| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexandre V Ivachtchenko, Yan A Ivanenkov, Andrey V Skorenk. 5-HT(6) receptor modulators: a patent update. Part 2. Diversity in heterocyclic scaffolds. Expert opinion on therapeutic patents. vol 22. issue 10. 2013-02-12. PMID:22957857. |
available biological data clearly indicate that 5-ht(6)r antagonists can be used as effective regulators in a variety of contexts, including memory formation, age-related cognitive impairments and memory deficits associated with conditions such as schizophrenia, parkinson's disease (pd) and alzheimer's disease (ad). |
2013-02-12 |
2023-08-12 |
Not clear |
| Martin Korte, Ulrike Herrmann, Xiaomin Zhang, Andreas Draguh. The role of APP and APLP for synaptic transmission, plasticity, and network function: lessons from genetic mouse models. Experimental brain research. vol 217. issue 3-4. 2012-12-13. PMID:22006270. |
app, however, plays a key role in the molecular pathology of alzheimer's disease (ad), indicating that it is somehow involved in synaptic transmission, synaptic plasticity, memory formation, and maintenance of neurons. |
2012-12-13 |
2023-08-12 |
mouse |
| Alexandre V Ivachtchenko, Yan A Ivanenko. 5HT(6) receptor antagonists: a patent update. Part 1. Sulfonyl derivatives. Expert opinion on therapeutic patents. vol 22. issue 8. 2012-11-27. PMID:22816965. |
available biological data clearly indicate that 5ht(6)r antagonists can be used as effective regulators in a variety of contexts, including memory formation, age-related cognitive impairments and memory deficits associated with conditions such as schizophrenia, parkinson's disease and alzheimer's disease. |
2012-11-27 |
2023-08-12 |
Not clear |
| Neha Kabra Woods, Jaya Padmanabha. Neuronal calcium signaling and Alzheimer's disease. Advances in experimental medicine and biology. vol 740. 2012-09-18. PMID:22453989. |
since functional synapses and synaptic transmission are fundamental processes in memory formation, alterations in these processes can lead to neuronal dysfunction and memory deficit as seen in alzheimer's disease. |
2012-09-18 |
2023-08-12 |
mouse |
| Petra Popovics, Alan J Stewar. Putative roles for phospholipase Cη enzymes in neuronal Ca2+ signal modulation. Biochemical Society transactions. vol 40. issue 1. 2012-05-18. PMID:22260706. |
driven by the specific localization of plcη enzymes in different brain areas, in the present paper, we discuss the roles that they may play in neural processes, including differentiation, memory formation, circadian rhythm regulation, neurotransmitter/hormone release and the pathogenesis of neurodegenerative disorders associated with aberrant ca2+ signalling, such as alzheimer's disease. |
2012-05-18 |
2023-08-12 |
Not clear |
| Lin Li, Zhi-Feng Zhang, Christian Holscher, Chong Gao, Yuan-Hong Jiang, Yue-Ze Li. (Val⁸) glucagon-like peptide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains. European journal of pharmacology. vol 674. issue 2-3. 2012-05-03. PMID:22115895. |
the results shown that streptozotocin induced a series of alzheimer disease -like changes in behaviour, a significant decline in learning and memory formation, an increased expression of total tau and an increased ratio of phosphorylated tau, and damage to nucleus and nucleolus as seen in electron micrographs. |
2012-05-03 |
2023-08-12 |
rat |
| Bonnie van Geldorp, Elke P C Konings, Ilse A D A van Tilborg, Roy P C Kessel. Associative working memory and subsequent episodic memory in Alzheimer's disease. Neuroreport. vol 23. issue 2. 2012-04-12. PMID:22182961. |
we investigated associative working memory in relation to subsequent episodic memory formation in patients with early alzheimer's disease to examine whether these findings reflect deficits in long-term encoding rather than 'pure' working memory processing. |
2012-04-12 |
2023-08-12 |
human |
| Alfredo Meneses, Georgina Pérez-García, Teresa Ponce-Lopez, Carlos Castill. 5-HT6 receptor memory and amnesia: behavioral pharmacology--learning and memory processes. International review of neurobiology. vol 96. 2012-01-05. PMID:21329783. |
available evidence indicates that diverse 5-ht6 receptor antagonists produce promnesic and/or antiamnesic effects in diverse conditions, including memory formation, age-related cognitive impairments, memory deficits in diseases such as schizophrenia, parkinson, and alzheimer's disease (ad). |
2012-01-05 |
2023-08-12 |
human |
| Shigeru Maeda, Yukiko Arai, Hitoshi Higuchi, Yumiko Tomoyasu, Ryuichiro Mizuno, Toru Takahashi, Takuya Miyawak. Induction of apoptotic change in the rat hippocampus caused by ferric nitrilotriacetate. Redox report : communications in free radical research. vol 16. issue 3. 2011-11-28. PMID:21801493. |
in alzheimer's disease, the hippocampus is vulnerable to oxidative stress, leading to impairment in memory formation. |
2011-11-28 |
2023-08-12 |
rat |
| Olivia Engmann, Tibor Hortobágyi, Andrew J Thompson, Jennifer Guadagno, Claire Troakes, Salvador Soriano, Safa Al-Sarraj, Yong Kim, Karl Peter Gies. Cyclin-dependent kinase 5 activator p25 is generated during memory formation and is reduced at an early stage in Alzheimer's disease. Biological psychiatry. vol 70. issue 2. 2011-10-27. PMID:21616478. |
cyclin-dependent kinase 5 activator p25 is generated during memory formation and is reduced at an early stage in alzheimer's disease. |
2011-10-27 |
2023-08-12 |
mouse |
| Nobuo Nagai, Osamu Matsu. Roles of fibrinolytic system components in the nervous system. Pathophysiology : the official journal of the International Society for Pathophysiology. vol 17. issue 2. 2011-07-14. PMID:19500952. |
recent studies have remarkably clarified the physiological roles of fibrinolytic system components on memory formation, neuronal plasticity, neuronal migration, neuronal cell death and axonal regeneration, together with their pathophysiological roles in ischemic stroke, intracerebral hemorrhage and alzheimer disease in the central nervous system. |
2011-07-14 |
2023-08-12 |
Not clear |
| Alejandro O Sodero, Laura Trovò, Francesca Iannilli, Paul Van Veldhoven, Carlos G Dotti, Mauricio G Marti. Regulation of tyrosine kinase B activity by the Cyp46/cholesterol loss pathway in mature hippocampal neurons: relevance for neuronal survival under stress and in aging. Journal of neurochemistry. vol 116. issue 5. 2011-03-30. PMID:21214568. |
with age, mnemonic, motor and sensorial alterations occur, and it is believed that extra failures in the mechanisms used for memory formation and storage are the cause of neurodegenerative pathologies like alzheimer's disease. |
2011-03-30 |
2023-08-12 |
Not clear |
| R C Klein, B E Mace, S D Moore, P M Sulliva. Progressive loss of synaptic integrity in human apolipoprotein E4 targeted replacement mice and attenuation by apolipoprotein E2. Neuroscience. vol 171. issue 4. 2011-03-10. PMID:20951774. |
our previous work showed that 7 month old human apoe4 targeted replacement (tr) mice displayed significant synaptic deficits in the principal neurons of the lateral amygdala, a region that is critical for memory formation and also one of the primary regions affected in alzheimer's disease, compared to apoe3 tr mice. |
2011-03-10 |
2023-08-12 |
mouse |
| Yitshak I Francis, Mauro Fà, Haider Ashraf, Hong Zhang, Agnieszka Staniszewski, David S Latchman, Ottavio Aranci. Dysregulation of histone acetylation in the APP/PS1 mouse model of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 18. issue 1. 2010-06-04. PMID:19625751. |
the involvement of the epigenetic modulation of memory formation has also been proposed in neuropathological models, although up to now no clear-cut connection has been demonstrated between histone modifications and the etiology of alzheimer's disease (ad). |
2010-06-04 |
2023-08-12 |
mouse |
| Howard B Eichenbau. An animal model for the treatment of Alzheimer's disease: potential for a new direction in therapies that enhance the epigenic mechanisms of memory formation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 4. 2010-04-28. PMID:20145633. |
an animal model for the treatment of alzheimer's disease: potential for a new direction in therapies that enhance the epigenic mechanisms of memory formation. |
2010-04-28 |
2023-08-12 |
Not clear |
| Talib Abbas, Emilie Faivre, Christian Hölsche. Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease. Behavioural brain research. vol 205. issue 1. 2010-01-12. PMID:19573562. |
impairment of synaptic plasticity and memory formation in glp-1 receptor ko mice: interaction between type 2 diabetes and alzheimer's disease. |
2010-01-12 |
2023-08-12 |
mouse |
| Masuo Ohn. Failures to reconsolidate memory in a mouse model of Alzheimer's disease. Neurobiology of learning and memory. vol 92. issue 3. 2009-11-05. PMID:19435612. |
previous studies have demonstrated that the formation of spatial, contextual and trace conditioning memories are impaired in animal models of alzheimer's disease (ad), consistent with the observations that the first sign of cognitive decline in ad includes difficulties in the acquisition of new information or memory formation. |
2009-11-05 |
2023-08-12 |
mouse |
| Kwok-On Lai, Nancy Y I. Recent advances in understanding the roles of Cdk5 in synaptic plasticity. Biochimica et biophysica acta. vol 1792. issue 8. 2009-10-06. PMID:19442718. |
importantly, dysregulation of cdk5 has been linked to alzheimer's disease, which involves perturbations in synaptic functions and memory formation. |
2009-10-06 |
2023-08-12 |
Not clear |
| Bruce Fischl, Allison A Stevens, Niranjini Rajendran, B T Thomas Yeo, Douglas N Greve, Koen Van Leemput, Jonathan R Polimeni, Sita Kakunoori, Randy L Buckner, Jennifer Pacheco, David H Salat, Jennifer Melcher, Matthew P Frosch, Bradley T Hyman, P Ellen Grant, Bruce R Rosen, André J W van der Kouwe, Graham C Wiggins, Lawrence L Wald, Jean C Augustinac. Predicting the location of entorhinal cortex from MRI. NeuroImage. vol 47. issue 1. 2009-08-24. PMID:19376238. |
entorhinal cortex (ec) is a medial temporal lobe area critical to memory formation and spatial navigation that is among the earliest parts of the brain affected by alzheimer's disease (ad). |
2009-08-24 |
2023-08-12 |
Not clear |
| Karl Peter Gies. GSK-3: a key player in neurodegeneration and memory. IUBMB life. vol 61. issue 5. 2009-07-16. PMID:19391164. |
it is emerging that glycogen synthase kinase-3 (gsk-3) is a key signalling molecule that induces neurodegeneration and deficits in memory formation related to alzheimer's disease (ad). |
2009-07-16 |
2023-08-12 |
mouse |