| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuting Li, Haohong Li, Xing Liu, Guobin Bao, Yezheng Tao, Ziyan Wu, Peng Xia, Chunfu Wu, Baoming Li, Lan M. Regulation of amygdalar PKA by beta-arrestin-2/phosphodiesterase-4 complex is critical for fear conditioning. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 51. 2010-02-18. PMID:19955404. |
arrb2(-/-) mice exhibit impaired conditioned fear memory and long-term potentiation at the lateral amygdalar synapses. |
2010-02-18 |
2023-08-12 |
mouse |
| Yuting Li, Haohong Li, Xing Liu, Guobin Bao, Yezheng Tao, Ziyan Wu, Peng Xia, Chunfu Wu, Baoming Li, Lan M. Regulation of amygdalar PKA by beta-arrestin-2/phosphodiesterase-4 complex is critical for fear conditioning. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 51. 2010-02-18. PMID:19955404. |
moreover, expression of the beta-arrestin-2 in the lateral amygdala of arrb2(-/-) mice, but not its mutant form that is incapable of binding pde-4, restores basal pka activity and rescues conditioned fear memory. |
2010-02-18 |
2023-08-12 |
mouse |
| Jonathan E Ploski, Kevin W Park, Junli Ping, Melissa S Monsey, Glenn E Schaf. Identification of plasticity-associated genes regulated by Pavlovian fear conditioning in the lateral amygdala. Journal of neurochemistry. vol 112. issue 3. 2010-02-16. PMID:19912470. |
most recent studies aimed at defining the cellular and molecular mechanisms of pavlovian fear conditioning have focused on protein kinase signaling pathways and the transcription factor camp-response element binding protein (creb) that promote fear memory consolidation in the lateral nucleus of the amygdala (la). |
2010-02-16 |
2023-08-12 |
rat |
| Sabiha K Barot, Ain Chung, Jeansok J Kim, Ilene L Bernstei. Functional imaging of stimulus convergence in amygdalar neurons during Pavlovian fear conditioning. PloS one. vol 4. issue 7. 2009-11-10. PMID:19582153. |
a fundamental issue in fear conditioning regards the existence and location of neurons in the brain that receive convergent information about the conditioned stimulus (cs) and unconditioned stimulus (us) during the acquisition of conditioned fear memory. |
2009-11-10 |
2023-08-12 |
Not clear |
| Machiko Matsumoto, Mitsuhiro Yoshioka, Hiroko Togash. Early postnatal stress and neural circuit underlying emotional regulation. International review of neurobiology. vol 85. 2009-09-10. PMID:19607963. |
fear-related freezing behavior during exposure to contextual fear conditioning (cfc) was markedly attenuated in the 2w-fs group, presumably due to disturbance of the retention for fear memory, an effect that was attributable to synaptic changes in the hippocampal ca1 field. |
2009-09-10 |
2023-08-12 |
rat |
| Raffael Kalisch, Beatrice Holt, Predrag Petrovic, Benedetto De Martino, Stefan Klöppel, Christian Büchel, Raymond J Dola. The NMDA agonist D-cycloserine facilitates fear memory consolidation in humans. Cerebral cortex (New York, N.Y. : 1991). vol 19. issue 1. 2009-03-09. PMID:18477687. |
using a fear conditioning and extinction paradigm in healthy normal volunteers, we show that postlearning administration of the nmda partial agonist d-cycloserine (dcs) facilitates fear memory consolidation, evidenced behaviorally by enhanced skin conductance responses, relative to placebo, for presentations of a conditioned stimulus (cs) at a memory test performed 72 h later. |
2009-03-09 |
2023-08-12 |
human |
| XinLing Zheng, Fang Liu, XingWen Wu, BaoMing L. Infusion of methylphenidate into the basolateral nucleus of amygdala or anterior cingulate cortex enhances fear memory consolidation in rats. Science in China. Series C, Life sciences. vol 51. issue 9. 2008-11-04. PMID:18726527. |
in the present study, we investigated the effect of direct infusion of mpd into the basolateral nucleus of amygdala (bla) or the anterior cingulate cortex (acc) on conditioned fear memory. |
2008-11-04 |
2023-08-12 |
rat |
| Christian Kluge, Christian Stoppel, Csaba Szinyei, Oliver Stork, Hans-Christian Pap. Role of the somatostatin system in contextual fear memory and hippocampal synaptic plasticity. Learning & memory (Cold Spring Harbor, N.Y.). vol 15. issue 4. 2008-07-21. PMID:18391186. |
here, we have made use of mice with somatostatin deficiency, based upon genetic invalidation or pharmacologically induced depletion, and pavlovian fear conditioning in order to address the contribution of the somatostatin system to associative fear memory. |
2008-07-21 |
2023-08-12 |
mouse |
| Glenn E Schafe, Michael W Swank, Sarina M Rodrigues, Jacek Debiec, Valérie Doyèr. Phosphorylation of ERK/MAP kinase is required for long-term potentiation in anatomically restricted regions of the lateral amygdala in vivo. Learning & memory (Cold Spring Harbor, N.Y.). vol 15. issue 2. 2008-02-20. PMID:18230673. |
we have previously shown that the extracellular signal-regulated kinase/mitogen-activated protein kinase (erk/ mapk) is transiently activated in anatomically restricted regions of the lateral amygdala (la) following pavlovian fear conditioning and that blockade of erk/mapk activation in the la impairs both fear memory consolidation and long-term potentiation (ltp) in the amygdala, in vitro. |
2008-02-20 |
2023-08-12 |
Not clear |
| Kamila Markram, Miguel Angel Lopez Fernandez, Djoher Nora Abrous, Carmen Sand. Amygdala upregulation of NCAM polysialylation induced by auditory fear conditioning is not required for memory formation, but plays a role in fear extinction. Neurobiology of learning and memory. vol 87. issue 4. 2007-07-16. PMID:17223582. |
these results suggest that upregulation of psa-ncam is a correlate of fear conditioning that is not necessary for the establishment of fear memory in the amygdala, but participates in mechanisms precluding fear extinction. |
2007-07-16 |
2023-08-12 |
Not clear |
| Jonathan L C Lee, Amy L Milton, Barry J Everit. Reconsolidation and extinction of conditioned fear: inhibition and potentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 39. 2006-11-27. PMID:17005868. |
here, we used dcs and the noncompetitive nmda receptor antagonist (+)-5-methyl-10,11-dihydro-sh-dibenzo[a,d]cyclohepten-5,10-imine maleate (mk-801) to investigate the effects of enhancing and blocking nmda receptor-mediated glutamatergic transmission on the reconsolidation and extinction of a conditioned fear memory. |
2006-11-27 |
2023-08-12 |
Not clear |
| Jacek Debiec, Joseph E LeDou. Noradrenergic signaling in the amygdala contributes to the reconsolidation of fear memory: treatment implications for PTSD. Annals of the New York Academy of Sciences. vol 1071. 2006-09-20. PMID:16891611. |
using classical fear conditioning in rats, we have recently demonstrated that noradrenergic blockade in the la following reactivation of fear memory by retrieval disrupts memory reconsolidation and lastingly impairs fear memory. |
2006-09-20 |
2023-08-12 |
rat |
| Enver Melik, Emine Babar, Elif Ozen, Tuncay Ozgune. Hypofunction of the dorsal hippocampal NMDA receptors impairs retrieval of memory to partially presented foreground context in a single-trial fear conditioning in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 16. issue 4. 2006-08-04. PMID:16176870. |
in the present study, the effects of n-methyl-d-aspartate (nmda) receptor antagonist, d,l-2-amino-5-phosphonopentanoic acid (ap5) bilaterally infused into the dorsal hippocampus (2.0 microl /5 microg), on the retrieval of fear memory to partial and whole foreground cues were evaluated by using a step-through passive avoidance and pavlovian fear conditioning. |
2006-08-04 |
2023-08-12 |
rat |
| Tomonori Fujiwara, Tatsuya Mishima, Takefumi Kofuji, Tomoki Chiba, Keiji Tanaka, Akitsugu Yamamoto, Kimio Akagaw. Analysis of knock-out mice to determine the role of HPC-1/syntaxin 1A in expressing synaptic plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 21. 2006-06-08. PMID:16723534. |
also, although ko mice exhibited normal spatial memory in the hidden platform test, consolidation of conditioned fear memory was impaired. |
2006-06-08 |
2023-08-12 |
mouse |
| Tomonori Fujiwara, Tatsuya Mishima, Takefumi Kofuji, Tomoki Chiba, Keiji Tanaka, Akitsugu Yamamoto, Kimio Akagaw. Analysis of knock-out mice to determine the role of HPC-1/syntaxin 1A in expressing synaptic plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 21. 2006-06-08. PMID:16723534. |
interestingly, the ko mice had impaired conditioned fear memory extinction. |
2006-06-08 |
2023-08-12 |
mouse |
| Jeansok J Kim, Min Whan Jun. Neural circuits and mechanisms involved in Pavlovian fear conditioning: a critical review. Neuroscience and biobehavioral reviews. vol 30. issue 2. 2006-05-05. PMID:16120461. |
converging lines of evidence indicate that the amygdala is necessarily involved in the acquisition, storage and expression of conditioned fear memory, and long-term potentiation (ltp) in the lateral nucleus of the amygdala is often proposed as the underlying synaptic mechanism of associative fear memory. |
2006-05-05 |
2023-08-12 |
Not clear |
| Xin-Qiu Liu, Bao-Ming L. [Beta-adrenoceptors in amygdala are involved in conditioned fear memory]. Sheng li ke xue jin zhan [Progress in physiology]. vol 36. issue 2. 2006-05-03. PMID:16222981. |
[beta-adrenoceptors in amygdala are involved in conditioned fear memory]. |
2006-05-03 |
2023-08-12 |
Not clear |
| Bradley W Schroeder, Patricia Shinnick-Gallaghe. Fear learning induces persistent facilitation of amygdala synaptic transmission. The European journal of neuroscience. vol 22. issue 7. 2006-01-23. PMID:16197518. |
however, the absence of lfs-ltp 10 days following fear conditioning suggests that amygdala physiology 1 day following fear learning may reflect a dynamic state during memory stabilization that is inactive during the long-term storage of fear memory. |
2006-01-23 |
2023-08-12 |
rat |
| Bing Mei, Chunxia Li, Suzhen Dong, Cecilia H Jiang, Huimin Wang, Yinghe H. Distinct gene expression profiles in hippocampus and amygdala after fear conditioning. Brain research bulletin. vol 67. issue 1-2. 2005-12-13. PMID:16140156. |
it is well known that the hippocampus and amygdala are involved in the formations of fear conditioning memories, and both contextual and cued fear memory requires activation of the nmda receptors. |
2005-12-13 |
2023-08-12 |
Not clear |
| Stephen Mare. Synaptic mechanisms of associative memory in the amygdala. Neuron. vol 47. issue 6. 2005-12-07. PMID:16157273. |
recent work in the amygdala reveals that ltp and pavlovian fear conditioning induce similar changes in postsynaptic ampa-type glutamate receptors and that occluding these changes by viral-mediated overexpression of a dominant-negative glur1 construct attenuates both ltp and fear memory in rats. |
2005-12-07 |
2023-08-12 |
rat |