| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tehila Beiser, Elvira Lisniansky, Moriya Weitz, Alexey Bingor, Etty Grad, Kobi Rosenblum, Claire Thornton, Rami Yak. A functional eEF2K-eEF2 pathway in the NAc is critical for the expression of cocaine-induced psychomotor sensitisation and conditioned place preference. Translational psychiatry. vol 12. issue 1. 2022-11-02. PMID:36319619. |
a functional eef2k-eef2 pathway in the nac is critical for the expression of cocaine-induced psychomotor sensitisation and conditioned place preference. |
2022-11-02 |
2023-08-14 |
mouse |
| Daozhong Jin, Hong Chen, Shao-Rui Chen, Hui-Lin Pa. α2δ-1 Protein drives opioid-induced conditioned reward and synaptic NMDA receptor hyperactivity in the nucleus accumbens. Journal of neurochemistry. 2022-10-12. PMID:36222452. |
correspondingly, systemically administered gabapentin, cacna2d1 ablation, or microinjection of the α2δ-1 c terminus-interfering peptide into the nac core attenuated morphine-induced conditioned place preference and locomotor sensitization. |
2022-10-12 |
2023-08-14 |
mouse |
| Jia-Ying Li, Yang-Jung Yu, Chun-Lin Su, Yu-Qi Shen, Chih-Hua Chang, Po-Wu Gea. Modulation of methamphetamine memory reconsolidation by neural projection from basolateral amygdala to nucleus accumbens. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022-09-15. PMID:36109595. |
the basolateral amygdala (bla) involves the association of conditioned cues with reward and aversive valences and projects the information to the nucleus accumbens (nac) that mediates reward-seeking. |
2022-09-15 |
2023-08-14 |
mouse |
| Haleh Amirteymori, Saeideh Karimi-Haghighi, Mahboobeh Mirmohammadi, Maryam Majidinezhad, Elahe Khosrowabadi, Abbas Haghparas. Hypocretin/orexin system in the nucleus accumbens as a promising player in the extinction and reinstatement of methamphetamine-induced CPP. Progress in neuro-psychopharmacology & biological psychiatry. 2022-08-21. PMID:35988849. |
in the current study, an unbiased place conditioning paradigm was performed to inquire the role of the hypocretin/orexin system in the nac in the extinction and reinstatement of methamphetamine (meth)-induced conditioned place preference (cpp). |
2022-08-21 |
2023-08-14 |
rat |
| Benfu Wang, Xiaowei Yang, Wenhua Zhou, Huaqiang Zhu, Qingquan Lian, Jianping Yan. Involvement of the ERK signaling pathways in the NAc in propofol-seeking behavior induced by cues in rats. Pharmacology, biochemistry, and behavior. 2022-08-15. PMID:35970339. |
u0126 (5.0 μg/side, lateral ventricle (lv)) pretreatment significantly decreased the active responses induced by conditioned cues, which was associated with a large decline in the expression of p-erk in the nac. |
2022-08-15 |
2023-08-14 |
rat |
| M Gilli, T G Hollaert, H M Setbon, A des Rieux, J G Leprinc. Quality of Cure in Depth of Commercially Available Bulk-fill Composites: A Layer-by-layer Mechanical and Biological Evaluation. Operative dentistry. 2022-08-02. PMID:35917249. |
a similar experiment was repeated with conditioned media produced in contact with uncured composites, with and without the addition of 4 mm nac. |
2022-08-02 |
2023-08-14 |
human |
| Xiaojie Li, Bing Xie, Yun Lu, Hongyu Yang, Jian Wang, Feng Yu, Ludi Zhang, Bin Cong, Di Wen, Chunling M. Transcriptomic Analysis of Long Non-coding RNA-MicroRNA-mRNA Interactions in the Nucleus Accumbens Related to Morphine Addiction in Mice. Frontiers in psychiatry. vol 13. 2022-06-20. PMID:35722589. |
in this research, rna sequencing (rna-seq) was used to examine the expression profiles of lncrnas, mirnas and mrnas on the nucleus accumbens (nac) tissues of mice trained with morphine or saline conditioned place preference (cpp), with differential expression of 31 lncrnas, 393 mirnas, and 371 mrnas found. |
2022-06-20 |
2023-08-14 |
mouse |
| Li Zhu, Feifei Wu, Zhilan Yan, Lijun He, Shufei Wang, Haohao Hu, Eyleen L K Goh, Yingjie Zhu, Fanglin Guan, Teng Che. A novel microRNA, novel-m009C, regulates methamphetamine rewarding effects. Molecular psychiatry. 2022-06-17. PMID:35715487. |
increasing novel-m009c levels in the nac attenuated meth-induced conditioned place preference (cpp) and hyperlocomotion, whereas inhibiting novel-m009c expression in the nac enhanced these effects but did not change the preference of mice for a natural reward, i.e., sucrose. |
2022-06-17 |
2023-08-14 |
mouse |
| Lisha Deng, Zheng Chu, Baijia Li, Peng Liu, Gang Lei, Liu Yang, Leile Zhang, Shaofu Li, Yiming Wang, Yonghui Dan. BDNF-AAV has protective effects on morphine-induced conditioned place preference through BDNF, TrkB, and CREB concentration changes in the VTA and NAc. Neuroscience letters. vol 782. 2022-06-02. PMID:35653819. |
bdnf-aav has protective effects on morphine-induced conditioned place preference through bdnf, trkb, and creb concentration changes in the vta and nac. |
2022-06-02 |
2023-08-14 |
mouse |
| Joshua P Stamos, Sisi Ma, Anthony P Pawlak, Nofar Engelhard, Jon C Horvitz, Mark O Wes. Reward vs. motoric activations in Nucleus Accumbens Core of rats during pavlovian conditioning. The European journal of neuroscience. 2022-05-01. PMID:35491443. |
the nucleus accumbens (nac) core plays an important role in processing of events related to food reward, such as conditioned cues, approach, or consumption. |
2022-05-01 |
2023-08-13 |
rat |
| Inês M Amaral, Alex Hofer, Rana El Rawa. Implication of Extracellular Signal-Regulated Kinase in the Expression of Natural Reward: Evidence Not Found. Frontiers in behavioral neuroscience. vol 16. 2022-04-04. PMID:35368299. |
for that, u0126 was bilaterally infused into the nac core of rats conditioned with cocaine in one context and with si in the opposite context before assessing the expression of reward-related learning. |
2022-04-04 |
2023-08-13 |
rat |
| Timothy J O'Neal, Mollie X Bernstein, Derek J MacDougall, Susan M Ferguso. A Conditioned Place Preference for Heroin Is Signaled by Increased Dopamine and Direct Pathway Activity and Decreased Indirect Pathway Activity in the Nucleus Accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-01-15. PMID:35031576. |
direct and indirect pathway medium spiny neurons (dmsns and imsns) have been shown to bidirectionally regulate cue-induced heroin-seeking in rats expressing addiction-like phenotypes, and a shift in nac activity toward the direct pathway has been shown in mice following cocaine conditioned place preference (cpp). |
2022-01-15 |
2023-08-13 |
mouse |
| Inês M Amaral, Laura Scheffauer, Angelika B Langeder, Alex Hofer, Rana El Rawa. Rewarding Social Interaction in Rats Increases CaMKII in the Nucleus Accumbens. Biomedicines. vol 9. issue 12. 2021-12-24. PMID:34944702. |
in the nac of rats expressing cocaine or social interaction conditioned place preference (cpp), αcamkii activation was induced in those expressing social interaction but not cocaine cpp. |
2021-12-24 |
2023-08-13 |
rat |
| Yue-Ying Liu, Le Liu, Lei Zhu, Xiu Yang, Kun Tong, Yue You, Li Yang, Yin Gao, Xu Li, Di-Shi Chen, Jing-Ru Hao, Nan Sun, Can Ga. dCA1-NAc shell glutamatergic projection mediates context-induced memory recall of morphine. Pharmacological research. vol 172. 2021-11-16. PMID:34461223. |
here, we used a common model of addiction-related behavior conditioned place preference paradigm, combined with immunofluorescence, chemogenetics, optogenetics, and electrophysiology techniques to characterize the projection of the dca1 to the nac shell, in context-induced relapse memory to morphine. |
2021-11-16 |
2023-08-13 |
mouse |
| Rebecca S Hofford, Nicholas L Mervosh, Tanner J Euston, Katherine R Meckel, Amon T Orr, Drew D Kiral. Alterations in microbiome composition and metabolic byproducts drive behavioral and transcriptional responses to morphine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 12. 2021-11-10. PMID:34127799. |
here we show that male mice with their gut microbiome depleted by nonabsorbable antibiotics (abx) exhibit decreased formation of morphine conditioned place preference across a range of doses (2.5-15 mg/kg), have decreased locomotor sensitization to morphine, and demonstrate marked changes in gene expression within the nucleus accumbens (nac) in response to high-dose morphine (20 mg/kg × 7 days). |
2021-11-10 |
2023-08-13 |
mouse |
| Bai-Chuang Shyu, Zhi-Yue Gao, José Jiun-Shian Wu, Alan Bo Han He, Cai-N Cheng, Andrew Chih Wei Huan. Methamphetamine and Modulation Functionality of the Prelimbic Cortex for Developing a Possible Treatment of Alzheimer's Disease in an Animal Model. Frontiers in aging neuroscience. vol 13. 2021-11-10. PMID:34744692. |
this study examined whether a low dose of mamph can induce conditioned taste aversion (cta) learning, or can increase plasma corticosterone levels, neural activity, and neural plasticity in the medial prefrontal cortex (mpfc) (responsible for cognitive function), the nucleus accumbens (nac) and the amygdala (related to rewarding and aversive emotion), and the hippocampus (responsible for spatial learning). |
2021-11-10 |
2023-08-13 |
rat |
| Seyedeh-Najmeh Katebi, Anahita Torkaman-Boutorabi, Nasim Vousooghi, Esmail Riahi, Abbas Haghparas. Systemic administration of N-acetylcysteine during the extinction period and on the reinstatement day decreased the maintenance of morphine rewarding properties in the rats. Behavioural brain research. vol 413. 2021-11-04. PMID:34256079. |
the present study tried to evaluate whether chronic administration of systemic nac during the extinction period and acute administration of systemic nac on the reinstatement day could reduce the maintenance of the morphine rewarding properties in the conditioned place preference (cpp) paradigm in the rats. |
2021-11-04 |
2023-08-13 |
rat |
| Ai T M Nguyen, Tran V B Quach, Peddanna Kotha, Szu-Yu Chien, Iona J MacDonald, Hsien-Yuan Lane, Cheng-Hao Tu, Jaung-Geng Lin, Yi-Hung Che. Electroacupuncture prevents cocaine-induced conditioned place preference reinstatement and attenuates ΔFosB and GluR2 expression. Scientific reports. vol 11. issue 1. 2021-11-03. PMID:34211013. |
this experimental study compared the effects of electroacupuncture (ea) at acupoints li4 and li11 with those of another potentially beneficial intervention, gabapentin (gbp), alone or in combination, on reinstatement of cocaine-induced conditioned place preference (cpp) and levels of Δfosb and glutamate receptor subunit 2 (glur2) expression in the nucleus accumbens (nac). |
2021-11-03 |
2023-08-13 |
Not clear |
| Patrick T Piantadosi, Dylan C M Yeates, Stan B Floresc. Prefrontal cortical and nucleus accumbens contributions to discriminative conditioned suppression of reward-seeking. Learning & memory (Cold Spring Harbor, N.Y.). vol 27. issue 10. 2021-10-22. PMID:32934096. |
here, we investigated how these mpfc and nac subregions contribute to discriminative fear conditioning, assessed by conditioned suppression of reward-seeking. |
2021-10-22 |
2023-08-13 |
Not clear |
| Catherine S Thomas, Aida Mohammadkhani, Madiha Rana, Min Qiao, Corey Baimel, Stephanie L Borglan. Optogenetic stimulation of lateral hypothalamic orexin/dynorphin inputs in the ventral tegmental area potentiates mesolimbic dopamine neurotransmission and promotes reward-seeking behaviours. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2021-10-19. PMID:34663867. |
we found that optical stimulation of lh orexin/dynorphin inputs in the vta potentiates mesolimbic dopamine neurotransmission in the nucleus accumbens (nac) core, produces real time and conditioned place preference, and increases the food cue-directed orientation in a pavlovian conditioning procedure. |
2021-10-19 |
2023-08-13 |
Not clear |