| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elham Hadipour, Zahra Tayarani-Najaran, Masoud Fereidon. Vitamin K2 protects PC12 cells against Aβ Nutritional neuroscience. vol 23. issue 5. 2021-01-20. PMID:30058479. |
vitamin k2 protects pc12 cells against aβ alzheimer's is an age-related disease with a hallmark of progressive loss of memory formation followed by a damage in the brain function due to the neural degeneration and extracellular beta-amyloid (aβ) plaques accumulation. |
2021-01-20 |
2023-08-13 |
Not clear |
| Evelien Van Hoeymissen, Koenraad Philippaert, Rudi Vennekens, Joris Vriens, Katharina Hel. Horizontal Hippocampal Slices of the Mouse Brain. Journal of visualized experiments : JoVE. issue 163. 2020-12-04. PMID:33044449. |
the hippocampus is a highly organized structure in the brain that is a part of the limbic system and is involved in memory formation and consolidation as well as the manifestation of severe brain disorders, including alzheimer's disease and epilepsy. |
2020-12-04 |
2023-08-13 |
mouse |
| Melissa Boldridge, Jody Shimabukuro, Keith Nakamatsu, Christian Won, Chad Jansen, Helen Turner, Lei Wan. Characterization of the C-terminal tail of the Arc protein. PloS one. vol 15. issue 9. 2020-11-13. PMID:32991626. |
the activity-regulated cytoskeleton-associate protein arc (or arg3.1) is specifically linked to memory formation and a number of cognitive disorders, including alzheimer's disease and schizophrenia. |
2020-11-13 |
2023-08-13 |
Not clear |
| Marielza Andrade Nunes, Mariana Toricelli, Natalia Mendes Schöwe, Helena Nascimento Malerba, Karis Ester Dong-Creste, Daniela Moura Azevedo Tuma Farah, Katia De Angelis, Maria Claudia Irigoyen, Fernand Gobeil, Tânia Araujo Viel, Hudson Sousa Buc. Kinin B2 Receptor Activation Prevents the Evolution of Alzheimer's Disease Pathological Characteristics in a Transgenic Mouse Model. Pharmaceuticals (Basel, Switzerland). vol 13. issue 10. 2020-11-03. PMID:33019732. |
alzheimer's disease is mainly characterized by remarkable neurodegeneration in brain areas related to memory formation. |
2020-11-03 |
2023-08-13 |
mouse |
| Katarzyna Grzelka, Przemysław Kurowski, Maciej Gawlak, Paweł Szulczy. Noradrenaline Modulates the Membrane Potential and Holding Current of Medial Prefrontal Cortex Pyramidal Neurons via β Frontiers in cellular neuroscience. vol 11. 2020-10-01. PMID:29209170. |
adrenergic innervation of mpfc pyramidal neurons plays an essential role in both physiology (control of memory formation, attention, working memory, and cognitive behavior) and pathophysiology (attention deficit hyperactivity disorder, posttraumatic stress disorder, cognitive deterioration after traumatic brain injury, behavioral changes related to addiction, alzheimer's disease and depression). |
2020-10-01 |
2023-08-13 |
rat |
| Ting Cao, Xiaojuan Zhou, Xianjie Zheng, Yue Cui, Joe Z Tsien, Chunxia Li, Huimin Wan. Histone Deacetylase Inhibitor Alleviates the Neurodegenerative Phenotypes and Histone Dysregulation in Presenilins-Deficient Mice. Frontiers in aging neuroscience. vol 10. 2020-10-01. PMID:29867447. |
histone acetylation has been shown to play a crucial role in memory formation, and histone deacetylase (hdac) inhibitor sodium butyrate (nab) has been demonstrated to improve memory performance and rescue the neurodegeneration of several alzheimer's disease (ad) mouse models. |
2020-10-01 |
2023-08-13 |
mouse |
| Walter J Lukiw, Theodore P A Kruck, Maire E Percy, Aileen I Pogue, Peter N Alexandrov, William J Walsh, Nathan M Sharfman, Vivian R Jaber, Yuhai Zhao, Wenhong Li, Catherine Bergeron, Frank Culicchia, Zhide Fang, Donald R C McLachla. Aluminum in neurological disease - a 36 year multicenter study. Journal of Alzheimer's disease & Parkinsonism. vol 8. issue 6. 2020-09-30. PMID:31179161. |
brodmann anatomical areas including the inferior, medial and superior temporal gyrus (a20-a22) were selected for analysis: (i) because of their essential functions in massive neural information processing operations including cognition and memory formation; and (ii) because subareas of these anatomical regions are unique to humans and are amongst the earliest areas affected by progressive neurodegenerative disorders such as alzheimer's disease (ad). |
2020-09-30 |
2023-08-13 |
human |
| Swananda Marathe, Muriel Jaquet, Jean-Marie Annoni, Lavinia Alber. Jagged1 Is Altered in Alzheimer's Disease and Regulates Spatial Memory Processing. Frontiers in cellular neuroscience. vol 11. 2020-09-29. PMID:28848392. |
notch signaling plays an instrumental role in hippocampus-dependent memory formation and recent evidence indicates a displacement of notch1 and a reduction its activity in hippocampal and cortical neurons from alzheimer's disease (ad) patients. |
2020-09-29 |
2023-08-13 |
mouse |
| Uwe Ueberham, Thomas Arend. Genomic Indexing by Somatic Gene Recombination of mRNA/ncRNA - Does It Play a Role in Genomic Mosaicism, Memory Formation, and Alzheimer's Disease? Frontiers in genetics. vol 11. 2020-09-28. PMID:32411177. |
genomic indexing by somatic gene recombination of mrna/ncrna - does it play a role in genomic mosaicism, memory formation, and alzheimer's disease? |
2020-09-28 |
2023-08-13 |
human |
| Kevin N Hascup, Jesse Britz, Caleigh A Findley, Shelley Tischkau, Erin R Hascu. LY379268 Does Not Have Long-Term Procognitive Effects nor Attenuate Glutamatergic Signaling in AβPP/PS1 Mice. Journal of Alzheimer's disease : JAD. vol 68. issue 3. 2020-08-27. PMID:30909243. |
chronically elevated basal glutamate levels are hypothesized to attenuate detection of physiological signals thereby inhibiting memory formation and retrieval, while inducing excitotoxicity-mediated neurodegeneration observed in alzheimer's disease (ad). |
2020-08-27 |
2023-08-13 |
mouse |
| Angela De Simone, Andrea Milell. Histone Deacetylase Inhibitors as Multitarget Ligands: New Players in Alzheimer's Disease Drug Discovery? ChemMedChem. vol 14. issue 11. 2020-03-23. PMID:30958639. |
due to the involvement of hdacs in neurodevelopment, memory formation, and cognitive processes, hdacis have been suggested as innovative agents for the treatment of neurodegenerative disorders such as alzheimer's disease (ad). |
2020-03-23 |
2023-08-13 |
Not clear |
| Pranesh Padmanabhan, Ramón Martínez-Mármol, Di Xia, Jürgen Götz, Frédéric A Meunie. Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines. eLife. vol 8. 2020-02-24. PMID:31237563. |
the src kinase fyn plays critical roles in memory formation and alzheimer's disease. |
2020-02-24 |
2023-08-13 |
mouse |
| Hua Zhang, Joseph Therriault, Min Su Kang, Kok Pin Ng, Tharick A Pascoal, Pedro Rosa-Neto, Serge Gauthie. Cerebrospinal fluid synaptosomal-associated protein 25 is a key player in synaptic degeneration in mild cognitive impairment and Alzheimer's disease. Alzheimer's research & therapy. vol 10. issue 1. 2019-08-06. PMID:30115118. |
there is accumulating evidence that synaptic loss precedes neuronal loss and correlates best with impaired memory formation in alzheimer's disease (ad). |
2019-08-06 |
2023-08-13 |
Not clear |
| Sandeep Kumar Mishra, Sonu Singh, Shubha Shukla, Rakesh Shukl. Intracerebroventricular streptozotocin impairs adult neurogenesis and cognitive functions via regulating neuroinflammation and insulin signaling in adult rats. Neurochemistry international. vol 113. 2019-04-10. PMID:29174383. |
neurogenesis is a complex process involved in memory formation and is known to be altered in alzheimer's disease (ad). |
2019-04-10 |
2023-08-13 |
rat |
| Talal Jamil Qazi, Zhenzhen Quan, Asif Mir, Hong Qin. Epigenetics in Alzheimer's Disease: Perspective of DNA Methylation. Molecular neurobiology. vol 55. issue 2. 2019-01-01. PMID:28092081. |
research over the years has shown that causes of alzheimer's disease are not well understood, but over the past years, the involvement of epigenetic mechanisms in the developing memory formation either under pathological or physiological conditions has become clear. |
2019-01-01 |
2023-08-13 |
Not clear |
| E I Pchitskaya, V A Zhemkov, I B Bezprozvann. Dynamic Microtubules in Alzheimer's Disease: Association with Dendritic Spine Pathology. Biochemistry. Biokhimiia. vol 83. issue 9. 2018-12-11. PMID:30472945. |
alzheimer's disease (ad) is the most common incurable neurodegenerative disorder that affects the processes of memory formation and storage. |
2018-12-11 |
2023-08-13 |
Not clear |
| Maitane Ortiz-Virumbrales, Cesar L Moreno, Ilya Kruglikov, Paula Marazuela, Andrew Sproul, Samson Jacob, Matthew Zimmer, Daniel Paull, Bin Zhang, Eric E Schadt, Michelle E Ehrlich, Rudolph E Tanzi, Ottavio Arancio, Scott Noggle, Sam Gand. CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer's PSEN2 Acta neuropathologica communications. vol 5. issue 1. 2018-06-13. PMID:29078805. |
crispr/cas9-correctable mutation-related molecular and physiological phenotypes in ipsc-derived alzheimer's psen2 basal forebrain cholinergic neurons (bfcns) are believed to be one of the first cell types to be affected in all forms of ad, and their dysfunction is clinically correlated with impaired short-term memory formation and retrieval. |
2018-06-13 |
2023-08-13 |
human |
| Stine Møllerud, Andrea Pinto, Laura Marconi, Karla Frydenvang, Thor Seneca Thorsen, Saara Laulumaa, Raminta Venskutonytė, Sebastian Winther, Ana Maria Cuñado Moral, Lucia Tamborini, Paola Conti, Darryl S Pickering, Jette Sandholm Kastru. Structure and Affinity of Two Bicyclic Glutamate Analogues at AMPA and Kainate Receptors. ACS chemical neuroscience. vol 8. issue 9. 2018-06-12. PMID:28691798. |
these receptors are important for learning and memory formation, but are also involved in the development of diseases such as alzheimer's disease, epilepsy and depression. |
2018-06-12 |
2023-08-13 |
Not clear |
| E Benito, B Ramachandran, H Schroeder, G Schmidt, H Urbanke, S Burkhardt, V Capece, C Dean, A Fische. The BET/BRD inhibitor JQ1 improves brain plasticity in WT and APP mice. Translational psychiatry. vol 7. issue 9. 2018-05-22. PMID:28949335. |
histone acetylation is essential for memory formation and its deregulation contributes to the pathogenesis of alzheimer's disease. |
2018-05-22 |
2023-08-13 |
mouse |
| Olivier Nicole, Senka Hadzibegovic, Judyta Gajda, Bruno Bontempi, Tiaza Bem, Pierre Meyran. Soluble amyloid beta oligomers block the learning-induced increase in hippocampal sharp wave-ripple rate and impair spatial memory formation. Scientific reports. vol 6. 2017-01-03. PMID:26947247. |
these results point to a crucial involvement of swrs in spatial memory formation and identify the aβ-induced impairment in swrs dynamics as a disruptive mechanism responsible for the spatial memory deficits associated with alzheimer's disease. |
2017-01-03 |
2023-08-13 |
mouse |