conditioned place preference induced by different doses of morphine administrations in rats. Frontiers in pharmacology. vol 14. 2023-02-10. PMID:36762112. |
to re-examine the paradoxical effect hypothesis of abused drugs, the present study concerned whether different doses of morphine disparately affect neuronal activity and associations among the subareas of the medial prefrontal cortex (mpfc: cingulate cortex 1-cg1, prelimbic cortex-prl, infralimbic cortex-il), the subregions of the nucleus accumbens (nac; both core and shell), and the basolateral amygdala (bla) following conditioned taste aversion (cta) and conditioned place preference (cpp). |
2023-02-10 |
2023-08-14 |
rat |